Insl3 (insulin-like 3) - Rat Genome Database

Name: Insl3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Insl3 (insulin-like 3) Rattus norvegicus

Analyze

Symbol:

Insl3

Name:

insulin-like 3

RGD ID:

620117

Description:

Enables G protein-coupled receptor binding activity. Involved in several processes, including male gonad development; oocyte maturation; and positive regulation of cAMP-mediated signaling. Located in extracellular space and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human INSL3 (insulin like 3); INTERACTS WITH (+)-taxifolin; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

ley-I-L; Leydig insulin-like peptide; Leydig insulin-like peptide relaxin-like factor; Leydig insulin-like peptide, relaxin-like factor; MGC112595; relaxin-like factor; Rlf

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	INSL3 (insulin like 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Insl3 (insulin-like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Insl3 (insulin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	INSL3 (insulin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	INSL3 (insulin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	INSL3 (insulin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Insl3 (insulin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Insl3 (insulin-like 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	INSL3 (insulin like 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	insl3 (insulin-like 3 (Leydig cell))	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	Ilp4	Alliance	DIOPT (InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	18,432,668 - 18,434,539 (+)	NCBI		GRCr8
mRatBN7.2	16	18,398,682 - 18,400,566 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	18,384,829 - 18,400,560 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	18,449,855 - 18,451,198 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	19,582,466 - 19,583,809 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	18,502,794 - 18,504,137 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	20,120,753 - 20,122,702 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,121,352 - 20,122,696 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	19,981,216 - 19,983,156 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	18,890,131 - 18,891,475 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	18,890,128 - 18,891,473 (+)	NCBI
Celera	16	18,601,812 - 18,603,156 (+)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cryptorchidism (ISO,ISS)

genetic disease (ISO)

Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 (ISO)

severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive (ISO)

Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, NK Cell-Negative (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-taxifolin (EXP)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrobenzenesulfonic acid (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

androgen antagonist (EXP)

atrazine (EXP,ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

Bisphenol A diglycidyl ether (ISO)

Bisphenol B (ISO)

bucladesine (EXP)

buta-1,3-diene (ISO)

butanal (ISO)

Butylbenzyl phthalate (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carmustine (ISO)

cetrorelix (ISO)

clofibrate (EXP)

copper(II) sulfate (ISO)

cypermethrin (EXP,ISO)

DDE (EXP)

desogestrel (ISO)

dexamethasone (EXP)

Di-n-hexyl phthalate (EXP)

dibromoacetic acid (EXP)

dibutyl phthalate (EXP)

Dicyclohexyl phthalate (EXP)

diethyl phthalate (EXP)

diethylstilbestrol (EXP)

diheptyl phthalate (EXP)

diisobutyl phthalate (EXP)

Diisodecyl phthalate (EXP)

diisononyl phthalate (EXP)

dipentyl phthalate (EXP)

flavonoids (EXP)

genistein (ISO)

gentamycin (EXP)

ketoconazole (EXP)

levonorgestrel (ISO)

mono(2-ethylhexyl) phthalate (EXP,ISO)

Monobutylphthalate (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

pentanal (ISO)

perfluoroheptanoic acid (EXP)

perfluorooctanoic acid (ISO)

perfluoroundecanoic acid (EXP)

propanal (ISO)

pyridaben (ISO)

quercetin (EXP)

simvastatin (EXP)

tamoxifen (ISO)

testosterone (ISO)

testosterone enanthate (EXP,ISO)

testosterone undecanoate (ISO)

trichloroethene (EXP)

triphenylstannane (EXP,ISO)

valproic acid (ISO)

vinclozolin (EXP)

ziram (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (IBA,IDA)

cell differentiation (IEA)

cell surface receptor signaling pathway via JAK-STAT (IEA)

cytokine-mediated signaling pathway (IEA)

growth hormone receptor signaling pathway via JAK-STAT (IEA)

in utero embryonic development (ISO)

intracellular signal transduction (IEA)

male gonad development (IDA,ISO)

negative regulation of apoptotic process (IDA)

negative regulation of cell population proliferation (IDA)

oocyte maturation (IDA)

positive regulation of cAMP-mediated signaling (IDA)

positive regulation of cell population proliferation (IDA)

positive regulation of epithelial cell migration (ISO)

positive regulation of wound healing (ISO)

regulation of apoptotic process (IEA)

regulation of male gonad development (ISO)

