Tgfbr3 (transforming growth factor beta receptor 3) - Rat Genome Database

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Gene: Tgfbr3 (transforming growth factor beta receptor 3) Rattus norvegicus
Analyze
Symbol: Tgfbr3
Name: transforming growth factor beta receptor 3
RGD ID: 61821
Description: Enables several functions, including activin binding activity; growth factor binding activity; and heparin binding activity. Involved in several processes, including animal organ regeneration; regulation of transforming growth factor beta receptor signaling pathway; and transforming growth factor beta receptor complex assembly. Located in extracellular space and membrane. Part of receptor complex. Orthologous to human TGFBR3 (transforming growth factor beta receptor 3); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: betaglycan; TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; transforming growth factor beta receptor III; transforming growth factor beta receptor type 3; transforming growth factor, beta receptor 3; transforming growth factor, beta receptor III
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2142,489,397 - 2,665,383 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl142,489,397 - 2,663,341 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx142,368,902 - 2,542,219 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0143,670,523 - 3,843,847 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0142,364,067 - 2,537,400 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,506,416 - 3,680,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,506,339 - 3,682,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0143,509,601 - 3,683,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4143,051,039 - 3,240,286 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1143,051,038 - 3,240,286 (+)NCBI
Celera142,505,821 - 2,679,576 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
genistein  (ISO)
hydroquinone  (ISO)
indometacin  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
N-nitrosodiethylamine  (EXP)
niclosamide  (ISO)
nitrofen  (EXP)
ouabain  (ISO)
ozone  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
picrotoxin  (EXP)
potassium chromate  (ISO)
progesterone  (EXP)
rac-lactic acid  (ISO)
ramipril  (EXP)
resveratrol  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
styrene  (ISO)
styrene oxide  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
apoptotic process involved in morphogenesis  (ISO)
blastocyst development  (ISO)
blood vessel development  (ISO)
blood vessel remodeling  (ISO)
BMP signaling pathway  (ISO)
cardiac epithelial to mesenchymal transition  (ISO)
cardiac muscle cell proliferation  (ISO)
cell migration  (IBA)
cell population proliferation  (ISO)
collagen metabolic process  (ISO)
definitive erythrocyte differentiation  (ISO)
definitive hemopoiesis  (ISO)
epicardium-derived cardiac fibroblast cell development  (ISO)
epithelial to mesenchymal transition  (IBA,ISO)
heart trabecula formation  (ISO)
heart trabecula morphogenesis  (ISO)
immune response  (ISO)
in utero embryonic development  (ISO)
intracellular signal transduction  (ISO)
liver development  (ISO)
muscular septum morphogenesis  (ISO)
negative regulation of apoptotic process involved in morphogenesis  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of epithelial cell migration  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of extracellular matrix assembly  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IDA)
osteoblast differentiation  (ISO)
outflow tract morphogenesis  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IMP,ISO)
protein-containing complex assembly  (IDA)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of JNK cascade  (ISO)
regulation of protein binding  (IDA)
regulation of transforming growth factor beta receptor signaling pathway  (IBA)
response to follicle-stimulating hormone  (ISO)
response to hypoxia  (IEP)
response to luteinizing hormone  (ISO)
response to prostaglandin E  (ISO)
roof of mouth development  (ISO)
secondary palate development  (ISO)
signal transduction  (NAS)
transforming growth factor beta receptor complex assembly  (IMP)
transforming growth factor beta receptor signaling pathway  (IBA,ISO,TAS)
vasculogenesis  (ISO)
vasculogenesis involved in coronary vascular morphogenesis  (ISO)
ventricular cardiac muscle tissue morphogenesis  (ISO)
ventricular compact myocardium morphogenesis  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Purification of the transforming growth factor-beta (TGF-beta) binding proteoglycan betaglycan. Andres JL, etal., J Biol Chem. 1991 Dec 5;266(34):23282-7.
2. Binding of two growth factor families to separate domains of the proteoglycan betaglycan. Andres JL, etal., J Biol Chem. 1992 Mar 25;267(9):5927-30.
3. Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta. Andres JL, etal., J Cell Biol. 1989 Dec;109(6 Pt 1):3137-45.
4. TGFbeta Type III and TGFbeta Type II receptors have distinct activities during epithelial-mesenchymal cell transformation in the embryonic heart. Boyer AS and Runyan RB, Dev Dyn. 2001 Aug;221(4):454-9.
5. Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia. Casagrandi D, etal., Mol Hum Reprod. 2003 Apr;9(4):199-203.
