Aco1 (aconitase 1) - Rat Genome Database

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Gene: Aco1 (aconitase 1) Rattus norvegicus
Symbol: Aco1
Name: aconitase 1
RGD ID: 2019
Description: Enables aconitate hydratase activity; iron-sulfur cluster binding activity; and mRNA binding activity. Involved in cellular iron ion homeostasis and liver development. Located in Golgi apparatus; cytosol; and endoplasmic reticulum. Used to study duodenal ulcer and non-alcoholic fatty liver disease. Orthologous to human ACO1 (aconitase 1); PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; citric acid cycle pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acon1; aconitase 1, soluble; AH; citrate hydro-lyase; cytoplasmic aconitate hydratase; IRE-BP 1; iron regulatory protein 1; iron-responsive element-binding protein; iron-responsive element-binding protein 1; IRP1; Ratireb
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2555,259,841 - 55,315,872 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl555,259,827 - 55,316,391 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx557,225,306 - 57,281,119 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0559,044,439 - 59,100,254 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0559,015,833 - 59,071,688 (+)NCBIRnor_WKY
Rnor_6.0556,425,076 - 56,481,218 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl556,425,024 - 56,481,218 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0560,972,013 - 61,027,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4557,536,675 - 57,591,765 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1557,536,853 - 57,591,944 (+)NCBI
Celera553,878,712 - 53,934,197 (+)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-nitrofluorene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butylated hydroxyanisole  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
cyproconazole  (EXP)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (EXP)
etoposide  (ISO)
fenofibrate  (EXP)
ferric ammonium citrate  (ISO)
Fluorocitric acid  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glucose  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hemin  (EXP)
hydrogen peroxide  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(3+) sulfate  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
KN-93  (EXP)
L-ethionine  (EXP)
lead nitrate  (ISO)
leflunomide  (EXP)
linalool  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP,ISO)
miconazole  (ISO)
mitomycin C  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitric oxide  (ISO)
okadaic acid  (EXP)
omeprazole  (EXP)
oxidopamine  (ISO)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
prochloraz  (EXP)
protein kinase inhibitor  (ISO)
quercetin  (EXP)
rotenone  (ISO)
sodium arsenite  (EXP)
Soman  (EXP)
superoxide  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Induction of aconitate hydratase in hepatocytes of starving rats. Eprintsev AT, etal., Biochemistry (Mosc) 2002 Jul;67(7):795-801.
2. The role of iron in anthracycline cardiotoxicity. Gammella E, etal., Front Pharmacol. 2014 Feb 26;5:25. doi: 10.3389/fphar.2014.00025. eCollection 2014.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Exercise decreases cytosolic aconitase activity in the liver, spleen, and bone marrow in rats. Ho KP, etal., Biochem Biophys Res Commun. 2001 Mar 23;282(1):264-7.
6. Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats. Khomenko T, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1277-86. doi: 10.1152/ajpgi.90257.2008. Epub 2009 Apr 2.
7. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
8. Disrupted iron metabolism and ensuing oxidative stress may mediate cognitive dysfunction induced by chronic cerebral hypoperfusion. Li Y, etal., Biol Trace Elem Res. 2012 Dec;150(1-3):242-8. doi: 10.1007/s12011-012-9455-0. Epub 2012 May 26.
9. Foot-shock stress-induced regional iron accumulation and altered iron homeostatic mechanisms in rat brain. Ma L, etal., Biol Trace Elem Res. 2008 Winter;126(1-3):204-13. doi: 10.1007/s12011-008-8197-5. Epub 2008 Aug 16.
10. Developmental changes of rat liver cytoplasmic and mitochondrial aconitate hydratases. Masini A, etal., Ital J Biochem. 1978 Sep-Oct;27(5):300-4.
