TGFBR3 (transforming growth factor beta receptor 3) - Rat Genome Database

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Pathways
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Gene: TGFBR3 (transforming growth factor beta receptor 3) Chlorocebus sabaeus
Analyze
Symbol: TGFBR3
Name: transforming growth factor beta receptor 3
RGD ID: 18571112
Description: ENCODES a protein that exhibits activin binding (ortholog); fibroblast growth factor binding (ortholog); heparin binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic process involved in morphogenesis (ortholog); blastocyst development (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH connective tissue disease (ortholog); COVID-19 (ortholog); endometrial adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transforming growth factor beta receptor type 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12041,353,182 - 41,565,357 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2041,353,325 - 41,565,343 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603376,431,842 - 76,637,238 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
apoptotic process involved in morphogenesis  (ISO)
blastocyst development  (ISO)
blood vessel development  (ISO)
blood vessel remodeling  (ISO)
BMP signaling pathway  (IEA,ISO)
cardiac epithelial to mesenchymal transition  (IEA)
cardiac muscle cell proliferation  (ISO)
cell migration  (IEA)
cell population proliferation  (ISO)
collagen metabolic process  (ISO)
definitive erythrocyte differentiation  (ISO)
definitive hemopoiesis  (ISO)
epicardium-derived cardiac fibroblast cell development  (ISO)
epithelial to mesenchymal transition  (IEA)
heart trabecula formation  (ISO)
heart trabecula morphogenesis  (ISO)
immune response  (IEA)
in utero embryonic development  (ISO)
intracellular signal transduction  (IEA)
liver development  (ISO)
muscular septum morphogenesis  (ISO)
negative regulation of apoptotic process involved in morphogenesis  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of epithelial cell migration  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of extracellular matrix assembly  (IEA)
negative regulation of gene expression  (ISO)
negative regulation of SMAD protein signal transduction  (IEA)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
osteoblast differentiation  (ISO)
outflow tract morphogenesis  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of SMAD protein signal transduction  (IEA)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
protein-containing complex assembly  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of JNK cascade  (ISO)
regulation of protein binding  (ISO)
regulation of transforming growth factor beta receptor signaling pathway  (IEA)
response to follicle-stimulating hormone  (IEA)
response to hypoxia  (ISO)
response to luteinizing hormone  (IEA)
response to prostaglandin E  (IEA)
roof of mouth development  (ISO)
secondary palate development  (ISO)
transforming growth factor beta receptor complex assembly  (ISO)
transforming growth factor beta receptor signaling pathway  (IEA,ISO)
vasculogenesis  (ISO)
vasculogenesis involved in coronary vascular morphogenesis  (ISO)
ventricular cardiac muscle tissue morphogenesis  (ISO)
ventricular compact myocardium morphogenesis  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
TGFBR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12041,353,182 - 41,565,357 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2041,353,325 - 41,565,343 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603376,431,842 - 76,637,238 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TGFBR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,680,343 - 91,906,002 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,680,343 - 91,906,335 (-)EnsemblGRCh38hg38GRCh38
GRCh37192,145,900 - 92,371,559 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,920,575 - 92,124,243 (-)NCBINCBI36Build 36hg18NCBI36
Build 34191,860,007 - 92,063,676NCBI
Celera190,391,974 - 90,597,757 (-)NCBICelera
Cytogenetic Map1p22.1NCBI
HuRef190,263,929 - 90,491,182 (-)NCBIHuRef
CHM1_1192,261,010 - 92,486,411 (-)NCBICHM1_1
T2T-CHM13v2.0191,524,931 - 91,750,857 (-)NCBIT2T-CHM13v2.0
Tgfbr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395107,254,433 - 107,437,495 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5107,254,436 - 107,437,495 (-)EnsemblGRCm39 Ensembl
GRCm385107,106,567 - 107,289,629 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5107,106,570 - 107,289,629 (-)EnsemblGRCm38mm10GRCm38
MGSCv375107,535,589 - 107,718,614 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365107,346,872 - 107,529,822 (-)NCBIMGSCv36mm8
Celera5104,218,970 - 104,402,013 (-)NCBICelera
Cytogenetic Map5E5NCBI
cM Map551.9NCBI
Tgfbr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8142,634,294 - 2,810,269 (+)NCBIGRCr8