Cellular Component

cytoplasm (IEA)

cytoskeleton (IEA)

cytosol (IEA)

endomembrane system (IEA)

extracellular space (IBA,IDA)

membrane (IEA)

perinuclear region of cytoplasm (IDA)

Molecular Function

ATP binding (IEA)

G protein-coupled receptor binding (IBA,IPI)

growth hormone receptor binding (IEA)

hormone activity (IEA)

non-membrane spanning protein tyrosine kinase activity (IEA)

protease binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Relaxin-like factor (RLF) serum concentrations and gubernaculum RLF receptor display in relation to pre- and neonatal development of rats.	Boockfor FR, etal., Reproduction. 2001 Dec;122(6):899-906.
2.	A novel mutation of the insulin-like 3 gene in patients with cryptorchidism.	Canto P, etal., J Hum Genet. 2003;48(2):86-90.
3.	Detection, localization, and action of the INSL3 receptor, LGR8, in rat kidney.	Fu P, etal., Ann N Y Acad Sci. 2005 May;1041:516-9.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Paracrine regulation of mammalian oocyte maturation and male germ cell survival.	Kawamura K, etal., Proc Natl Acad Sci U S A. 2004 May 11;101(19):7323-8. Epub 2004 May 3.
7.	The role of insulin 3, testosterone, Mullerian inhibiting substance and relaxin in rat gubernacular growth.	Kubota Y, etal., Mol Hum Reprod 2002 Oct;8(10):900-5.
8.	INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.	Kumagai J, etal., J Biol Chem 2002 Aug 30;277(35):31283-6.
9.	Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate.	McKinnell C, etal., Endocrinology. 2005 Oct;146(10):4536-44. Epub 2005 Jul 21.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
12.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
13.	GOA pipeline	RGD automated data pipeline
14.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Chemical synthesis and biological activity of rat INSL3.	Smith KJ, etal., J Pept Sci. 2001 Sep;7(9):495-501.
17.	Structure and expression of the rat relaxin-like factor (RLF) gene.	Spiess AN, etal., Mol Reprod Dev 1999 Dec;54(4):319-25.

Additional References at PubMed

PMID:10319319	PMID:12477932	PMID:15956681	PMID:16338306	PMID:17400582	PMID:18772241	PMID:19420383	PMID:19493424	PMID:20082125	PMID:20631401	PMID:21633115	PMID:23539510
PMID:24169563

Genomics

Comparative Map Data

Insl3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	18,432,668 - 18,434,539 (+)	NCBI		GRCr8
mRatBN7.2	16	18,398,682 - 18,400,566 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	18,384,829 - 18,400,560 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	18,449,855 - 18,451,198 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	19,582,466 - 19,583,809 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	18,502,794 - 18,504,137 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	20,120,753 - 20,122,702 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,121,352 - 20,122,696 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	19,981,216 - 19,983,156 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	18,890,131 - 18,891,475 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	18,890,128 - 18,891,473 (+)	NCBI
Celera	16	18,601,812 - 18,603,156 (+)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

INSL3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	17,816,512 - 17,821,519 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	17,816,512 - 17,821,574 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	17,927,321 - 17,932,328 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	17,788,322 - 17,793,320 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	17,788,321 - 17,793,320	NCBI
Celera	19	17,829,042 - 17,834,041 (-)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	17,492,756 - 17,497,784 (-)	NCBI		HuRef
CHM1_1	19	17,926,865 - 17,931,926 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	17,950,620 - 17,955,630 (-)	NCBI		T2T-CHM13v2.0

Insl3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	72,141,896 - 72,143,221 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	72,141,858 - 72,143,219 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	71,689,252 - 71,690,577 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	71,689,214 - 71,690,575 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	74,213,151 - 74,214,474 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	74,618,241 - 74,619,564 (+)	NCBI		MGSCv36	mm8
Celera	8	74,203,798 - 74,205,121 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.43	NCBI

Insl3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	3,413,246 - 3,416,025 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	3,413,764 - 3,415,691 (+)	NCBI	ChiLan1.0	ChiLan1.0

