Rrm2 (ribonucleotide reductase regulatory subunit M2)

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Gene: Rrm2 (ribonucleotide reductase regulatory subunit M2) Rattus norvegicus

Analyze

Symbol:

Rrm2

Name:

ribonucleotide reductase regulatory subunit M2

RGD ID:

1598310

Description:

Predicted to enable ferric iron binding activity; protein homodimerization activity; and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in mitotic cell cycle; positive regulation of cell population proliferation; and pyrimidine nucleobase metabolic process. Located in nuclear envelope. Used to study endometrial adenocarcinoma. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RRM2 (ribonucleotide reductase regulatory subunit M2); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC116120; ribonucleoside-diphosphate reductase subunit M2; Ribonucleotide reductase 2; ribonucleotide reductase M2; ribonucleotide reductase M2 (mapped); ribonucleotide reductase M2 polypeptide; ribonucleotide reductase small chain; ribonucleotide reductase small subunit; Rrm2_mapped

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	41,339,858 - 41,346,774 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	41,340,557 - 41,346,773 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	41,660,659 - 41,666,878 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	6	41,975,466 - 41,981,683 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	6	41,408,612 - 41,414,829 (+)	NCBI	Rnor_WKY
Rnor_6.0	6	43,884,627 - 43,890,818 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	43,884,678 - 43,889,515 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	60,756,160 - 60,762,351 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	42,350,541 - 42,356,748 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	6	40,627,438 - 40,633,641 (+)	NCBI		Celera
Cytogenetic Map	6	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (ISO)

breast carcinoma (ISO)

Colorectal Neoplasms (ISO)

COVID-19 (ISO)

endometrial adenocarcinoma (IAGP)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

lung adenocarcinoma (ISO)

lung non-small cell carcinoma (ISO)

pancreatic cancer (ISO)

polycystic ovary syndrome (ISO)

urinary bladder cancer (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO)

1,1-dichloroethene (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (ISO)

2-butoxyethanol (ISO)

3-chloropropane-1,2-diol (EXP)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

4-hydroxyphenyl retinamide (ISO)

4-nitroquinoline N-oxide (ISO)

5-azacytidine (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (ISO)

8-Br-cAMP (ISO)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

antimycin A (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bicalutamide (ISO)

biphenyl-4-amine (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

buspirone (EXP)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

calcitriol (ISO)

camptothecin (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

celastrol (ISO)

choline (ISO)

chromium(6+) (ISO)

chrysene (ISO)

ciclopirox (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (EXP,ISO)

cobalt atom (ISO)

cobalt dichloride (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

coumarin (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

CU-O LINKAGE (ISO)

Cuprizon (EXP)

cyanocob(III)alamin (ISO)

cycloheximide (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

cytarabine (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP,ISO)

diethyl maleate (EXP,ISO)

dioxygen (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

epoxiconazole (ISO)

erythromycin estolate (EXP)

ethanol (ISO)

finasteride (EXP)

fipronil (EXP)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

gamma-tocopherol (ISO)

gedunin (ISO)

gemcitabine (ISO)

genistein (ISO)

glycidol (EXP)

glycine betaine (EXP,ISO)

hydroxyurea (ISO)

indole-3-methanol (EXP)

iron atom (ISO)

iron(0) (ISO)

ivermectin (ISO)

ketamine (EXP)

L-methionine (ISO)

leflunomide (EXP,ISO)

levofloxacin (EXP)

lidocaine (EXP)

lipopolysaccharide (ISO)

lucanthone (ISO)

LY294002 (ISO)

lycopene (ISO)

MeIQx (ISO)

metformin (EXP)

methamphetamine (EXP,ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylseleninic acid (ISO)

miconazole (ISO)

mifepristone (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (ISO)

N-nitrosodiethylamine (EXP,ISO)

N-Nitrosopyrrolidine (ISO)

nefazodone (EXP)

nickel atom (ISO)

niclosamide (ISO)

nimesulide (EXP)

oxaliplatin (EXP)

ozone (ISO)

paclitaxel (ISO)

palbociclib (ISO)

paracetamol (ISO)

PCB138 (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (ISO)

phenformin (EXP)

phenobarbital (ISO)