mRatBN7.2142,489,397 - 2,665,383 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl142,489,397 - 2,663,341 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx142,368,902 - 2,542,219 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0143,670,523 - 3,843,847 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0142,364,067 - 2,537,400 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,506,416 - 3,680,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,506,339 - 3,682,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0143,509,601 - 3,683,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4143,051,039 - 3,240,286 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1143,051,038 - 3,240,286 (+)NCBI
Celera142,505,821 - 2,679,576 (+)NCBICelera
Cytogenetic Map14p22NCBI
Tgfbr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554232,573,795 - 2,765,772 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554232,573,851 - 2,765,353 (+)NCBIChiLan1.0ChiLan1.0
TGFBR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21135,146,660 - 135,348,758 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11134,298,168 - 134,503,852 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0194,337,275 - 94,539,229 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,080,452 - 93,285,587 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,080,452 - 93,285,587 (-)Ensemblpanpan1.1panPan2
TGFBR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1657,025,096 - 57,220,240 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl657,025,112 - 57,217,121 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha659,730,730 - 59,925,446 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0657,407,397 - 57,602,731 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl657,407,262 - 57,600,294 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1657,084,907 - 57,279,569 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0657,060,369 - 57,254,710 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0657,523,587 - 57,718,361 (+)NCBIUU_Cfam_GSD_1.0
Tgfbr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058101,608,922 - 101,793,829 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365377,175,516 - 7,336,895 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365377,154,125 - 7,340,218 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFBR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4125,110,072 - 125,316,796 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14125,109,939 - 125,310,788 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24136,671,290 - 136,820,333 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Tgfbr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247425,871,155 - 6,080,773 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 3 20
Low 17 40
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000017072   ⟹   ENSCSAP00000016563
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2041,353,325 - 41,565,343 (+)Ensembl
RefSeq Acc Id: XM_007977984   ⟹   XP_007976175
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12041,353,182 - 41,565,357 (+)NCBI
Vero_WHO_p1.0NW_02366603376,431,842 - 76,637,226 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007977985   ⟹   XP_007976176
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12041,353,182 - 41,565,357 (+)NCBI
Vero_WHO_p1.0NW_02366603376,431,842 - 76,637,226 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038002872   ⟹   XP_037858800
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603376,431,842 - 76,637,238 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007976175 (Get FASTA)   NCBI Sequence Viewer  
  XP_007976176 (Get FASTA)   NCBI Sequence Viewer  
  XP_037858800 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000016563
  ENSCSAP00000016563.1
Reference Protein Sequences
RefSeq Acc Id: XP_007976175   ⟸   XM_007977984
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S6S4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007976176   ⟸   XM_007977985
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCSAP00000016563   ⟸   ENSCSAT00000017072
RefSeq Acc Id: XP_037858800   ⟸   XM_038002872
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S6S4 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001461 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000017072.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.4100 UniProtKB/TrEMBL
  Zona pellucida, ZP-N domain UniProtKB/TrEMBL
InterPro ZP-C UniProtKB/TrEMBL
  ZP_chr UniProtKB/TrEMBL
  ZP_dom UniProtKB/TrEMBL
  ZP_dom_CS UniProtKB/TrEMBL
NCBI Gene TGFBR3 ENTREZGENE
PANTHER ENDOGLIN/TGF-BETA RECEPTOR TYPE III UniProtKB/TrEMBL
  TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 3 UniProtKB/TrEMBL
Pfam Zona_pellucida UniProtKB/TrEMBL
PRINTS ZPELLUCIDA UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  ZP_1 UniProtKB/TrEMBL
  ZP_2 UniProtKB/TrEMBL
SMART SM00241 UniProtKB/TrEMBL
UniProt A0A0D9S6S4 ENTREZGENE, UniProtKB/TrEMBL