Kif4a (kinesin family member 4A) - Rat Genome Database

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Gene: Kif4a (kinesin family member 4A) Rattus norvegicus
Analyze
Symbol: Kif4a
Name: kinesin family member 4A
RGD ID: 620526
Description: Predicted to enable microtubule motor activity. Predicted to be involved in mitotic cytokinesis and mitotic spindle midzone assembly. Predicted to be located in midbody and nucleoplasm. Predicted to be part of microtubule associated complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 100. Orthologous to several human genes including KIF4A (kinesin family member 4A); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chromosome-associated kinesin KIF4A; Kif4; kinesin family member 4; kinesin heavy chain member 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Kif4b  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X65,721,746 - 65,824,277 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,721,779 - 65,824,139 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,205,221 - 67,307,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,705,610 - 70,808,054 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,266,513 - 68,368,960 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,461,700 - 70,561,084 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,461,718 - 70,561,189 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,333,326 - 71,432,702 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,624,683 - 88,742,447 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X88,780,760 - 88,785,576 (+)NCBI
CeleraX66,080,644 - 66,182,985 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetohydrazide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dichloroacetic acid  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
gamma-tocopherol  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (ISO)
hydrazine  (ISO)
indometacin  (ISO)
isoflavones  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylparaben  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
omega-6 fatty acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally. Sekine Y, etal., J Cell Biol 1994 Oct;127(1):187-201.
Additional References at PubMed
PMID:15166316   PMID:15843429   PMID:19158085   PMID:19946888   PMID:25260485  


Genomics

Comparative Map Data
Kif4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X65,721,746 - 65,824,277 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,721,779 - 65,824,139 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,205,221 - 67,307,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,705,610 - 70,808,054 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,266,513 - 68,368,960 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,461,700 - 70,561,084 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,461,718 - 70,561,189 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,333,326 - 71,432,702 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,624,683 - 88,742,447 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X88,780,760 - 88,785,576 (+)NCBI
CeleraX66,080,644 - 66,182,985 (+)NCBICelera
Cytogenetic MapXq22NCBI
KIF4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X70,290,104 - 70,420,886 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX70,290,104 - 70,420,886 (+)EnsemblGRCh38hg38GRCh38
GRCh37X69,509,954 - 69,640,736 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X69,426,620 - 69,557,461 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X69,292,982 - 69,423,696NCBI
CeleraX69,863,214 - 69,994,090 (+)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX63,330,793 - 63,462,142 (+)NCBIHuRef
CHM1_1X69,403,837 - 69,534,667 (+)NCBICHM1_1
T2T-CHM13v2.0X68,723,423 - 68,854,206 (+)NCBIT2T-CHM13v2.0
Kif4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X99,669,693 - 99,770,878 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX99,669,343 - 99,770,820 (+)EnsemblGRCm39 Ensembl
GRCm38X100,626,065 - 100,727,271 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX100,625,737 - 100,727,214 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X97,821,404 - 97,922,610 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X96,828,456 - 96,929,658 (+)NCBIMGSCv36mm8
CeleraX87,552,092 - 87,652,016 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX43.72NCBI
Kif4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554759,845,633 - 9,970,564 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554759,845,633 - 9,969,965 (+)NCBIChiLan1.0ChiLan1.0
KIF4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X69,970,894 - 70,101,123 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X59,558,491 - 59,688,711 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X69,617,819 - 69,746,852 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX69,618,244 - 69,746,235 (+)Ensemblpanpan1.1panPan2
KIF4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X54,739,082 - 54,863,818 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX54,739,419 - 54,863,833 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX45,565,055 - 45,690,257 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X55,705,216 - 55,830,456 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX55,705,342 - 55,830,471 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X53,674,183 - 53,799,369 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X55,005,247 - 55,130,452 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X54,932,168 - 55,057,385 (+)NCBIUU_Cfam_GSD_1.0
Kif4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X47,299,454 - 47,426,152 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367621,061,526 - 1,187,863 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367621,062,570 - 1,194,192 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIF4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX56,319,529 - 56,447,553 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X56,319,453 - 56,447,560 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X63,514,246 - 63,642,350 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KIF4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X60,135,371 - 60,266,301 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660651,979,926 - 2,110,220 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kif4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624903261,084 - 386,670 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kif4a
204 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:107
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000003789
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat

Markers in Region
RH141063  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X65,823,914 - 65,824,095 (+)MAPPERmRatBN7.2
Rnor_6.0X70,560,850 - 70,561,030NCBIRnor6.0
Rnor_5.0X71,432,468 - 71,432,648UniSTSRnor5.0
RGSC_v3.4X88,741,826 - 88,742,006UniSTSRGSC3.4
CeleraX66,182,751 - 66,182,931UniSTS
Cytogenetic MapXq31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 26 28 22 13 22 33 18 28 8
Low 2 10 21 14 6 14 4 4 39 14 13 3 4
Below cutoff 7 8 5 5 4 6 2 3 4

Sequence


RefSeq Acc Id: ENSRNOT00000003789   ⟹   ENSRNOP00000003789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX70,461,776 - 70,561,084 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078233   ⟹   ENSRNOP00000073033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX65,721,779 - 65,824,139 (+)Ensembl
Rnor_6.0 EnsemblX70,461,718 - 70,561,189 (+)Ensembl
RefSeq Acc Id: NM_001400930   ⟹   NP_001387859
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X65,721,807 - 65,824,277 (+)NCBI
RefSeq Acc Id: XM_006257114   ⟹   XP_006257176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X65,721,746 - 65,824,151 (+)NCBI
Rnor_6.0X70,461,712 - 70,561,084 (+)NCBI
Rnor_5.0X71,333,326 - 71,432,702 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001387859 (Get FASTA)   NCBI Sequence Viewer  
  XP_006257176 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD39243 (Get FASTA)   NCBI Sequence Viewer  
  EDL95927 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073033
  ENSRNOP00000073033.1
RefSeq Acc Id: XP_006257176   ⟸   XM_006257114
- Peptide Label: isoform X1
- UniProtKB: E9PSJ3 (UniProtKB/TrEMBL),   A6IQ86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073033   ⟸   ENSRNOT00000078233
RefSeq Acc Id: ENSRNOP00000003789   ⟸   ENSRNOT00000003789
RefSeq Acc Id: NP_001387859   ⟸   NM_001400930
- UniProtKB: E9PSJ3 (UniProtKB/TrEMBL),   A6IQ86 (UniProtKB/TrEMBL)
Protein Domains
Kinesin motor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PSJ3-F1-model_v2 AlphaFold E9PSJ3 1-1231 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701868
Promoter ID:EPDNEW_R12390
Type:initiation region
Name:Kif4a_1
Description:kinesin family member 4A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X70,461,752 - 70,461,812EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620526 AgrOrtholog
BioCyc Gene G2FUF-2127 BioCyc
Ensembl Genes ENSRNOG00000038035 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078233 ENTREZGENE
  ENSRNOT00000078233.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.850.10 UniProtKB/TrEMBL
InterPro Kinesin-like_fam UniProtKB/TrEMBL
  Kinesin_motor_CS UniProtKB/TrEMBL
  Kinesin_motor_dom UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
KEGG Report rno:84393 UniProtKB/TrEMBL
NCBI Gene 84393 ENTREZGENE
PANTHER CHROMOSOME-ASSOCIATED KINESIN KIF4 UniProtKB/TrEMBL
  CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED UniProtKB/TrEMBL
Pfam Kinesin UniProtKB/TrEMBL
PhenoGen Kif4a PhenoGen
PRINTS KINESINHEAVY UniProtKB/TrEMBL
PROSITE KINESIN_MOTOR_DOMAIN1 UniProtKB/TrEMBL
  KINESIN_MOTOR_DOMAIN2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038035 RatGTEx
SMART KISc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
UniProt A6IQ86 ENTREZGENE, UniProtKB/TrEMBL
  E9PSJ3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-01-17 Kif4a  kinesin family member 4A  Kif4  kinesin family member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Kif4  kinesin family member 4    kinesin heavy chain member 4  Name updated 1299863 APPROVED
2002-08-07 Kif4  kinesin heavy chain member 4      Symbol and Name status set to provisional 70820 PROVISIONAL