(-)-demecolcine decreases expression ISO RGD:737202 6480464 Demecolcine results in decreased expression of FLT1 mRNA CTD PMID:23649840 (R)-lipoic acid multiple interactions ISO RGD:734184 6480464 Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA] CTD PMID:23608068 1,1-dichloroethene decreases expression ISO RGD:734184 6480464 vinylidene chloride results in decreased expression of FLT1 mRNA CTD PMID:26682919 17alpha-ethynylestradiol multiple interactions ISO RGD:734184 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FLT1 mRNA CTD PMID:17942748 17beta-estradiol decreases expression ISO RGD:737202 6480464 Estradiol results in decreased expression of FLT1 mRNA CTD PMID:19828145 17beta-estradiol decreases secretion ISO RGD:737202 6480464 Estradiol results in decreased secretion of FLT1 protein CTD PMID:19828145 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:734184 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:734184 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:737202 6480464 Tetrachlorodibenzodioxin results in increased expression of FLT1 mRNA CTD PMID:11007951 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:734184 6480464 Tetrachlorodibenzodioxin affects the expression of FLT1 mRNA CTD PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:734184 6480464 Tetrachlorodibenzodioxin results in decreased expression of FLT1 mRNA CTD PMID:19933214 , PMID:26290441 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of FLT1 mRNA, Tetrachlorodibenzodioxin results in increased expression of FLT1 mRNA alternative form CTD PMID:16495355 , PMID:24475139 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:734184 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FLT1 mRNA, Tetrachlorodibenzodioxin affects the reaction [AHR protein binds to FLT1 promoter] CTD PMID:17942748 , PMID:19654925 2-butoxyethanol increases expression ISO RGD:734184 6480464 n-butoxyethanol results in increased expression of FLT1 mRNA CTD PMID:19812364 2-hydroxypropanoic acid increases expression ISO RGD:737202 6480464 Lactic Acid results in increased expression of FLT1 mRNA CTD PMID:30851411 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression EXP 6480464 Puromycin Aminonucleoside results in increased expression of FLT1 protein CTD PMID:14752241 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine affects expression EXP 6480464 Puromycin Aminonucleoside affects the expression of FLT1 mRNA CTD PMID:11744811 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:23196670 4-hydroxyphenyl retinamide increases expression ISO RGD:734184 6480464 Fenretinide results in increased expression of FLT1 mRNA CTD PMID:28973697 5-fluorouracil decreases expression ISO RGD:734184 6480464 Fluorouracil results in decreased expression of FLT1 protein CTD PMID:18157009 5-fluorouracil multiple interactions ISO RGD:734184 6480464 IFNA1 protein promotes the reaction [Fluorouracil results in decreased expression of FLT1 protein] CTD PMID:18157009 Actein increases expression EXP 6480464 actein results in increased expression of FLT1 mRNA CTD PMID:19527300 afimoxifene decreases secretion ISO RGD:737202 6480464 afimoxifene results in decreased secretion of FLT1 protein CTD PMID:19828145 aflatoxin B1 decreases methylation ISO RGD:737202 6480464 Aflatoxin B1 results in decreased methylation of FLT1 exon CTD PMID:30157460 aflatoxin B2 increases methylation ISO RGD:737202 6480464 aflatoxin B2 results in increased methylation of FLT1 intron CTD PMID:30157460 aluminium oxide increases expression ISO RGD:737202 6480464 Aluminum Oxide results in increased expression of FLT1 mRNA CTD PMID:19464052 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of FLT1 mRNA CTD PMID:16483693 andrographolide decreases expression ISO RGD:737202 6480464 andrographolide results in decreased expression of FLT1 mRNA CTD PMID:28651835 belinostat increases expression ISO RGD:737202 6480464 belinostat results in increased expression of FLT1 mRNA CTD PMID:26272509 belinostat multiple interactions ISO RGD:737202 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA CTD PMID:27188386 benzo[a]pyrene multiple interactions ISO RGD:734184 6480464 Benzo(a)pyrene affects the reaction [AHR protein binds to FLT1 promoter] CTD PMID:19654925 benzo[a]pyrene affects methylation ISO RGD:737202 6480464 Benzo(a)pyrene affects the methylation of FLT1 intron CTD PMID:30157460 benzo[e]pyrene increases methylation ISO RGD:737202 6480464 benzo(e)pyrene results in increased methylation of FLT1 intron CTD PMID:30157460 bilirubin IXalpha multiple interactions ISO RGD:737202 6480464 Bilirubin inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein] CTD PMID:25371888 