Slc15a1 (solute carrier family 15 member 1) - Rat Genome Database
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Gene: Slc15a1 (solute carrier family 15 member 1) Rattus norvegicus
Analyze
Symbol: Slc15a1
Name: solute carrier family 15 member 1
RGD ID: 621736
Description: Exhibits channel inhibitor activity. Involved in negative regulation of amino acid transport. Localizes to apical plasma membrane. Orthologous to human SLC15A1 (solute carrier family 15 member 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: intestinal H(+)/peptide cotransporter; oligopeptide transporter, small intestine isoform; Pept1; peptide transporter 1; pineal gland-specific PEPT1; proton-coupled dipeptide cotransporter; solute carrier family 15 (oligopeptide transporter), member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SD  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.015106,800,081 - 106,844,668 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15106,800,081 - 106,844,426 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015110,194,618 - 110,238,806 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415106,549,586 - 106,592,594 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.115106,565,875 - 106,608,374 (-)NCBI
Celera1597,321,467 - 97,366,085 (-)NCBICelera
Cytogenetic Map15q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
azathioprine  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
benzoic acid  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (EXP)
cefixime  (ISO)
ceftibuten  (ISO)
cephalexin  (EXP)
cephradine  (ISO)
chromium(6+)  (ISO)
cilazapril monohydrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
endosulfan  (EXP)
ethanol  (EXP)
flutamide  (EXP)
fluvastatin  (ISO)
fonofos  (ISO)
fosinopril  (ISO)
furan  (EXP)
glycylsarcosine  (EXP,ISO)
ibuprofen  (ISO)
isotretinoin  (ISO)
MeIQx  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
Moexipril  (ISO)
N-Nitrosopyrrolidine  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
ozone  (EXP)
paracetamol  (ISO)
parathion  (ISO)
pentane-2,3-dione  (EXP)
perindopril  (ISO)
Phe-Ser  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quinapril hydrochloride  (ISO)
quinaprilat  (ISO)
rac-lactic acid  (ISO)
ramipril  (ISO)
Repaglinide  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
sirolimus  (ISO)
sodium hydrogencarbonate  (EXP)
spirapril  (ISO)
terbufos  (ISO)
titanium dioxide  (ISO)
trandolapril  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

Additional References at PubMed
PMID:7896779   PMID:11004485   PMID:12425457   PMID:14669333   PMID:15212161   PMID:15333706   PMID:15528259   PMID:15930458   PMID:16202478   PMID:16751172   PMID:16950402   PMID:17028260  
PMID:17081567   PMID:17372819   PMID:17638014   PMID:18028524   PMID:18367661   PMID:18583459   PMID:19439487   PMID:19577760   PMID:19913073   PMID:22114352   PMID:22677630   PMID:23660505  
PMID:25008848   PMID:25377315   PMID:25808120   PMID:26138652   PMID:26537751   PMID:28038428   PMID:28315445   PMID:29549253  


Genomics

Comparative Map Data
Slc15a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.015106,800,081 - 106,844,668 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15106,800,081 - 106,844,426 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015110,194,618 - 110,238,806 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415106,549,586 - 106,592,594 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.115106,565,875 - 106,608,374 (-)NCBI
Celera1597,321,467 - 97,366,085 (-)NCBICelera
Cytogenetic Map15q24NCBI
SLC15A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1398,683,801 - 98,752,672 (-)EnsemblGRCh38hg38GRCh38
GRCh381398,683,801 - 98,752,672 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371399,336,055 - 99,404,929 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361398,134,057 - 98,202,909 (-)NCBINCBI36hg18NCBI36
Build 341398,134,056 - 98,202,909NCBI
Celera1380,179,729 - 80,248,593 (-)NCBI
Cytogenetic Map13q32.2-q32.3NCBI
HuRef1379,930,271 - 79,998,840 (-)NCBIHuRef
CHM1_11399,305,811 - 99,374,685 (-)NCBICHM1_1
Slc15a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914121,697,033 - 121,742,666 (-)NCBIGRCm39mm39
GRCm3814121,459,621 - 121,505,254 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14121,459,621 - 121,505,252 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714121,858,843 - 121,904,476 (-)NCBIGRCm37mm9NCBIm37
MGSCv3614120,594,799 - 120,640,433 (-)NCBImm8
Celera14120,015,509 - 120,060,682 (-)NCBICelera
Cytogenetic Map14E5NCBI
Slc15a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540411,798,927 - 11,857,982 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540411,799,370 - 11,856,854 (+)NCBIChiLan1.0ChiLan1.0
SLC15A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11398,998,769 - 99,040,646 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1398,998,894 - 99,065,008 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01379,855,805 - 79,902,215 (-)NCBIMhudiblu_PPA_v0panPan3
SLC15A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2248,777,630 - 48,827,533 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12248,777,627 - 48,827,533 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Slc15a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647211,669,206 - 11,716,303 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC15A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1167,652,193 - 67,710,933 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11167,652,808 - 67,690,457 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21174,889,779 - 74,924,577 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC15A1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl377,345,567 - 77,383,715 (-)Ensembl
ChlSab1.1377,344,653 - 77,413,475 (-)NCBI
Slc15a1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479312,348,356 - 12,393,909 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1565520564110520564Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1575527634111246239Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1575761024109400896Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1581255292109133904Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1583947714111246239Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1584050550111246239Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1584050550111246239Rat
1358354Srcrt5Stress Responsive Cort QTL 53.38blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)15105348517108369033Rat


