RRM2 (ribonucleotide reductase regulatory subunit M2) - Rat Genome Database

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Gene: RRM2 (ribonucleotide reductase regulatory subunit M2) Canis lupus familiaris
Analyze
Symbol: RRM2
Name: ribonucleotide reductase regulatory subunit M2
RGD ID: 12185834
Description: ENCODES a protein that exhibits ferric iron binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN blastocyst development (ortholog); deoxyribonucleotide metabolic process (ortholog); positive regulation of cell population proliferation (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Animal Disease Models (ortholog); breast carcinoma (ortholog); Colorectal Neoplasms (ortholog); FOUND IN nuclear envelope (ortholog); ribonucleoside-diphosphate reductase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase M2 polypeptide
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1177,106,515 - 7,113,868 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl177,104,961 - 7,122,939 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha177,033,016 - 7,052,810 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0177,204,147 - 7,223,928 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl177,204,143 - 7,220,570 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1177,095,785 - 7,115,556 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0177,098,343 - 7,118,126 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0177,112,515 - 7,132,291 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202   PMID:37756605  


Genomics

Comparative Map Data
RRM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1177,106,515 - 7,113,868 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl177,104,961 - 7,122,939 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha177,033,016 - 7,052,810 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0177,204,147 - 7,223,928 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl177,204,143 - 7,220,570 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1177,095,785 - 7,115,556 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0177,098,343 - 7,118,126 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0177,112,515 - 7,132,291 (+)NCBIUU_Cfam_GSD_1.0
RRM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38210,122,568 - 10,211,010 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl210,120,698 - 10,211,725 (+)EnsemblGRCh38hg38GRCh38
GRCh37210,262,695 - 10,351,136 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36210,180,184 - 10,188,074 (+)NCBINCBI36Build 36hg18NCBI36
Build 34210,213,332 - 10,221,220NCBI
Celera210,178,748 - 10,187,595 (+)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef210,113,982 - 10,122,746 (+)NCBIHuRef
CHM1_1210,192,499 - 10,201,334 (+)NCBICHM1_1
T2T-CHM13v2.0210,151,280 - 10,239,549 (+)NCBIT2T-CHM13v2.0
Rrm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391224,758,253 - 24,764,145 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1224,758,240 - 24,764,145 (+)EnsemblGRCm39 Ensembl
GRCm381224,708,254 - 24,714,146 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1224,708,241 - 24,714,146 (+)EnsemblGRCm38mm10GRCm38
MGSCv371225,393,119 - 25,399,011 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361225,297,362 - 25,303,186 (+)NCBIMGSCv36mm8
Celera1226,164,274 - 26,170,181 (+)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.5NCBI
Rrm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8647,044,755 - 47,075,370 (+)NCBIGRCr8
mRatBN7.2641,339,858 - 41,346,774 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl641,340,557 - 41,346,773 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx641,660,659 - 41,666,878 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0641,975,466 - 41,981,683 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0641,408,612 - 41,414,829 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0643,884,627 - 43,890,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl643,884,678 - 43,889,515 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0660,756,160 - 60,762,351 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4642,350,541 - 42,356,748 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera640,627,438 - 40,633,641 (+)NCBICelera
Cytogenetic Map6q16NCBI
Rrm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554875,476,954 - 5,483,049 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554875,477,097 - 5,481,422 (+)NCBIChiLan1.0ChiLan1.0
RRM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212116,388,124 - 116,396,941 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A116,392,095 - 116,400,912 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A10,119,508 - 10,128,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A10,275,598 - 10,284,640 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A10,275,598 - 10,284,640 (+)Ensemblpanpan1.1panPan2
Rrm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629251,592,999 - 51,596,629 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365326,348,041 - 6,390,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RRM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3126,347,819 - 126,365,644 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13126,357,198 - 126,367,145 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RRM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11497,512,690 - 97,519,734 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1497,512,832 - 97,521,932 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604514,794,522 - 14,803,100 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rrm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248654,985,620 - 4,990,120 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248654,984,353 - 4,990,187 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RRM2
74 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 6 8
Low 2 11 6 3 8 6
Below cutoff 5 11 6 6 4 9 2

