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Gene: RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B) Homo sapiens
Symbol: RRM2B
Name: ribonucleotide reductase regulatory TP53 inducible subunit M2B
Description: Predicted to have ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Predicted to be involved in deoxyribonucleotide biosynthetic process. Localizes to the cytosol and nucleoplasm. Implicated in chronic progressive external ophthalmoplegia; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686M05248; MGC102856; MGC42116; MTDPS8A; MTDPS8B; p53-inducible ribonucleotide reductase small subunit 2 homolog; p53-inducible ribonucleotide reductase small subunit 2 short form beta; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2; ribonucleoside-diphosphate reductase subunit M2 B; ribonucleotide reductase M2 B (TP53 inducible); TP53-inducible ribonucleotide reductase M2 B
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl8102,204,502 - 102,238,961 (-)Ensembl
GRCh38 Ensembl8102,204,502 - 102,239,118 (-)Ensembl
GRCh388102,204,501 - 102,238,961 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378103,216,729 - 103,251,346 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,285,907 - 103,320,522 (-)NCBINCBI36hg18NCBI36
Build 348103,285,907 - 103,320,522NCBI
Celera899,401,627 - 99,436,245 (-)NCBI
Cytogenetic Map8q22.3NCBI
HuRef898,415,432 - 98,450,050 (-)NCBIHuRef
CHM1_18103,257,019 - 103,291,637 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RRM2B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1314438
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.