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Gene: Rrm2 (ribonucleotide reductase regulatory subunit M2) Rattus norvegicus
Symbol: Rrm2
Name: ribonucleotide reductase regulatory subunit M2
RGD ID: 1598310
Description: Predicted to have ferric iron binding activity; protein homodimerization activity; and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in mitotic cell cycle; positive regulation of cell population proliferation; and pyrimidine nucleobase metabolic process. Localizes to nuclear envelope. Used to study endometrial adenocarcinoma. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RRM2 (ribonucleotide reductase regulatory subunit M2); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: MGC116120; ribonucleoside-diphosphate reductase subunit M2; Ribonucleotide reductase 2; ribonucleotide reductase M2; ribonucleotide reductase M2 (mapped); ribonucleotide reductase M2 polypeptide; ribonucleotide reductase small chain; ribonucleotide reductase small subunit; Rrm2_mapped
Homo sapiens (human) : RRM2 (ribonucleotide reductase regulatory subunit M2)  HGNC  Alliance
Mus musculus (house mouse) : Rrm2 (ribonucleotide reductase M2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rrm2 (ribonucleotide reductase regulatory subunit M2)
Pan paniscus (bonobo/pygmy chimpanzee) : RRM2 (ribonucleotide reductase regulatory subunit M2)
Canis lupus familiaris (dog) : RRM2 (ribonucleotide reductase regulatory subunit M2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rrm2 (ribonucleotide reductase regulatory subunit M2)
Sus scrofa (pig) : RRM2 (ribonucleotide reductase regulatory subunit M2)
Chlorocebus sabaeus (African green monkey) : RRM2 (ribonucleotide reductase regulatory subunit M2)
Heterocephalus glaber (naked mole-rat) : Rrm2 (ribonucleotide reductase regulatory subunit M2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0643,884,627 - 43,890,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl643,884,678 - 43,889,515 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0660,756,160 - 60,762,351 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4642,350,541 - 42,356,748 (+)NCBIRGSC3.4rn4RGSC3.4
Celera640,627,438 - 40,633,641 (+)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Rrm2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1598310
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.