Polg (DNA polymerase gamma, catalytic subunit) - Rat Genome Database

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Gene: Polg (DNA polymerase gamma, catalytic subunit) Rattus norvegicus
Analyze
Symbol: Polg
Name: DNA polymerase gamma, catalytic subunit
RGD ID: 620057
Description: Enables DNA-directed DNA polymerase activity. Involved in several processes, including cellular response to glucose stimulus; response to gamma radiation; and response to hyperoxia. Located in terminal bouton. Part of gamma DNA polymerase complex. Used to study Alpers-Huttenlocher syndrome and hepatocellular carcinoma. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including mitochondrial DNA depletion syndrome (multiple); mitochondrial myopathy (multiple); neurodegenerative disease (multiple); ovarian disease (multiple); and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. Orthologous to human POLG (DNA polymerase gamma, catalytic subunit); INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3'-5' exodeoxyribonuclease; 5'-deoxyribose-phosphate lyase; DNA polymerase gamma; DNA polymerase subunit gamma-1; DNA-directed DNA polymerase gamma; mitochondrial DNA polymerase catalytic subunit; polG-alpha; polymerase (DNA directed), gamma; polymerase (DNA) gamma, catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,792,119 - 142,808,933 (-)NCBIGRCr8
mRatBN7.21133,382,764 - 133,399,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,382,766 - 133,398,567 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1141,292,744 - 141,307,834 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01148,462,157 - 148,477,247 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,379,870 - 141,394,960 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,172,117 - 141,188,893 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,172,531 - 141,188,031 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,133,892 - 142,150,597 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,197,075 - 135,212,178 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11135,275,417 - 135,290,521 (-)NCBI
Celera1125,446,563 - 125,461,666 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Alpers-Huttenlocher syndrome  (IAGP,ISO)
Ataxia  (ISO)
autistic disorder  (ISO)
autosomal dominant progressive external ophthalmoplegia 1  (ISO)
autosomal recessive progressive external ophthalmoplegia 1  (ISO)
benign neonatal seizures  (ISO)
bipolar disorder  (ISS)
Bloom syndrome  (ISO)
Camptocormia  (ISO)
cardiomyopathy  (ISO)
cerebellar ataxia  (ISO)
CEREBELLAR ATAXIA INFANTILE WITH PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA  (ISO)
Charcot-Marie-Tooth disease axonal type 2U  (ISO)
Chemical and Drug Induced Liver Injury  (IAGP,ISO)
Childhood Myocerebrohepatopathy Spectrum  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
colorectal cancer  (ISO)
D-2-hydroxyglutaric aciduria 2  (ISO)
Developmental Disabilities  (ISO)
dilated cardiomyopathy 1B  (ISO)
epilepsy  (ISO)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Fanconi anemia  (ISO)
Fanconi anemia complementation group I  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (IAGP)
hereditary spastic paraplegia  (ISO)
hypertrophic cardiomyopathy  (ISO)
intellectual disability  (ISO)
Lennox-Gastaut syndrome  (ISO)
Loeys-Dietz syndrome 2  (ISO)
male infertility  (ISO)
MELAS syndrome  (ISO)
microcephaly  (ISO)
mitochondrial DNA depletion syndrome  (ISO)
mitochondrial DNA depletion syndrome 1  (ISO)
mitochondrial DNA depletion syndrome 4B  (ISO)
mitochondrial DNA depletion syndrome 7  (ISO)
mitochondrial DNA depletion syndrome 8A  (ISO)
Mitochondrial DNA Depletion Syndrome, MNGIE Type  (ISO)
mitochondrial encephalomyopathy  (ISO)
mitochondrial metabolism disease  (ISO)
mood disorder  (ISO,ISS)
multiple sclerosis  (ISO)
myelodysplastic syndrome  (ISS)
Nervous System Malformations  (ISO)
Parkinson's disease  (ISO)
Parkinson's disease 20  (ISO)
Parkinsonism  (ISO)
Plagiocephaly  (ISO)
polyneuropathy  (ISO)
Premature Aging  (ISO)
premature menopause  (ISO)
Presbycusis  (ISO)
Primary Ovarian Failure  (ISO)
primary ovarian insufficiency  (ISO)
primary progressive multiple sclerosis  (ISO)
Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Recessive  (ISO)
progressive myoclonus epilepsy 5  (ISO)
sensory ataxic neuropathy, dysarthria, and ophthalmoparesis  (ISO)
Spinocerebellar Ataxia with Epilepsy  (ISO)
Spinocerebellar Ataxias  (ISO)
status epilepticus  (IEP)
vascular dementia  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetohydrazide  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
aspartame  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium dihydroxide  (ISO)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
chloramphenicol  (ISO)
clofibric acid  (EXP)
crocidolite asbestos  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
dimethylarsinic acid  (ISO)
doxorubicin  (EXP,ISO)
favipiravir  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
hydrazine  (ISO)
indole-3-methanol  (EXP)
ketamine  (EXP)
leflunomide  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenethyl caffeate  (EXP)
pirinixic acid  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP,ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mono-allelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome. Chan SS, etal., DNA Repair (Amst). 2005 Dec 8;4(12):1381-9. Epub 2005 Sep 21.
2. Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondria. Cortina MS, etal., Exp Eye Res. 2005 Dec;81(6):742-50. Epub 2005 Jun 24.
3. Effects of mitochondrial mutations on hearing and cochlear pathology with age. Crawley BK and Keithley EM, Hear Res. 2011 Oct;280(1-2):201-8. doi: 10.1016/j.heares.2011.05.015. Epub 2011 Jun 1.
4. Early-onset familial parkinsonism due to POLG mutations. Davidzon G, etal., Ann Neurol. 2006 May;59(5):859-62.
5. Novel polymerase gamma (POLG1) gene mutation in the linker domain associated with parkinsonism. Dolhun R, etal., BMC Neurol. 2013 Jul 18;13:92. doi: 10.1186/1471-2377-13-92.
6. POLG1 variations presenting as multiple sclerosis. Echaniz-Laguna A, etal., Arch Neurol. 2010 Sep;67(9):1140-3. doi: 10.1001/archneurol.2010.219.
7. POLG1 mutations cause a syndromic epilepsy with occipital lobe predilection. Engelsen BA, etal., Brain. 2008 Mar;131(Pt 3):818-28. doi: 10.1093/brain/awn007. Epub 2008 Jan 30.
8. Infantile hepatocerebral syndromes associated with mutations in the mitochondrial DNA polymerase-gammaA. Ferrari G, etal., Brain. 2005 Apr;128(Pt 4):723-31. Epub 2005 Feb 2.
9. Clinical and genetic heterogeneity in progressive external ophthalmoplegia due to mutations in polymerase gamma. Filosto M, etal., Arch Neurol. 2003 Sep;60(9):1279-84.
10. Sensory ataxic neuropathy with dysarthria/dysphagia and ophthalmoplegia (SANDO). Two case reports. Gati I, etal., Acta Myol. 2011 Dec;30(3):188-90.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Association of novel POLG mutations and multiple mitochondrial DNA deletions with variable clinical phenotypes in a Spanish population. Gonzalez-Vioque E, etal., Arch Neurol. 2006 Jan;63(1):107-11.
14. Mutation of the linker region of the polymerase gamma-1 (POLG1) gene associated with progressive external ophthalmoplegia and Parkinsonism. Hudson G, etal., Arch Neurol. 2007 Apr;64(4):553-7.
15. Variants p.Q1236H and p.E1143G in mitochondrial DNA polymerase gamma POLG1 are not associated with increased risk for valproate-induced hepatotoxicity or pancreatic toxicity: A retrospective cohort study of patients with epilepsy. Hynynen J, etal., Epilepsia. 2018 Nov;59(11):2125-2136. doi: 10.1111/epi.14568. Epub 2018 Sep 26.
16. Acute liver failure after valproate exposure in patients with POLG1 mutations and the prognosis after liver transplantation. Hynynen J, etal., Liver Transpl. 2014 Nov;20(11):1402-12. doi: 10.1002/lt.23965. Epub 2014 Oct 3.
17. Mitochondrial DNA damage and impaired base excision repair during epileptogenesis. Jarrett SG, etal., Neurobiol Dis. 2008 Apr;30(1):130-8. Epub 2008 Jan 5.
