Gene: Sirt6 (sirtuin 6) Rattus norvegicus
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Symbol: Sirt6
Name: sirtuin 6
Description: ENCODES a protein that exhibits protein deacetylase activity; chromatin binding (ortholog); NAD(P)+-protein-arginine ADP-ribosyltransferase activity (ortholog); INVOLVED IN post-embryonic cardiac muscle cell growth involved in heart morphogenesis; response to nutrient levels; base-excision repair (ortholog); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; ASSOCIATED WITH Cardiomegaly; nonalcoholic fatty liver disease; obesity; FOUND IN cytoplasm; nucleus; nuclear telomeric heterochromatin (ortholog); INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; C60 fullerene
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC299638; MGC114368; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)
Orthologs:
Homo sapiens (human) : SIRT6 (sirtuin 6)  HGNC  Alliance
Mus musculus (house mouse) : Sirt6 (sirtuin 6)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirt6 (sirtuin 6)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRT6 (sirtuin 6)
Canis lupus familiaris (dog) : SIRT6 (sirtuin 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirt6 (sirtuin 6)
Sus scrofa (pig) : SIRT6 (sirtuin 6)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0710,937,622 - 10,943,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0711,106,748 - 11,112,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,555,269 - 9,560,695 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.179,555,269 - 9,560,695 (+)NCBI
Celera76,273,425 - 6,278,851 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Sirt6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305216
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-02-05
Status: ACTIVE