Sirt6 (sirtuin 6) - Rat Genome Database

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Gene: Sirt6 (sirtuin 6) Rattus norvegicus
Analyze
Symbol: Sirt6
Name: sirtuin 6
RGD ID: 1305216
Description: Exhibits protein deacetylase activity. Involved in post-embryonic cardiac muscle cell growth involved in heart morphogenesis and response to nutrient levels. Localizes to cytoplasm and nucleus. Biomarker of non-alcoholic fatty liver disease; obesity; and transient cerebral ischemia. Orthologous to human SIRT6 (sirtuin 6); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC299638; MGC114368; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,082,312 - 8,087,776 (+)NCBI
Rnor_6.0 Ensembl710,937,599 - 10,943,063 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0710,937,622 - 10,943,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0711,106,748 - 11,112,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,555,269 - 9,560,695 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.179,555,269 - 9,560,695 (+)NCBI
Celera76,273,425 - 6,278,851 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome, subtelomeric region  (ISO)
cytoplasm  (IDA)
nucleolus  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12477932   PMID:15795229   PMID:16079181   PMID:16439206   PMID:18242175   PMID:18337721   PMID:19135889   PMID:19913571   PMID:20141841   PMID:21847107   PMID:22449973   PMID:23201774  
PMID:23217706   PMID:23566837   PMID:24063863   PMID:24105743   PMID:24495875   PMID:24510807   PMID:25475987   PMID:25819580   PMID:26732053   PMID:26786260   PMID:27016702   PMID:27094368  
PMID:27457971   PMID:27534902   PMID:28130175   PMID:30671172   PMID:31115579   PMID:32394287   PMID:32745152  


Genomics

Comparative Map Data
Sirt6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,082,312 - 8,087,776 (+)NCBI
Rnor_6.0 Ensembl710,937,599 - 10,943,063 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0710,937,622 - 10,943,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0711,106,748 - 11,112,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,555,269 - 9,560,695 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.179,555,269 - 9,560,695 (+)NCBI
Celera76,273,425 - 6,278,851 (+)NCBICelera
Cytogenetic Map7q11NCBI
SIRT6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl194,174,109 - 4,182,566 (-)EnsemblGRCh38hg38GRCh38
GRCh38194,174,109 - 4,182,563 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37194,174,106 - 4,182,560 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,125,106 - 4,133,596 (-)NCBINCBI36hg18NCBI36
Build 34194,125,105 - 4,133,596NCBI
Celera194,113,565 - 4,122,051 (-)NCBI
Cytogenetic Map19p13.3NCBI
HuRef193,937,486 - 3,945,942 (-)NCBIHuRef
CHM1_1194,173,652 - 4,182,147 (-)NCBICHM1_1
Sirt6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,457,621 - 81,463,631 (-)NCBIGRCm39mm39
GRCm39 Ensembl1081,457,619 - 81,463,631 (-)Ensembl
GRCm381081,621,787 - 81,627,792 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,621,785 - 81,627,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv371081,084,531 - 81,090,353 (-)NCBIGRCm37mm9NCBIm37
MGSCv361081,024,916 - 81,030,687 (-)NCBImm8
Celera1082,644,967 - 82,650,787 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Sirt6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,644,023 - 4,650,083 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,641,883 - 4,650,518 (+)NCBIChiLan1.0ChiLan1.0
SIRT6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1194,146,057 - 4,154,132 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,146,057 - 4,154,126 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0193,196,092 - 3,204,602 (-)NCBIMhudiblu_PPA_v0panPan3
SIRT6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,412,989 - 55,424,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,412,646 - 55,424,944 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,140,555 - 55,152,607 (+)NCBI
ROS_Cfam_1.02056,071,820 - 56,083,846 (+)NCBI
UMICH_Zoey_3.12055,131,653 - 55,143,673 (+)NCBI
UNSW_CanFamBas_1.02055,612,837 - 55,624,841 (+)NCBI
UU_Cfam_GSD_1.02055,811,751 - 55,823,816 (+)NCBI
Sirt6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,440,673 - 215,447,621 (+)NCBI
SpeTri2.0NW_0049365882,387,162 - 2,394,066 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,568,436 - 74,577,772 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,568,539 - 74,577,774 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,063,186 - 75,071,642 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,924,230 - 3,932,583 (-)NCBI
ChlSab1.1 Ensembl63,924,230 - 3,932,590 (-)Ensembl
Sirt6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248285,441,973 - 5,449,549 (+)NCBI

