Slc15a1 (solute carrier family 15 member 1) - Rat Genome Database

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Gene: Slc15a1 (solute carrier family 15 member 1) Rattus norvegicus
Analyze
Symbol: Slc15a1
Name: solute carrier family 15 member 1 (Ensembl:solute carrier family 15 (oligopeptide transporter), member 1)
RGD ID: 621736
Description: Enables channel inhibitor activity. Involved in metanephric proximal tubule development and negative regulation of amino acid transport. Located in apical plasma membrane. Orthologous to human SLC15A1 (solute carrier family 15 member 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: intestinal H(+)/peptide cotransporter; oligopeptide transporter, small intestine isoform; Pept1; peptide transporter 1; pineal gland-specific PEPT1; proton-coupled dipeptide cotransporter; solute carrier family 15 (oligopeptide transporter), member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SD  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21598,537,641 - 98,582,544 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1598,537,641 - 98,582,545 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15102,471,246 - 102,515,756 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.015103,572,123 - 103,616,870 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.015100,499,818 - 100,544,563 (-)NCBIRnor_WKY
Rnor_6.015106,800,081 - 106,844,668 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15106,800,081 - 106,844,426 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015110,194,618 - 110,238,806 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415106,549,586 - 106,592,594 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115106,565,875 - 106,608,374 (-)NCBI
Celera1597,321,467 - 97,366,085 (-)NCBICelera
Cytogenetic Map15q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
azathioprine  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
benzoic acid  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (EXP)
cefixime  (ISO)
ceftibuten  (ISO)
cephalexin  (EXP)
cephradine  (ISO)
chromium(6+)  (ISO)
cilazapril monohydrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
endosulfan  (EXP)
ethanol  (EXP)
flutamide  (EXP)
fluvastatin  (ISO)
fonofos  (ISO)
fosinopril  (ISO)
furan  (EXP)
glycylsarcosine  (EXP,ISO)
ibuprofen  (ISO)
isotretinoin  (ISO)
MeIQx  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
Moexipril  (ISO)
N-Nitrosopyrrolidine  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentane-2,3-dione  (EXP)
perindopril  (ISO)
Phe-Ser  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
quinapril hydrochloride  (ISO)
quinaprilat  (ISO)
rac-lactic acid  (ISO)
ramipril  (ISO)
Repaglinide  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
sirolimus  (ISO)
sodium hydrogencarbonate  (EXP)
spirapril  (ISO)
terbufos  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trandolapril  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IDA,IEA,ISO)
brush border  (IEA,ISO)
membrane  (IBA,IDA,IEA,ISO)
plasma membrane  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Regional expression and dietary regulation of rat small intestinal peptide and amino acid transporter mRNAs. Erickson RH, etal., Biochem Biophys Res Commun 1995 Nov 2;216(1):249-57.
2. A novel pineal-specific product of the oligopeptide transporter PepT1 gene: circadian expression mediated by cAMP activation of an intronic promoter. Gaildrat P, etal., J Biol Chem. 2005 Apr 29;280(17):16851-60. Epub 2005 Jan 31.
3. Regulation of oligopeptide transporter (Pept-1) in experimental diabetes. Gangopadhyay A, etal., Am J Physiol Gastrointest Liver Physiol 2002 Jul;283(1):G133-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Expression and cellular distribution during development of the peptide transporter (PepT1) in the small intestinal epithelium of the rat. Hussain I, etal., Cell Tissue Res 2002 Jan;307(1):139-42.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells. Minocha E, etal., In Vitro Cell Dev Biol Anim. 2019 Feb;55(2):138-147. doi: 10.1007/s11626-018-00315-2. Epub 2019 Jan 15.
9. Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter. Miyamoto K, etal., Biochim Biophys Acta 1996 Feb 7;1305(1-2):34-8.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Diurnal rhythm of H+-peptide cotransporter in rat small intestine. Pan X, etal., Am J Physiol Gastrointest Liver Physiol 2002 Jul;283(1):G57-64.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney. Saito H, etal., J Pharmacol Exp Ther 1995 Dec;275(3):1631-7.
16. Role of PEPT2 in peptide/mimetic trafficking at the blood-cerebrospinal fluid barrier: studies in rat choroid plexus epithelial cells in primary culture. Shu C, etal., J Pharmacol Exp Ther 2002 Jun;301(3):820-9.
Additional References at PubMed
PMID:7896779   PMID:11004485   PMID:12425457   PMID:14669333   PMID:15212161   PMID:15333706   PMID:15528259   PMID:15930458   PMID:16202478   PMID:16751172   PMID:16950402   PMID:17028260  
PMID:17081567   PMID:17372819   PMID:17638014   PMID:18028524   PMID:18367661   PMID:18583459   PMID:19439487   PMID:19577760   PMID:19913073   PMID:22114352   PMID:22677630   PMID:23660505  
PMID:25008848   PMID:25377315   PMID:25808120   PMID:26138652   PMID:26537751   PMID:28038428   PMID:28315445   PMID:29549253   PMID:32341465   PMID:35226682   PMID:35386060   PMID:36567554  


