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Gene: Skp2 (S-phase kinase associated protein 2) Rattus norvegicus
Symbol: Skp2
Name: S-phase kinase associated protein 2
RGD ID: 1562456
Description: Predicted to have identical protein binding activity. Involved in cellular response to cell-matrix adhesion and positive regulation of smooth muscle cell proliferation. Predicted to localize to SCF ubiquitin ligase complex; cytosol; and nuclear lumen. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2); PARTICIPATES IN Notch signaling pathway; p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH acetamide; bisphenol A; C60 fullerene.
Type: protein-coding
Also known as: LOC294790; RGD1562456; S-phase kinase-associated protein 2; S-phase kinase-associated protein 2 (p45); S-phase kinase-associated protein 2, E3 ubiquitin protein ligase; similar to S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (F-box/WD-40 protein 1) (FWD1); similar to S-phase kinase-associated protein 2 (F-box protein Skp2) (F-box/WD-40 protein 1)
Homo sapiens (human) : SKP2 (S-phase kinase associated protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Skp2 (S-phase kinase-associated protein 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Skp2 (S-phase kinase associated protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SKP2 (S-phase kinase associated protein 2)
Canis lupus familiaris (dog) : SKP2 (S-phase kinase associated protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Skp2 (S-phase kinase associated protein 2)
Sus scrofa (pig) : SKP2 (S-phase kinase associated protein 2)
Chlorocebus sabaeus (African green monkey) : SKP2 (S-phase kinase associated protein 2)
Heterocephalus glaber (naked mole-rat) : Skp2 (S-phase kinase associated protein 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0258,506,146 - 58,534,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl258,506,151 - 58,534,211 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0277,593,574 - 77,621,639 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4258,769,164 - 58,797,229 (-)NCBIRGSC3.4rn4RGSC3.4
Celera253,770,002 - 53,798,066 (-)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Skp2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1562456
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.