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_038498229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038560765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038624794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038690703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_540076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005311146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005311147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005311148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005338271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005338272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005338273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005372066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005372067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005372068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005406161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005406162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005406163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005439819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005439820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005439821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000005482   ⟹   ENSCAFP00000005080
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl177,104,961 - 7,122,939 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000075996   ⟹   ENSCAFP00000062946
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl177,104,961 - 7,112,681 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845045792   ⟹   ENSCAFP00845035945
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl177,204,143 - 7,220,570 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845045923   ⟹   ENSCAFP00845036052
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl177,204,153 - 7,211,484 (+)Ensembl
RefSeq Acc Id: XM_038498229   ⟹   XP_038354157
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1177,095,786 - 7,103,134 (+)NCBI
RefSeq Acc Id: XM_038560765   ⟹   XP_038416693
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0177,112,515 - 7,119,866 (+)NCBI
RefSeq Acc Id: XM_038624794   ⟹   XP_038480722
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0177,098,343 - 7,105,703 (+)NCBI
RefSeq Acc Id: XM_038690703   ⟹   XP_038546631
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0177,204,147 - 7,211,507 (+)NCBI
RefSeq Acc Id: XM_540076   ⟹   XP_540076
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1177,106,515 - 7,113,868 (+)NCBI
Dog10K_Boxer_Tasha177,033,016 - 7,040,380 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005311146
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha177,033,016 - 7,052,808 (+)NCBI
RefSeq Acc Id: XR_005311147
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha177,033,016 - 7,052,810 (+)NCBI
RefSeq Acc Id: XR_005311148
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha177,033,016 - 7,052,808 (+)NCBI
RefSeq Acc Id: XR_005338271
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1177,095,785 - 7,115,550 (+)NCBI
RefSeq Acc Id: XR_005338272
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1177,095,785 - 7,115,556 (+)NCBI
RefSeq Acc Id: XR_005338273
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1177,095,785 - 7,115,550 (+)NCBI
RefSeq Acc Id: XR_005372066
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0177,112,515 - 7,132,285 (+)NCBI
RefSeq Acc Id: XR_005372067
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0177,112,515 - 7,132,291 (+)NCBI
RefSeq Acc Id: XR_005372068
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0177,112,515 - 7,132,285 (+)NCBI
RefSeq Acc Id: XR_005406161
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0177,098,343 - 7,118,124 (+)NCBI
RefSeq Acc Id: XR_005406162
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0177,098,343 - 7,118,126 (+)NCBI
RefSeq Acc Id: XR_005406163
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0177,098,343 - 7,118,124 (+)NCBI
RefSeq Acc Id: XR_005439819
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0177,204,147 - 7,223,926 (+)NCBI
RefSeq Acc Id: XR_005439820
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0177,204,147 - 7,223,928 (+)NCBI
RefSeq Acc Id: XR_005439821
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0177,204,147 - 7,223,926 (+)NCBI
RefSeq Acc Id: XP_540076   ⟸   XM_540076
- UniProtKB: A0A8C0RDC7 (UniProtKB/TrEMBL),   A0A8P0PBR8 (UniProtKB/TrEMBL),   A0A8C0LSI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000005080   ⟸   ENSCAFT00000005482
RefSeq Acc Id: ENSCAFP00000062946   ⟸   ENSCAFT00000075996
RefSeq Acc Id: XP_038354157   ⟸   XM_038498229
RefSeq Acc Id: XP_038480722   ⟸   XM_038624794
RefSeq Acc Id: XP_038546631   ⟸   XM_038690703
- UniProtKB: A0A8C0QHV8 (UniProtKB/TrEMBL),   A0A8I3PMS4 (UniProtKB/TrEMBL),   A0A8C0LSI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038416693   ⟸   XM_038560765
- UniProtKB: A0A8C0LSI8 (UniProtKB/TrEMBL),   A0A8C0QHV8 (UniProtKB/TrEMBL),   A0A8I3PMS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845036052   ⟸   ENSCAFT00845045923
RefSeq Acc Id: ENSCAFP00845035945   ⟸   ENSCAFT00845045792

Promoters
RGD ID:13686160
Promoter ID:EPDNEW_C4228
Type:single initiation site
Name:RRM2_1
Description:ribonucleotide reductase regulatory subunit M2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1177,106,506 - 7,106,566EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003409 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030005549 UniProtKB/TrEMBL
  ENSCAFG00040006884 UniProtKB/TrEMBL
  ENSCAFG00845025952 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000005482.5 UniProtKB/TrEMBL
  ENSCAFT00000075996.2 UniProtKB/TrEMBL
  ENSCAFT00030010190.1 UniProtKB/TrEMBL
  ENSCAFT00030010244.1 UniProtKB/TrEMBL
  ENSCAFT00040012800.1 UniProtKB/TrEMBL
  ENSCAFT00845045792.1 UniProtKB/TrEMBL
  ENSCAFT00845045923 ENTREZGENE
  ENSCAFT00845045923.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.620.20 UniProtKB/TrEMBL
InterPro Ferritin-like_SF UniProtKB/TrEMBL
  RNR-like UniProtKB/TrEMBL
  RNR_small UniProtKB/TrEMBL
  RNR_small_AS UniProtKB/TrEMBL
  RNR_small_fam UniProtKB/TrEMBL
KEGG Report cfa:482963 UniProtKB/TrEMBL
NCBI Gene RRM2 ENTREZGENE
PANTHER PTHR23409 UniProtKB/TrEMBL
  RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 UniProtKB/TrEMBL
Pfam Ribonuc_red_sm UniProtKB/TrEMBL
PROSITE RIBORED_SMALL UniProtKB/TrEMBL
Superfamily-SCOP SSF47240 UniProtKB/TrEMBL
UniProt A0A8C0LSI8 ENTREZGENE
  A0A8C0MG86_CANLF UniProtKB/TrEMBL
  A0A8C0QHV8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RDC7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PMS4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PSC7_CANLF UniProtKB/TrEMBL
  A0A8P0PBR8 ENTREZGENE
UniProt Secondary A0A8P0N6C2 UniProtKB/TrEMBL
  A0A8P0PBR8 UniProtKB/TrEMBL
VGNC ID VGNC:45761 ENTREZGENE