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:734184 6480464 Diethylhexyl Phthalate results in decreased expression of FLT1 mRNA CTD PMID:29753845 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of FLT1 mRNA CTD PMID:25181051 bromochloroacetic acid decreases expression ISO RGD:734184 6480464 bromochloroacetic acid results in decreased expression of FLT1 protein CTD PMID:21296659 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of FLT1 mRNA CTD PMID:19167457 cadmium atom increases activity ISO RGD:737202 6480464 Cadmium results in increased activity of FLT1 protein CTD PMID:25343777 cadmium atom multiple interactions ISO RGD:737202 6480464 Acetylcysteine inhibits the reaction [Cadmium results in increased expression of FLT1 mRNA] CTD PMID:29408318 cadmium atom increases expression ISO RGD:737202 6480464 Cadmium results in increased expression of FLT1 mRNA CTD PMID:29408318 calcitriol increases expression ISO RGD:737202 6480464 Calcitriol results in increased expression of FLT1 mRNA CTD PMID:26485663 carbon nanotube decreases expression ISO RGD:734184 6480464 Nanotubes, Carbon analog results in decreased expression of FLT1 mRNA, Nanotubes, Carbon results in decreased expression of FLT1 mRNA CTD PMID:25554681 , PMID:25620056 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of FLT1 mRNA CTD PMID:23125180 cholesterol increases expression ISO RGD:737202 6480464 Cholesterol results in increased expression of FLT1 mRNA CTD PMID:26296894 choline multiple interactions ISO RGD:734184 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FLT1 gene CTD PMID:20938992 cisplatin increases expression ISO RGD:734184 6480464 Cisplatin results in increased expression of FLT1 CTD PMID:21975929 cisplatin increases expression ISO RGD:737202 6480464 Cisplatin results in increased expression of FLT1 mRNA CTD PMID:27392435 cobalt dichloride multiple interactions ISO RGD:737202 6480464 Edaravone inhibits the reaction [cobaltous chloride results in increased expression of FLT1 mRNA], Edaravone inhibits the reaction [cobaltous chloride results in increased expression of FLT1 protein] CTD PMID:24840734 cobalt dichloride increases expression ISO RGD:737202 6480464 cobaltous chloride results in increased expression of FLT1 mRNA, cobaltous chloride results in increased expression of FLT1 protein CTD PMID:24840734 cobalt dichloride decreases expression ISO RGD:737202 6480464 cobaltous chloride results in decreased expression of FLT1 mRNA CTD PMID:19320972 copper atom increases response to substance EXP 6480464 VEGFR-1 protein results in increased susceptibility to Copper CTD PMID:19542178 copper atom increases expression EXP 6480464 Copper results in increased expression of FLT1 mRNA CTD PMID:30556269 copper(0) increases response to substance EXP 6480464 VEGFR-1 protein results in increased susceptibility to Copper CTD PMID:19542178 copper(0) increases expression EXP 6480464 Copper results in increased expression of FLT1 mRNA CTD PMID:30556269 copper(2+) increases response to substance EXP 6480464 VEGFR-1 protein results in increased susceptibility to Copper CTD PMID:19542178 copper(2+) increases expression EXP 6480464 Copper results in increased expression of FLT1 mRNA CTD PMID:30556269 corticosterone increases expression EXP 6480464 Corticosterone results in increased expression of FLT1 mRNA CTD PMID:15755911 crocidolite asbestos increases secretion ISO RGD:737202 6480464 Asbestos, Crocidolite results in increased secretion of FLT1 protein CTD PMID:21762757 crocidolite asbestos multiple interactions ISO RGD:737202 6480464 RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased secretion of FLT1 protein] CTD PMID:21762757 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of FLT1 protein] CTD PMID:23845850 curcumin decreases expression ISO RGD:737202 6480464 Curcumin results in decreased expression of FLT1 protein CTD PMID:18593936 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of FLT1 mRNA CTD PMID:12110003 cyclosporin A multiple interactions EXP 6480464 [Hydralazine co-treated with Hydrochlorothiazide] inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA], nilvadipine inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA] CTD PMID:12110003 DAPT multiple interactions ISO RGD:734184 6480464 N-(N-(3, 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of FLT1 protein] CTD PMID:21843347 dexamethasone increases expression ISO RGD:737202 6480464 Dexamethasone results in increased expression of FLT1 mRNA CTD PMID:19853017 dextran sulfate multiple interactions ISO RGD:734184 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of FLT1 mRNA CTD PMID:29950665 diazoxide multiple interactions ISO RGD:737202 6480464 