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Gene: Mmp8 (matrix metallopeptidase 8) Rattus norvegicus
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Symbol: Mmp8
Name: matrix metallopeptidase 8
Description: Exhibits calcium ion binding activity; metallopeptidase activity; and zinc ion binding activity. Involved in several processes, including positive regulation of neuroinflammatory response; positive regulation of nitric oxide biosynthetic process; and positive regulation of tumor necrosis factor secretion. Localizes to the extracellular space. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in breast cancer and carotid artery disease. Orthologous to human MMP8 (matrix metallopeptidase 8); INTERACTS WITH 17alpha-ethynylestradiol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: matrix metalloproteinase-8; MMP-8; neutrophil collagenase; neutrophil collagenease
Orthologs:
Homo sapiens (human) : MMP8 (matrix metallopeptidase 8)  HGNC  Alliance
Mus musculus (house mouse) : Mmp8 (matrix metallopeptidase 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mmp8 (matrix metallopeptidase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : MMP8 (matrix metallopeptidase 8)
Canis lupus familiaris (dog) : MMP8 (matrix metallopeptidase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mmp8 (matrix metallopeptidase 8)
Sus scrofa (pig) : MMP8 (matrix metallopeptidase 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.085,768,808 - 5,777,741 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.085,771,659 - 5,780,576 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,402,124 - 4,410,976 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.184,402,123 - 4,410,976 (+)NCBI
Celera86,283,716 - 6,292,568 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Mmp8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 631408
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.