6. Betaglycan localization in the female rat pituitary: implications for the regulation of follicle-stimulating hormone by inhibin. Chapman SC and Woodruff TK, Endocrinology 2003 Dec;144(12):5640-9. Epub 2003 Sep 18.
7. Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors. Chapman SC, etal., Mol Cell Endocrinol. 2002 Oct 31;196(1-2):79-93.
8. Genomic profiling identifies alterations in TGFbeta signaling through loss of TGFbeta receptor expression in human renal cell carcinogenesis and progression. Copland JA, etal., Oncogene. 2003 Sep 11;22(39):8053-62.
9. Rodent adrenocortical cells display high affinity binding sites and proteins for inhibin A, and express components required for autocrine signalling by activins and bone morphogenetic proteins. Farnworth PG, etal., J Endocrinol. 2006 Mar;188(3):451-65.
10. Inhibin alpha-subunit and the inhibin coreceptor betaglycan are downregulated in endometrial carcinoma. Florio P, etal., Eur J Endocrinol. 2005 Feb;152(2):277-84.
11. Expression of transforming growth factor-beta receptors types II and III within various cells in the rat periodontium. Gao J, etal., J Periodontal Res. 1999 Feb;34(2):113-22.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Dynamic expression patterns of transforming growth factor-beta(2) and transforming growth factor-beta receptors in experimental glomerulonephritis. Hartner A, etal., J Mol Med. 2003 Jan;81(1):32-42. Epub 2002 Dec 14.
15. Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Lewis KA, etal., Nature. 2000 Mar 23;404(6776):411-4.
16. The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands. Lin HY, etal., J Biol Chem. 1995 Feb 10;270(6):2747-54.
17. Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system. Lopez-Casillas F, etal., Cell 1991 Nov 15;67(4):785-95.
18. Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites. Lopez-Casillas F, etal., J Cell Biol. 1994 Feb;124(4):557-68.
19. The distribution of betaglycan protein and mRNA in rat brain, pituitary, and gonads: implications for a role for betaglycan in inhibin-mediated reproductive functions. MacConell LA, etal., Endocrinology 2002 Mar;143(3):1066-75.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors. Moren A, etal., Biochem Biophys Res Commun. 1992 Nov 30;189(1):356-62.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Changes in TGF-beta receptors of rat hepatocytes during primary culture and liver regeneration: increased expression of TGF-beta receptors associated with increased sensitivity to TGF-beta-mediated growth inhibition. Nishikawa Y, etal., J Cell Physiol. 1998 Sep;176(3):612-23.
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
29. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
30. Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia. Vicencio AG, etal., J Appl Physiol 2002 Sep;93(3):1123-30.
31. Expression cloning and characterization of the TGF-beta type III receptor. Wang XF, etal., Cell 1991 Nov 15;67(4):797-805.
32. Expression of TGF beta1 genes and their receptor types I, II, and III in low- and high-grade malignancy non-Hodgkin's lymphomas. Woszczyk D, etal., Med Sci Monit. 2004 Jan;10(1):CR33-7.
Additional References at PubMed
PMID:9659379   PMID:9921650   PMID:11157754   PMID:11546783   PMID:12773577   PMID:12958365   PMID:14557487   PMID:15292974   PMID:15878966   PMID:16413747   PMID:16502470   PMID:16886151  
PMID:17295310   PMID:17636036   PMID:17704211   PMID:17823118   PMID:17999987   PMID:18184661   PMID:18236212   PMID:19019833   PMID:19056867   PMID:19199708   PMID:19372236   PMID:21402931  
PMID:22960625   PMID:23376485   PMID:25359088   PMID:25382630   PMID:30598510  


Genomics

Comparative Map Data
Tgfbr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2142,489,397 - 2,665,383 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl142,489,397 - 2,663,341 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx142,368,902 - 2,542,219 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0143,670,523 - 3,843,847 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0142,364,067 - 2,537,400 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,506,416 - 3,680,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,506,339 - 3,682,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0143,509,601 - 3,683,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4143,051,039 - 3,240,286 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1143,051,038 - 3,240,286 (+)NCBI
Celera142,505,821 - 2,679,576 (+)NCBICelera
Cytogenetic Map14p22NCBI
TGFBR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,680,343 - 91,906,002 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,680,343 - 91,906,335 (-)EnsemblGRCh38hg38GRCh38
