Flt1 (Fms related receptor tyrosine kinase 1) - Rat Genome Database

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Gene: Flt1 (Fms related receptor tyrosine kinase 1) Rattus norvegicus
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Symbol: Flt1
Name: Fms related receptor tyrosine kinase 1
RGD ID: 2621
Description: Enables ATP binding activity; growth factor binding activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including liver regeneration; negative regulation of vascular endothelial growth factor production; and positive regulation of cell population proliferation. Located in extracellular space and plasma membrane. Used to study corneal neovascularization. Biomarker of breast cancer; diabetic retinopathy; liver cirrhosis; myocardial infarction; and vascular dementia. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1); PARTICIPATES IN vascular endothelial growth factor signaling pathway; axitinib pharmacodynamics pathway; bevacizumab pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLT-1; FMS-like tyrosine kinase 1; FMS-related tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); LOC100911280; tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor 1-like; vascular endothelial growth factor/vascular permeability factor receptor; VEGFR-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2127,296,899 - 7,468,626 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl127,297,292 - 7,468,626 (+)Ensembl
Rnor_6.0129,033,993 - 9,205,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,034,308 - 9,205,905 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01210,927,827 - 10,959,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,858,092 - 8,035,966 (+)NCBIRGSC3.4rn4RGSC3.4
Celera129,039,046 - 9,210,055 (+)NCBICelera
RH 3.4 Map12 RGD
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (IMP)
allergic contact dermatitis  (ISO)
angiosarcoma  (ISO)
arteriovenous malformations of the brain  (ISO)
atrial fibrillation  (ISO)
background diabetic retinopathy  (ISO)
breast cancer  (IEP)
Breast Neoplasms  (ISO)
Bronchopulmonary Dysplasia  (ISO)
cerebral cavernous malformation  (ISO)
Cerebral Hemorrhage  (IEP,ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (IMP,ISO)
chronic obstructive pulmonary disease  (ISO)
colon carcinoma  (ISO)
corneal neovascularization  (IMP)
Coronary Disease  (ISO)
COVID-19  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IEP,ISO)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
hydrophthalmos  (ISO)
ischemia  (ISO)
Kawasaki disease  (ISO)
Kidney Neoplasms  (ISO)
Kuhnt-Junius degeneration  (ISO)
leiomyosarcoma  (ISO)
Leydig cell tumor  (ISO)
liver cirrhosis  (IEP,ISO)
macular degeneration  (ISO)
macular retinal edema  (ISO)
melanoma  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
myocardial infarction  (IEP)
nasopharynx carcinoma  (ISO)
Neointima  (IEP,IMP)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
osteochondrodysplasia  (ISO)
Otitis Media with Effusion  (IEP)
Ovarian Neoplasms  (ISO)
pre-eclampsia  (ISO)
proliferative diabetic retinopathy  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
Recurrence  (ISO)
renal cell carcinoma  (ISO)
retinopathy of prematurity  (ISO)
Sepsis  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (IEP)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)
vascular dementia  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(R)-lipoic acid  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5-Hydroxycapric acid  (ISO)
Actein  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bilirubin IXalpha  (ISO)
biphenyl-2-ol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
DAPT  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazoxide  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edaravone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
eugenol  (EXP)
fenvalerate  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furosemide  (EXP)
geldanamycin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
indoles  (EXP)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lanreotide  (EXP)
lipoic acid  (ISO)
losartan  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
Nilvadipine  (EXP)
NS 1619  (ISO)
orphenadrine  (EXP)
oxaliplatin  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
Paxilline  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (EXP,ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
rebaudioside A  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
tauroursodeoxycholic acid  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
Verbenalin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
angiogenesis  (IEA,ISO)
blood vessel morphogenesis  (ISO,ISS)
branching involved in blood vessel morphogenesis  (ISO)
cell migration  (IBA,ISO,ISS)
cellular response to hypoxia  (IEP)
cellular response to vascular endothelial growth factor stimulus  (ISO)
embryonic morphogenesis  (ISO,ISS)
female pregnancy  (IEP)
hematopoietic progenitor cell differentiation  (IBA)
hyaloid vascular plexus regression  (ISO,ISS)
intracellular receptor signaling pathway  (IMP)
liver regeneration  (IEP)
monocyte chemotaxis  (IEA,ISO)
negative regulation of sprouting angiogenesis  (IDA)
negative regulation of vascular endothelial cell proliferation  (IEA,ISO)
negative regulation of vascular endothelial growth factor production  (IDA)
peptidyl-tyrosine phosphorylation  (IEA,ISO,ISS)
positive regulation of angiogenesis  (IBA,IEA,ISO)
positive regulation of cell migration  (IEA,IMP,ISO)
positive regulation of fibroblast proliferation  (IDA)
positive regulation of glial cell proliferation  (IMP)
positive regulation of hematopoietic progenitor cell differentiation  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of MAP kinase activity  (IEA,ISO)
positive regulation of MAPK cascade  (IMP,ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IEA,ISO)
positive regulation of phospholipase C activity  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IDA)
positive regulation of vascular permeability  (ISO)
post-embryonic camera-type eye morphogenesis  (ISO)
protein autophosphorylation  (IEA,ISO,ISS)
protein phosphorylation  (IDA)
regulation of smooth muscle contraction  (IDA)
response to activity  (IEP)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to hypoxia  (IDA,IEP,ISO)
sprouting angiogenesis  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
vascular endothelial growth factor receptor signaling pathway  (ISO)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA,ISO)
vascular endothelial growth factor signaling pathway  (IEA)

