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Gene: Flt1 (Fms related receptor tyrosine kinase 1) Rattus norvegicus
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Symbol: Flt1
Name: Fms related receptor tyrosine kinase 1
RGD ID: 2621
Description: Exhibits ATP binding activity; growth factor binding activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including liver regeneration; negative regulation of vascular endothelial growth factor production; and positive regulation of cell population proliferation. Localizes to extracellular space and plasma membrane. Used to study corneal neovascularization. Biomarker of breast cancer; diabetic retinopathy; liver cirrhosis; myocardial infarction; and vascular dementia. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1); PARTICIPATES IN vascular endothelial growth factor signaling pathway; axitinib pharmacodynamics pathway; bevacizumab pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLT-1; FMS-like tyrosine kinase 1; FMS-related tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); LOC100911280; tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor 1-like; vascular endothelial growth factor/vascular permeability factor receptor; VEGFR-1
Orthologs:
Homo sapiens (human) : FLT1 (fms related receptor tyrosine kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Flt1 (FMS-like tyrosine kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flt1 (fms related receptor tyrosine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FLT1 (fms related receptor tyrosine kinase 1)
Canis lupus familiaris (dog) : FLT1 (fms related receptor tyrosine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flt1 (fms related receptor tyrosine kinase 1)
Sus scrofa (pig) : FLT1 (fms related receptor tyrosine kinase 1)
Chlorocebus sabaeus (African green monkey) : FLT1 (fms related receptor tyrosine kinase 1)
Heterocephalus glaber (naked mole-rat) : Flt1 (fms related receptor tyrosine kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0129,033,993 - 9,205,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,034,308 - 9,205,905 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01210,927,827 - 10,959,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,858,092 - 8,035,966 (+)NCBIRGSC3.4rn4RGSC3.4
Celera129,039,046 - 9,210,055 (+)NCBICelera
Cytogenetic Map12p11NCBI
RH 3.4 Map12 RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Flt1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2621
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.