11. High Fat Diet Induces Liver Steatosis and Early Dysregulation of Iron Metabolism in Rats. Meli R, etal., PLoS One. 2013 Jun 21;8(6):e66570. doi: 10.1371/journal.pone.0066570. Print 2013.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. IRP1 activity and expression are increased in the liver and the spleen of rats fed fish oil-rich diets and are related to oxidative stress. Miret S, etal., J Nutr. 2003 Apr;133(4):999-1003.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Subcellular localization of iron regulatory proteins to Golgi and ER membranes. Patton SM, etal., J Cell Sci. 2005 Oct 1;118(Pt 19):4365-73. Epub 2005 Sep 6.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. IF/TA-related metabolic changes--proteome analysis of rat renal allografts. Reuter S, etal., Nephrol Dial Transplant. 2010 Aug;25(8):2492-501. doi: 10.1093/ndt/gfq043. Epub 2010 Feb 22.
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. The iron-sulfur cluster of iron regulatory protein 1 modulates the accessibility of RNA binding and phosphorylation sites. Schalinske KL, etal., Biochemistry. 1997 Apr 1;36(13):3950-8.
21. Rat duodenal IRP1 activity and iron absorption in iron deficiency and after HO perfusion. Schumann K, etal., Eur J Clin Invest. 2004 Apr;34(4):275-82.
22. Molecular pharmacology of the interaction of anthracyclines with iron. Xu X, etal., Mol Pharmacol. 2005 Aug;68(2):261-71. Epub 2005 May 9.
23. The iron-responsive element binding protein. Purification, cloning, and regulation in rat liver. Yu Y, etal., J Biol Chem 1992 Sep 15;267(26):19005-10.
Additional References at PubMed
PMID:1281544   PMID:1946430   PMID:8041788   PMID:8262972   PMID:14726953   PMID:15604406   PMID:15625891   PMID:15629469   PMID:16198227   PMID:16407072   PMID:16527810   PMID:18005658  
PMID:18177727   PMID:18614015   PMID:19056867   PMID:22544036   PMID:22585610   PMID:22871113   PMID:22900282   PMID:23087176   PMID:23376485   PMID:23376588   PMID:23533145   PMID:23891004  
PMID:24601712   PMID:25106854   PMID:25652229   PMID:27914013  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2555,259,841 - 55,315,872 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl555,259,827 - 55,316,391 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx557,225,306 - 57,281,119 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0559,044,439 - 59,100,254 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0559,015,833 - 59,071,688 (+)NCBIRnor_WKY
Rnor_6.0556,425,076 - 56,481,218 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl556,425,024 - 56,481,218 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0560,972,013 - 61,027,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4557,536,675 - 57,591,765 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1557,536,853 - 57,591,944 (+)NCBI
Celera553,878,712 - 53,934,197 (+)NCBICelera
Cytogenetic Map5q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38932,384,643 - 32,454,769 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl932,384,603 - 32,454,769 (+)EnsemblGRCh38hg38GRCh38
GRCh37932,384,641 - 32,454,767 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36932,374,650 - 32,440,830 (+)NCBINCBI36Build 36hg18NCBI36
Build 34932,374,649 - 32,440,830NCBI
Celera932,314,541 - 32,380,796 (+)NCBICelera
Cytogenetic Map9p21.1ENTREZGENE
HuRef932,340,337 - 32,406,624 (+)NCBIHuRef
CHM1_1932,384,455 - 32,450,692 (+)NCBICHM1_1
T2T-CHM13v2.0932,400,543 - 32,470,694 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39440,143,265 - 40,199,009 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl440,143,081 - 40,198,338 (+)EnsemblGRCm39 Ensembl
GRCm38440,143,265 - 40,199,009 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl440,143,081 - 40,198,338 (+)EnsemblGRCm38mm10GRCm38
MGSCv37440,090,298 - 40,146,042 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36440,328,401 - 40,386,991 (+)NCBIMGSCv36mm8
Celera439,806,276 - 39,861,986 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map420.24NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554723,141,257 - 3,170,959 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554723,141,473 - 3,170,959 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1932,967,993 - 33,035,177 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl932,967,993 - 33,035,177 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0932,157,763 - 32,225,116 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11149,699,072 - 49,758,783 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1149,699,109 - 49,923,257 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1148,322,141 - 48,381,344 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01150,638,076 - 50,697,301 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1150,638,068 - 50,698,739 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11149,303,601 - 49,362,955 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01149,170,094 - 49,229,515 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01149,928,796 - 49,988,168 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947164,534,060 - 164,592,528 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365241,081,696 - 1,134,971 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365241,081,672 - 1,134,971 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1033,937,833 - 34,001,900 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11033,937,833 - 34,001,895 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21038,194,977 - 38,259,631 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11247,771,140 - 47,874,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1247,806,436 - 47,874,227 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603844,664,516 - 44,768,114 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473637,063,246 - 37,126,702 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473637,063,540 - 37,127,772 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Aco1