PhIP (EXP)

phytoestrogen (ISO)

picoxystrobin (ISO)

pinosylvin (ISO)

piperonyl butoxide (EXP)

pirinixic acid (ISO)

piroxicam (ISO)

potassium dichromate (ISO)

progesterone (ISO)

propanal (ISO)

propiconazole (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (EXP,ISO)

serpentine asbestos (ISO)

silicon dioxide (EXP,ISO)

sodium arsenite (ISO)

sodium dichromate (EXP,ISO)

Soman (EXP)

sulindac sulfide (ISO)

sunitinib (ISO)

tamibarotene (ISO)

tebufenpyrad (ISO)

testosterone (EXP,ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thalidomide (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (EXP,ISO)

tocopherol (ISO)

toluene 2,4-diisocyanate (ISO)

topotecan (EXP)

trans-pinosylvin (ISO)

Tributyltin oxide (ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

troglitazone (ISO)

trovafloxacin (EXP,ISO)

Tungsten carbide (ISO)

tunicamycin (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vincaleukoblastine (ISO)

vincristine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

2'-deoxyribonucleotide biosynthetic process (ISO)

blastocyst development (ISO)

deoxyribonucleotide biosynthetic process (IBA,IEA,ISO,ISS)

deoxyribonucleotide metabolic process (ISO)

DNA replication (IEA)

mitotic cell cycle (IEP)

positive regulation of cell population proliferation (IMP)

positive regulation of G1/S transition of mitotic cell cycle (ISO)

protein heterotetramerization (ISO)

pyrimidine nucleobase metabolic process (IEP)

ribonucleoside diphosphate metabolic process (ISO)

Cellular Component

cytosol (IBA)

cytosol (ISO)

nuclear envelope (IDA)

ribonucleoside-diphosphate reductase complex (ISO)

Molecular Function

ferric iron binding (ISO)

identical protein binding (ISO)

molecular_function (ND)

oxidoreductase activity (IEA)

protein binding (ISO)

protein homodimerization activity (ISO)

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor (IBA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

adenine phoshoribosyltransferase deficiency pathway (ISO)

adenosine monophosphate deaminase deficiency pathway (ISO)

adenylosuccinate lyase deficiency pathway (ISO)

AICA-ribosuria pathway (ISO)

azathioprine pharmacodynamics pathway (ISO)

beta-ureidopropionase deficiency pathway (ISO)

dihydropyrimidinase deficiency pathway (ISO)

gemcitabine pharmacodynamics pathway (ISO)

gemcitabine pharmacokinetics pathway (ISO)

glutathione metabolic pathway (IEA)

Kelley-Seegmiller syndrome pathway (ISO)

Lesch-Nyhan syndrome pathway (ISO)

mercaptopurine pharmacodynamics pathway (ISO)

mitochondrial neurogastrointestinal encephalopathy syndrome pathway (ISO)

molybdenum cofactor deficiency pathway (ISO)

orotic aciduria 1 pathway (ISO)

p53 signaling pathway (IEA)

purine metabolic pathway (IEA,ISO)

purine nucleoside phosphorylase deficiency pathway (ISO)

pyrimidine metabolic pathway (IEA,ISO)

tioguanine pharmacodynamics pathway (ISO)

xanthinuria type I pathway (ISO)

xanthinuria pathway (ISO)

xanthinuria type II pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Oncogene amplification in the proximal part of chromosome 6 in rat endometrial adenocarcinoma as revealed by combined BAC/PAC FISH, chromosome painting, zoo-FISH, and allelotyping.	Adamovic T, etal., Genes Chromosomes Cancer. 2005 Oct;44(2):139-53.
2.	Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients.	Boukovinas I, etal., PLoS One. 2008;3(11):e3695. doi: 10.1371/journal.pone.0003695. Epub 2008 Nov 11.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Replication of the hepatitis B virus requires a calcium-dependent HBx-induced G1 phase arrest of hepatocytes.	Gearhart TL and Bouchard MJ, Virology. 2010 Nov 10;407(1):14-25. Epub 2010 Aug 16.
5.	Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation in vitro and in vivo.	Heidel JD, etal., Clin Cancer Res. 2007 Apr 1;13(7):2207-15.
6.	Cross-species comparison of orthologous gene expression in human bladder cancer and carcinogen-induced rodent models.	Lu Y, etal., Am J Transl Res. 2010 Sep 20;3(1):8-27.
7.	The regulation of ribonucleoside diphosphate reductase by the tumor promoter orotic acid in normal rat liver in vivo.	Manjeshwar S, etal., Mol Carcinog. 1999 Mar;24(3):188-96.
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
10.	Gemcitabine-based chemogene therapy for pancreatic cancer using Ad-dCK::UMK GDEPT and TS/RR siRNA strategies.	Rejiba S, etal., Neoplasia. 2009 Jul;11(7):637-50.
11.	GOA pipeline	RGD automated data pipeline
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation
14.	Immunohistochemical detection of ribonucleotide reductase in human breast-tumors.	Saeki T, etal., Int J Oncol. 1995 Mar;6(3):523-9.
15.	Evidence that mammalian ribonucleotide reductase is a nuclear membrane associated glycoprotein.	Sikorska M, etal., Biochem Cell Biol. 1990 May;68(5):880-8.
16.	Changes in the cytoplasmic and nuclear activities of the ribonucleotide reductase holoenzyme and its subunits in regenerating liver cells in normal and thyroparathyroidectomized rats.	Youdale T, etal., Can J Biochem Cell Biol. 1984 Sep;62(9):914-9.

