Polg (DNA polymerase gamma, catalytic subunit) - Rat Genome Database
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Gene: Polg (DNA polymerase gamma, catalytic subunit) Rattus norvegicus
Analyze
Symbol: Polg
Name: DNA polymerase gamma, catalytic subunit
RGD ID: 620057
Description: Exhibits DNA-directed DNA polymerase activity. Involved in several processes, including cellular response to glucose stimulus; response to gamma radiation; and response to hyperoxia. Localizes to gamma DNA polymerase complex and terminal bouton. Used to study Alpers-Huttenlocher syndrome and hepatocellular carcinoma. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including mitochondrial DNA depletion syndrome (multiple); mitochondrial myopathy (multiple); neurodegenerative disease (multiple); ovarian disease (multiple); and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. Orthologous to human POLG (DNA polymerase gamma, catalytic subunit); INTERACTS WITH (+)-pilocarpine; 3,3',4,4',5-pentachlorobiphenyl; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DNA polymerase gamma; DNA polymerase subunit gamma-1; DNA-directed DNA polymerase gamma; mitochondrial DNA polymerase catalytic subunit; polG-alpha; polymerase (DNA directed), gamma; polymerase (DNA) gamma, catalytic subunit
Orthologs:
Homo sapiens (human) : POLG (DNA polymerase gamma, catalytic subunit)  HGNC  Alliance
Mus musculus (house mouse) : Polg (polymerase (DNA directed), gamma)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Polg (DNA polymerase gamma, catalytic subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : POLG (DNA polymerase gamma, catalytic subunit)
Canis lupus familiaris (dog) : POLG (DNA polymerase gamma, catalytic subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Polg (DNA polymerase gamma, catalytic subunit)
Sus scrofa (pig) : POLG (DNA polymerase gamma, catalytic subunit)
Chlorocebus sabaeus (African green monkey) : POLG (DNA polymerase gamma, catalytic subunit)
Heterocephalus glaber (naked mole-rat) : Polg (DNA polymerase gamma, catalytic subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01141,172,117 - 141,188,893 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,172,531 - 141,188,031 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,133,892 - 142,150,597 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,197,075 - 135,212,178 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11135,275,417 - 135,290,521 (-)NCBI
Celera1125,446,563 - 125,461,666 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Alpers-Huttenlocher syndrome  (IAGP,ISO)
Ataxia  (ISO)
autistic disorder  (ISO)
autosomal dominant progressive external ophthalmoplegia 1  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2N  (ISO)
autosomal recessive progressive external ophthalmoplegia 1  (ISO)
benign neonatal seizures  (ISO)
bipolar disorder  (ISS)
Camptocormia  (ISO)
cardiomyopathy  (ISO)
cerebellar ataxia  (ISO)
CEREBELLAR ATAXIA INFANTILE WITH PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA  (ISO)
Chemical and Drug Induced Liver Injury  (IAGP,ISO)
chronic progressive external ophthalmoplegia  (ISO)
Developmental Disabilities  (ISO)
epilepsy  (ISO)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Fanconi anemia  (ISO)
Fanconi anemia complementation group I  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (IAGP)
intellectual disability  (ISO)
Lennox-Gastaut syndrome  (ISO)
male infertility  (ISO)
microcephaly  (ISO)
mitochondrial DNA depletion syndrome  (ISO)
mitochondrial DNA depletion syndrome 1  (ISO)
mitochondrial DNA depletion syndrome 4B  (ISO)
mitochondrial DNA depletion syndrome 7  (ISO)
mitochondrial DNA depletion syndrome 8A  (ISO)
mitochondrial DNA depletion syndrome 8b  (ISO)
Mitochondrial DNA Depletion Syndrome, MNGIE Type  (ISO)
mitochondrial encephalomyopathy  (ISO)
mitochondrial metabolism disease  (ISO)
mood disorder  (ISO,ISS)
multiple sclerosis  (ISO)
myelodysplastic syndrome  (ISS)
neuromuscular disease  (ISO)
Parkinson's disease  (ISO)
Parkinsonian Disorders  (ISO)
Plagiocephaly  (ISO)
polyneuropathy  (ISO)
Premature Aging  (ISO)
premature menopause  (ISO)
premature ovarian failure  (ISO)
Presbycusis  (ISO)
primary progressive multiple sclerosis  (ISO)
Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Recessive  (ISO)
sensory ataxic neuropathy, dysarthria, and ophthalmoparesis  (ISO)
Spinocerebellar Ataxia with Epilepsy  (ISO)
Spinocerebellar Ataxias  (ISO)
status epilepticus  (IEP)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Chan SS, etal., DNA Repair (Amst). 2005 Dec 8;4(12):1381-9. Epub 2005 Sep 21.
