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Gene: Aco1 (aconitase 1) Rattus norvegicus
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Symbol: Aco1
Name: aconitase 1
Description: Exhibits aconitate hydratase activity; iron-sulfur cluster binding activity; and mRNA binding activity. Involved in cellular iron ion homeostasis and liver development. Localizes to the Golgi apparatus; cytosol; and endoplasmic reticulum. Used to study duodenal ulcer and non-alcoholic fatty liver disease. Orthologous to human ACO1 (aconitase 1); PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; citric acid cycle pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Acon1; aconitase 1, soluble; AH; citrate hydro-lyase; cytoplasmic aconitate hydratase; IRE-BP 1; iron regulatory protein 1; iron-responsive element-binding protein; iron-responsive element-binding protein 1; IRP1; Ratireb
Orthologs:
Homo sapiens (human) : ACO1 (aconitase 1)  HGNC  Alliance
Mus musculus (house mouse) : Aco1 (aconitase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aco1 (aconitase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ACO1 (aconitase 1)
Canis lupus familiaris (dog) : ACO1 (aconitase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aco1 (aconitase 1)
Sus scrofa (pig) : ACO1 (aconitase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0556,425,076 - 56,481,218 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl556,425,024 - 56,481,218 (+)Ensembl
Rnor_5.0560,972,013 - 61,027,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4557,536,675 - 57,591,765 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1557,536,853 - 57,591,944 (+)NCBI
Celera553,878,712 - 53,934,197 (+)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Aco1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2019
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.