Cellular Component

References

References - curated
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Additional References at PubMed
PMID:1312256   PMID:7596436   PMID:8356051   PMID:8605350   PMID:9299537   PMID:9689083   PMID:10471394   PMID:11312102   PMID:11513746   PMID:11591653   PMID:12366396   PMID:12753865  
PMID:12796773   PMID:12923895   PMID:14633857   PMID:14982871   PMID:15001553   PMID:15601856   PMID:15838270   PMID:15919309   PMID:15952180   PMID:16109918   PMID:17311300   PMID:17402857  
PMID:17854994   PMID:17889862   PMID:18079407   PMID:18321563   PMID:18421240   PMID:18586890   PMID:18772315   PMID:18948613   PMID:19098424   PMID:19575935   PMID:19720604   PMID:19758562  
PMID:20103598   PMID:20362592   PMID:20572782   PMID:20725052   PMID:21423176   PMID:21555675   PMID:21642504   PMID:21928073   PMID:22886301   PMID:22955733   PMID:23193111   PMID:23382219  
PMID:24704473   PMID:25184477   PMID:25268360   PMID:27280428   PMID:27620880   PMID:28457321   PMID:28570669   PMID:28637396   PMID:28958753   PMID:29270751   PMID:29397206   PMID:30543046  
PMID:31583245   PMID:32039444   PMID:32972452  