Genomics

Comparative Map Data
Slc15a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21598,537,641 - 98,582,544 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1598,537,641 - 98,582,545 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15102,471,246 - 102,515,756 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.015103,572,123 - 103,616,870 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.015100,499,818 - 100,544,563 (-)NCBIRnor_WKY
Rnor_6.015106,800,081 - 106,844,668 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15106,800,081 - 106,844,426 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015110,194,618 - 110,238,806 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415106,549,586 - 106,592,594 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115106,565,875 - 106,608,374 (-)NCBI
Celera1597,321,467 - 97,366,085 (-)NCBICelera
Cytogenetic Map15q24NCBI
SLC15A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381398,683,801 - 98,752,672 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1398,683,801 - 98,752,672 (-)EnsemblGRCh38hg38GRCh38
GRCh371399,336,055 - 99,404,926 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361398,134,057 - 98,202,909 (-)NCBINCBI36Build 36hg18NCBI36
Build 341398,134,056 - 98,202,909NCBI
Celera1380,179,729 - 80,248,593 (-)NCBICelera
Cytogenetic Map13q32.2-q32.3NCBI
HuRef1379,930,271 - 79,998,840 (-)NCBIHuRef
CHM1_11399,305,811 - 99,374,685 (-)NCBICHM1_1
T2T-CHM13v2.01397,893,752 - 97,962,601 (-)NCBIT2T-CHM13v2.0
Slc15a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914121,697,033 - 121,742,666 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14121,697,033 - 121,742,664 (-)EnsemblGRCm39 Ensembl
GRCm3814121,459,621 - 121,505,254 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14121,459,621 - 121,505,252 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714121,858,843 - 121,904,476 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614120,594,799 - 120,640,433 (-)NCBIMGSCv36mm8
Celera14120,015,509 - 120,060,682 (-)NCBICelera
Cytogenetic Map14E5NCBI
Slc15a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540411,798,927 - 11,857,982 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540411,799,370 - 11,856,854 (+)NCBIChiLan1.0ChiLan1.0
SLC15A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11398,998,769 - 99,040,646 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1398,998,894 - 99,065,008 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01379,855,805 - 79,902,215 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC15A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12248,777,627 - 48,827,533 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2248,777,630 - 48,827,533 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2248,560,003 - 48,609,797 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02249,220,704 - 49,270,801 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2249,220,707 - 49,270,801 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12248,870,251 - 48,919,979 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02248,905,695 - 48,955,899 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02248,941,445 - 48,991,309 (-)NCBIUU_Cfam_GSD_1.0
Slc15a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945184,235,002 - 184,283,235 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647211,669,206 - 11,716,303 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647211,669,206 - 11,716,303 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC15A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1167,652,193 - 67,710,933 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11167,652,808 - 67,690,457 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21174,889,779 - 74,924,577 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC15A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1377,344,653 - 77,413,475 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl377,345,567 - 77,383,715 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604633,834,919 - 33,873,568 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc15a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479312,348,819 - 12,394,497 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479312,348,356 - 12,393,909 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc15a1
218 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:76
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000015890
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat
1358354Srcrt5Stress Responsive Cort QTL 53.38blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)159815000199043291Rat