GRCh37192,145,900 - 92,371,559 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,920,575 - 92,124,243 (-)NCBINCBI36Build 36hg18NCBI36
Build 34191,860,007 - 92,063,676NCBI
Celera190,391,974 - 90,597,757 (-)NCBICelera
Cytogenetic Map1p22.1NCBI
HuRef190,263,929 - 90,491,182 (-)NCBIHuRef
CHM1_1192,261,010 - 92,486,411 (-)NCBICHM1_1
T2T-CHM13v2.0191,524,931 - 91,750,857 (-)NCBIT2T-CHM13v2.0
Tgfbr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395107,254,433 - 107,437,495 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5107,254,436 - 107,437,495 (-)EnsemblGRCm39 Ensembl
GRCm385107,106,567 - 107,289,629 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5107,106,570 - 107,289,629 (-)EnsemblGRCm38mm10GRCm38
MGSCv375107,535,589 - 107,718,614 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365107,346,872 - 107,529,822 (-)NCBIMGSCv36mm8
Celera5104,218,970 - 104,402,013 (-)NCBICelera
Cytogenetic Map5E5NCBI
cM Map551.9NCBI
Tgfbr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554232,573,795 - 2,765,772 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554232,573,851 - 2,765,353 (+)NCBIChiLan1.0ChiLan1.0
TGFBR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11134,298,168 - 134,503,852 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0194,337,275 - 94,539,229 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,080,452 - 93,285,587 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,080,452 - 93,285,587 (-)Ensemblpanpan1.1panPan2
TGFBR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1657,025,096 - 57,220,240 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl657,025,112 - 57,217,121 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha659,730,730 - 59,925,446 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0657,407,397 - 57,602,731 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl657,407,262 - 57,600,294 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1657,084,907 - 57,279,569 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0657,060,369 - 57,254,710 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0657,523,587 - 57,718,361 (+)NCBIUU_Cfam_GSD_1.0
Tgfbr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058101,608,922 - 101,793,829 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365377,175,516 - 7,336,895 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365377,154,125 - 7,340,218 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFBR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4125,110,072 - 125,316,796 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14125,109,939 - 125,310,788 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24136,671,290 - 136,820,333 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TGFBR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12041,353,182 - 41,565,357 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2041,353,325 - 41,565,343 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603376,431,842 - 76,637,238 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfbr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247425,871,155 - 6,080,773 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tgfbr3
922 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:98
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000002867
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat

Markers in Region
D14Rat69  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2142,534,241 - 2,534,422 (+)MAPPERmRatBN7.2
Rnor_6.0143,551,502 - 3,551,682NCBIRnor6.0
Rnor_5.0143,554,725 - 3,554,905UniSTSRnor5.0
RGSC_v3.4143,095,371 - 3,095,793RGDRGSC3.4
RGSC_v3.4143,095,581 - 3,095,761UniSTSRGSC3.4
RGSC_v3.1143,095,581 - 3,095,761RGD
Celera142,550,526 - 2,550,706UniSTS
RH 3.4 Map1446.1RGD
RH 3.4 Map1446.1UniSTS
RH 2.0 Map1461.5RGD
SHRSP x BN Map142.29RGD
Cytogenetic Map14p22UniSTS
D14Wox30  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2142,487,650 - 2,487,796 (+)MAPPERmRatBN7.2
Rnor_6.0143,504,670 - 3,504,815NCBIRnor6.0
Rnor_5.0143,507,855 - 3,508,000UniSTSRnor5.0
RGSC_v3.4143,049,293 - 3,049,438UniSTSRGSC3.4
Celera142,504,075 - 2,504,220UniSTS
Cytogenetic Map14p22UniSTS
RH143675  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2142,662,789 - 2,662,918 (+)MAPPERmRatBN7.2
Rnor_6.0143,679,957 - 3,680,085NCBIRnor6.0
Rnor_5.0143,683,263 - 3,683,391UniSTSRnor5.0
RGSC_v3.4143,239,735 - 3,239,863UniSTSRGSC3.4
Celera142,679,025 - 2,679,153UniSTS
RH 3.4 Map1445.2UniSTS
Cytogenetic Map14p22UniSTS
AU049133  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2142,642,124 - 2,642,301 (+)MAPPERmRatBN7.2
Rnor_6.0143,659,276 - 3,659,452NCBIRnor6.0
Rnor_5.0143,662,499 - 3,662,675UniSTSRnor5.0
RGSC_v3.4143,204,499 - 3,204,675UniSTSRGSC3.4
Celera142,658,397 - 2,658,573UniSTS
Cytogenetic Map14p22UniSTS
