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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pld1
Name: phospholipase D1
Acc ID: CHEBI:53490
Term: N-formyl-L-methionyl-L-leucyl-L-phenylalanine
Definition: A tripeptide composed of L-Met, L-Leu and L-Phe in a linear sequence with a formyl group at the amino terminus. It acts as a potent inducer of leucocyte chemotaxis and macrophage activator as well as a ligand for the FPR receptor.
Chemical ID: MESH:D009240
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pld1multiple interactionsEXP 6480464CTDPLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Reactive Oxygen Species]PMID:17560994
Pld1multiple interactionsISOPLD1 (Homo sapiens)6480464CTDPLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein]PMID:11427526
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