TPO (thyroid peroxidase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: TPO (thyroid peroxidase) Sus scrofa
Analyze
Symbol: TPO
Name: thyroid peroxidase
RGD ID: 13938894
Description: ENCODES a protein that exhibits iodide peroxidase activity; INVOLVED IN thyroid hormone generation; cellular response to nitric oxide (ortholog); response to lipid (ortholog); PARTICIPATES IN thyroid hormone biosynthetic pathway; ASSOCIATED WITH autoimmune disease (ortholog); congenital hypothyroidism (ortholog); Developmental Disabilities (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog); INTERACTS WITH 1,3-benzothiazole-2-thiol; 2,3-dimethoxynaphthalene-1,4-dione; 6-propyl-2-thiouracil
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: thyroid peroxidase (332 AA)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3132,384,583 - 132,408,943 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13132,384,677 - 132,409,750 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23141,795,655 - 141,820,693 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:1497352   PMID:3654642   PMID:3780975   PMID:12387814   PMID:20621020  


Genomics

Comparative Map Data
TPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3132,384,583 - 132,408,943 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13132,384,677 - 132,409,750 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23141,795,655 - 141,820,693 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl21,374,066 - 1,543,711 (+)EnsemblGRCh38hg38GRCh38
GRCh3821,413,288 - 1,543,673 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3721,417,235 - 1,547,445 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3621,396,242 - 1,525,502 (+)NCBINCBI36hg18NCBI36
Build 3421,396,241 - 1,525,502NCBI
Celera21,466,953 - 1,592,423 (+)NCBI
Cytogenetic Map2p25.3NCBI
HuRef21,408,795 - 1,531,941 (+)NCBIHuRef
CHM1_121,409,624 - 1,546,343 (+)NCBICHM1_1
Tpo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391230,104,658 - 30,182,983 (-)NCBIGRCm39mm39
GRCm39 Ensembl1230,104,658 - 30,182,623 (-)Ensembl
GRCm381230,054,659 - 30,132,984 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1230,054,659 - 30,132,624 (-)EnsemblGRCm38mm10GRCm38
MGSCv371230,739,526 - 30,817,474 (-)NCBIGRCm37mm9NCBIm37
MGSCv361230,640,713 - 30,718,661 (-)NCBImm8
Celera1231,518,105 - 31,587,543 (-)NCBICelera
Cytogenetic Map12A2NCBI
cM Map1213.0NCBI
Tpo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2646,698,402 - 46,768,199 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl646,698,414 - 46,768,199 (-)Ensembl
Rnor_6.0649,020,918 - 49,089,855 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl649,021,044 - 49,089,855 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0657,702,091 - 57,770,914 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4647,954,848 - 48,025,740 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1647,957,973 - 48,028,866 (-)NCBI
Celera645,906,515 - 45,971,940 (-)NCBICelera
RH 3.4 Map6299.2RGD
Cytogenetic Map6q16NCBI
Tpo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955487494,746 - 529,416 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955487485,029 - 530,287 (-)NCBIChiLan1.0ChiLan1.0
TPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A1,334,608 - 1,493,308 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A1,335,556 - 1,493,055 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A1,364,083 - 1,491,284 (+)NCBIMhudiblu_PPA_v0panPan3
TPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.117773,790 - 810,044 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl17773,790 - 810,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha17760,899 - 796,526 (+)NCBI
ROS_Cfam_1.017830,903 - 866,744 (+)NCBI
UMICH_Zoey_3.117755,185 - 790,848 (+)NCBI
UNSW_CanFamBas_1.017775,417 - 811,064 (+)NCBI
UU_Cfam_GSD_1.017775,279 - 810,948 (+)NCBI
Tpo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629245,635,285 - 45,680,483 (+)NCBI
SpeTri2.0NW_004936532391,181 - 435,132 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114106,148,214 - 106,255,442 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl14106,146,946 - 106,255,298 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660455,734,964 - 5,848,587 (+)NCBIVero_WHO_p1.0
Tpo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248461,934,084 - 1,962,637 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system nervous system renal system reproductive system
High
Medium
Low 2 1
Below cutoff 1 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000041290   ⟹   ENSSSCP00000057613
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl3132,386,890 - 132,408,943 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000047642   ⟹   ENSSSCP00000036696
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl3132,384,583 - 132,408,943 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000059599   ⟹   ENSSSCP00000049112
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl3132,384,820 - 132,408,943 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000067144   ⟹   ENSSSCP00000074299
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl3132,384,583 - 132,408,943 (-)Ensembl
RefSeq Acc Id: NM_001184752   ⟹   NP_001171681
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.13132,384,820 - 132,408,943 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021085890   ⟹   XP_020941549
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.13132,384,677 - 132,405,560 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021085891   ⟹   XP_020941550
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.13132,384,747 - 132,409,750 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020941549   ⟸   XM_021085890
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020941550   ⟸   XM_021085891
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001171681   ⟸   NM_001184752
- UniProtKB: D6NHN4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000057613   ⟸   ENSSSCT00000041290
RefSeq Acc Id: ENSSSCP00000049112   ⟸   ENSSSCT00000059599
RefSeq Acc Id: ENSSSCP00000036696   ⟸   ENSSSCT00000047642
RefSeq Acc Id: ENSSSCP00000074299   ⟸   ENSSSCT00000067144
Protein Domains
EGF-like   Sushi


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000033193 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070018015 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000036696 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000049112 UniProtKB/TrEMBL
  ENSSSCP00000057613 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000074299 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070029742 UniProtKB/TrEMBL
  ENSSSCP00070029754 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000041290 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000047642 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000059599 UniProtKB/TrEMBL
  ENSSSCT00000067144 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070035586 UniProtKB/TrEMBL
  ENSSSCT00070035598 UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:445522 UniProtKB/TrEMBL
NCBI Gene TPO ENTREZGENE
PANTHER PTHR11475:SF60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ANPEROXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEROXIDASE_1 UniProtKB/Swiss-Prot
  PEROXIDASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286ZYA2_PIG UniProtKB/TrEMBL
  A0A287AZ10_PIG UniProtKB/TrEMBL
  A0A287BMG7_PIG UniProtKB/TrEMBL
  A0A4X1UKH9_PIG UniProtKB/TrEMBL
  A0A4X1UKI9_PIG UniProtKB/TrEMBL
  A0A5G2RAF1_PIG UniProtKB/TrEMBL
  D6NHN4 ENTREZGENE, UniProtKB/TrEMBL
  D6NHN5_PIG UniProtKB/TrEMBL
  P09933 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:94341 ENTREZGENE