AU049415  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2142,621,023 - 2,621,151 (+)MAPPERmRatBN7.2
Rnor_6.0143,638,443 - 3,638,570NCBIRnor6.0
Rnor_5.0143,641,666 - 3,641,793UniSTSRnor5.0
RGSC_v3.4143,183,398 - 3,183,525UniSTSRGSC3.4
Celera142,637,296 - 2,637,423UniSTS
Cytogenetic Map14p22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 38 35 24 14 24 3 3 14 35 40 11 3
Low 2 5 22 17 5 17 5 8 60 1 5
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000002867   ⟹   ENSRNOP00000002867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl142,489,397 - 2,663,341 (+)Ensembl
Rnor_6.0 Ensembl143,506,339 - 3,682,545 (+)Ensembl
RefSeq Acc Id: NM_017256   ⟹   NP_058952
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2142,489,397 - 2,663,341 (+)NCBI
Rnor_6.0143,506,416 - 3,680,508 (+)NCBI
Rnor_5.0143,509,601 - 3,683,814 (+)NCBI
RGSC_v3.4143,051,039 - 3,240,286 (+)RGD
Celera142,505,821 - 2,679,576 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091791   ⟹   XP_038947719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2142,576,672 - 2,665,383 (+)NCBI
RefSeq Acc Id: XM_039091792   ⟹   XP_038947720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2142,576,672 - 2,665,383 (+)NCBI
RefSeq Acc Id: NP_058952   ⟸   NM_017256
- Peptide Label: precursor
- UniProtKB: P26342 (UniProtKB/Swiss-Prot),   A6KPK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002867   ⟸   ENSRNOT00000002867
RefSeq Acc Id: XP_038947720   ⟸   XM_039091792
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038947719   ⟸   XM_039091791
- Peptide Label: isoform X1
Protein Domains
ZP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26342-F1-model_v2 AlphaFold P26342 1-853 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699162
Promoter ID:EPDNEW_R9687
Type:initiation region
Name:Tgfbr3_1
Description:transforming growth factor beta receptor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0143,506,331 - 3,506,391EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61821 AgrOrtholog
BioCyc Gene G2FUF-16609 BioCyc
Ensembl Genes ENSRNOG00000002093 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055024620 UniProtKB/Swiss-Prot
  ENSRNOG00060010131 UniProtKB/Swiss-Prot
  ENSRNOG00065013029 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002867 ENTREZGENE
  ENSRNOT00000002867.5 UniProtKB/Swiss-Prot
  ENSRNOT00055042376 UniProtKB/Swiss-Prot
  ENSRNOT00060017107 UniProtKB/Swiss-Prot
  ENSRNOT00065021353 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.4100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zona pellucida, ZP-N domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ZP-C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_chr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_dom_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29610 ENTREZGENE
PANTHER ENDOGLIN/TGF-BETA RECEPTOR TYPE III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Zona_pellucida UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tgfbr3 PhenoGen
PRINTS ZPELLUCIDA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ZP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002093 RatGTEx
  ENSRNOG00055024620 RatGTEx
  ENSRNOG00060010131 RatGTEx
  ENSRNOG00065013029 RatGTEx
SMART SM00241 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC208061
UniProt A6KPK0 ENTREZGENE, UniProtKB/TrEMBL
  P26342 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-05 Tgfbr3  transforming growth factor beta receptor 3  Tgfbr3  transforming growth factor, beta receptor III  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Tgfbr3  transforming growth factor, beta receptor 3      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Tgfbr3  transforming growth factor, beta receptor 3      Name updated 70585 PROVISIONAL
2001-05-08 Tgfr3  transforming growth factor, beta receptor III      Typographical error in gene symbol 62408 WITHDRAWN
2001-05-08 Tgfbr3  transforming growth factor, beta receptor III      Original symbol typographical error corrected 62408 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization integral cellular membrane protein 61766
gene_expression expressed in reproductive tissues and cells, brain and pituitary gland 730228
gene_physical_interaction binds inhibin A and TGF beta 730228
gene_physical_interaction specifically binds TGF beta 1 729942
gene_process may modulate effects of inhibin and TGF beta in reproductive tissues 730228
gene_process may regulate TGF beta II receptor function or expression 729942
gene_process may regulate follicle-stimulating hormone (FSH) release from pituitary by regulation of inhibin 1299110
gene_protein 853 amino acid core protein; expressed as a membrane-anchored proteoglycan 61766
gene_regulation expression levels in lung are downregulated following hypoxia 727411