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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1598310
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rrm2
Name: ribonucleotide reductase regulatory subunit M2
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rrm2affects expressionISORRM2 (Homo sapiens)6480464CTDDoxorubicin affects the expression of RRM2 mRNAPMID:15205334
Rrm2decreases expressionISORRM2 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of RRM2 mRNAPMID:29803840 PMID:30031762
Rrm2multiple interactionsISORRM2 (Homo sapiens)6480464CTDRRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]PMID:16896004
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