Rrm2 (ribonucleotide reductase regulatory subunit M2) - Rat Genome Database

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Gene: Rrm2 (ribonucleotide reductase regulatory subunit M2) Heterocephalus glaber
Analyze
Symbol: Rrm2
Name: ribonucleotide reductase regulatory subunit M2
RGD ID: 18919209
Description: ENCODES a protein that exhibits ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor (ortholog); INVOLVED IN blastocyst development (ortholog); deoxyribonucleotide metabolic process (ortholog); positive regulation of cell population proliferation (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Animal Disease Models (ortholog); breast carcinoma (ortholog); Colorectal Neoplasms (ortholog); FOUND IN nuclear envelope (ortholog); ribonucleoside-diphosphate reductase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Ribonucleoside-diphosphate reductase subunit M2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248654,985,620 - 4,990,120 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248654,984,353 - 4,990,187 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rrm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248654,985,620 - 4,990,120 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248654,984,353 - 4,990,187 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RRM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38210,122,568 - 10,211,010 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl210,120,698 - 10,211,725 (+)EnsemblGRCh38hg38GRCh38
GRCh37210,262,695 - 10,351,136 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36210,180,184 - 10,188,074 (+)NCBINCBI36Build 36hg18NCBI36
Build 34210,213,332 - 10,221,220NCBI
Celera210,178,748 - 10,187,595 (+)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef210,113,982 - 10,122,746 (+)NCBIHuRef
CHM1_1210,192,499 - 10,201,334 (+)NCBICHM1_1
T2T-CHM13v2.0210,151,280 - 10,239,549 (+)NCBIT2T-CHM13v2.0
Rrm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391224,758,253 - 24,764,145 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1224,758,240 - 24,764,145 (+)EnsemblGRCm39 Ensembl
GRCm381224,708,254 - 24,714,146 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1224,708,241 - 24,714,146 (+)EnsemblGRCm38mm10GRCm38
MGSCv371225,393,119 - 25,399,011 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361225,297,362 - 25,303,186 (+)NCBIMGSCv36mm8
Celera1226,164,274 - 26,170,181 (+)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.5NCBI
Rrm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8647,044,755 - 47,075,370 (+)NCBIGRCr8
mRatBN7.2641,339,858 - 41,346,774 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl641,340,557 - 41,346,773 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx641,660,659 - 41,666,878 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0641,975,466 - 41,981,683 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0641,408,612 - 41,414,829 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0643,884,627 - 43,890,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl643,884,678 - 43,889,515 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0660,756,160 - 60,762,351 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4642,350,541 - 42,356,748 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera640,627,438 - 40,633,641 (+)NCBICelera
Cytogenetic Map6q16NCBI
Rrm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554875,476,954 - 5,483,049 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554875,477,097 - 5,481,422 (+)NCBIChiLan1.0ChiLan1.0
RRM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212116,388,124 - 116,396,941 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A116,392,095 - 116,400,912 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A10,119,508 - 10,128,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A10,275,598 - 10,284,640 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A10,275,598 - 10,284,640 (+)Ensemblpanpan1.1panPan2
RRM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1177,106,515 - 7,113,868 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl177,104,961 - 7,122,939 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha177,033,016 - 7,052,810 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0177,204,147 - 7,223,928 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl177,204,143 - 7,220,570 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1177,095,785 - 7,115,556 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0177,098,343 - 7,118,126 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0177,112,515 - 7,132,291 (+)NCBIUU_Cfam_GSD_1.0
Rrm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629251,592,999 - 51,596,629 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365326,348,041 - 6,390,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RRM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3126,347,819 - 126,365,644 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13126,357,198 - 126,367,145 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RRM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11497,512,690 - 97,519,734 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1497,512,832 - 97,521,932 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604514,794,522 - 14,803,100 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000001159   ⟹   ENSHGLP00000001117
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248654,985,620 - 4,990,120 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000001160   ⟹   ENSHGLP00000001118
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248654,985,620 - 4,989,359 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000001161   ⟹   ENSHGLP00000001119
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248654,986,692 - 4,989,626 (-)Ensembl
RefSeq Acc Id: XM_004869967   ⟹   XP_004870024
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248654,984,353 - 4,990,187 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004870024 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB04447 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000001117
GenBank Protein JAO01085 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004870024   ⟸   XM_004869967
- UniProtKB: G5B586 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000001118   ⟸   ENSHGLT00000001160
RefSeq Acc Id: ENSHGLP00000001119   ⟸   ENSHGLT00000001161
RefSeq Acc Id: ENSHGLP00000001117   ⟸   ENSHGLT00000001159


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000000884 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000001159 ENTREZGENE
Gene3D-CATH 1.10.620.20 UniProtKB/TrEMBL
InterPro Ferritin-like_SF UniProtKB/TrEMBL
  RNR-like UniProtKB/TrEMBL
  RNR_small UniProtKB/TrEMBL
  RNR_small_AS UniProtKB/TrEMBL
  RNR_small_fam UniProtKB/TrEMBL
KEGG Report hgl:101700655 UniProtKB/TrEMBL
NCBI Gene Rrm2 ENTREZGENE
PANTHER PTHR23409 UniProtKB/TrEMBL
  RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 UniProtKB/TrEMBL
Pfam Ribonuc_red_sm UniProtKB/TrEMBL
PROSITE RIBORED_SMALL UniProtKB/TrEMBL
Superfamily-SCOP SSF47240 UniProtKB/TrEMBL
UniProt G5B586 ENTREZGENE, UniProtKB/TrEMBL