278 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:413
Count of miRNA genes:225
Interacting mature miRNAs:257
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2555,315,609 - 55,315,814 (+)MAPPERmRatBN7.2
Rnor_6.0556,480,960 - 56,481,164NCBIRnor6.0
Rnor_5.0561,027,447 - 61,027,651UniSTSRnor5.0
RGSC_v3.4557,591,507 - 57,591,711UniSTSRGSC3.4
Celera553,933,939 - 53,934,143UniSTS
Cytogenetic Map5q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2555,315,623 - 55,315,818 (+)MAPPERmRatBN7.2
Rnor_6.0556,480,974 - 56,481,168NCBIRnor6.0
Rnor_5.0561,027,461 - 61,027,655UniSTSRnor5.0
RGSC_v3.4557,591,521 - 57,591,715UniSTSRGSC3.4
Celera553,933,953 - 53,934,147UniSTS
Cytogenetic Map5q22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 74 35 36 11 8
Low 5
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008337   ⟹   ENSRNOP00000008337
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl555,259,827 - 55,315,872 (+)Ensembl
Rnor_6.0 Ensembl556,425,024 - 56,481,218 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100040   ⟹   ENSRNOP00000078636
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl555,259,827 - 55,316,391 (+)Ensembl
RefSeq Acc Id: NM_017321   ⟹   NP_059017
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2555,259,841 - 55,315,872 (+)NCBI
Rnor_6.0556,425,076 - 56,481,218 (+)NCBI
Rnor_5.0560,972,013 - 61,027,705 (+)NCBI
RGSC_v3.4557,536,675 - 57,591,765 (+)RGD
Celera553,878,712 - 53,934,197 (+)RGD
Protein Sequences
Protein RefSeqs NP_059017 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein Q63270 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_059017   ⟸   NM_017321
- UniProtKB: G3V6S2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008337   ⟸   ENSRNOT00000008337
RefSeq Acc Id: ENSRNOP00000078636   ⟸   ENSRNOT00000100040
Protein Domains
Aconitase   Aconitase_C

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63270-F1-model_v2 AlphaFold Q63270 1-889 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693627
Promoter ID:EPDNEW_R4152
Type:initiation region
Description:aconitase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0556,425,070 - 56,425,130EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2019 AgrOrtholog
BioCyc Gene G2FUF-41607 BioCyc
BioCyc Pathway PWY-5690 [TCA cycle II (plants and fungi)] BioCyc
Ensembl Genes ENSRNOG00000005849 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008337.3 UniProtKB/TrEMBL
  ENSRNOP00000078636.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008337.5 UniProtKB/TrEMBL
  ENSRNOT00000100040.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.499.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AcnA_IRP_Swivel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acnase/IPM_dHydase_lsu_aba_1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acoase/IPM_deHydtase_lsu_aba UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase/3IPM_dehydase_swvl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase/IRP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase_4Fe-4S_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase_4Fe-4S_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AconitaseA/IPMdHydase_ssu_swvl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRE-BP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50655 UniProtKB/Swiss-Prot
PANTHER PTHR11670 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11670:SF32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aconitase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aco1 PhenoGen
  ACONITASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53732 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs aconitase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACOC_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Aco1  aconitase 1  Aco1  aconitase 1, soluble  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Aco1  aconitase 1, soluble  Aco1  aconitase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Aco1  aconitase 1  Ratireb  iron-responsive element-binding protein  Data Merged 737654 APPROVED
2002-11-06 Aco1  aconitase 1    Aconitase 1, soluble  Name updated 625702 APPROVED
2002-08-07 Ratireb  iron-responsive element-binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Aco1  Aconitase 1, soluble      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology shows 95% identity with human IRE-BP and 98% identity with mouse IRE-BP 633751