Tgfbr3 (transforming growth factor, beta receptor III) - Rat Genome Database

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Gene: Tgfbr3 (transforming growth factor, beta receptor III) Mus musculus
Analyze
Symbol: Tgfbr3
Name: transforming growth factor, beta receptor III
RGD ID: 62112
MGI Page MGI
Description: Enables several functions, including PDZ domain binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity. Involved in several processes, including definitive erythrocyte differentiation; heart development; and positive regulation of SMAD protein signal transduction. Acts upstream of or within several processes, including negative regulation of apoptotic process involved in morphogenesis; positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and vasculogenesis. Located in cell surface and endoplasmic reticulum. Is expressed in several structures, including brain; early conceptus; heart; jaw; and ovary. Orthologous to human TGFBR3 (transforming growth factor beta receptor 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110036H20Rik; AU015626; AW215636; betagl; betaglycan; TB; TBRIII; TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; transforming growth factor beta receptor III; transforming growth factor beta receptor type 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395107,254,433 - 107,437,495 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5107,254,436 - 107,437,495 (-)EnsemblGRCm39 Ensembl
GRCm385107,106,567 - 107,289,629 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5107,106,570 - 107,289,629 (-)EnsemblGRCm38mm10GRCm38
MGSCv375107,535,589 - 107,718,614 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365107,346,872 - 107,529,822 (-)NCBIMGSCv36mm8
Celera5104,218,970 - 104,402,013 (-)NCBICelera
Cytogenetic Map5E5NCBI
cM Map551.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
cisplatin  (EXP)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
N-nitrosodiethylamine  (ISO)
niclosamide  (ISO)
nitrofen  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
picrotoxin  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
ramipril  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP)
streptozocin  (ISO)
styrene  (ISO)
styrene oxide  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
apoptotic process involved in morphogenesis  (IMP)
blastocyst development  (IDA)
blood vessel development  (IMP)
blood vessel diameter maintenance  (TAS)
blood vessel remodeling  (IMP)
BMP signaling pathway  (IMP,ISO)
cardiac epithelial to mesenchymal transition  (ISO)
cardiac muscle cell proliferation  (IMP)
cell migration  (IBA)
cell population proliferation  (IMP)
collagen metabolic process  (IGI)
coronary vasculature development  (TAS)
coronary vasculature morphogenesis  (TAS)
definitive erythrocyte differentiation  (IMP)
definitive hemopoiesis  (IMP)
epicardial cell to mesenchymal cell transition  (TAS)
epicardium-derived cardiac fibroblast cell development  (IMP)
epithelial to mesenchymal transition  (IBA,ISO)
heart trabecula formation  (IMP)
heart trabecula morphogenesis  (IMP)
immune response  (ISO)
in utero embryonic development  (IMP)
intracellular signal transduction  (ISO)
liver development  (IMP)
muscular septum morphogenesis  (IMP)
negative regulation of apoptotic process involved in morphogenesis  (IMP)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of epithelial cell migration  (IMP)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of epithelial to mesenchymal transition  (IMP)
negative regulation of extracellular matrix assembly  (ISO)
negative regulation of gene expression  (IDA)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
osteoblast differentiation  (IMP)
outflow tract morphogenesis  (IMP)
positive regulation of BMP signaling pathway  (IMP)
