Gene: Flt1 (FMS-related tyrosine kinase 1) Rattus norvegicus
Symbol: Flt1
Name: FMS-related tyrosine kinase 1
Description: ENCODES a protein that exhibits ATP binding; growth factor binding; transmembrane receptor protein tyrosine kinase activity; INVOLVED IN activation of MAPKK activity; aging; cellular response to hypoxia; PARTICIPATES IN vascular endothelial growth factor signaling pathway; axitinib pharmacodynamics pathway; bevacizumab pharmacodynamics pathway; ASSOCIATED WITH Acute Lung Injury; Breast Neoplasms; Cerebral Hemorrhage; FOUND IN extracellular space; plasma membrane; actin cytoskeleton (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3,3',4,4',5-pentachlorobiphenyl
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLT-1; FMS-like tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); LOC100911280; tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor 1-like; vascular endothelial growth factor/vascular permeability factor receptor; VEGFR-1
Homo sapiens (human) : FLT1 (fms related tyrosine kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Flt1 (FMS-like tyrosine kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flt1 (fms related tyrosine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FLT1 (fms related tyrosine kinase 1)
Canis lupus familiaris (dog) : FLT1 (fms related tyrosine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flt1 (fms related tyrosine kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0129,033,993 - 9,205,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01210,927,827 - 10,959,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,858,092 - 8,035,966 (+)NCBIRGSC3.4rn4RGSC3.4
Celera129,039,046 - 9,210,055 (+)NCBICelera
Cytogenetic Map12p11NCBI
RH 3.4 Map12 RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Flt1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2621
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2018-03-20
Status: ACTIVE