INSL3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	45,071,128 - 45,072,446 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	45,050,526 - 45,072,805 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	44,983,087 - 44,984,405 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	45,556,269 - 45,557,587 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	45,535,982 - 45,557,946 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	44,792,679 - 44,793,993 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	45,202,958 - 45,204,276 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	45,478,927 - 45,480,245 (+)	NCBI		UU_Cfam_GSD_1.0

INSL3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	59,929,584 - 59,931,219 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	59,929,591 - 59,931,220 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	59,499,023 - 59,500,652 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	2	q12-q13	NCBI

INSL3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	16,291,220 - 16,296,705 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	16,291,563 - 16,296,643 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	3,092,222 - 3,097,819 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Insl3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624908	1,368,660 - 1,369,740 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Insl3
9 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	138
Count of miRNA genes:	105
Interacting mature miRNAs:	118
Transcripts:	ENSRNOT00000025347
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	22477621	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26727669	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26727669	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	26727669	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	30836262	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	32139025	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33418960	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39533930	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39533930	Rat
631561	Hcuc2	Hepatic copper content QTL 2	2.8		liver copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	39533949	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	1	43534949	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1	44588133	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	44977551	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	832236	46053497	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	832236	59492508	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	832236	59492508	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	832236	59492508	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	832236	59492508	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3380150	21361552	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3380150	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4227609	43025077	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4227609	46975965	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	4227609	48972724	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	49227609	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	60252231	Rat
631517	Scl9	Serum cholesterol level QTL 9	3.3		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	16	15726433	21034895	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High											1
Medium					1						19
Low	3		12	3	18	3	1	1	1	6	10	7	1
Below cutoff		28	34	28		28	2	4	38	24	11	3	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053680	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006252820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF139918	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF139920	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098653	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000025347 ⟹ ENSRNOP00000025349

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	20,121,352 - 20,122,696 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000080146 ⟹ ENSRNOP00000073659

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	18,384,829 - 18,400,560 (+)	Ensembl

RefSeq Acc Id:

NM_053680 ⟹ NP_446132

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	18,433,189 - 18,434,533 (+)	NCBI
mRatBN7.2	16	18,399,216 - 18,400,560 (+)	NCBI
Rnor_6.0	16	20,121,352 - 20,122,696 (+)	NCBI
Rnor_5.0	16	19,981,216 - 19,983,156 (+)	NCBI
RGSC_v3.4	16	18,890,131 - 18,891,475 (+)	RGD
Celera	16	18,601,812 - 18,603,156 (+)	RGD

Sequence:

show sequence

ATGCACGCACTGCTGCTACTGCTGCTCCTGGCTCTAGGGTCCGCGCTGCGCTCCCCGCAGCCCC
CGGAGGCGCGCGCCAAGCTCTGTGGTCACCACCTGGTGCGTGCGCTGGTGCGGGTGTGCGGTGG
CCCGCGTTGGTCACCCGAGGCCACGCAGCCTGTGGACACCCGCGACCGGGAGCTGCTGCAGTGG
CTGGAGCAACGACATCTCCTGCACGCGCTCGTGGCCGATGCGGATCCCGCGCTAGACCCGGACC
CCGCGCTGGACCCGCAGCTTCCTCACCAGGCTTCTCAGCGCCAGCGCCGCAGTGTGGCCACCAA
CGCTGTGCACCGCTGCTGTCTCACTGGCTGCACCCAGCAAGACCTTTTGGGTCTGTGTCCCCAC
TGAAGGATTGTAGGGCTCAGGTGGTGTGTGTCAATTATTCCCCACCTNACAGCTGTGCCAATGA
AACACCCCCGGATTGCCTTGGAGGATCCCTAGTTTATTCATAGATCCCAGAAACCAAGGACCAC
AGGTCCTGTCCCCAGGGAGCCCCATCATGACCTGTGCCCACCTCCTCCCTGTGGGCCAACAGTC
TAAATAAAAAAGCAACTTG

hide sequence

RefSeq Acc Id:

XM_006252820 ⟹ XP_006252882

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	18,432,668 - 18,434,539 (+)	NCBI
mRatBN7.2	16	18,398,682 - 18,400,566 (+)	NCBI
Rnor_6.0	16	20,120,753 - 20,122,702 (+)	NCBI
Rnor_5.0	16	19,981,216 - 19,983,156 (+)	NCBI

