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Gene: Rrm2 (ribonucleotide reductase regulatory subunit M2) Rattus norvegicus
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Symbol: Rrm2
Name: ribonucleotide reductase regulatory subunit M2
Description: Predicted to have ferric iron binding activity; protein homodimerization activity; and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in mitotic cell cycle; positive regulation of cell population proliferation; and pyrimidine nucleobase metabolic process. Localizes to the nuclear envelope. Used to study endometrial adenocarcinoma. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RRM2 (ribonucleotide reductase regulatory subunit M2); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC116120; ribonucleoside-diphosphate reductase subunit M2; Ribonucleotide reductase 2; ribonucleotide reductase M2; ribonucleotide reductase M2 (mapped); ribonucleotide reductase M2 polypeptide; ribonucleotide reductase small chain; ribonucleotide reductase small subunit; Rrm2_mapped
Orthologs:
Homo sapiens (human) : RRM2 (ribonucleotide reductase regulatory subunit M2)  HGNC  Alliance
Mus musculus (house mouse) : Rrm2 (ribonucleotide reductase M2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rrm2 (ribonucleotide reductase regulatory subunit M2)
Pan paniscus (bonobo/pygmy chimpanzee) : RRM2 (ribonucleotide reductase regulatory subunit M2)
Canis lupus familiaris (dog) : RRM2 (ribonucleotide reductase regulatory subunit M2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rrm2 (ribonucleotide reductase regulatory subunit M2)
Sus scrofa (pig) : RRM2 (ribonucleotide reductase regulatory subunit M2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0643,884,627 - 43,890,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0660,756,160 - 60,762,351 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4642,350,541 - 42,356,748 (+)NCBIRGSC3.4rn4RGSC3.4
Celera640,627,438 - 40,633,641 (+)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Rrm2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1598310
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.