positive regulation of cardiac muscle cell proliferation  (IMP)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of SMAD protein signal transduction  (IMP,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IMP,ISO)
protein-containing complex assembly  (ISO)
regulation of ERK1 and ERK2 cascade  (IMP)
regulation of JNK cascade  (IMP)
regulation of protein binding  (ISO)
regulation of transforming growth factor beta receptor signaling pathway  (IBA)
response to follicle-stimulating hormone  (ISO)
response to hypoxia  (ISO)
response to luteinizing hormone  (ISO)
response to prostaglandin E  (ISO)
roof of mouth development  (IMP)
secondary palate development  (IMP)
transforming growth factor beta receptor complex assembly  (ISO)
transforming growth factor beta receptor signaling pathway  (IBA,IDA,IGI,IMP,ISO)
vasculogenesis  (IMP)
vasculogenesis involved in coronary vascular morphogenesis  (IMP,TAS)
ventricular cardiac muscle tissue morphogenesis  (IMP)
ventricular compact myocardium morphogenesis  (IMP)
ventricular septum morphogenesis  (IMP)
visceral serous pericardium development  (TAS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axial skeleton morphology  (IAGP)
abnormal blood vessel morphology  (IEA)
abnormal definitive hematopoiesis  (IAGP)
abnormal epicardium morphology  (IAGP)
abnormal femur morphology  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal fetal cardiomyocyte proliferation  (IAGP)
abnormal interventricular septum muscular part morphology  (IAGP)
abnormal kidney morphology  (IEA)
abnormal liver development  (IAGP)
abnormal liver size  (IEA)
abnormal palatal shelf bone ossification  (IAGP)
abnormal palatal shelf fusion at midline  (IAGP)
abnormal palate development  (IAGP)
abnormal placenta morphology  (IEA)
abnormal placenta vasculature  (IEA)
abnormal skeleton development  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal trochanter morphology  (IAGP)
abnormal truncus arteriosus septation  (IAGP)
abnormal vasculogenesis  (IAGP)
absent deltoid tuberosity  (IAGP)
decreased myocardial fiber number  (IAGP)
decreased palatal shelf size  (IAGP)
decreased spleen white pulp amount  (IAGP)
decreased tongue size  (IAGP)
edema  (IEA)
embryonic growth retardation  (IEA)
enlarged kidney  (IEA)
failure of palatal shelf elevation  (IAGP)
hemorrhage  (IEA)
increased circulating follicle stimulating hormone level  (IAGP)
increased follicle stimulating hormone level  (IAGP)
increased ovary weight  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
microphthalmia  (IEA)
muscular ventricular septal defect  (IAGP)
pale liver  (IEA)
preweaning lethality, complete penetrance  (IEA)
rib fusion  (IAGP)
thin myocardium  (IAGP)
trabecula carnea hypoplasia  (IAGP)
transposition of great arteries  (IAGP)
ventricle myocardium hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia. Casagrandi D, etal., Mol Hum Reprod. 2003 Apr;9(4):199-203.
2. Genomic profiling identifies alterations in TGFbeta signaling through loss of TGFbeta receptor expression in human renal cell carcinogenesis and progression. Copland JA, etal., Oncogene. 2003 Sep 11;22(39):8053-62.
3. Inhibin alpha-subunit and the inhibin coreceptor betaglycan are downregulated in endometrial carcinoma. Florio P, etal., Eur J Endocrinol. 2005 Feb;152(2):277-84.
4. Dynamic expression patterns of transforming growth factor-beta(2) and transforming growth factor-beta receptors in experimental glomerulonephritis. Hartner A, etal., J Mol Med. 2003 Jan;81(1):32-42. Epub 2002 Dec 14.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
16. Expression of TGF beta1 genes and their receptor types I, II, and III in low- and high-grade malignancy non-Hodgkin's lymphomas. Woszczyk D, etal., Med Sci Monit. 2004 Jan;10(1):CR33-7.
Additional References at PubMed
PMID:7813789   PMID:8268187   PMID:8883836   PMID:9659379   PMID:9921650   PMID:10349636   PMID:10922068   PMID:10949049   PMID:11042159   PMID:11076861   PMID:11546783   PMID:12070302  
PMID:12399463   PMID:12477932   PMID:12773577   PMID:14610273   PMID:14701881   PMID:14764882   PMID:14996829   PMID:15342483   PMID:15459394   PMID:15489334   PMID:15640362   PMID:16141072  
PMID:16141073   PMID:16602821   PMID:16978288   PMID:17160136   PMID:17168649   PMID:17244351   PMID:17295310   PMID:17704211   PMID:17823118   PMID:18095342   PMID:18236212   PMID:18287559  
PMID:18340042   PMID:19524135   PMID:19539053   PMID:19696014   PMID:19726563   PMID:20299672   PMID:20967564   PMID:21267068   PMID:21297076   PMID:21402931   PMID:21533152   PMID:21731673  
PMID:21792916   PMID:21871877   PMID:21873635   PMID:22237159   PMID:22560297   PMID:22952931   PMID:22960625   PMID:23303681   PMID:23562608   PMID:23826237   PMID:23925295   PMID:24161934  
PMID:24347165   PMID:24760528   PMID:24859004   PMID:24870032   PMID:24952961   PMID:25077702   PMID:25382630   PMID:25759071   PMID:26120030   PMID:26277894   PMID:26645362   PMID:27180663  
PMID:27224923   PMID:27497782   PMID:27505173   PMID:28559372   PMID:29050936   PMID:30364975   PMID:30382077   PMID:30467960   PMID:30929801   PMID:32001436   PMID:32220631   PMID:32325033  
PMID:33153107   PMID:33227706   PMID:33300886   PMID:34910520   PMID:36855628   PMID:37023750  


Genomics

Comparative Map Data
Tgfbr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395107,254,433 - 107,437,495 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5107,254,436 - 107,437,495 (-)EnsemblGRCm39 Ensembl
GRCm385107,106,567 - 107,289,629 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5107,106,570 - 107,289,629 (-)EnsemblGRCm38mm10GRCm38
MGSCv375107,535,589 - 107,718,614 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365107,346,872 - 107,529,822 (-)NCBIMGSCv36mm8
Celera5104,218,970 - 104,402,013 (-)NCBICelera
Cytogenetic Map5E5NCBI
cM Map551.9NCBI
TGFBR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,680,343 - 91,906,002 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,680,343 - 91,906,335 (-)EnsemblGRCh38hg38GRCh38
GRCh37192,145,900 - 92,371,559 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,920,575 - 92,124,243 (-)NCBINCBI36Build 36hg18NCBI36
Build 34191,860,007 - 92,063,676NCBI
Celera190,391,974 - 90,597,757 (-)NCBICelera
Cytogenetic Map1p22.1NCBI
HuRef190,263,929 - 90,491,182 (-)NCBIHuRef
CHM1_1192,261,010 - 92,486,411 (-)NCBICHM1_1
T2T-CHM13v2.0191,524,931 - 91,750,857 (-)NCBIT2T-CHM13v2.0
Tgfbr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8142,634,294 - 2,810,269 (+)NCBIGRCr8
mRatBN7.2142,489,397 - 2,665,383 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl142,489,397 - 2,663,341 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx142,368,902 - 2,542,219 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0143,670,523 - 3,843,847 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0142,364,067 - 2,537,400 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,506,416 - 3,680,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,506,339 - 3,682,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0143,509,601 - 3,683,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4143,051,039 - 3,240,286 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1143,051,038 - 3,240,286 (+)NCBI
Celera142,505,821 - 2,679,576 (+)NCBICelera
Cytogenetic Map14p22NCBI
Tgfbr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554232,573,795 - 2,765,772 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554232,573,851 - 2,765,353 (+)NCBIChiLan1.0ChiLan1.0
TGFBR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21135,146,660 - 135,348,758 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11134,298,168 - 134,503,852 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0194,337,275 - 94,539,229 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,080,452 - 93,285,587 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,080,452 - 93,285,587 (-)Ensemblpanpan1.1panPan2
TGFBR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1657,025,096 - 57,220,240 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl657,025,112 - 57,217,121 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha659,730,730 - 59,925,446 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0657,407,397 - 57,602,731 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl657,407,262 - 57,600,294 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1657,084,907 - 57,279,569 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0657,060,369 - 57,254,710 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0657,523,587 - 57,718,361 (+)NCBIUU_Cfam_GSD_1.0