2. Cortina MS, etal., Exp Eye Res. 2005 Dec;81(6):742-50. Epub 2005 Jun 24.
3. Crawley BK and Keithley EM, Hear Res. 2011 Oct;280(1-2):201-8. doi: 10.1016/j.heares.2011.05.015. Epub 2011 Jun 1.
4. Davidzon G, etal., Ann Neurol. 2006 May;59(5):859-62.
5. Dolhun R, etal., BMC Neurol. 2013 Jul 18;13:92. doi: 10.1186/1471-2377-13-92.
6. Echaniz-Laguna A, etal., Arch Neurol. 2010 Sep;67(9):1140-3. doi: 10.1001/archneurol.2010.219.
7. Engelsen BA, etal., Brain. 2008 Mar;131(Pt 3):818-28. doi: 10.1093/brain/awn007. Epub 2008 Jan 30.
8. Ferrari G, etal., Brain. 2005 Apr;128(Pt 4):723-31. Epub 2005 Feb 2.
9. Filosto M, etal., Arch Neurol. 2003 Sep;60(9):1279-84.
10. Gati I, etal., Acta Myol. 2011 Dec;30(3):188-90.
11. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. GOA data from the GO Consortium
13. Gonzalez-Vioque E, etal., Arch Neurol. 2006 Jan;63(1):107-11.
14. Hudson G, etal., Arch Neurol. 2007 Apr;64(4):553-7.
15. Hynynen J, etal., Epilepsia. 2018 Nov;59(11):2125-2136. doi: 10.1111/epi.14568. Epub 2018 Sep 26.
16. Hynynen J, etal., Liver Transpl. 2014 Nov;20(11):1402-12. doi: 10.1002/lt.23965. Epub 2014 Oct 3.
17. Jarrett SG, etal., Neurobiol Dis. 2008 Apr;30(1):130-8. Epub 2008 Jan 5.
18. Jinno S, etal., Mech Ageing Dev. 1995 Nov 24;85(2-3):95-107.
19. Kaneko T, etal., Mech Ageing Dev. 2002 Sep;123(11):1521-8.
20. Kasahara T, etal., Mol Psychiatry. 2006 Jun;11(6):577-93, 523.
21. Kollberg G, etal., J Neuropathol Exp Neurol. 2006 Aug;65(8):758-68.
22. Kurt B, etal., Arch Neurol. 2010 Feb;67(2):239-44. doi: 10.1001/archneurol.2009.332.
23. Lestienne P Biochem Biophys Res Commun 1987 Aug 14;146(3):1146-53.
24. Lewis W, etal., Lab Invest. 2007 Apr;87(4):326-35. Epub 2006 Feb 19.
25. Long X, etal., Bull Cancer. 2017 Jun;104(6):500-507. doi: 10.1016/j.bulcan.2017.02.005. Epub 2017 Apr 28.
26. Luoma P, etal., Lancet. 2004 Sep 4-10;364(9437):875-82.
27. MGD data from the GO Consortium
28. Milone M, etal., Neuromuscul Disord. 2008 Aug;18(8):626-32. doi: 10.1016/j.nmd.2008.05.009. Epub 2008 Jun 27.
29. NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. Ogihara M, etal., Exp Mol Pathol 2002 Dec;73(3):234-41.
31. OMIM Disease Annotation Pipeline
32. Pagnamenta AT, etal., Hum Reprod. 2006 Oct;21(10):2467-73. Epub 2006 Apr 4.
33. RGD automated data pipeline
34. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. RGD automated import pipeline for gene-chemical interactions
36. Ropp PA and Copeland WC, Genomics 1996 Sep 15;36(3):449-58.
37. Schicks J, etal., Mov Disord. 2010 Nov 15;25(15):2678-82. doi: 10.1002/mds.23286.
38. Sofou K, etal., Eur J Paediatr Neurol. 2012 Jul;16(4):379-89. doi: 10.1016/j.ejpn.2011.12.006. Epub 2012 Jan 10.
39. Tewari S, etal., Antioxid Redox Signal. 2012 Aug 1;17(3):492-504. doi: 10.1089/ars.2011.4333. Epub 2012 Feb 17.
40. Tewari S, etal., Invest Ophthalmol Vis Sci. 2012 Jul 24;53(8):4881-8. doi: 10.1167/iovs.12-9732.
41. Trifunovic A, etal., Nature. 2004 May 27;429(6990):417-23.
42. Van Goethem G, etal., Eur J Hum Genet. 2003 Jul;11(7):547-9.
43. Van Goethem G, etal., Nat Genet 2001 Jul;28(3):211-2.
44. Van Goethem G, etal., Neuromuscul Disord. 2003 Feb;13(2):133-42.
45. Winterthun S, etal., Neurology. 2005 Apr 12;64(7):1204-8.
Additional References at PubMed
PMID:10608893   PMID:12865426   PMID:14651853   PMID:14739292   PMID:15167897   PMID:15177179   PMID:15888483   PMID:18063578   PMID:18614015   PMID:19837034   PMID:19858216   PMID:20808729  
PMID:23376485   PMID:25378300   PMID:26123486   PMID:26446790   PMID:26554610   PMID:28430993  


Genomics

Comparative Map Data
Polg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01141,172,117 - 141,188,893 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,172,531 - 141,188,031 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,133,892 - 142,150,597 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,197,075 - 135,212,178 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11135,275,417 - 135,290,521 (-)NCBI
Celera1125,446,563 - 125,461,666 (-)NCBICelera
Cytogenetic Map1q31NCBI
POLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1589,305,198 - 89,334,861 (-)EnsemblGRCh38hg38GRCh38
GRCh381589,316,320 - 89,334,824 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371589,859,536 - 89,878,026 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361587,660,554 - 87,679,030 (-)NCBINCBI36hg18NCBI36
Build 341587,660,552 - 87,679,030NCBI