Genomics

Candidate Gene Status
Flt1 is a candidate Gene for QTL Cia12
Comparative Map Data
Flt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2127,296,899 - 7,468,626 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl127,297,292 - 7,468,626 (+)Ensembl
Rnor_6.0129,033,993 - 9,205,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,034,308 - 9,205,905 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01210,927,827 - 10,959,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,858,092 - 8,035,966 (+)NCBIRGSC3.4rn4RGSC3.4
Celera129,039,046 - 9,210,055 (+)NCBICelera
RH 3.4 Map12 RGD
Cytogenetic Map12p11NCBI
FLT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1328,300,346 - 28,495,145 (-)EnsemblGRCh38hg38GRCh38
GRCh381328,300,346 - 28,495,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371328,874,483 - 29,069,265 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,774,389 - 27,967,265 (-)NCBINCBI36hg18NCBI36
Build 341327,773,789 - 27,967,232NCBI
Celera139,949,266 - 10,144,048 (-)NCBI
Cytogenetic Map13q12.3NCBI
HuRef139,695,411 - 9,890,006 (-)NCBIHuRef
CHM1_11328,842,736 - 29,037,594 (-)NCBICHM1_1
Flt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,498,414 - 147,663,419 (-)NCBIGRCm39mm39
GRCm39 Ensembl5147,498,414 - 147,662,821 (-)Ensembl
GRCm385147,561,604 - 147,726,438 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,561,604 - 147,726,011 (-)EnsemblGRCm38mm10GRCm38
MGSCv375148,373,772 - 148,537,564 (-)NCBIGRCm37mm9NCBIm37
MGSCv365147,872,545 - 148,036,337 (-)NCBImm8
Celera5145,555,589 - 145,721,706 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map587.01NCBI
Flt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554977,653,248 - 7,831,472 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554977,653,309 - 7,831,737 (-)NCBIChiLan1.0ChiLan1.0
FLT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11327,926,256 - 28,120,493 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0139,584,850 - 9,779,542 (-)NCBIMhudiblu_PPA_v0panPan3
FLT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12511,231,958 - 11,410,379 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2511,231,737 - 11,407,621 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2511,295,043 - 11,473,288 (+)NCBI
ROS_Cfam_1.02511,359,770 - 11,538,425 (+)NCBI
UMICH_Zoey_3.12511,255,914 - 11,434,257 (+)NCBI
UNSW_CanFamBas_1.02511,248,371 - 11,426,845 (+)NCBI
UU_Cfam_GSD_1.02511,290,416 - 11,468,726 (+)NCBI
Flt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945172,334,859 - 172,512,069 (+)NCBI
SpeTri2.0NW_00493647223,442,946 - 23,617,523 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,620,700 - 5,795,264 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,620,698 - 5,797,095 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2115,307,309 - 5,483,546 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FLT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.137,412,506 - 7,608,122 (-)NCBI
ChlSab1.1 Ensembl37,412,172 - 7,607,967 (-)Ensembl
Vero_WHO_p1.0NW_02366605736,781,262 - 36,977,028 (+)NCBI
Flt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477610,043,113 - 10,218,598 (+)NCBI