Related Rat Strains
The following Strains have been annotated to Slc15a1
SD


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 15 3
Low 1 8 26 10 18 10 7 8 19 20 28 10 7
Below cutoff 10 12 12 12 1 2 39 10 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015890   ⟹   ENSRNOP00000015890
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1598,537,641 - 98,582,545 (-)Ensembl
Rnor_6.0 Ensembl15106,800,081 - 106,844,426 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097752   ⟹   ENSRNOP00000093919
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1598,537,641 - 98,582,545 (-)Ensembl
RefSeq Acc Id: NM_001079838   ⟹   NP_001073307
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21598,538,409 - 98,542,522 (-)NCBI
Rnor_6.015106,800,849 - 106,804,962 (-)NCBI
Rnor_5.015110,194,618 - 110,238,806 (-)NCBI
Celera1597,322,235 - 97,326,344 (-)NCBI
Sequence:
RefSeq Acc Id: NM_057121   ⟹   NP_476462
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21598,537,641 - 98,582,544 (-)NCBI
Rnor_6.015106,800,081 - 106,844,426 (-)NCBI
Rnor_5.015110,194,618 - 110,238,806 (-)NCBI
RGSC_v3.415106,549,586 - 106,592,594 (-)RGD
Celera1597,321,467 - 97,366,085 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_476462   ⟸   NM_057121
- Peptide Label: isoform PepT1
- UniProtKB: F1LMZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001073307   ⟸   NM_001079838
- Peptide Label: isoform pgPepT1
- UniProtKB: P51574 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015890   ⟸   ENSRNOT00000015890
RefSeq Acc Id: ENSRNOP00000093919   ⟸   ENSRNOT00000097752

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51574-F1-model_v2 AlphaFold P51574 1-710 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699878
Promoter ID:EPDNEW_R10402
Type:multiple initiation site
Name:Slc15a1_1
Description:solute carrier family 15 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.015106,844,410 - 106,844,470EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621736 AgrOrtholog
BioCyc Gene G2FUF-12376 BioCyc
Ensembl Genes ENSRNOG00000011598 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015890 ENTREZGENE
  ENSRNOP00000015890.7 UniProtKB/TrEMBL
  ENSRNOP00000093919.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015890 ENTREZGENE
  ENSRNOT00000015890.7 UniProtKB/TrEMBL
  ENSRNOT00000097752.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oligopep_transport UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POT_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTR2_symporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117261 UniProtKB/Swiss-Prot
NCBI Gene 117261 ENTREZGENE
PANTHER PTHR11654 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PTR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc15a1 PhenoGen
PROSITE PTR2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTR2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs 2A1704 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AKI9_RAT UniProtKB/TrEMBL
  F1LMZ1 ENTREZGENE, UniProtKB/TrEMBL
  P51574 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5EML1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc15a1  solute carrier family 15 member 1  Slc15a1  solute carrier family 15 (oligopeptide transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Slc15a1  solute carrier family 15 (oligopeptide transporter), member 1      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Slc15a1  solute carrier family 15 (oligopeptide transporter), member 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
null small peptides and peptide-like drug transporter  
null small peptides and peptide-like drug transporter  
gene_cellular_localization localizes to brush-border membranes of intestinal mucosa and kidney 625752
gene_disease associated with diabetes 625752
gene_expression expressed in small intestine and kidneys 628344
gene_expression mRNA expression shows a little diurnal rhythm 628344
gene_expression expressed in intestinal mucosa and renal tubules 625752
gene_function small peptides and peptide-like drug transporter 628344
gene_function acts as a transporter mediating the absorption of oligopeptides 625752
gene_process involved in the conservation of peptide-bound amino nitrogen 625752
gene_process involved in the conservation of peptide-bound amino nitrogen 628344
gene_process mediates the uphill transport of oligopeptides based on an inwardly directed proton gradient 625752
gene_regulation short term starvation increases the expression of the protein and dietary administration reduces expression 625752
gene_regulation short term starvation increases the expression of the protein and dietary administration reduces expression 628344
gene_regulation diabetes increases RNA and protein expression 625752
gene_regulation transactivation of the gene promoter increased by dipeptides and some amino acids in Caco-2 cells 625752