Mmp8 (matrix metallopeptidase 8) - Rat Genome Database

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Gene: Mmp8 (matrix metallopeptidase 8) Rattus norvegicus
Analyze
Symbol: Mmp8
Name: matrix metallopeptidase 8
RGD ID: 631408
Description: Enables metal ion binding activity and peptidase activity. Involved in several processes, including cellular response to lipopolysaccharide; positive regulation of neuroinflammatory response; and positive regulation of tumor necrosis factor production. Located in extracellular space. Biomarker of brain infarction and congestive heart failure. Human ortholog(s) of this gene implicated in breast cancer and carotid artery disease. Orthologous to human MMP8 (matrix metallopeptidase 8); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: matrix metalloproteinase-8; MMP-8; neutrophil collagenase; neutrophil collagenease
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,008,873 - 13,018,729 (+)NCBIGRCr8
mRatBN7.284,724,009 - 4,733,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,724,029 - 4,733,520 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,683,788 - 8,692,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,981,565 - 6,990,437 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,983,774 - 4,992,630 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,768,808 - 5,777,741 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,768,811 - 5,778,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,771,659 - 5,780,576 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,402,124 - 4,410,976 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,402,123 - 4,410,976 (+)NCBI
Celera86,283,716 - 6,292,568 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,10-phenanthroline  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-hydroxypicolinic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cyclophosphamide  (EXP)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofurans  (ISO)
diclofenac  (EXP)
dieckol  (ISO)
dioxygen  (EXP,ISO)
doxycycline  (ISO)
ethyl methanesulfonate  (ISO)
ethylenediaminetetraacetic acid  (ISO)
fasudil  (ISO)
fentin chloride  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
graphene oxide  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
megestrol acetate  (EXP)
metacetamol  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
prinomastat  (ISO)
progesterone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular matrix  (IEA)
extracellular space  (IDA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
2. Up-regulation of trypsin and mesenchymal MMP-8 during development of hyperoxic lung injury in the rat. Cederqvist K, etal., Pediatr Res. 2006 Oct;60(4):395-400. Epub 2006 Aug 28.
3. Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis. Decock J, etal., BMC Cancer. 2008 Mar 20;8:77.
4. Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis. Decock J, etal., Cancer Res. 2007 Nov 1;67(21):10214-21.
5. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Repair after cholestatic liver injury correlates with neutrophil infiltration and matrix metalloproteinase 8 activity. Harty MW, etal., Surgery. 2005 Aug;138(2):313-20.
8. Osteoblasts and osteocytes express MMP2 and -8 and TIMP1, -2, and -3 along with extracellular matrix molecules during appositional bone formation. Hatori K, etal., Anat Rec A Discov Mol Cell Evol Biol 2004 Apr;277(2):262-71.
9. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
10. Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-a activation. Lee EJ, etal., J Immunol. 2014 Sep 1;193(5):2384-93. doi: 10.4049/jimmunol.1303240. Epub 2014 Jul 21.
11. Effects of 17 beta-estradiol on the expression of interstitial collagenases-8 and -13 (MMP-8 and MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in ovariectomized rat osteoblastic cells. Li J, etal., J Mol Histol 2004 Nov;35(8-9):723-31.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. Peterson JT, etal., Cardiovasc Res. 2000 May;46(2):307-15.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteinase inducer glycosylation forms. Sluijter JP, etal., Stroke. 2006 Jan;37(1):235-9. Epub 2005 Dec 8.
18. Cytokine-regulated expression of collagenase-2 (MMP-8) is involved in the progression of ovarian cancer. Stadlmann S, etal., Eur J Cancer. 2003 Nov;39(17):2499-505.
19. MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis. Tchetverikov I, etal., Ann Rheum Dis. 2004 Jul;63(7):881-3.
20. Enhanced production and activation of matrix metalloproteinase-7 (matrilysin) in human endometrial carcinomas. Ueno H, etal., Int J Cancer. 1999 Oct 22;84(5):470-7.
21. Matrix metalloproteinase-8 and -9 are increased at the site of abdominal aortic aneurysm rupture. Wilson WR, etal., Circulation. 2006 Jan 24;113(3):438-45.
Additional References at PubMed
PMID:2164002   PMID:16192646   PMID:18615687   PMID:19346731   PMID:19583703   PMID:19847888   PMID:19923067   PMID:20923679   PMID:21447140   PMID:21697883   PMID:21826658   PMID:21875735  
PMID:22687332   PMID:23154389   PMID:23619615   PMID:23845380   PMID:23974514   PMID:24006456   PMID:24784232   PMID:26055433   PMID:28260878   PMID:33468174   PMID:34550870   PMID:34830409  
PMID:36322784  