18. Induction of DNA polymerase beta and gamma in the lungs of age-related oxygen tolerant rats. Jinno S, etal., Mech Ageing Dev. 1995 Nov 24;85(2-3):95-107.
19. Age-related changes in the induction of DNA polymerases in rat liver by gamma-ray irradiation. Kaneko T, etal., Mech Ageing Dev. 2002 Sep;123(11):1521-8.
20. Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes. Kasahara T, etal., Mol Psychiatry. 2006 Jun;11(6):577-93, 523.
21. POLG1 mutations associated with progressive encephalopathy in childhood. Kollberg G, etal., J Neuropathol Exp Neurol. 2006 Aug;65(8):758-68.
22. A novel POLG gene mutation in 4 children with Alpers-like hepatocerebral syndromes. Kurt B, etal., Arch Neurol. 2010 Feb;67(2):239-44. doi: 10.1001/archneurol.2009.332.
23. Evidence for a direct role of the DNA polymerase gamma in the replication of the human mitochondrial DNA in vitro. Lestienne P Biochem Biophys Res Commun 1987 Aug 14;146(3):1146-53.
24. Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma. Lewis W, etal., Lab Invest. 2007 Apr;87(4):326-35. Epub 2006 Feb 19.
25. Polymorphisms in POLG were associated with the prognosis and mtDNA content in hepatocellular carcinoma patients. Long X, etal., Bull Cancer. 2017 Jun;104(6):500-507. doi: 10.1016/j.bulcan.2017.02.005. Epub 2017 Apr 28.
26. Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study. Luoma P, etal., Lancet. 2004 Sep 4-10;364(9437):875-82.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Sensory ataxic neuropathy with ophthalmoparesis caused by POLG mutations. Milone M, etal., Neuromuscul Disord. 2008 Aug;18(8):626-32. doi: 10.1016/j.nmd.2008.05.009. Epub 2008 Jun 27.
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. Increase in DNA polymerase gamma in the hearts of adriamycin-administered rats. Ogihara M, etal., Exp Mol Pathol 2002 Dec;73(3):234-41.
31. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
32. Dominant inheritance of premature ovarian failure associated with mutant mitochondrial DNA polymerase gamma. Pagnamenta AT, etal., Hum Reprod. 2006 Oct;21(10):2467-73. Epub 2006 Apr 4.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma. Ropp PA and Copeland WC, Genomics 1996 Sep 15;36(3):449-58.
37. POLG, but not PEO1, is a frequent cause of cerebellar ataxia in Central Europe. Schicks J, etal., Mov Disord. 2010 Nov 15;25(15):2678-82. doi: 10.1002/mds.23286.
38. Phenotypic and genotypic variability in Alpers syndrome. Sofou K, etal., Eur J Paediatr Neurol. 2012 Jul;16(4):379-89. doi: 10.1016/j.ejpn.2011.12.006. Epub 2012 Jan 10.
39. Damaged mitochondrial DNA replication system and the development of diabetic retinopathy. Tewari S, etal., Antioxid Redox Signal. 2012 Aug 1;17(3):492-504. doi: 10.1089/ars.2011.4333. Epub 2012 Feb 17.
40. Mitochondria DNA replication and DNA methylation in the metabolic memory associated with continued progression of diabetic retinopathy. Tewari S, etal., Invest Ophthalmol Vis Sci. 2012 Jul 24;53(8):4881-8. doi: 10.1167/iovs.12-9732.
41. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Trifunovic A, etal., Nature. 2004 May 27;429(6990):417-23.
42. Novel POLG mutations in progressive external ophthalmoplegia mimicking mitochondrial neurogastrointestinal encephalomyopathy. Van Goethem G, etal., Eur J Hum Genet. 2003 Jul;11(7):547-9.
43. Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions. Van Goethem G, etal., Nat Genet 2001 Jul;28(3):211-2.
44. Recessive POLG mutations presenting with sensory and ataxic neuropathy in compound heterozygote patients with progressive external ophthalmoplegia. Van Goethem G, etal., Neuromuscul Disord. 2003 Feb;13(2):133-42.