Additional References at PubMed

PMID:2684652	PMID:8130196	PMID:8612737	PMID:8876648	PMID:12477932	PMID:12655059	PMID:15489334	PMID:16829694	PMID:16861739	PMID:19176520	PMID:21925507	PMID:26902285
PMID:34868394

Genomics

Comparative Map Data

Rrm2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	41,339,858 - 41,346,774 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	41,340,557 - 41,346,773 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	41,660,659 - 41,666,878 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	6	41,975,466 - 41,981,683 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	6	41,408,612 - 41,414,829 (+)	NCBI	Rnor_WKY
Rnor_6.0	6	43,884,627 - 43,890,818 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	43,884,678 - 43,889,515 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	60,756,160 - 60,762,351 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	42,350,541 - 42,356,748 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	6	40,627,438 - 40,633,641 (+)	NCBI		Celera
Cytogenetic Map	6	q16	NCBI

RRM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	10,122,568 - 10,211,010 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	10,120,698 - 10,211,725 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	10,262,695 - 10,351,136 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	10,180,184 - 10,188,074 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	10,213,332 - 10,221,220	NCBI
Celera	2	10,178,748 - 10,187,595 (+)	NCBI		Celera
Cytogenetic Map	2	p25.1	NCBI
HuRef	2	10,113,982 - 10,122,746 (+)	NCBI		HuRef
CHM1_1	2	10,192,499 - 10,201,334 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	10,151,280 - 10,239,549 (+)	NCBI		T2T-CHM13v2.0

Rrm2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	24,758,253 - 24,764,145 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	24,758,240 - 24,764,145 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	24,708,254 - 24,714,146 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	24,708,241 - 24,714,146 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	25,393,119 - 25,399,011 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	25,297,362 - 25,303,186 (+)	NCBI		MGSCv36	mm8
Celera	12	26,164,274 - 26,170,181 (+)	NCBI		Celera
Cytogenetic Map	12	A1.3	NCBI
cM Map	12	8.5	NCBI

Rrm2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955487	5,476,954 - 5,483,049 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955487	5,477,097 - 5,481,422 (+)	NCBI	ChiLan1.0	ChiLan1.0

RRM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2A	10,275,598 - 10,284,640 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	10,275,598 - 10,284,640 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2A	10,119,508 - 10,128,318 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

RRM2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	7,106,515 - 7,113,868 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	7,104,961 - 7,122,939 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	7,033,016 - 7,052,810 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	7,204,147 - 7,223,928 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	7,204,143 - 7,220,570 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	7,095,785 - 7,115,556 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	7,098,343 - 7,118,126 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	7,112,515 - 7,132,291 (+)	NCBI		UU_Cfam_GSD_1.0

Rrm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	51,592,999 - 51,596,629 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936532	6,348,041 - 6,390,144 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RRM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	126,347,819 - 126,365,644 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	126,357,198 - 126,367,145 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