Position Markers
RH128538  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0710,942,693 - 10,942,894NCBIRnor6.0
Rnor_5.0711,111,819 - 11,112,020UniSTSRnor5.0
RGSC_v3.479,560,340 - 9,560,541UniSTSRGSC3.4
Celera76,278,496 - 6,278,697UniSTS
Cytogenetic Map7q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7134147172Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7134828535Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7134828535Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7137009673Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7138119654Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7265313832258115Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7591147750911477Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7595196950951969Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7975804554758045Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:64
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000008758
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 31 16 15 16 1 74 31 38 11
Low 8 26 25 4 25 8 10 4 3 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008758   ⟹   ENSRNOP00000008758
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl710,937,599 - 10,943,063 (+)Ensembl
RefSeq Acc Id: NM_001031649   ⟹   NP_001026819
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,082,349 - 8,087,776 (+)NCBI
Rnor_6.0710,937,622 - 10,943,048 (+)NCBI
Rnor_5.0711,106,748 - 11,112,174 (+)NCBI
RGSC_v3.479,555,269 - 9,560,695 (+)RGD
Celera76,273,425 - 6,278,851 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240896   ⟹   XP_006240958
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0710,937,637 - 10,943,048 (+)NCBI
Rnor_5.0711,106,748 - 11,112,174 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765092   ⟹   XP_008763314
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0710,937,742 - 10,943,048 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594720   ⟹   XP_017450209
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0710,937,637 - 10,943,048 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078666   ⟹   XP_038934594
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,082,796 - 8,087,776 (+)NCBI
RefSeq Acc Id: XM_039078667   ⟹   XP_038934595
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,082,519 - 8,087,776 (+)NCBI
RefSeq Acc Id: XM_039078668   ⟹   XP_038934596
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,082,519 - 8,087,776 (+)NCBI
RefSeq Acc Id: XM_039078669   ⟹   XP_038934597
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,082,312 - 8,087,776 (+)NCBI
RefSeq Acc Id: XM_039078670   ⟹   XP_038934598
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,082,364 - 8,087,776 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001026819   ⟸   NM_001031649
- UniProtKB: Q4FZY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240958   ⟸   XM_006240896
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008763314   ⟸   XM_008765092
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017450209   ⟸   XM_017594720
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000008758   ⟸   ENSRNOT00000008758
RefSeq Acc Id: XP_038934597   ⟸   XM_039078669
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038934598   ⟸   XM_039078670
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038934595   ⟸   XM_039078667
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038934596   ⟸   XM_039078668
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038934594   ⟸   XM_039078666
- Peptide Label: isoform X1
Protein Domains
Deacetylase sirtuin-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694965
Promoter ID:EPDNEW_R5489
Type:initiation region
Name:Sirt6_1
Description:sirtuin 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0710,937,645 - 10,937,705EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305216 AgrOrtholog
Ensembl Genes ENSRNOG00000006393 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008758 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008758 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7461534 IMAGE-MGC_LOAD
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  NAD-dep_histone_deAcase_SIR2 UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/TrEMBL
KEGG Report rno:299638 UniProtKB/TrEMBL
MGC_CLONE MGC:114368 IMAGE-MGC_LOAD
NCBI Gene 299638 ENTREZGENE
Pfam SIR2 UniProtKB/TrEMBL
PhenoGen Sirt6 PhenoGen
PROSITE SIRTUIN UniProtKB/TrEMBL
Superfamily-SCOP SSF52467 UniProtKB/TrEMBL
UniProt Q4FZY2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Sirt6  sirtuin 6  Sirt6  sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-25 Sirt6  sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)  Sirt6  sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Sirt6  sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)  Sirt6_predicted  sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Sirt6_predicted  sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED