Pdyn (prodynorphin) - Rat Genome Database

Name: Pdyn
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Pdyn (prodynorphin) Rattus norvegicus

Analyze

Symbol:

Pdyn

Name:

prodynorphin

RGD ID:

62054

Description:

Predicted to enable opioid receptor binding activity. Predicted to be involved in chemical synaptic transmission; neuropeptide signaling pathway; and sensory perception. Located in neuronal cell body. Is active in neuronal dense core vesicle lumen and synaptic vesicle. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 23 and temporal lobe epilepsy. Orthologous to human PDYN (prodynorphin); INTERACTS WITH (R,R)-tramadol; (S)-amphetamine; 1,3-dinitrobenzene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

beta-neoendorphin-dynorphin; preprodynorphin; proenkephalin B; proenkephalin-B

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PDYN (prodynorphin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Pdyn (prodynorphin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pdyn (prodynorphin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PDYN (prodynorphin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PDYN (prodynorphin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pdyn (prodynorphin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PDYN (prodynorphin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PDYN (prodynorphin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pdyn (prodynorphin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Pdyn (prodynorphin)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PDYN (prodynorphin)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pdyn (prodynorphin)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	116,900,990 - 116,913,334 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	116,900,992 - 116,913,334 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	120,798,229 - 120,810,577 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	129,393,853 - 129,406,201 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	127,054,324 - 127,066,672 (-)	NCBI	Rnor_WKY
Rnor_6.0	3	122,194,327 - 122,206,671 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	122,194,329 - 122,206,671 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	127,809,688 - 127,822,296 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	117,291,025 - 117,303,367 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	117,196,597 - 117,208,923 (-)	NCBI
Celera	3	115,716,443 - 115,728,785 (-)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol use disorder (ISO)

amnestic disorder (ISO)

amphetamine abuse (ISO)

autosomal dominant cerebellar ataxia (ISO)

Bradycardia (ISO)

cholestasis (ISO)

Cocaine-Related Disorders (ISO)

Drug-Induced Dyskinesia (ISO)

Dyskinesias (ISO)

Experimental Diabetes Mellitus (IEP)

genetic disease (ISO)

Huntington's disease-like 1 (ISO)

Hyperalgesia (ISO)

Hypercapnia (ISO)

Hypotension (ISO)

Hypoxia (ISO)

movement disease (ISO)

Pain (ISO)

pantothenate kinase-associated neurodegeneration (ISO)

Parkinsonism (ISO)

Pruritus (ISO)

Respiration Disorders (ISO)

respiratory failure (ISO)

sensory system disease (ISO)

spinocerebellar ataxia type 23 (ISO)

temporal lobe epilepsy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R,R)-tramadol (EXP)

(S)-amphetamine (EXP,ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine (EXP)

2-hydroxypropanoic acid (EXP)

2-methyl-6-(phenylethynyl)pyridine (EXP)

3,4-methylenedioxymethamphetamine (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

5-aza-2'-deoxycytidine (ISO)

8-OH-DPAT (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP)

alpha-Neoendorphin (EXP)

amiodarone (ISO)

ammonium chloride (EXP)

amphetamine (EXP,ISO)

baclofen (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

capsaicin (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP,ISO)

cisplatin (ISO)

cocaine (EXP,ISO)

corticosterone (EXP,ISO)

decabromodiphenyl ether (EXP)

dexamethasone (EXP)

dextran sulfate (ISO)

diazepam (EXP)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

Dynorphin B (EXP)

entinostat (ISO)

epoxomicin (EXP,ISO)

ethanol (ISO)

fentanyl (EXP)

fluoxetine (EXP)

folic acid (ISO)

fomepizole (ISO)

ginsenoside Re (ISO)

glyphosate (EXP)

heroin (ISO)

hydrogen peroxide (ISO)

kainic acid (EXP)

lead diacetate (EXP)

lipopolysaccharide (ISO)

maneb (EXP)

methamphetamine (EXP,ISO)

methoxychlor (EXP)

morphine (EXP,ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

Nandrolone decanoate (EXP)

Norbinaltorphimine (ISO)

oxidopamine (EXP,ISO)

Oxymorphone (EXP)

ozone (ISO)

panobinostat (ISO)

paracetamol (ISO)

paraquat (EXP)

pentobarbital (EXP)

pirinixic acid (ISO)

potassium atom (ISO)

prochloraz (EXP)

rac-lactic acid (EXP)

raloxifene (EXP)

resveratrol (ISO)

ritanserin (EXP)

SB 431542 (ISO)

scopolamine (EXP,ISO)

SL-327 (EXP)

sodium arsenite (ISO)

thimerosal (ISO)

titanium dioxide (ISO)

tramadol (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

U69593 (EXP)

valproic acid (EXP,ISO)

vanoxerine dihydrochloride (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chemical synaptic transmission (IBA,IEA)

neuropeptide signaling pathway (IBA,IEA)

regulation of neurotransmitter secretion (TAS)

sensory perception (IBA)

Cellular Component

axon terminus (IBA)

dendrite (IBA)

extracellular region (IEA)

hippocampal mossy fiber to CA3 synapse (IEA,ISO)

neuronal cell body (IBA,IDA)

neuronal dense core vesicle (IEA,ISO)

neuronal dense core vesicle lumen (IDA)

plasma membrane (IBA,IEA,ISO)

synaptic vesicle (IDA)

Molecular Function

opioid peptide activity (IEA)

opioid receptor binding (IBA)

protein binding (IPI)

References

References - curated

#	Reference Title	Reference Citation
1.	Sequence and expression of the rat prodynorphin gene.	Civelli O, etal., Proc Natl Acad Sci U S A 1985 Jun;82(12):4291-5.
2.	Characterization of the rat prodynorphin gene.	Douglass J, etal., Mol Endocrinol 1989 Dec;3(12):2070-8.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Colocalization of CART peptide with prodynorphin and dopamine D1 receptors in the rat nucleus accumbens.	Hubert GW and Kuhar MJ, Neuropeptides. 2006 Dec;40(6):409-15. Epub 2006 Oct 24.
5.	Dynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic rats.	Jolivalt CG, etal., Diabetologia. 2006 Nov;49(11):2775-85. Epub 2006 Aug 19.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	Expression of the prodynorphin gene after experimental brain injury and its role in behavioral dysfunction.	Redell JB, etal., Exp Biol Med (Maywood) 2003 Mar;228(3):261-9.
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy.	Stogmann E, etal., Ann Neurol 2002 Feb;51(2):260-3.
14.	Dynorphin-immunoreactive terminals in the rat nucleus accumbens: cellular sites for modulation of target neurons and interactions with catecholamine afferents.	Van Bockstaele EJ, etal., J Comp Neurol. 1994 Mar 1;341(1):1-15. doi: 10.1002/cne.903410102.
15.	Further studies on possible dynorphin involvement in the ovulatory luteinizing hormone surge in the proestrous rat.	Zhang Q, etal., Endocrine 2002 Aug;18(3):231-8.

Additional References at PubMed

PMID:8276115	PMID:9047294	PMID:12373547	PMID:14960343	PMID:14997015	PMID:15300902	PMID:15894804	PMID:16966485	PMID:17401159	PMID:17722034	PMID:18381633	PMID:18472331
PMID:20531238	PMID:20728507	PMID:20973986	PMID:21171319	PMID:21723305	PMID:21958458	PMID:22508514	PMID:22641014	PMID:22698692	PMID:23391862	PMID:23877505	PMID:23959730
PMID:24021806	PMID:24231353	PMID:24816773	PMID:25766322	PMID:27072528	PMID:27074815	PMID:30207304	PMID:30218420	PMID:31155522	PMID:33908346	PMID:36244036

Genomics

Comparative Map Data

Pdyn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	116,900,990 - 116,913,334 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	116,900,992 - 116,913,334 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	120,798,229 - 120,810,577 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	129,393,853 - 129,406,201 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	127,054,324 - 127,066,672 (-)	NCBI	Rnor_WKY
Rnor_6.0	3	122,194,327 - 122,206,671 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	122,194,329 - 122,206,671 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	127,809,688 - 127,822,296 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	117,291,025 - 117,303,367 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	117,196,597 - 117,208,923 (-)	NCBI
Celera	3	115,716,443 - 115,728,785 (-)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

PDYN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	1,978,756 - 1,994,285 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	20	1,978,757 - 1,994,285 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	1,959,402 - 1,974,931 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	1,907,402 - 1,922,702 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	1,907,402 - 1,922,702	NCBI
Celera	20	2,023,375 - 2,038,860 (-)	NCBI		Celera
Cytogenetic Map	20	p13	NCBI
HuRef	20	1,909,347 - 1,924,873 (-)	NCBI		HuRef
CHM1_1	20	1,959,620 - 1,975,149 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	2,008,889 - 2,024,418 (-)	NCBI		T2T-CHM13v2.0

Pdyn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	129,528,469 - 129,541,858 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	129,528,485 - 129,541,764 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	129,686,549 - 129,699,938 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	129,686,565 - 129,699,844 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	129,513,737 - 129,515,604 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	129,378,007 - 129,391,274 (-)	NCBI		MGSCv36	mm8
Celera	2	130,916,433 - 130,918,300 (-)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	63.19	NCBI

Pdyn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	13,106,062 - 13,119,515 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	13,106,087 - 13,119,497 (-)	NCBI	ChiLan1.0	ChiLan1.0

PDYN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	20	2,969,613 - 2,985,594 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	2,092,171 - 2,108,141 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	1,856,850 - 1,872,452 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	1,856,850 - 1,872,452 (-)	Ensembl	panpan1.1		panPan2

PDYN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	19,043,955 - 19,057,413 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	19,053,870 - 19,056,364 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	18,871,870 - 18,885,766 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	19,500,321 - 19,514,217 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	19,498,268 - 19,514,210 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	19,056,568 - 19,070,465 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	19,167,367 - 19,181,264 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	19,495,948 - 19,509,844 (+)	NCBI		UU_Cfam_GSD_1.0

Pdyn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	168,127,664 - 168,140,097 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	16,559,217 - 16,571,678 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936485	16,559,371 - 16,571,461 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDYN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	33,505,079 - 33,521,532 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	33,505,075 - 33,521,534 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PDYN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	54,535,516 - 54,551,085 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	54,535,240 - 54,551,104 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666087	951,337 - 967,337 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pdyn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	3,237,942 - 3,253,503 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	3,239,101 - 3,253,507 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pdyn
74 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	425
Count of miRNA genes:	226
Interacting mature miRNAs:	282
Transcripts:	ENSRNOT00000037576
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	89772419	134772419	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	91797474	136797474	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	112287552	135181505	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1358204	Insglur1	Insulin/glucose ratio QTL 1	3.8		blood glucose amount (VT:0000188)	serum insulin level (CMO:0000358)	3	115638168	135181505	Rat
1358204	Insglur1	Insulin/glucose ratio QTL 1	3.8		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	3	115638168	135181505	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			7						26		6
Low			1						40	16	28
Below cutoff	3	21	18	10	9	10	3	3	6	2	6	6	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019374	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591511	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M10088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000037576 ⟹ ENSRNOP00000038921

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	116,900,992 - 116,913,334 (-)	Ensembl
Rnor_6.0 Ensembl	3	122,194,329 - 122,206,671 (-)	Ensembl

RefSeq Acc Id:

NM_019374 ⟹ NP_062247

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	116,900,992 - 116,913,334 (-)	NCBI
Rnor_6.0	3	122,194,329 - 122,206,671 (-)	NCBI
Rnor_5.0	3	127,809,688 - 127,822,296 (+)	NCBI
RGSC_v3.4	3	117,291,025 - 117,303,367 (-)	RGD
Celera	3	115,716,443 - 115,728,785 (-)	RGD

Sequence:

show sequence

GGAGTAAGGCTCACAGAACTGCCATAGGGGGATTTGGTAGCCTTCAAGGCTTCCTCTGTGGCAC
TTCTCTGAGCTAGCGTCAGGGCTCCTTCTGAATCTTGGATCGGCCATCCTATCACCTGATCAGC
CAGAAGCCTGCCAGCGACAAAGCAGCACGCAGGTCACTCATCCACAGGCTTTGAGATCTGCGTG
GGGGGAGCTCTTGAAGCAGCCCCAGCAGGAAGGGTGATACAGAATGGCGTGGTCCAGGCTGATG
CTGGCAGCTTGCCTCCTTGTGATCCCCTCTGAGGTTACAGCAGACTGCCTGTCCTTGTGTTCCC
TGTGTGCAGTGAGGACGCAGGATGGGCCCCATCCCATCAACCCCCTGATTTGCTCCCTGGAGTG
CCAGGACCTGGTGCCGCCCTCGGAGGAGTGGGAGACATGCCGGGGCTTTTGGTCTTTTCTCACC
CTGACTGCCTCTGGGCTCCATGGCAAGGATGACTTGGAGAATGAGGTTGCTTTGGAAGAAGGCT
ACACGGAACTGACCAAGCTCTTGGAGCCCCTCCTGAAGGAGCTGGAGAAAGGCCAACTCCTTAC
CAGCGTCTCAGAGGAAAAGCTCAGGGGTCTCTCCAGCAGGTTTGGCAACGGAAGAGAATCTGAG
CTACTGGGCACTGACCTGATGAATGATGAAGCCGCACAGGCTGGCACGCTCCATTTCAACGAGG
AGGACTTGAGAAAACAGGCCAAACGCTATGGCGGCTTTTTGCGCAAATACCCCAAGAGGAGCTC
CGAGATGGCTGGGGACGAGGACAGGGGCCAGGATGGGGATCAGGTAGGGCATGAGGACCTGTAC
AAACGCTATGGGGGCTTCCTGCGGCGCATTCGCCCCAAGCTTAAGTGGGACAACCAGAAACGCT
ATGGTGGTTTTCTGCGGCGTCAGTTCAAGGTGGTGACTCGGTCCCAGGAGAACCCCAATACCTA
TTCCGAAGATTTAGATGTTTGATGGATAACACTTCCCCTCCATGGAGTTGGGTCTGCCGGCTTC
CTGCTTCATCCTCCTCTGCTTATTCCTTCGCTTGCTCCGTTCAGCATTCCCATGAAAACATCTA
AACCCAGCCCACGCCCTGTTCCGCCTAGGAGTGGAGTGTTCGTTTGCGGGCAGTGGTGGGGAAG
AGTGGGGATCCCTTGCTAATCCATCCAGTGTCCGGCTCAAACCCCTAGACCTCTAAACTACCAC
TACCAAGGGTAGCTCTTTGACATCAGCCCAACTGCTCTATCCCTGTGACCCCTTCCCACCCTAG
AATCCAGAGAACCTTGTCTTTGTACCTATAGGTCTGTGGTCTCCAAACTTCACTGATCACGTCC
TCCTCTTGGAAGAAAAATGAGCACTCCCTGTTAGTATTGCATGTGAACCATGAGGCATACAGTG
TAGAAACATAAAACAAGATATGTGCAAAATACATGCAAATGAAGATCCTAACTGCATTCTCAGC
CACACAGGCTCGTCTTGTGCACACTGCTCTGGAAAGCTACAGGCTAAATGAAAAGCCTTTTCAG
GGACAGGGATTATAACCCTAGAGAGGCCAGGCCTCTAGCATGCTAATTGTATGTGCATCCAGAG
TTCTCATGGTTTCCAAGGTGCCTTGGAAAAGCCCAGCTCCTAGACCCTGGTGAGGGCAGTGCCT
TTCCCAAGAGTGACACCCCCTGCTCACGAGGAAAAGCCATTCCTCTGAAGGCTGAAGTGATAAG
GGGGGGAGCAAAGCAAACTAATTTGTTCTGTACAACAAATTCAGAATTTGGGCCAGTTCCCACA
GCCCTCATTAAAAAAGATCAGTTTCACACTTCTAGCCCACGAGGAACTGAATCGTAGTGGAGCT
GATGCAGCTGAGCGCAGCTGTGCTCCTCAGTAGTTGACTTGGCTGCGGGAGCCAGAGCCATTTG
GCTGAGCCATTTGGCCGGGCATATGCACTGGCACTGGGAAGGGGGATCCAGAAGCAGTAGCTGA
AGGAGAGACTGGTCCCCCTCGGTATTACACTGAGCCTCGTTCTCCATGTCTCCAAATAAAAGCA
GAGAAAGAGGATCAAGTGGGTTCGCTGGATTCAAATAACCCAGAATCAGAGGCCAGGTCCTCTT
TGGTTTCCTCTCCCCATCAGATATTTAGATTGGTAGGTTAAGGAGATGGGGCTGGACGGGAGAG
AAAGCAGTCTGGATTTGCGTATTTGGTAGGAAGCAGACTGGATTTGCATCTTTGCATAAGATAA
CTTGAGTGTCCCTCTCCACACACAGTCCACAGCCTTTAGAGCTCTTCATGTGTTCTGAAATGTG
TAGATTGTTTTATGGTGACTTGTGCGCTGCTTAAAAAAAAATCACATTTATCCAAATTACTTGG
AACATGTGAGTCCTTAATAGGTCTGTGTAGTTTCCTGCTTCTCTGGTACAATAAATAAAGTTAT
GCAGATG

hide sequence

RefSeq Acc Id:

XM_017591511 ⟹ XP_017447000

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	116,900,990 - 116,904,600 (-)	NCBI
Rnor_6.0	3	122,194,327 - 122,197,725 (-)	NCBI

Sequence:

show sequence

CACATGAGTAAGAGATGGCTTTGTCCACTCCAGATACACTTCACCATCTTGTCCTTCTCTCTCT
CCAACAGAAGGGTGATACAGAATGGCGTGGTCCAGGCTGATGCTGGCAGCTTGCCTCCTTGTGA
TCCCCTCTGAGGTTACAGCAGACTGCCTGTCCTTGTGTTCCCTGTGTGCAGTGAGGACGCAGGA
TGGGCCCCATCCCATCAACCCCCTGATTTGCTCCCTGGAGTGCCAGGACCTGGTGCCGCCCTCG
GAGGAGTGGGAGACATGCCGGGGCTTTTGGTCTTTTCTCACCCTGACTGCCTCTGGGCTCCATG
GCAAGGATGACTTGGAGAATGAGGTTGCTTTGGAAGAAGGCTACACGGAACTGACCAAGCTCTT
GGAGCCCCTCCTGAAGGAGCTGGAGAAAGGCCAACTCCTTACCAGCGTCTCAGAGGAAAAGCTC
AGGGGTCTCTCCAGCAGGTTTGGCAACGGAAGAGAATCTGAGCTACTGGGCACTGACCTGATGA
ATGATGAAGCCGCACAGGCTGGCACGCTCCATTTCAACGAGGAGGACTTGAGAAAACAGGCCAA
ACGCTATGGCGGCTTTTTGCGCAAATACCCCAAGAGGAGCTCCGAGATGGCTGGGGACGAGGAC
AGGGGCCAGGATGGGGATCAGGTAGGGCATGAGGACCTGTACAAACGCTATGGGGGCTTCCTGC
GGCGCATTCGCCCCAAGCTTAAGTGGGACAACCAGAAACGCTATGGTGGTTTTCTGCGGCGTCA
GTTCAAGGTGGTGACTCGGTCCCAGGAGAACCCCAATACCTATTCCGAAGATTTAGATGTTTGA
TGGATAACACTTCCCCTCCATGGAGTTGGGTCTGCCGGCTTCCTGCTTCATCCTCCTCTGCTTA
TTCCTTCGCTTGCTCCGTTCAGCATTCCCATGAAAACATCTAAACCCAGCCCACGCCCTGTTCC
GCCTAGGAGTGGAGTGTTCGTTTGCGGGCAGTGGTGGGGAAGAGTGGGGATCCCTTGCTAATCC
ATCCAGTGTCCGGCTCAAACCCCTAGACCTCTAAACTACCACTACCAAGGGTAGCTCTTTGACA
TCAGCCCAACTGCTCTATCCCTGTGACCCCTTCCCACCCTAGAATCCAGAGAACCTTGTCTTTG
TACCTATAGGTCTGTGGTCTCCAAACTTCACTGATCACGTCCTCCTCTTGGAAGAAAAATGAGC
ACTCCCTGTTAGTATTGCATGTGAACCATGAGGCATACAGTGTAGAAACATAAAACAAGATATG
TGCAAAATACATGCAAATGAAGATCCTAACTGCATTCTCAGCCACACAGGCTCGTCTTGTGCAC
ACTGCTCTGGAAAGCTACAGGCTAAATGAAAAGCCTTTTCAGGGACAGGGATTATAACCCTAGA
GAGGCCAGGCCTCTAGCATGCTAATTGTATGTGCATCCAGAGTTCTCATGGTTTCCAAGGTGCC
TTGGAAAAGCCCAGCTCCTAGACCCTGGTGAGGGCAGTGCCTTTCCCAAGAGTGACACCCCCTG
CTCACGAGGAAAAGCCATTCCTCTGAAGGCTGAAGTGATAAGGGGGGGAGCAAAGCAAACTAAT
TTGTTCTGTACAACAAATTCAGAATTTGGGCCAGTTCCCACAGCCCTCATTAAAAAAGATCAGT
TTCACACTTCTAGCCCACGAGGAACTGAATCGTAGTGGAGCTGATGCAGCTGAGCGCAGCTGTG
CTCCTCAGTAGTTGACTTGGCTGCGGGAGCCAGAGCCATTTGGCTGAGCCATTTGGCCGGGCAT
ATGCACTGGCACTGGGAAGGGGGATCCAGAAGCAGTAGCTGAAGGAGAGACTGGTCCCCCTCGG
TATTACACTGAGCCTCGTTCTCCATGTCTCCAAATAAAAGCAGAGAAAGAGGATCAAGTGGGTT
CGCTGGATTCAAATAACCCAGAATCAGAGGCCAGGTCCTCTTTGGTTTCCTCTCCCCATCAGAT
ATTTAGATTGGTAGGTTAAGGAGATGGGGCTGGACGGGAGAGAAAGCAGTCTGGATTTGCGTAT
TTGGTAGGAAGCAGACTGGATTTGCATCTTTGCATAAGATAACTTGAGTGTCCCTCTCCACACA
CAGTCCACAGCCTTTAGAGCTCTTCATGTGTTCTGAAATGTGTAGATTGTTTTATGGTGACTTG
TGCGCTGCTTAAAAAAAAATCACATTTATCCAAATTACTTGGAACATGTGAGTCCTTAATAGGT
CTGTGTAGTTTCCTGCTTCTCTGGTACAATAAATAAAGTTATGCAGATGGC

hide sequence

Protein Sequences


Protein RefSeqs	NP_062247	(Get FASTA)	NCBI Sequence Viewer
	XP_017447000	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41118	(Get FASTA)	NCBI Sequence Viewer
	EDL80169	(Get FASTA)	NCBI Sequence Viewer
	EDL80170	(Get FASTA)	NCBI Sequence Viewer
	P06300	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_062247 ⟸ NM_019374
- Peptide Label:	preproprotein
- UniProtKB:	F1M7S3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAWSRLMLAACLLVIPSEVTADCLSLCSLCAVRTQDGPHPINPLICSLECQDLVPPSEEWETCR GFWSFLTLTASGLHGKDDLENEVALEEGYTELTKLLEPLLKELEKGQLLTSVSEEKLRGLSSRF GNGRESELLGTDLMNDEAAQAGTLHFNEEDLRKQAKRYGGFLRKYPKRSSEMAGDEDRGQDGDQ VGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQENPNTYSEDLDV hide sequence

RefSeq Acc Id:	XP_017447000 ⟸ XM_017591511
- Peptide Label:	isoform X1
- UniProtKB:	F1M7S3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAWSRLMLAACLLVIPSEVTADCLSLCSLCAVRTQDGPHPINPLICSLECQDLVPPSEEWETCR GFWSFLTLTASGLHGKDDLENEVALEEGYTELTKLLEPLLKELEKGQLLTSVSEEKLRGLSSRF GNGRESELLGTDLMNDEAAQAGTLHFNEEDLRKQAKRYGGFLRKYPKRSSEMAGDEDRGQDGDQ VGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQENPNTYSEDLDV hide sequence

RefSeq Acc Id:

ENSRNOP00000038921 ⟸ ENSRNOT00000037576

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P06300-F1-model_v2	AlphaFold	P06300	1-248	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:62054	AgrOrtholog
BioCyc Gene	G2FUF-47892	BioCyc
Ensembl Genes	ENSRNOG00000026036	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000038921	ENTREZGENE
	ENSRNOP00000038921.3	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000037576	ENTREZGENE
	ENSRNOT00000037576.4	UniProtKB/TrEMBL
InterPro	Opioid_neupept	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Proenkphlin_B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29190	UniProtKB/TrEMBL
NCBI Gene	29190	ENTREZGENE
PANTHER	PTHR11438	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11438:SF4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Opiods_neuropep	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pdyn	PhenoGen
PRINTS	OPIOIDPRCRSR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PENKBPRCRSR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	OPIOIDS_PRECURSOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	F1M7S3	ENTREZGENE, UniProtKB/TrEMBL
	P06300	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q63193	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Pdyn	prodynorphin			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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