RRM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	97,512,690 - 97,519,734 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	97,512,832 - 97,521,932 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	14,794,522 - 14,803,100 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rrm2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624865	4,985,620 - 4,990,120 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624865	4,984,353 - 4,990,187 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rrm2
24 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	106
Count of miRNA genes:	98
Interacting mature miRNAs:	103
Transcripts:	ENSRNOT00000011163
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	42487980	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	42487980	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	42487980	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42838846	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	43394190	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	54641141	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	11735669	72593685	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	11735669	72593685	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
2292589	Emca10	Estrogen-induced mammary cancer QTL 10		0.048	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	16536140	61536140	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	16536140	71636405	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	20338777	62613667	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	32074428	72227641	Rat
634318	Bw118	Body weight QTL 118	3.55		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	6	33309549	57730294	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	33309549	81132889	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	34434137	77102317	Rat
1354632	Scl29	Serum cholesterol level QTL 29	3.74		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	6	35098709	71636405	Rat
634307	Bp141	Blood pressure QTL 141	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	35230417	80230417	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	35691618	57730540	Rat
9590290	Uminl2	Urine mineral level QTL 2	3.96	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	6	38783989	83783989	Rat
9590306	Scort18	Serum corticosterone level QTL 18	2.88	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat
9590140	Scort4	Serum corticosterone level QTL 4	14.49	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat

Markers in Region

RH128375

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	23,879,602 - 23,879,800 (-)	MAPPER	mRatBN7.2
mRatBN7.2	6	41,346,372 - 41,346,570 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	43,890,417 - 43,890,614	NCBI	Rnor6.0
Rnor_6.0	19	25,393,828 - 25,394,025	NCBI	Rnor6.0
Rnor_5.0	19	36,370,006 - 36,370,203	UniSTS	Rnor5.0
Rnor_5.0	6	60,761,950 - 60,762,147	UniSTS	Rnor5.0
Celera	19	23,428,502 - 23,428,699	UniSTS
Celera	6	40,633,240 - 40,633,437	UniSTS
Cytogenetic Map	6	q16	UniSTS

RH137293

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	41,345,135 - 41,345,454 (+)	MAPPER	mRatBN7.2
mRatBN7.2	19	23,880,707 - 23,880,923 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	43,889,191 - 43,889,509	NCBI	Rnor6.0
Rnor_6.0	19	25,392,702 - 25,392,917	NCBI	Rnor6.0
Rnor_5.0	19	36,368,880 - 36,369,095	UniSTS	Rnor5.0
Rnor_5.0	6	60,760,724 - 60,761,042	UniSTS	Rnor5.0
Celera	19	23,429,607 - 23,429,822	UniSTS
Celera	6	40,632,004 - 40,632,322	UniSTS
Cytogenetic Map	6	q16	UniSTS

PMC207566P3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	23,881,059 - 23,881,293 (-)	MAPPER	mRatBN7.2
Rnor_6.0	19	25,392,332 - 25,392,565	NCBI	Rnor6.0
Rnor_5.0	19	36,368,510 - 36,368,743	UniSTS	Rnor5.0
RGSC_v3.4	19	25,564,412 - 25,564,645	UniSTS	RGSC3.4
Celera	19	23,429,959 - 23,430,192	UniSTS
Cytogenetic Map	6	q16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	28	33	26	17	26			49	20	31	1
Low		12	22	13	2	13	4	6	21	14	10	10	4
Below cutoff		3	2	2		2	4	5	4	1			4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112489	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC099082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220381	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000091551 ⟹ ENSRNOP00000073334

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	41,340,557 - 41,346,773 (+)	Ensembl
Rnor_6.0 Ensembl	6	43,884,678 - 43,889,515 (+)	Ensembl

RefSeq Acc Id:

NM_001025740 ⟹ NP_001020911

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	41,340,569 - 41,346,774 (+)	NCBI
Rnor_6.0	6	43,884,627 - 43,890,818 (+)	NCBI
Rnor_5.0	6	60,756,160 - 60,762,351 (+)	NCBI
RGSC_v3.4	6	42,350,541 - 42,356,748 (+)	RGD
Celera	6	40,627,438 - 40,633,641 (+)	RGD

Sequence:

show sequence

TCCAGCTGTTCCCTCTTCTCCTCGTCCTCTCCACCTCTGCCTTCGTTCGCCATGCTCTCGGTCC
GCGCCCCGCTCGCCACCATCGCTGACCAGCAGCAGCTGCACTTGTCGCCCCTGAAGCGACTCAG
TCTGGCTGACAAGGAGAACACGCCCCCAACCCTCAGCAGCGCCCGCGTCCTGGCTAGCAAGGCT
GCAAGGAGAATCTTCCAGGACTCTGCCGAGCTGGAAAGTAAAGCACCCACTAAGCCCAGCATTG
AGGAAGAGCCGTTACTGAGAGAAAATCCCCGCCGTTTCGTTGTCTTTCCCATCGAATACCATGA
TATCTGGCAGATGTACAAGAAAGCTGAGGCCTCCTTTTGGACTGCCGAGGAGGTGGACCTTTCC
AAGGATATTCAGCACTGGGAAGCTCTGAAACCAGATGAGAGACATTTTATATCTCATGTTCTGG
CCTTCTTTGCGGCGAGTGACGGCATAGTCAATGAGAACTTGGTGGAGCGATTTAGCCAAGAAGT
TCAAGTCACAGAGGCCCGCTGTTTCTATGGCTTCCAAATTGCCATGGAGAACATACACTCCGAA
ATGTACAGTCTCCTTATTGACACTTACATTAAAGATTCCAAAGAAAGAGAATATCTCTTCAACG
CCATTGAGACAATGCCTTGTGTGAAGAAGAAGGCTGACTGGGCCTTGCGTTGGATTGGGGACAA
AGAGGCTACGTATGGAGAACGAGTTGTGGCCTTCGCTGCGGTAGAAGGAATCTTCTTTTCTGGT
TCTTTTGCATCAATATTCTGGCTCAAGAAACGGGGACTGATGCCGGGCCTTACATTTTCCAATG
AGCTTATTAGCAGAGATGAGGGTCTGCACTGTGACTTTGCCTGCCTGATGTTCAAGCACCTGGT
ACACAAGCCCTCGGAGCAGAGAGTAAAAGAAATAATTACCAACTCGGTCAGGATAGAGCAGGAG
TTCCTCACAGAGGCCCTGCCTGTGAAGCTCATCGGGATGAATTGCACCTTGATGAAGCAGTACA
TCGAGTTTGTGGCCGACAGGCTTATGCTGGAGCTGGGTTTTAACAAGATTTTCAAAGTAGAAAA
TCCATTTGACTTCATGGAGAATATTTCACTAGAAGGAAAAACAAACTTCTTTGAGAAGCGAGTA
GGCGAGTACCAGAGGATGGGAGTAATGTCAAATTCGACAGAAAATTCTTTCACCTTGGATGCTG
ACTTCTAAGCAACCGATCCGTGTGCTCTTTGCTGATTATTCTCCCCTTGTCATTAAAAGAAATC
AGCAAAACCAAACAACTGGCTACACCACGAATTGTCGTTAAATTTGCTAACTGGTGTCTAAAAG
CCGTGTAGCTACCTCGGTCCTGCTTGCTAGGTTTGCCACTAGAAGGAAGCATACTTAAAACAAT
GGCTACTTGGATCCTCAGGGAGATCCTGTCTGCAAGTCGCGTGGTCACCCTTAGCTTCATCAAA
GCACTAACAGCTCACCCGGCCAGGCTTCATGAGCACTGACCCTCAAGCAAGCAGGTTTATTAAA
CATTTAGATGCCAACCTCACTTACTGTTTCCTGCAGTCATGGAGAGTTTACTTAACAAGTTTGT
AAATAATAAAACTGGCACTTTGCACACAGACTTGGTACTATCCTAGGGGAAGGCCTGCTTTATT
TGGTTTCTAGACCGAGTAGGAAGTGATCCATTTACCACTGAGGGCAGCCCCATTCAGAGTCTTA
AGTGACTAAGCCAGTGTTGAACAAGCAATTTCCAGGCTTTGTTCTTCAGGGAACTTCCCATCAG
CTTTGAAGTCGGTCCTGTGCACCCTAGGCACATGGATCAGTTCACAAGTGGGGTTCAGTGGAGA
GAACTTCCCCCTCAGAAGTCACTTGAAACTTAGATGAGATTTGGGACACTTGCTGGTTGACTCT
GTCTCATTTGTGTAAAAAGTAGTTTTTTTTTTTTTTTTTTTCCAAGTTATACTTTGTCCCATTC
CTAGTTAGTACAAAGTCTTGAAAGGGCCTTTGTAGGGCTTTTTAAGTCAGGGTCTTAACTATGT
AACTCTGGCTTGGCCTGGAACTTGCTATGTAGACCAGGTTACCCTCAAACTTGCCTGTCTTCCC
AAATACTGGGATTAAGGTTTCTGTGACCATACCTGGCTTTACCTGATTAATTCCTAAACACCAG
AAAACCAGTACTGTATGAGATGTTAATGTGTGTTCCTTTCAGACTGGAGTACAGACCAGTAGAT
AACAGATAACAGCTGGTTCACCTTAATCTGCCTTTTTGTGTATTAATCTGTGTTTAGAGAACGG
AACAATAGCCAGAATTCACCTAGCGAGTTCGAGGCCAGTTGGTGTATATGTGGGACTCTTAACC
AAAACAGCAAGCGTTCCCTGGGGTAGTTCACAATGATCTCCAGCTTCCTTGTTAACCAGATAAC
TGCAAGTCAGATGTATGACCCTGGTTGGTTTATTGTATTGATATGTTTCTGTAATATGAGTAAA
TTATTGTTACTTAAAAGTAATAAATTCAAGTTTCAAAATTGAAAAAAAAAAAAAAAAAAAAAAA
AAA