Celera1566,260,895 - 66,279,201 (-)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1565,971,419 - 65,989,730 (-)NCBIHuRef
CHM1_11589,700,576 - 89,719,066 (-)NCBICHM1_1
Polg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,095,979 - 79,117,659 (-)NCBI
GRCm38779,446,231 - 79,467,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,446,231 - 79,466,362 (-)EnsemblGRCm38mm10GRCm38
MGSCv37786,594,269 - 86,611,159 (-)NCBIGRCm37mm9NCBIm37
MGSCv36779,322,896 - 79,339,786 (-)NCBImm8
Celera776,851,749 - 76,868,637 (-)NCBICelera
Cytogenetic Map7D2NCBI
Polg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,773,473 - 15,788,651 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541615,773,005 - 15,788,736 (+)NCBIChiLan1.0ChiLan1.0
POLG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11587,214,451 - 87,234,739 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1587,214,451 - 87,234,739 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01568,008,214 - 68,028,241 (-)NCBIMhudiblu_PPA_v0panPan3
POLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl352,357,068 - 52,421,544 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1352,357,062 - 52,373,768 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Polg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648315,178,947 - 15,196,277 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl754,889,153 - 54,906,856 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1754,889,150 - 54,907,167 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2759,864,727 - 59,882,439 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POLG
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl297,863,277 - 7,882,068 (-)Ensembl
ChlSab1.1297,864,319 - 7,881,577 (-)NCBI
Polg
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476816,493,123 - 16,509,747 (-)NCBI

Position Markers
MARC_7859-7860:996688105:3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01141,172,760 - 141,173,346NCBIRnor6.0
Rnor_5.01142,134,535 - 142,135,121UniSTSRnor5.0
RGSC_v3.41135,197,105 - 135,197,691UniSTSRGSC3.4
Celera1125,446,593 - 125,447,179UniSTS
Cytogenetic Map1q31UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)149147799156446783Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)158354072161711996Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)190804143161321256Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)194201400184846632Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)194201400197187904Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194364073153076991Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)195304961156446783Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)199983293188289386Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)199983293198656062Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)199983293216213510Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)199983293216325819Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100131562236763528Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100354344145354344Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1106002252202571904Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1108057233167517487Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1108417193153417193Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1108417193153417193Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1108986301161784422Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1108986301219232156Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1108986301219232156Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1108986301238830534Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1109634374154634374Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1110620749155620749Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1110620749155620749Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1111446783156446783Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1111446783156446783Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1113593576158593576Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1122614824201146953Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1122614824262664716Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1124090312169090312Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1124603592188289386Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