45. Autosomal recessive mitochondrial ataxic syndrome due to mitochondrial polymerase gamma mutations. Winterthun S, etal., Neurology. 2005 Apr 12;64(7):1204-8.
Additional References at PubMed
PMID:10608893   PMID:12865426   PMID:14651853   PMID:14739292   PMID:15167897   PMID:15177179   PMID:15888483   PMID:18063578   PMID:18614015   PMID:19837034   PMID:19858216   PMID:20808729  
PMID:23376485   PMID:25378300   PMID:26123486   PMID:26446790   PMID:26554610   PMID:28430993   PMID:32958672  


Genomics

Comparative Map Data
Polg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,792,119 - 142,808,933 (-)NCBIGRCr8
mRatBN7.21133,382,764 - 133,399,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,382,766 - 133,398,567 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1141,292,744 - 141,307,834 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01148,462,157 - 148,477,247 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,379,870 - 141,394,960 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,172,117 - 141,188,893 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,172,531 - 141,188,031 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,133,892 - 142,150,597 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,197,075 - 135,212,178 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11135,275,417 - 135,290,521 (-)NCBI
Celera1125,446,563 - 125,461,666 (-)NCBICelera
Cytogenetic Map1q31NCBI
POLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381589,316,320 - 89,334,824 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1589,305,198 - 89,334,861 (-)EnsemblGRCh38hg38GRCh38
GRCh371589,859,551 - 89,878,055 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361587,660,554 - 87,679,030 (-)NCBINCBI36Build 36hg18NCBI36
Build 341587,660,552 - 87,679,030NCBI
Celera1566,260,895 - 66,279,201 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1565,971,419 - 65,989,730 (-)NCBIHuRef
CHM1_11589,700,576 - 89,719,066 (-)NCBICHM1_1
T2T-CHM13v2.01587,071,147 - 87,089,647 (-)NCBIT2T-CHM13v2.0
Polg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,095,979 - 79,117,659 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,095,979 - 79,116,110 (-)EnsemblGRCm39 Ensembl
GRCm38779,446,231 - 79,467,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,446,231 - 79,466,362 (-)EnsemblGRCm38mm10GRCm38
MGSCv37786,594,269 - 86,611,159 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36779,322,896 - 79,339,786 (-)NCBIMGSCv36mm8
Celera776,851,749 - 76,868,637 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.04NCBI
Polg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,773,473 - 15,788,651 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541615,773,005 - 15,788,736 (+)NCBIChiLan1.0ChiLan1.0
POLG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21678,864,098 - 78,883,228 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11582,568,484 - 82,587,617 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01568,008,214 - 68,028,241 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11587,214,451 - 87,234,739 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1587,214,451 - 87,234,739 (-)Ensemblpanpan1.1panPan2
POLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,357,062 - 52,373,768 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl352,357,068 - 52,421,544 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha354,991,836 - 55,008,948 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0352,774,064 - 52,791,169 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl352,774,083 - 52,790,068 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1352,296,790 - 52,313,882 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0352,507,050 - 52,523,743 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0352,846,762 - 52,863,883 (-)NCBIUU_Cfam_GSD_1.0
Polg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640131,138,186 - 131,155,546 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,179,342 - 15,195,258 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,178,947 - 15,196,277 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl754,889,157 - 54,906,844 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1754,889,150 - 54,907,167 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2759,864,727 - 59,882,439 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POLG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1297,864,319 - 7,881,577 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl297,863,277 - 7,882,068 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605938,932,949 - 38,951,612 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Polg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476816,491,555 - 16,509,900 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476816,493,123 - 16,509,747 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Polg
56 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:102
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000044567
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat

Markers in Region
MARC_7859-7860:996688105:3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21133,383,406 - 133,383,993 (+)MAPPERmRatBN7.2
Rnor_6.01141,172,760 - 141,173,346NCBIRnor6.0
Rnor_5.01142,134,535 - 142,135,121UniSTSRnor5.0
RGSC_v3.41135,197,105 - 135,197,691UniSTSRGSC3.4
Celera1125,446,593 - 125,447,179UniSTS
Cytogenetic Map1q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000044567   ⟹   ENSRNOP00000047900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1133,382,766 - 133,398,567 (-)Ensembl
Rnor_6.0 Ensembl1141,172,531 - 141,188,031 (-)Ensembl
RefSeq Acc Id: NM_053528   ⟹   NP_445980
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,792,119 - 142,808,838 (-)NCBI
mRatBN7.21133,382,764 - 133,399,483 (-)NCBI
Rnor_6.01141,172,730 - 141,187,833 (-)NCBI
Rnor_5.01142,133,892 - 142,150,597 (-)NCBI
RGSC_v3.41135,197,075 - 135,212,178 (-)RGD
Celera1125,446,563 - 125,461,666 (-)RGD
Sequence:
RefSeq Acc Id: XM_008759561   ⟹   XP_008757783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,792,119 - 142,808,928 (-)NCBI
mRatBN7.21133,382,764 - 133,399,568 (-)NCBI
Rnor_6.01141,172,117 - 141,188,893 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092948   ⟹   XP_038948876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,792,119 - 142,808,933 (-)NCBI
mRatBN7.21133,382,764 - 133,399,571 (-)NCBI
RefSeq Acc Id: XM_063275928   ⟹   XP_063131998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,792,119 - 142,808,728 (-)NCBI
RefSeq Acc Id: XM_063275929   ⟹   XP_063131999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,792,119 - 142,808,924 (-)NCBI
RefSeq Acc Id: XM_063275941   ⟹   XP_063132011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,792,119 - 142,808,928 (-)NCBI
RefSeq Acc Id: NP_445980   ⟸   NM_053528
- UniProtKB: Q9QYV8 (UniProtKB/Swiss-Prot),   Q9QYV7 (UniProtKB/Swiss-Prot),   A6JC54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757783   ⟸   XM_008759561
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QQ69 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047900   ⟸   ENSRNOT00000044567
RefSeq Acc Id: XP_038948876   ⟸   XM_039092948
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132011   ⟸   XM_063275941
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063131999   ⟸   XM_063275929
- Peptide Label: isoform X2
- UniProtKB: Q9QYV8 (UniProtKB/Swiss-Prot),   Q9QYV7 (UniProtKB/Swiss-Prot),   A6JC54 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131998   ⟸   XM_063275928
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QQ69 (UniProtKB/TrEMBL)
Protein Domains
DNA mitochondrial polymerase exonuclease   DNA-directed DNA polymerase family A palm

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYV8-F1-model_v2 AlphaFold Q9QYV8 1-1216 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620057 AgrOrtholog
BioCyc Gene G2FUF-58806 BioCyc
Ensembl Genes ENSRNOG00000032293 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044567.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.3960 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5' to 3' exonuclease, C-terminal subdomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DNA-dir_DNA_pol_A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-dir_DNA_pol_A_mt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-dir_DNA_pol_A_palm_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA/RNA_pol_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNApol_Exo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLG_palm_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85472 UniProtKB/Swiss-Prot
NCBI Gene 85472 ENTREZGENE
PANTHER DNA POLYMERASE SUBUNIT GAMMA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10267 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DNApol_Exo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Polg PhenoGen
PIRSF DNA_pol_mt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS DNAPOLG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DNA_POLYMERASE_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032293 RatGTEx
SMART POLAc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53098 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56672 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QQ69 ENTREZGENE, UniProtKB/TrEMBL
  A6JC52_RAT UniProtKB/TrEMBL
  A6JC54 ENTREZGENE, UniProtKB/TrEMBL
  DPOG1_RAT UniProtKB/Swiss-Prot
  Q9QYV7 ENTREZGENE
  Q9QYV8 ENTREZGENE
UniProt Secondary Q9QYV7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-21 Polg  DNA polymerase gamma, catalytic subunit  Polg  polymerase (DNA) gamma, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-09 Polg  polymerase (DNA) gamma, catalytic subunit  Polg  polymerase (DNA directed), gamma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Polg  polymerase (DNA directed), gamma    DNA polymerase gamma  Name updated 1299863 APPROVED
2002-08-07 Polg  DNA polymerase gamma      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression activity present in heart 724601
gene_regulation activity induced by adriamycin treatment 724601