Related Rat Strains
The following Strains have been annotated to Slc15a1
SD

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:76
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000015890
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 15 3
Low 1 8 26 10 18 10 7 8 19 20 28 10 7
Below cutoff 10 12 12 12 1 2 39 10 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015890   ⟹   ENSRNOP00000015890
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl15106,800,081 - 106,844,426 (-)Ensembl
RefSeq Acc Id: NM_001079838   ⟹   NP_001073307
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.015106,800,849 - 106,804,962 (-)NCBI
Rnor_5.015110,194,618 - 110,238,806 (-)NCBI
Celera1597,322,235 - 97,326,344 (-)NCBI
Sequence:
RefSeq Acc Id: NM_057121   ⟹   NP_476462
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.015106,800,081 - 106,844,426 (-)NCBI
Rnor_5.015110,194,618 - 110,238,806 (-)NCBI
RGSC_v3.415106,549,586 - 106,592,594 (-)RGD
Celera1597,321,467 - 97,366,085 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252470   ⟹   XP_006252532
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.015106,800,690 - 106,844,668 (-)NCBI
Rnor_5.015110,194,618 - 110,238,806 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_476462   ⟸   NM_057121
- Peptide Label: isoform PepT1
- Sequence:
RefSeq Acc Id: NP_001073307   ⟸   NM_001079838
- Peptide Label: isoform pgPepT1
- UniProtKB: P51574 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006252532   ⟸   XM_006252470
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000015890   ⟸   ENSRNOT00000015890

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699878
Promoter ID:EPDNEW_R10402
Type:multiple initiation site
Name:Slc15a1_1
Description:solute carrier family 15 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.015106,844,410 - 106,844,470EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621736 AgrOrtholog
Ensembl Genes ENSRNOG00000011598 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015890 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015890 ENTREZGENE, UniProtKB/TrEMBL
InterPro MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oligopep_transport UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POT_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTR2_symporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117261 UniProtKB/Swiss-Prot
NCBI Gene 117261 ENTREZGENE
PANTHER PTHR11654 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PTR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc15a1 PhenoGen
PROSITE PTR2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTR2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs 2A1704 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.10500 ENTREZGENE
UniProt F1LMZ1_RAT UniProtKB/TrEMBL
  P51574 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5EML1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc15a1  solute carrier family 15 member 1  Slc15a1  solute carrier family 15 (oligopeptide transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Slc15a1  solute carrier family 15 (oligopeptide transporter), member 1      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Slc15a1  solute carrier family 15 (oligopeptide transporter), member 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
null small peptides and peptide-like drug transporter  
null small peptides and peptide-like drug transporter  
gene_cellular_localization localizes to brush-border membranes of intestinal mucosa and kidney 625752
gene_disease associated with diabetes 625752
gene_expression expressed in small intestine and kidneys 628344
gene_expression mRNA expression shows a little diurnal rhythm 628344
gene_expression expressed in intestinal mucosa and renal tubules 625752
gene_function small peptides and peptide-like drug transporter 628344
gene_function acts as a transporter mediating the absorption of oligopeptides 625752
gene_process involved in the conservation of peptide-bound amino nitrogen 625752
gene_process involved in the conservation of peptide-bound amino nitrogen 628344
gene_process mediates the uphill transport of oligopeptides based on an inwardly directed proton gradient 625752
gene_regulation short term starvation increases the expression of the protein and dietary administration reduces expression 625752
gene_regulation short term starvation increases the expression of the protein and dietary administration reduces expression 628344
gene_regulation diabetes increases RNA and protein expression 625752
gene_regulation transactivation of the gene promoter increased by dipeptides and some amino acids in Caco-2 cells 625752