hide sequence

RefSeq Acc Id:

XM_039112489 ⟹ XP_038968417

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	41,339,858 - 41,346,774 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020911	(Get FASTA)	NCBI Sequence Viewer
	XP_038968417	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH99082	(Get FASTA)	NCBI Sequence Viewer
	EDM03186	(Get FASTA)	NCBI Sequence Viewer
	Q4KLN6	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001020911 ⟸ NM_001025740

- UniProtKB:

Q4KLN6 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MLSVRAPLATIADQQQLHLSPLKRLSLADKENTPPTLSSARVLASKAARRIFQDSAELESKAPT
KPSIEEEPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFI
SHVLAFFAASDGIVNENLVERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDSKERE
YLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGL
TFSNELISRDEGLHCDFACLMFKHLVHKPSEQRVKEIITNSVRIEQEFLTEALPVKLIGMNCTL
MKQYIEFVADRLMLELGFNKIFKVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSNSTENSF
TLDADF

hide sequence

RefSeq Acc Id:

ENSRNOP00000073334 ⟸ ENSRNOT00000091551

RefSeq Acc Id:	XP_038968417 ⟸ XM_039112489
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2R734 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4KLN6-F1-model_v2	AlphaFold	Q4KLN6	1-390	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694523

Promoter ID:

EPDNEW_R5046

Type:

multiple initiation site

Name:

Rrm2_1

Description:

ribonucleotide reductase regulatory subunit M2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	43,884,618 - 43,884,678	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1598310	AgrOrtholog
BioCyc Gene	G2FUF-38023	BioCyc
BioCyc Pathway	PWY-7184 [pyrimidine deoxyribonucleotides de novo biosynthesis I]	BioCyc
	PWY-7210 [pyrimidine deoxyribonucleotides biosynthesis from CTP]	BioCyc
	PWY-7226 [guanosine deoxyribonucleotides de novo biosynthesis I]	BioCyc
	PWY-7227 [adenosine deoxyribonucleotides de novo biosynthesis I]	BioCyc
Ensembl Genes	ENSRNOG00000054286	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000073334	ENTREZGENE
	ENSRNOP00000073334.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000091551	ENTREZGENE
	ENSRNOT00000091551.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.620.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7443729	IMAGE-MGC_LOAD
InterPro	Ferritin-like_SF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RNR-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RNR_small	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RNR_small_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RNR_small_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:362720	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:116120	IMAGE-MGC_LOAD
NCBI Gene	362720	ENTREZGENE
PANTHER	PTHR23409	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Ribonuc_red_sm	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	RRM2	RGD
PhenoGen	Rrm2	PhenoGen
PROSITE	RIBORED_SMALL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47240	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2R734	ENTREZGENE, UniProtKB/TrEMBL
	Q4KLN6	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-21	Rrm2	ribonucleotide reductase regulatory subunit M2	Rrm2	ribonucleotide reductase M2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2007-04-13		ribonucleotide reductase M2	Rrm2	ribonucleotide reductase M2 (mapped)	Name updated	737654	APPROVED
2007-04-12	Rrm2	ribonucleotide reductase M2 (mapped)	Rrm2_mapped	ribonucleotide reductase M2 (mapped)	Data Merged	737654	APPROVED
2006-11-20	Rrm2	ribonucleotide reductase M2 (mapped)			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-11-17	Rrm2_mapped	ribonucleotide reductase M2 (mapped)			Symbol and Name updated	1556543	APPROVED
2002-06-10	Rrm2	Ribonucleotide reductase 2			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_process	human homolog is required for formation of deoxyribonucleotides from ribonucleotides	704404

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)