Sequence:

show sequence

TGGGAGAGGAGAGGTCTTGGCCAGACCCCAAGGACACCCCCTTCCCTCCTGCCCAGCTGCATGC
AGTCCTTGGCTCGCCAGGGGAGCTGGTTCCGGGCAGAGGCAGTGCAAGGGGCAGAGGCCAAGGC
TGGAGCTAGGCTGAACCAGCCCTGTGCACCCCAGGACAGTGCCTGCAGTCACCCACCACAGTCA
GGAGGTAGAGGGACAGGAGAAGAACCATTTAGACTTATCCTCCCGTCTTCCAGCCTCAGTTTCC
CTCTTTGACAAAACCAAGTCATAAATACCTCCTCCCATCTCCTTCACAGCCCAAACTGCCTCCA
ACTTACAGCAATTCTCCTGCCTCAGCTTTTTCACTGCTAGCAAGACTGTCAACCTTACAAAAGG
GGAAGGGCACTTGGCTTGTTTTAAATGTTGGGGGGCGGCTCCTGGCACAGTGCTGCACCTGGGA
GAGGGACTTCAGGGTCCCAAGCTGGACACACAGCCCCTGACCGTGACCTGAGCCTCGACCTCCT
CGGTGCTGCTCGTCGTGTTCCCTCCAAGGCCCATGGGCGGCGCAAGGCGGCTATAAGGAGCGTC
CTTACCCGCTGCCTCCTGCCACCATGCACGCACTGCTGCTACTGCTGCTCCTGGCTCTAGGGTC
CGCGCTGCGCTCCCCGCAGCCCCCGGAGGCGCGCGCCAAGCTCTGTGGTCACCACCTGGTGCGT
GCGCTGGTGCGGGTGTGCGGTGGCCCGCGTTGGTCACCCGAGGCCACGCAGCCTGTGGACACCC
GCGACCGGACCTCACCCTTCCATGGCCACAAACTGGGGTGCACAGGAGGCAAACAGGCACACAG
AGTTGGAGGGGAGCTGCTGCAGTGGCTGGAGCAACGACATCTCCTGCACGCGCTCGTGGCCGAT
GCGGATCCCGCGCTAGACCCGGACCCCGCGCTGGACCCGCAGCTTCCTCACCAGGCTTCTCAGC
GCCAGCGCCGCAGTGTGGCCACCAACGCTGTGCACCGCTGCTGTCTCACTGGCTGCACCCAGCA
AGACCTTTTGGGTCTGTGTCCCCACTGAAGGATTGTAGGGCTCAGGTGGTGTGTGTCAATTATT
CCCCACCTCACAGCTGTGCCAATGAAACACCCCCGGATTGCCTTGGAGGATCCCTAGTTTATTC
ATAGATCCCAGAAACCAAGGACCACAGGTCCTGTCCCCAGGGAGCCCCATCATGACCTGTGCCC
ACCTCCTCCCTGTGGGCCAACAGTCTAAATAAAAAAGCAACTTGATGTTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_446132	(Get FASTA)	NCBI Sequence Viewer
	XP_006252882	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD33663	(Get FASTA)	NCBI Sequence Viewer
	AAD33851	(Get FASTA)	NCBI Sequence Viewer
	AAH98653	(Get FASTA)	NCBI Sequence Viewer
	EDL90760	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000073659
	ENSRNOP00000073659.2
	ENSRNOP00055013109
	ENSRNOP00060015527
	ENSRNOP00065028608
GenBank Protein	Q9WUK0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_446132 ⟸ NM_053680
- Peptide Label:	precursor
- UniProtKB:	Q9WUK1 (UniProtKB/Swiss-Prot), Q9WUK0 (UniProtKB/Swiss-Prot), A6K9X7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MHALLLLLLLALGSALRSPQPPEARAKLCGHHLVRALVRVCGGPRWSPEATQPVDTRDRELLQW LEQRHLLHALVADADPALDPDPALDPQLPHQASQRQRRSVATNAVHRCCLTGCTQQDLLGLCPH hide sequence

RefSeq Acc Id:	XP_006252882 ⟸ XM_006252820
- Peptide Label:	isoform X1
- Sequence:	show sequence MHALLLLLLLALGSALRSPQPPEARAKLCGHHLVRALVRVCGGPRWSPEATQPVDTRDRTSPFH GHKLGCTGGKQAHRVGGELLQWLEQRHLLHALVADADPALDPDPALDPQLPHQASQRQRRSVAT NAVHRCCLTGCTQQDLLGLCPH hide sequence