1125875758262433692Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1126240667217054291Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1129208943174208943Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130779148198585664Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1130779148199254774Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1130779148199254774Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1130779148199254774Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130779320219238476Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130917121152871103Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131334152176334152Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131334152176334152Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978178076978Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978178076978Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978184188922Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1133946489178946489Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1134089429179089429Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1137787261236763528Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1137787261236763528Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1139523928170246858Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:102
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000044567
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 57 41 19 41 7 10 74 35 41 11 7
Low 9 1 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000044567   ⟹   ENSRNOP00000047900
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1141,172,531 - 141,188,031 (-)Ensembl
RefSeq Acc Id: NM_053528   ⟹   NP_445980
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01141,172,730 - 141,187,833 (-)NCBI
Rnor_5.01142,133,892 - 142,150,597 (-)NCBI
RGSC_v3.41135,197,075 - 135,212,178 (-)RGD
Celera1125,446,563 - 125,461,666 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229410   ⟹   XP_006229472
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01141,172,117 - 141,188,891 (-)NCBI
Rnor_5.01142,133,892 - 142,150,597 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759561   ⟹   XP_008757783
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01141,172,117 - 141,188,893 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_445980   ⟸   NM_053528
- UniProtKB: Q9QYV8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006229472   ⟸   XM_006229410
- Peptide Label: isoform X2
- UniProtKB: Q9QYV8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008757783   ⟸   XM_008759561
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000047900   ⟸   ENSRNOT00000044567

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620057 AgrOrtholog
Ensembl Genes ENSRNOG00000032293 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000047900 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000044567 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro DNA-dir_DNA_pol_A_CS UniProtKB/Swiss-Prot
  DNA-dir_DNA_pol_A_mt UniProtKB/Swiss-Prot
  DNA-dir_DNA_pol_A_palm_dom UniProtKB/Swiss-Prot
  DNA/RNA_pol_sf UniProtKB/Swiss-Prot
  DNApol_Exo UniProtKB/Swiss-Prot
  RNaseH-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:85472 UniProtKB/Swiss-Prot
NCBI Gene 85472 ENTREZGENE
PANTHER PTHR10267 UniProtKB/Swiss-Prot
Pfam DNA_pol_A UniProtKB/Swiss-Prot
  DNApol_Exo UniProtKB/Swiss-Prot
PhenoGen Polg PhenoGen
PIRSF DNA_pol_mt UniProtKB/Swiss-Prot
PRINTS DNAPOLG UniProtKB/Swiss-Prot
PROSITE DNA_POLYMERASE_A UniProtKB/Swiss-Prot
SMART POLAc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53098 UniProtKB/Swiss-Prot
  SSF56672 UniProtKB/Swiss-Prot
UniGene Rn.19327 ENTREZGENE
UniProt DPOG1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9QYV7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-21 Polg  DNA polymerase gamma, catalytic subunit  Polg  polymerase (DNA) gamma, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-09 Polg  polymerase (DNA) gamma, catalytic subunit  Polg  polymerase (DNA directed), gamma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Polg  polymerase (DNA directed), gamma    DNA polymerase gamma  Name updated 1299863 APPROVED
2002-08-07 Polg  DNA polymerase gamma      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression activity present in heart 724601
gene_regulation activity induced by adriamycin treatment 724601