Position Markers
D12Got4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,419,974 - 7,420,119 (+)MAPPERmRatBN7.2
Rnor_6.0129,157,242 - 9,157,386NCBIRnor6.0
Rnor_5.01211,276,512 - 11,276,656UniSTSRnor5.0
RGSC_v3.4127,989,430 - 7,989,575RGDRGSC3.4
RGSC_v3.4127,989,431 - 7,989,575UniSTSRGSC3.4
RGSC_v3.1128,019,359 - 8,019,503RGD
Celera129,161,501 - 9,161,645UniSTS
RH 3.4 Map1278.6UniSTS
RH 3.4 Map1278.6RGD
RH 2.0 Map1265.2RGD
Cytogenetic Map12p11UniSTS
RH142805  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,373,601 - 7,373,808 (+)MAPPERmRatBN7.2
Rnor_6.0129,111,054 - 9,111,260NCBIRnor6.0
Rnor_5.01211,230,613 - 11,230,819UniSTSRnor5.0
RGSC_v3.4127,943,881 - 7,944,087UniSTSRGSC3.4
Celera129,115,304 - 9,115,510UniSTS
RH 3.4 Map1274.7UniSTS
Cytogenetic Map12p11UniSTS
AW531954  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,388,774 - 7,388,932 (+)MAPPERmRatBN7.2
Rnor_6.0129,126,047 - 9,126,204NCBIRnor6.0
Rnor_5.01211,245,471 - 11,245,628UniSTSRnor5.0
RGSC_v3.4127,958,213 - 7,958,370UniSTSRGSC3.4
Celera129,130,303 - 9,130,460UniSTS
RH 3.4 Map1283.6UniSTS
Cytogenetic Map12p11UniSTS
AW534418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,428,613 - 7,428,780 (+)MAPPERmRatBN7.2
Rnor_6.0129,165,880 - 9,166,046NCBIRnor6.0
Rnor_5.01211,285,150 - 11,285,316UniSTSRnor5.0
RGSC_v3.4127,998,069 - 7,998,235UniSTSRGSC3.4
Celera129,170,109 - 9,170,275UniSTS
RH 3.4 Map1284.6UniSTS
Cytogenetic Map12p11UniSTS
RH94413  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,466,375 - 7,466,463 (+)MAPPERmRatBN7.2
Rnor_6.0129,203,636 - 9,203,723NCBIRnor6.0
Rnor_5.01211,322,790 - 11,322,877UniSTSRnor5.0
RGSC_v3.4128,035,831 - 8,035,918UniSTSRGSC3.4
Celera129,207,805 - 9,207,892UniSTS
RH 3.4 Map1281.9UniSTS
Cytogenetic Map12p11UniSTS
BF390975  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,387,710 - 7,387,886 (+)MAPPERmRatBN7.2
Rnor_6.0129,124,983 - 9,125,158NCBIRnor6.0
Rnor_5.01211,244,407 - 11,244,582UniSTSRnor5.0
RGSC_v3.4127,957,149 - 7,957,324UniSTSRGSC3.4
Celera129,129,239 - 9,129,414UniSTS
RH 3.4 Map1287.01UniSTS
Cytogenetic Map12p11UniSTS
Flt1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,446,427 - 7,448,109 (+)MAPPERmRatBN7.2
Rnor_6.0129,183,689 - 9,185,370NCBIRnor6.0
Rnor_5.01211,302,959 - 11,304,640UniSTSRnor5.0
RGSC_v3.4128,015,880 - 8,017,561UniSTSRGSC3.4
Celera129,187,906 - 9,189,587UniSTS
Cytogenetic Map12p11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12390696910373166Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:114
Interacting mature miRNAs:127
Transcripts:ENSRNOT00000001248
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37 12 2 13 2 6 7 24 31 10 11 6
Low 3 6 45 39 6 39 2 4 50 4 31 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001248   ⟹   ENSRNOP00000001248
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl127,297,292 - 7,468,626 (+)Ensembl
Rnor_6.0 Ensembl129,034,308 - 9,205,905 (+)Ensembl
RefSeq Acc Id: NM_001309381   ⟹   NP_001296310
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2127,297,292 - 7,391,757 (+)NCBI
Rnor_6.0129,034,409 - 9,129,029 (+)NCBI
Celera129,039,046 - 9,133,285 (+)NCBI
Sequence:
RefSeq Acc Id: NM_019306   ⟹   NP_062179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2127,297,292 - 7,468,626 (+)NCBI
Rnor_6.0129,034,409 - 9,205,886 (+)NCBI
Rnor_5.01210,927,827 - 10,959,880 (-)NCBI
RGSC_v3.4127,858,092 - 8,035,966 (+)RGD
Celera129,039,046 - 9,210,055 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768998   ⟹   XP_008767220
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2127,296,899 - 7,393,673 (+)NCBI
Rnor_6.0129,033,993 - 9,130,272 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062179   ⟸   NM_019306
- Peptide Label: isoform 1 precursor
- UniProtKB: G3V633 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767220   ⟸   XM_008768998
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001296310   ⟸   NM_001309381
- Peptide Label: isoform 2 precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000001248   ⟸   ENSRNOT00000001248
Protein Domains
Ig-like   Ig-like C2-type   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698401
Promoter ID:EPDNEW_R8925
Type:single initiation site
Name:Flt1_1
Description:FMS-related tyrosine kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0129,034,365 - 9,034,425EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2621 AgrOrtholog
Ensembl Genes ENSRNOG00000000940 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001248 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001248 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR-2_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 54251 ENTREZGENE
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR-2_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB FLT1 RGD
PhenoGen Flt1 PhenoGen
PRINTS VEGFRECEPTR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC208889
UniProt G3V633 ENTREZGENE, UniProtKB/TrEMBL
  P53767 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-03 Flt1  Fms related receptor tyrosine kinase 1  Flt1  FMS-related tyrosine kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-06-08 Flt1  FMS-related tyrosine kinase 1  LOC100911280  vascular endothelial growth factor receptor 1-like  Data Merged 737654 APPROVED
2012-07-05 LOC100911280  vascular endothelial growth factor receptor 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-04-29 Flt1  FMS-related tyrosine kinase 1  Flt1  fms-related tyrosine kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Flt1  fms-related tyrosine kinase 1  Flt1  FMS-like tyrosine kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Flt1  FMS-like tyrosine kinase 1    Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)  Name updated 625702 APPROVED
2002-06-10 Flt1  Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver sinusoidal endothelial cells 728597