Tgfbr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058101,608,922 - 101,793,829 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365377,175,516 - 7,336,895 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365377,154,125 - 7,340,218 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFBR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4125,110,072 - 125,316,796 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14125,109,939 - 125,310,788 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24136,671,290 - 136,820,333 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TGFBR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12041,353,182 - 41,565,357 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2041,353,325 - 41,565,343 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603376,431,842 - 76,637,238 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfbr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247425,871,155 - 6,080,773 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tgfbr3
5243 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1500
Count of miRNA genes:691
Interacting mature miRNAs:885
Transcripts:ENSMUST00000031224, ENSMUST00000136882, ENSMUST00000138469, ENSMUST00000146591
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
10045978Tir10_mtrypanosome infection response 10 (mouse)Not determined598019649114021986Mouse
1301042Elmaz1_melevated maze behavior 1 (mouse)Not determined598019649116876624Mouse
1301877Bbaa3_mB.burgdorferi-associated arthritis 3 (mouse)Not determined599455285112465722Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
25314310Syncl4_msynaptonemal complex length 4 (mouse)5103047866115538059Mouse
25314317Sccor3_msynaptonemal complex length to mean MLH1 count ratio 3 (mouse)5104347866114738061Mouse
11528550Sluc33_msusceptibility to lung cancer 33 (mouse)5104386871120711986Mouse
1357886Diht_mdopamine-induced hypothermia (mouse)Not determined5104498738115101540Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse

Markers in Region
AI464151  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385107,212,531 - 107,212,662UniSTSGRCm38
MGSCv375107,641,550 - 107,641,681UniSTSGRCm37
Celera5104,324,936 - 104,325,067UniSTS
Cytogenetic Map5E5UniSTS
Whitehead/MRC_RH51295.43UniSTS
AU015626  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv375107,537,137 - 107,537,258UniSTSGRCm37
MGSCv375107,537,154 - 107,537,388UniSTSGRCm37
Celera5104,220,518 - 104,220,639UniSTS
Celera5104,220,535 - 104,220,769UniSTS
Whitehead/MRC_RH51295.73UniSTS
Whitehead/MRC_RH51299.66UniSTS
AF039601  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385107,108,520 - 107,108,650UniSTSGRCm38
MGSCv375107,537,539 - 107,537,669UniSTSGRCm37
Celera5104,220,920 - 104,221,050UniSTS
Cytogenetic Map5E5UniSTS
Whitehead/MRC_RH51285.22UniSTS
Tgfbr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385107,109,093 - 107,109,692UniSTSGRCm38
MGSCv375107,538,112 - 107,538,711UniSTSGRCm37
Celera5104,221,493 - 104,222,092UniSTS
Cytogenetic Map5E5UniSTS
cM Map5 UniSTS
D5Mit175  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385107,173,096 - 107,173,175UniSTSGRCm38
MGSCv375107,602,115 - 107,602,194UniSTSGRCm37
Celera5104,285,765 - 104,285,844UniSTS
Cytogenetic Map5E5UniSTS
cM Map558.0UniSTS
Whitehead Genetic540.4UniSTS
Whitehead/MRC_RH51295.53UniSTS
Whitehead_YAC5 UniSTS
RH143675  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385107,108,988 - 107,109,112UniSTSGRCm38
MGSCv375107,538,007 - 107,538,131UniSTSGRCm37
Celera5104,221,388 - 104,221,512UniSTS
Cytogenetic Map5E5UniSTS
AW215636  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385107,106,655 - 107,106,768UniSTSGRCm38
MGSCv375107,535,674 - 107,535,787UniSTSGRCm37
Celera5104,219,055 - 104,219,168UniSTS
Cytogenetic Map5E5UniSTS
Whitehead/MRC_RH51299.77UniSTS
AU049133  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385107,130,160 - 107,130,301UniSTSGRCm38
MGSCv375107,559,179 - 107,559,320UniSTSGRCm37
Celera5104,242,713 - 104,242,854UniSTS
Cytogenetic Map5E5UniSTS
Tgfbr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385107,108,563 - 107,108,813UniSTSGRCm38
MGSCv375107,537,582 - 107,537,832UniSTSGRCm37
Celera5104,220,963 - 104,221,213UniSTS
Cytogenetic Map5E5UniSTS
cM Map5 UniSTS