RefSeq Acc Id:

ENSRNOP00000025349 ⟸ ENSRNOT00000025347

RefSeq Acc Id:

ENSRNOP00000073659 ⟸ ENSRNOT00000080146

Protein Domains

FERM Insulin-like Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9WUK0-F1-model_v2	AlphaFold	Q9WUK0	1-128	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700009

Promoter ID:

EPDNEW_R10532

Type:

multiple initiation site

Name:

Insl3_1

Description:

insulin-like 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	20,121,360 - 20,121,420	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620117	AgrOrtholog
BioCyc Gene	G2FUF-11828	BioCyc
Ensembl Genes	ENSRNOG00000018669	UniProtKB/TrEMBL
	ENSRNOG00000018757	Ensembl
	ENSRNOG00000068505	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00055009650	UniProtKB/Swiss-Prot
	ENSRNOG00060011653	UniProtKB/Swiss-Prot
	ENSRNOG00065020905	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000080146	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000080146.2	UniProtKB/Swiss-Prot
	ENSRNOT00055016310	UniProtKB/Swiss-Prot
	ENSRNOT00060019730	UniProtKB/Swiss-Prot
	ENSRNOT00065035501	UniProtKB/Swiss-Prot
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
	3.30.505.10	UniProtKB/TrEMBL
	Insulin-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7386551	IMAGE-MGC_LOAD
InterPro	Band_41_domain	UniProtKB/TrEMBL
	FERM_domain	UniProtKB/TrEMBL
	FERM_F1	UniProtKB/TrEMBL
	FERM_F2	UniProtKB/TrEMBL
	INSL3/INSL4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Insulin-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Insulin-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Insulin_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Insulin_family	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Jak1_PHL_dom	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Tyr_kinase_non-rcpt_Jak/Tyk2	UniProtKB/TrEMBL
	Tyr_kinase_non-rcpt_Jak3	UniProtKB/TrEMBL
KEGG Report	rno:114215	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:112595	IMAGE-MGC_LOAD
NCBI Gene	114215	ENTREZGENE
PANTHER	INSULIN-LIKE 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10423	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE HOPSCOTCH	UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE JAK3	UniProtKB/TrEMBL
Pfam	FERM_F1	UniProtKB/TrEMBL
	FERM_F2	UniProtKB/TrEMBL
	Insulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Jak1_Phl	UniProtKB/TrEMBL
	PK_Tyr_Ser-Thr	UniProtKB/TrEMBL
PhenoGen	Insl3	PhenoGen
PIRSF	TyrPK_Jak	UniProtKB/TrEMBL
PRINTS	INSULINFAMLY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	JANUSKINASE	UniProtKB/TrEMBL
	JANUSKINASE3	UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/TrEMBL
PROSITE	FERM_3	UniProtKB/TrEMBL
	INSULIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018669	RatGTEx
	ENSRNOG00000018757	RatGTEx
	ENSRNOG00000068505	RatGTEx
	ENSRNOG00055009650	RatGTEx
	ENSRNOG00060011653	RatGTEx
	ENSRNOG00065020905	RatGTEx
SMART	B41	UniProtKB/TrEMBL
	IlGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
	SSF56994	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K636_RAT	UniProtKB/TrEMBL
	A6K9X7	ENTREZGENE, UniProtKB/TrEMBL
	INSL3_RAT	UniProtKB/Swiss-Prot
	Q4KMB3_RAT	UniProtKB/TrEMBL
	Q9WUK0	ENTREZGENE
	Q9WUK1	ENTREZGENE
UniProt Secondary	Q9WUK1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-26	Insl3	insulin-like 3			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Insl3	insulin-like 3			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_disease	mutated protein is found in patients with cryptorchidism or defective testis due to abnormal gubernaculum development	633070
gene_expression	expressed in the testis Leydig cells, ovarian theca and luteal cells	633070
gene_function	binds to gubernacular homogenates and induces growth of gubernaculum	633070
gene_mutations_overexpression	overexpression in females leads to ovary descent	633070
gene_product	member of the relaxin family	633070

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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