Genomics

Comparative Map Data
Mmp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,008,873 - 13,018,729 (+)NCBIGRCr8
mRatBN7.284,724,009 - 4,733,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,724,029 - 4,733,520 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,683,788 - 8,692,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,981,565 - 6,990,437 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,983,774 - 4,992,630 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,768,808 - 5,777,741 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,768,811 - 5,778,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,771,659 - 5,780,576 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,402,124 - 4,410,976 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,402,123 - 4,410,976 (+)NCBI
Celera86,283,716 - 6,292,568 (+)NCBICelera
Cytogenetic Map8q11NCBI
MMP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,711,796 - 102,724,954 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,711,796 - 102,727,050 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,582,527 - 102,595,685 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,088,540 - 102,100,868 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411102,088,539 - 102,100,868NCBI
Celera1199,743,725 - 99,756,878 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,509,472 - 98,522,626 (-)NCBIHuRef
CHM1_111102,465,498 - 102,478,648 (-)NCBICHM1_1
T2T-CHM13v2.011102,713,966 - 102,727,115 (-)NCBIT2T-CHM13v2.0
Mmp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,558,430 - 7,568,487 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,558,457 - 7,568,486 (+)EnsemblGRCm39 Ensembl
GRCm3897,558,429 - 7,568,486 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,558,456 - 7,568,485 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,558,429 - 7,568,486 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,558,460 - 7,568,485 (+)NCBIMGSCv36mm8
Celera94,948,941 - 4,958,998 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Mmp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,928,997 - 5,939,012 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,928,997 - 5,939,012 (-)NCBIChiLan1.0ChiLan1.0
MMP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,503,121 - 103,516,444 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,591,436 - 104,604,786 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,650,408 - 97,663,731 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111101,143,372 - 101,156,695 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,143,268 - 101,156,736 (-)Ensemblpanpan1.1panPan2
MMP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,036,381 - 29,047,180 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,035,820 - 29,046,808 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha528,984,875 - 28,995,648 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,087,831 - 29,098,581 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,087,795 - 29,098,209 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,122,825 - 29,133,583 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,002,064 - 29,012,820 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,177,264 - 29,188,014 (+)NCBIUU_Cfam_GSD_1.0
Mmp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494786,297,496 - 86,305,565 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,228,950 - 5,238,948 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,228,950 - 5,238,948 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,384,033 - 33,396,947 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,384,034 - 33,397,637 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,330,738 - 37,343,699 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,097,620 - 94,110,114 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,097,896 - 94,109,432 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,764,839 - 31,777,953 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624878164,171 - 175,654 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624878124,396 - 174,584 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mmp8
36 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:25
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000013936
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 6 33 62 82 84 53 25 53 6 170 75 43 29 47 31

Sequence


Ensembl Acc Id: ENSRNOT00000013936   ⟹   ENSRNOP00000013936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl84,724,029 - 4,733,520 (+)Ensembl
Rnor_6.0 Ensembl85,768,811 - 5,778,702 (+)Ensembl
RefSeq Acc Id: NM_022221   ⟹   NP_071557
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,008,890 - 13,018,729 (+)NCBI
mRatBN7.284,724,025 - 4,733,864 (+)NCBI
Rnor_6.085,768,889 - 5,777,741 (+)NCBI
Rnor_5.085,771,659 - 5,780,576 (+)NCBI
RGSC_v3.484,402,124 - 4,410,976 (+)RGD
Celera86,283,716 - 6,292,568 (+)RGD
Sequence:
RefSeq Acc Id: XR_005487913
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,008,873 - 13,017,733 (+)NCBI
mRatBN7.284,724,009 - 4,732,868 (+)NCBI
Protein Sequences
Protein RefSeqs NP_071557 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA07432 (Get FASTA)   NCBI Sequence Viewer  
  EDL78530 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013936.1
GenBank Protein O88766 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071557   ⟸   NM_022221
- Peptide Label: preproprotein
- UniProtKB: O88766 (UniProtKB/Swiss-Prot),   G3V7D0 (UniProtKB/TrEMBL),   A6JN36 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013936   ⟸   ENSRNOT00000013936
Protein Domains
Peptidase metallopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88766-F1-model_v2 AlphaFold O88766 1-466 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695734
Promoter ID:EPDNEW_R6259
Type:single initiation site
Name:Mmp8_1
Description:matrix metallopeptidase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.085,768,810 - 5,768,870EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631408 AgrOrtholog
BioCyc Gene G2FUF-31786 BioCyc
Ensembl Genes ENSRNOG00000009907 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013936.4 UniProtKB/TrEMBL
Gene3D-CATH 2.110.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Hemopexin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M10A_MMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:63849 UniProtKB/Swiss-Prot
NCBI Gene 63849 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10201:SF137 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hemopexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mmp8 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009907 RatGTEx
SMART SM00120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnMc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JN36 ENTREZGENE, UniProtKB/TrEMBL
  G3V7D0 ENTREZGENE, UniProtKB/TrEMBL
  MMP8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Mmp8  matrix metallopeptidase 8    neutrophil collagenease  Name updated 1299863 APPROVED