AU015626  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385107,108,135 - 107,108,369UniSTSGRCm38
MGSCv375107,537,154 - 107,537,388UniSTSGRCm37
Celera5104,220,535 - 104,220,769UniSTS
Cytogenetic Map5E5UniSTS
Whitehead/MRC_RH51295.73UniSTS
AU015626  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385107,108,118 - 107,108,239UniSTSGRCm38
MGSCv375107,537,137 - 107,537,258UniSTSGRCm37
Celera5104,220,518 - 104,220,639UniSTS
Cytogenetic Map5E5UniSTS
Whitehead/MRC_RH51299.66UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000031224   ⟹   ENSMUSP00000031224
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5107,254,436 - 107,437,495 (-)Ensembl
GRCm38.p6 Ensembl5107,106,570 - 107,289,629 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136882   ⟹   ENSMUSP00000123644
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5107,266,063 - 107,280,789 (-)Ensembl
GRCm38.p6 Ensembl5107,118,197 - 107,132,923 (-)Ensembl
RefSeq Acc Id: ENSMUST00000138469
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5107,257,147 - 107,340,233 (-)Ensembl
GRCm38.p6 Ensembl5107,109,281 - 107,192,367 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146591
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5107,295,846 - 107,437,461 (-)Ensembl
GRCm38.p6 Ensembl5107,147,980 - 107,289,595 (-)Ensembl
RefSeq Acc Id: NM_011578   ⟹   NP_035708
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395107,254,433 - 107,437,495 (-)NCBI
GRCm385107,106,567 - 107,289,629 (-)NCBI
MGSCv375107,535,589 - 107,718,614 (-)RGD
Celera5104,218,970 - 104,402,013 (-)RGD
cM Map5 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_035708 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC28564 (Get FASTA)   NCBI Sequence Viewer  
  AAH70428 (Get FASTA)   NCBI Sequence Viewer  
  BAE38560 (Get FASTA)   NCBI Sequence Viewer  
  EDL20169 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000031224
  ENSMUSP00000031224.9
  ENSMUSP00000123644.2
GenBank Protein O88393 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_035708   ⟸   NM_011578
- Peptide Label: precursor
- UniProtKB: Q6NS72 (UniProtKB/Swiss-Prot),   O88393 (UniProtKB/Swiss-Prot),   A0A0R4J097 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000031224   ⟸   ENSMUST00000031224
RefSeq Acc Id: ENSMUSP00000123644   ⟸   ENSMUST00000136882
Protein Domains
ZP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88393-F1-model_v2 AlphaFold O88393 1-850 view protein structure

Promoters
RGD ID:6887406
Promoter ID:EPDNEW_M7154
Type:initiation region
Name:Tgfbr3_1
Description:Mus musculus transforming growth factor, beta receptor III ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385107,289,542 - 107,289,602EPDNEW
RGD ID:6838490
Promoter ID:MM_KWN:43219
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2
Transcripts:OTTMUST00000069771
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365107,561,656 - 107,562,817 (-)MPROMDB
RGD ID:6838488
Promoter ID:MM_KWN:43220
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2
Transcripts:OTTMUST00000069770
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365107,620,976 - 107,622,337 (-)MPROMDB
RGD ID:6838489
Promoter ID:MM_KWN:43222
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000069768,   OTTMUST00000069769
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365107,718,264 - 107,718,764 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104637 AgrOrtholog
Ensembl Genes ENSMUSG00000029287 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031224 ENTREZGENE
  ENSMUST00000031224.15 UniProtKB/TrEMBL
  ENSMUST00000136882.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.4100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zona pellucida, ZP-N domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ZP-C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_chr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_dom_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104637 ENTREZGENE
NCBI Gene 21814 ENTREZGENE
PANTHER ENDOGLIN/TGF-BETA RECEPTOR TYPE III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Zona_pellucida UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tgfbr3 PhenoGen
PRINTS ZPELLUCIDA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ZP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00241 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J097 ENTREZGENE, UniProtKB/TrEMBL
  F6VPT9_MOUSE UniProtKB/TrEMBL
  O88393 ENTREZGENE
  Q3TM82_MOUSE UniProtKB/TrEMBL
  Q6NS72 ENTREZGENE
  TGBR3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q6NS72 UniProtKB/Swiss-Prot