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] more ... CTD PMID:25371888 dioxygen multiple interactions ISO RGD:737202 6480464 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] more ... CTD PMID:25371888 dioxygen increases expression ISO RGD:737202 6480464 Oxygen deficiency results in increased expression of FLT1 mRNA, Oxygen deficiency results in increased expression of FLT1 protein CTD PMID:18679377 more ... dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of FLT1 mRNA CTD PMID:10613739 , PMID:11981751 disodium selenite decreases expression ISO RGD:737202 6480464 Sodium Selenite results in decreased expression of FLT1 mRNA CTD PMID:18175754 diuron increases expression EXP 6480464 Diuron results in increased expression of FLT1 mRNA CTD PMID:21551480 dorsomorphin multiple interactions ISO RGD:737202 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin increases expression ISO RGD:734184 6480464 Doxorubicin results in increased expression of FLT1 mRNA CTD PMID:19277126 doxorubicin decreases expression ISO RGD:737202 6480464 Doxorubicin results in decreased expression of FLT1 mRNA CTD PMID:29803840 edaravone multiple interactions ISO RGD:737202 6480464 Edaravone inhibits the reaction [cobaltous chloride results in increased expression of FLT1 mRNA], Edaravone inhibits the reaction [cobaltous chloride results in increased expression of FLT1 protein] CTD PMID:24840734 entinostat increases expression ISO RGD:737202 6480464 entinostat results in increased expression of FLT1 mRNA CTD PMID:26272509 entinostat multiple interactions ISO RGD:737202 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA CTD PMID:27188386 ethanol increases expression ISO RGD:734184 6480464 Ethanol results in increased expression of FLT1 mRNA CTD PMID:22198099 eugenol multiple interactions EXP 6480464 Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of FLT1 mRNA] CTD PMID:20434464 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of FLT1 mRNA CTD PMID:18035473 folic acid multiple interactions ISO RGD:734184 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FLT1 gene CTD PMID:20938992 formaldehyde decreases expression ISO RGD:737202 6480464 Formaldehyde results in decreased expression of FLT1 mRNA CTD PMID:23649840 furosemide increases expression EXP 6480464 Furosemide results in increased expression of FLT1 mRNA CTD PMID:16526316 geldanamycin increases expression ISO RGD:737202 6480464 geldanamycin results in increased expression of FLT1 mRNA CTD PMID:26705709 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of FLT1 mRNA CTD PMID:22061828 hydralazine multiple interactions EXP 6480464 [Hydralazine co-treated with Hydrochlorothiazide] inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA] CTD PMID:12110003 hydrochlorothiazide multiple interactions EXP 6480464 [Hydralazine co-treated with Hydrochlorothiazide] inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA] CTD PMID:12110003 indoles decreases expression EXP 6480464 Indoles results in decreased expression of FLT1 mRNA CTD PMID:20521778 isoprenaline increases expression ISO RGD:734184 6480464 Isoproterenol results in increased expression of FLT1 mRNA CTD PMID:20003209 L-ascorbic acid decreases expression ISO RGD:737202 6480464 Ascorbic Acid results in decreased expression of FLT1 mRNA CTD PMID:21919647 L-methionine multiple interactions ISO RGD:734184 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FLT1 gene CTD PMID:20938992 lanreotide multiple interactions EXP 6480464 lanreotide inhibits the reaction [Diethylnitrosamine results in increased expression of FLT1 mRNA] CTD PMID:19874807 lipoic acid multiple interactions ISO RGD:734184 6480464 Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA] CTD PMID:23608068 losartan decreases expression ISO RGD:734184 6480464 Losartan results in decreased expression of FLT1 mRNA, Losartan results in decreased expression of FLT1 protein CTD PMID:19771429 manganese(II) chloride increases expression ISO RGD:734184 6480464 manganese chloride results in increased expression of FLT1 mRNA CTD PMID:17467022 mercury dibromide increases expression ISO RGD:737202 6480464 mercuric bromide results in increased expression of FLT1 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:737202 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA CTD PMID:27188386 methamphetamine increases expression ISO RGD:734184 6480464 Methamphetamine results in increased expression of FLT1 mRNA CTD PMID:26307267 methapyrilene increases methylation ISO RGD:737202 6480464 Methapyrilene results in increased methylation of FLT1 intron CTD PMID:30157460 methyl methanesulfonate decreases expression ISO RGD:737202 6480464 Methyl Methanesulfonate results in decreased expression of FLT1 mRNA CTD PMID:23649840 methylmercury chloride increases expression ISO RGD:737202 6480464 methylmercuric chloride results in increased expression of FLT1 mRNA CTD PMID:28001369 mifepristone decreases expression EXP 6480464 Mifepristone results in decreased expression of FLT1 mRNA CTD PMID:25972201 N-acetyl-L-cysteine increases expression ISO RGD:737202 6480464 Acetylcysteine results in increased expression of FLT1 protein CTD PMID:17992120 N-acetyl-L-cysteine multiple interactions ISO RGD:737202 6480464 Acetylcysteine inhibits the reaction [Cadmium results in increased expression of FLT1 mRNA], Acetylcysteine inhibits the reaction [Water Pollutants, Chemical results in increased expression of FLT1 mRNA] CTD PMID:29408318 N-methyl-N'-nitro-N-nitrosoguanidine increases expression EXP 6480464 Methylnitronitrosoguanidine results in increased expression of FLT1 mRNA CTD PMID:20434464 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions EXP 6480464 Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of FLT1 mRNA] CTD PMID:20434464 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of FLT1 mRNA CTD PMID:11981751 , PMID:19874807 N-nitrosodiethylamine decreases expression EXP 6480464 Diethylnitrosamine results in decreased expression of FLT1 mRNA CTD PMID:20360939 N-nitrosodiethylamine multiple interactions EXP 6480464 lanreotide inhibits the reaction [Diethylnitrosamine results in increased expression of FLT1 mRNA] CTD PMID:19874807 nickel atom increases expression ISO RGD:737202 6480464 Nickel results in increased expression of FLT1 mRNA CTD PMID:25583101 nickel sulfate increases expression ISO RGD:737202 6480464 nickel sulfate results in increased expression of FLT1 mRNA CTD PMID:22714537 Nilvadipine multiple interactions EXP 6480464 nilvadipine inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA] CTD PMID:12110003 NS 1619 multiple interactions ISO RGD:737202 6480464 NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein], paxilline inhibits the reaction [NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 orphenadrine affects expression EXP 6480464 Orphenadrine affects the expression of FLT1 mRNA CTD PMID:23665939 oxaliplatin increases expression ISO RGD:737202 6480464 oxaliplatin results in increased expression of FLT1 protein CTD PMID:18790786 paclitaxel increases expression ISO RGD:734184 6480464 Paclitaxel results in increased expression of FLT1 CTD PMID:21975929 panobinostat multiple interactions ISO RGD:737202 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA CTD PMID:27188386 panobinostat increases expression ISO RGD:737202 6480464 panobinostat results in increased expression of FLT1 mRNA CTD PMID:26272509 paracetamol increases expression ISO RGD:734184 6480464 Acetaminophen results in increased expression of FLT1 mRNA, Acetaminophen results in increased expression of FLT1 protein CTD PMID:16565415 , PMID:21135413 paracetamol decreases expression ISO RGD:737202 6480464 Acetaminophen results in decreased expression of FLT1 mRNA CTD PMID:27761495 paracetamol increases expression ISO RGD:737202 6480464 Acetaminophen results in increased expression of FLT1 mRNA CTD PMID:27761495 , PMID:29067470 paracetamol affects expression ISO RGD:734184 6480464 Acetaminophen affects the expression of FLT1 mRNA CTD PMID:17562736 paracetamol multiple interactions ISO RGD:734184 6480464 FLT1 protein affects the reaction [Acetaminophen results in decreased expression of IL6 mRNA] more ... CTD PMID:21135413 Paxilline multiple interactions ISO RGD:737202 6480464 paxilline inhibits the reaction [NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 perfluorooctane-1-sulfonic acid decreases activity ISO RGD:737202 6480464 perfluorooctane sulfonic acid results in decreased activity of FLT1 protein CTD PMID:21251949 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of FLT1 mRNA CTD PMID:12832660 more ... phenylephrine multiple interactions EXP 6480464 FLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein] CTD PMID:19542178 phenylephrine increases expression EXP 6480464 Phenylephrine results in increased expression of FLT1 protein CTD PMID:24903162 phenylmercury acetate increases expression ISO RGD:737202 6480464 Phenylmercuric Acetate results in increased expression of FLT1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:737202 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA CTD PMID:27188386 phorbol 13-acetate 12-myristate increases expression ISO RGD:737202 6480464 Tetradecanoylphorbol Acetate results in increased expression of FLT1 mRNA CTD PMID:19205902 phorbol 13-acetate 12-myristate increases secretion ISO RGD:737202 6480464 Tetradecanoylphorbol Acetate results in increased secretion of FLT1 protein CTD PMID:22197494 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:737202 6480464 ATP7A protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of FLT1 mRNA], resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of FLT1 protein] CTD PMID:19205902 , PMID:22197494 phosgene affects expression ISO RGD:734184 6480464 Phosgene affects the expression of FLT1 protein CTD PMID:15256155 phosgene decreases expression EXP 6480464 Phosgene results in decreased expression of FLT1 mRNA, Phosgene results in decreased expression of FLT1 protein CTD PMID:18645720 ponatinib decreases activity ISO RGD:737202 6480464 ponatinib analog results in decreased activity of FLT1 protein, ponatinib results in decreased activity of FLT1 protein CTD PMID:19878872 , PMID:21561767 potassium dichromate increases expression ISO RGD:734184 6480464 Potassium Dichromate results in increased expression of FLT1 mRNA CTD PMID:23608068 potassium dichromate multiple interactions ISO RGD:734184 6480464 Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA] CTD PMID:23608068 progesterone affects expression ISO RGD:734184 6480464 Progesterone affects the expression of FLT1 mRNA CTD PMID:17251523 protein kinase inhibitor multiple interactions ISO RGD:737202 6480464 Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FLT1 mRNA] CTD PMID:28003376 rac-lactic acid increases expression ISO RGD:737202 6480464 Lactic Acid results in increased expression of FLT1 mRNA CTD PMID:30851411 resveratrol multiple interactions ISO RGD:737202 6480464 resveratrol inhibits the reaction [2-furoyl-LIGRLO-amide results in increased expression of FLT1 mRNA] more ... CTD PMID:22197494 , PMID:26933402 resveratrol decreases secretion ISO RGD:737202 6480464 resveratrol results in decreased secretion of FLT1 protein CTD PMID:22197494 , PMID:26933402 resveratrol decreases expression ISO RGD:737202 6480464 resveratrol results in decreased expression of FLT1 mRNA, resveratrol results in decreased expression of FLT1 protein CTD PMID:17992120 , PMID:26933402 rotenone increases expression EXP 6480464 Rotenone results in increased expression of FLT1 mRNA CTD PMID:19013527 S-butyl-DL-homocysteine (S,R)-sulfoximine increases expression ISO RGD:734184 6480464 Buthionine Sulfoximine results in increased expression of FLT1 mRNA CTD PMID:15878706 SB 431542 multiple interactions ISO RGD:737202 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 serpentine asbestos decreases expression ISO RGD:734184 6480464 Asbestos, Serpentine results in decreased expression of FLT1 mRNA CTD PMID:16251409 silicon dioxide increases expression ISO RGD:737202 6480464 Silicon Dioxide analog results in increased expression of FLT1 mRNA CTD PMID:23806026 silver atom decreases expression ISO RGD:734184 6480464 Silver results in decreased expression of FLT1 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:734184 6480464 Silver results in decreased expression of FLT1 mRNA CTD PMID:27131904 silver(1+) decreases expression ISO RGD:734184 6480464 Silver results in decreased expression of FLT1 mRNA CTD PMID:27131904 simvastatin increases expression EXP 6480464 Simvastatin results in increased expression of FLT1 mRNA CTD PMID:19109527 simvastatin multiple interactions EXP 6480464 Simvastatin inhibits the reaction [Streptozocin results in increased expression of FLT1 mRNA], Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased expression of FLT1 protein] CTD PMID:20821229 sodium arsenite decreases expression ISO RGD:737202 6480464 sodium arsenite results in decreased expression of FLT1 mRNA CTD PMID:12634122 sodium arsenite multiple interactions ISO RGD:737202 6480464 DAB2 protein affects the reaction [sodium arsenite affects the localization of FLT1 protein] CTD PMID:29044176 sodium arsenite affects localization ISO RGD:737202 6480464 sodium arsenite affects the localization of FLT1 protein CTD PMID:29044176 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of FLT1 mRNA CTD PMID:20821229 streptozocin increases expression ISO RGD:734184 6480464 Streptozocin results in increased expression of FLT1 mRNA CTD PMID:26073000 streptozocin multiple interactions EXP 6480464 Simvastatin inhibits the reaction [Streptozocin results in increased expression of FLT1 mRNA] more ... CTD PMID:20821229 tauroursodeoxycholic acid multiple interactions ISO RGD:737202 6480464 tauroursodeoxycholic acid inhibits the reaction [Dronabinol results in increased expression of FLT1 mRNA] CTD PMID:31054322 tetrachloromethane multiple interactions EXP 6480464 Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of FLT1 protein] CTD PMID:23845850 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of FLT1 protein CTD PMID:23845850 thioacetamide increases secretion ISO RGD:737202 6480464 Thioacetamide results in increased secretion of FLT1 protein CTD PMID:27605418 titanium dioxide multiple interactions ISO RGD:734184 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of FLT1 mRNA CTD PMID:29950665 toluene increases expression EXP 6480464 Toluene results in increased expression of FLT1 mRNA CTD PMID:22967744 trichostatin A increases expression ISO RGD:737202 6480464 trichostatin A results in increased expression of FLT1 mRNA CTD PMID:24935251 more ... trichostatin A multiple interactions ISO RGD:737202 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA CTD PMID:27188386 troglitazone multiple interactions ISO RGD:734184 6480464 [Urethane co-treated with troglitazone] results in increased expression of FLT1 mRNA CTD PMID:18465119 troglitazone decreases expression ISO RGD:734184 6480464 troglitazone results in decreased expression of FLT1 mRNA CTD PMID:28973697 troglitazone increases expression ISO RGD:734184 6480464 troglitazone results in increased expression of FLT1 mRNA CTD PMID:17569031 tunicamycin decreases expression ISO RGD:734184 6480464 Tunicamycin results in decreased expression of FLT1 mRNA CTD PMID:24370435 tyrphostin AG 1478 multiple interactions ISO RGD:737202 6480464 RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased secretion of FLT1 protein], RTKI cpd inhibits the reaction [calcium silicate results in increased secretion of FLT1 protein] CTD PMID:21762757 urethane multiple interactions ISO RGD:734184 6480464 [Urethane co-treated with troglitazone] results in increased expression of FLT1 mRNA CTD PMID:18465119 urethane increases expression ISO RGD:734184 6480464 Urethane results in increased expression of FLT1 mRNA CTD PMID:18465119 valproic acid increases methylation ISO RGD:737202 6480464 Valproic Acid results in increased methylation of FLT1 gene CTD PMID:29154799 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of FLT1 mRNA CTD PMID:29427782 valproic acid multiple interactions ISO RGD:737202 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:737202 6480464 Valproic Acid results in increased expression of FLT1 mRNA CTD PMID:23179753 more ... valproic acid affects expression ISO RGD:737202 6480464 Valproic Acid affects the expression of FLT1 mRNA CTD PMID:25979313 Verbenalin multiple interactions ISO RGD:737202 6480464 FLT1 protein alternative form inhibits the reaction [cornin iridoid results in increased expression of VEGFA protein] CTD PMID:23702325 Verbenalin decreases response to substance ISO RGD:737202 6480464 FLT1 protein alternative form results in decreased susceptibility to cornin iridoid CTD PMID:23702325 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of FLT1 mRNA CTD PMID:19015723 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of FLT1 mRNA CTD PMID:23034163 vincristine decreases expression ISO RGD:737202 6480464 Vincristine results in decreased expression of FLT1 mRNA CTD PMID:23649840 vorinostat multiple interactions ISO RGD:737202 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA CTD PMID:27188386 vorinostat increases expression ISO RGD:737202 6480464 vorinostat results in increased expression of FLT1 mRNA CTD PMID:26272509 zinc atom increases expression EXP 6480464 Zinc results in increased expression of FLT1 mRNA CTD PMID:17074742 zinc atom decreases expression ISO RGD:737202 6480464 Zinc deficiency results in decreased expression of FLT1 mRNA CTD PMID:18356318 zinc protoporphyrin multiple interactions ISO RGD:737202 6480464 zinc protoporphyrin inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 zinc sulfate increases expression EXP 6480464 Zinc Sulfate results in increased expression of FLT1 mRNA CTD PMID:17074742 zinc(0) increases expression EXP 6480464 Zinc results in increased expression of FLT1 mRNA CTD PMID:17074742 zinc(0) decreases expression ISO RGD:737202 6480464 Zinc deficiency results in decreased expression of FLT1 mRNA CTD PMID:18356318
Biological Process activation of MAPKK activity IMP 1582498 RGD aging IEP 10402145 RGD angiogenesis ISO RGD:734184 1624291 MGI:MGI:1857717 (MGI:MGI:3045573 , PMID:14982871) RGD MGI:MGI:3045573 , PMID:14982871 blood vessel morphogenesis ISO RGD:734184 1624291 (MGI:MGI:74275, PMID:7596436) RGD MGI:MGI:74275 , PMID:7596436 blood vessel morphogenesis ISS UniProtKB:P35969 1600115 GO_REF:0000024 UniProt GO_REF:0000024 branching involved in blood vessel morphogenesis ISO RGD:734184 1624291 MGI:MGI:1857717 (MGI:MGI:3045573 , PMID:14982871) RGD MGI:MGI:3045573 , PMID:14982871 cell migration ISO RGD:737202 1624291 (PMID:8605350) RGD PMID:8605350 cell migration ISS UniProtKB:P35969 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cell migration ISO RGD:734184 1624291 MGI:MGI:103178 (MGI:MGI:1277612 more ... RGD MGI:MGI:1277612 more ... cell migration IBA MGI:MGI:95558 more ... 13792537 PMID:21873635 GO_Central cellular response to hypoxia IEP 634296 RGD cellular response to vascular endothelial growth factor stimulus ISO RGD:737202 1624291 (PMID:8605350) RGD PMID:8605350 chemotaxis IEA UniProtKB-KW:KW-0145 1600115 GO_REF:0000037 UniProt GO_REF:0000037 embryonic morphogenesis ISO RGD:734184 1624291 (MGI:MGI:74275, PMID:7596436) RGD MGI:MGI:74275 , PMID:7596436 embryonic morphogenesis ISS UniProtKB:P35969 1600115 GO_REF:0000024 UniProt GO_REF:0000024 female pregnancy IEP 10402123 RGD intracellular receptor signaling pathway IMP 1626619 RGD liver regeneration IEP 10402121 RGD monocyte chemotaxis ISO RGD:737202 1624291 (PMID:18079407), (PMID:8605350) RGD PMID:18079407 , PMID:8605350 monocyte chemotaxis IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of sprouting angiogenesis IDA 10402115 RGD negative regulation of vascular endothelial cell proliferation IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of vascular endothelial cell proliferation ISO RGD:737202 1624291 RNAcentral:URS000016D2D4_9606, RNAcentral:URS000058760A_9606 (PMID:22955733) RGD PMID:22955733 negative regulation of vascular endothelial growth factor production IDA 10402115 RGD peptidyl-tyrosine phosphorylation ISO RGD:737202 1624291 (PMID:11513746), (PMID:9299537) RGD PMID:11513746 , PMID:9299537 peptidyl-tyrosine phosphorylation ISS UniProtKB:P17948 1600115 GO_REF:0000024 UniProt GO_REF:0000024 peptidyl-tyrosine phosphorylation IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of angiogenesis IBA PANTHER:PTN002814447 , UniProtKB:P17948 13792537 PMID:21873635 GO_Central positive regulation of angiogenesis IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of angiogenesis ISO RGD:737202 1624291 (PMID:14633857), (PMID:28637396) RGD PMID:14633857 , PMID:28637396 positive regulation of cell migration IMP 2289969 adventitial fibroblasts of the thoracic aorta RGD positive regulation of cell migration IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell migration ISO RGD:737202 1624291 (PMID:8605350) RGD PMID:8605350 positive regulation of fibroblast proliferation NOT IDA 2289969 adventitial fibroblasts of the thoracic aorta RGD positive regulation of glial cell proliferation IMP 10402148 RGD positive regulation of hematopoietic progenitor cell differentiation ISO RGD:734184 1624291 MGI:MGI:1857717 (MGI:MGI:5543371 , PMID:18772315) RGD MGI:MGI:5543371 , PMID:18772315 positive regulation of MAP kinase activity ISO RGD:737202 1624291 (PMID:9299537) RGD PMID:9299537 positive regulation of MAP kinase activity IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of MAPK cascade ISO RGD:737202 1624291 (PMID:9299537) RGD PMID:9299537 positive regulation of phosphatidylinositol 3-kinase activity ISO RGD:737202 1624291 (PMID:11312102) RGD PMID:11312102 positive regulation of phosphatidylinositol 3-kinase activity IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of phosphatidylinositol 3-kinase signaling ISO RGD:737202 1624291 (PMID:14633857) RGD PMID:14633857 positive regulation of phosphatidylinositol 3-kinase signaling IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of phospholipase C activity ISO RGD:737202 1624291 (PMID:11312102) RGD PMID:11312102 positive regulation of phospholipase C activity IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of smooth muscle cell proliferation IDA 1582498 RGD positive regulation of vascular endothelial growth factor receptor signaling pathway ISO RGD:737202 1624291 (PMID:1312256) RGD PMID:1312256 positive regulation of vascular endothelial growth factor receptor signaling pathway IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of vascular permeability ISO RGD:14046679 1624291 (PMID:17311300) RGD PMID:17311300 post-embryonic camera-type eye morphogenesis ISO RGD:734184 1624291 MGI:MGI:96683 (MGI:MGI:5318610 , PMID:22426483) RGD MGI:MGI:5318610 , PMID:22426483 protein autophosphorylation ISO RGD:737202 1624291 (PMID:11513746), (PMID:9299537) RGD PMID:11513746 , PMID:9299537 protein autophosphorylation ISS UniProtKB:P17948 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein autophosphorylation IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein phosphorylation IDA 1626619 RGD regulation of smooth muscle contraction IDA 1582498 RGD response to activity IEP 10402145 RGD response to estradiol IEP 10402151 RGD response to ethanol IEP 10402149 RGD response to hypoxia IDA 1582498 RGD response to hypoxia ISO RGD:734184 1624291 MGI:MGI:1857717 (MGI:MGI:5543371 , PMID:18772315) RGD MGI:MGI:5543371 , PMID:18772315 response to hypoxia IEP 10402123 RGD sprouting angiogenesis ISO RGD:734184 1624291 MGI:MGI:1857717 (MGI:MGI:4360124 , PMID:19758562) RGD MGI:MGI:4360124 , PMID:19758562 sprouting angiogenesis IBA MGI:MGI:95558 more ... 13792537 PMID:21873635 GO_Central transmembrane receptor protein tyrosine kinase signaling pathway IBA FB:FBgn0003366 more ... 13792537 PMID:21873635 GO_Central vascular endothelial growth factor receptor signaling pathway ISO RGD:734184 1624291 MGI:MGI:1934260 (MGI:MGI:1277612 , PMID:9689083) RGD MGI:MGI:1277612 , PMID:9689083 vascular endothelial growth factor receptor signaling pathway IEA InterPro:IPR009135 1600115 GO_REF:0000002 InterPro GO_REF:0000002 vascular endothelial growth factor receptor signaling pathway ISO RGD:737202 1624291 (PMID:11312102), (PMID:9299537) RGD PMID:11312102 , PMID:9299537 vascular endothelial growth factor receptor-1 signaling pathway ISO RGD:737202 1624291 (PMID:15952180) RGD PMID:15952180 vascular endothelial growth factor receptor-1 signaling pathway IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 vascular endothelial growth factor signaling pathway IEA GO:0005021 1600115 GO_REF:0000108 GOC GO_REF:0000108 Cellular Component actin cytoskeleton IEA UniProtKB:L7RSL3 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 actin cytoskeleton ISO RGD:737202 1624291 RGD GO_REF:0000052 actin cytoskeleton IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 endosome IEA UniProtKB-SubCell:SL-0101 1600115 GO_REF:0000039 UniProt GO_REF:0000039 extracellular space ISO RGD:734184 1624291 (MGI:MGI:5648606, PMID:25184477) RGD MGI:MGI:5648606 , PMID:25184477 extracellular space IDA 10402115 RGD integral component of plasma membrane ISO RGD:737202 1624291 (PMID:11513746) RGD PMID:11513746 integral component of plasma membrane ISS UniProtKB:P17948 1600115 GO_REF:0000024 UniProt GO_REF:0000024 integral component of plasma membrane IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 integral component of plasma membrane IBA FB:FBgn0003366 more ... 13792537 PMID:21873635 GO_Central nucleus ISO RGD:734184 1624291 (MGI:MGI:5461755, PMID:22886301) RGD MGI:MGI:5461755 , PMID:22886301 plasma membrane IDA 2289969 RGD plasma membrane ISO RGD:737202 1624291 RGD GO_REF:0000052 receptor complex ISO RGD:737202 1624291 (PMID:23382219) RGD PMID:23382219 receptor complex IBA FB:FBgn0015380 more ... 13792537 PMID:21873635 GO_Central receptor complex IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function ATP binding IDA 1626619 RGD ATP binding IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000038 UniProt GO_REF:0000038 growth factor binding IPI RGD:731072 2289969 RGD growth factor binding IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 growth factor binding ISO RGD:737202 1624291 UniProtKB:P15692 more ... RGD PMID:10471394 more ... identical protein binding ISO RGD:734184 1624291 UniProtKB:P35969 (MGI:MGI:3609918 , PMID:11591653) RGD MGI:MGI:3609918 , PMID:11591653 placental growth factor-activated receptor activity ISO RGD:737202 1624291 (PMID:12796773) RGD PMID:12796773 placental growth factor-activated receptor activity IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding ISO RGD:737202 1624291 UniProtKB:P08631 more ... RGD PMID:10543948 more ... protein binding ISO RGD:734184 1624291 UniProtKB:Q8R464 (MGI:MGI:6271409 , PMID:25893857) RGD MGI:MGI:6271409 , PMID:25893857 transmembrane receptor protein tyrosine kinase activity IDA 1626619 RGD transmembrane receptor protein tyrosine kinase activity IBA FB:FBgn0003733 more ... 13792537 PMID:21873635 GO_Central vascular endothelial growth factor binding IBA PANTHER:PTN001974926 , UniProtKB:P35968 13792537 PMID:21873635 GO_Central vascular endothelial growth factor-activated receptor activity IMP 1626621 RGD vascular endothelial growth factor-activated receptor activity ISO RGD:737202 1624291 (PMID:11312102), (PMID:1312256), (PMID:9299537) RGD PMID:11312102 more ... vascular endothelial growth factor-activated receptor activity IBA MGI:MGI:95558 more ... 13792537 PMID:21873635 GO_Central vascular endothelial growth factor-activated receptor activity ISO RGD:734184 1624291 (MGI:MGI:3047093, PMID:8356051) RGD MGI:MGI:3047093 , PMID:8356051 VEGF-A-activated receptor activity ISO RGD:737202 1624291 (PMID:8605350) RGD PMID:8605350 VEGF-A-activated receptor activity IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107 VEGF-B-activated receptor activity ISO RGD:737202 1624291 (PMID:15952180) RGD PMID:15952180 VEGF-B-activated receptor activity IEA UniProtKB:P17948 , ensembl:ENSP000002823971600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
