RGD Reference Report - Inhibin alpha-subunit and the inhibin coreceptor betaglycan are downregulated in endometrial carcinoma. - Rat Genome Database

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Inhibin alpha-subunit and the inhibin coreceptor betaglycan are downregulated in endometrial carcinoma.

Authors: Florio, P  Ciarmela, P  Reis, FM  Toti, P  Galleri, L  Santopietro, R  Tiso, E  Tosi, P  Petraglia, F 
Citation: Florio P, etal., Eur J Endocrinol. 2005 Feb;152(2):277-84.
RGD ID: 1579943
Pubmed: PMID:15745937   (View Abstract at PubMed)
DOI: DOI:10.1530/eje.1.01849   (Journal Full-text)

OBJECTIVE: In the present study we evaluated the protein distribution and mRNA levels of inhibin alpha-subunit and its coreceptor betaglycan in endometrial adenocarcinoma. DESIGN: Two groups of postmenopausal women were studied: the first group had recently diagnosed endometrial adenocarcinoma (n = 16; age range 61-79 years), and the second group (n = 12; age range 64-78 years) had undergone hysterectomy for uterine prolapse and served as control. METHODS: Inhibin alpha-subunit and betaglycan gene expression and tissue distribution were evaluated by semiquantitative RT-PCR and immunohistochemistry respectively. RESULTS: Inhibin alpha-subunit and betaglycan mRNAs were expressed by both healthy and tumoral endometria, but their expression was significantly lower in endometrial carcinoma (P < 0.001, based on Student's t test). Inhibin alpha-subunit expression was much weaker in the glands of tumours than in non-neoplastic specimens. Betaglycan protein was identified in the epithelial cells lining non-tumoral endometrium, and in endothelial cells of both normal and tumoral endometria. Well-differentiated neoplastic cells had a faint and scarce betaglycan staining, and poorly differentiated cells did not express betaglycan at all. CONCLUSIONS: The lower inhibin alpha and betaglycan expression in endometrial adenocarcinoma suggests that the inhibin action may be disrupted. However, the expression of betaglycan in the endothelia of the tumour vasculature suggests that a selective vascular response to inhibin may be possible in these tumours.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TGFBR3Humanendometrial adenocarcinoma  IEP mRNA:decreased expression:endometriumRGD 
Tgfbr3Ratendometrial adenocarcinoma  ISOTGFBR3 (Homo sapiens)mRNA:decreased expression:endometriumRGD 
Tgfbr3Mouseendometrial adenocarcinoma  ISOTGFBR3 (Homo sapiens)mRNA:decreased expression:endometriumRGD 
INHAHumanEndometrial Neoplasms  IEP mRNA:decreased expression:endometriumRGD 
InhaRatEndometrial Neoplasms  ISOINHA (Homo sapiens)mRNA:decreased expression:endometriumRGD 
InhaMouseEndometrial Neoplasms  ISOINHA (Homo sapiens)mRNA:decreased expression:endometriumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Inha  (inhibin subunit alpha)
Tgfbr3  (transforming growth factor beta receptor 3)

Genes (Mus musculus)
Inha  (inhibin alpha)
Tgfbr3  (transforming growth factor, beta receptor III)

Genes (Homo sapiens)
INHA  (inhibin subunit alpha)
TGFBR3  (transforming growth factor beta receptor 3)


Additional Information