Insl3 (insulin-like 3) - Rat Genome Database

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Gene: Insl3 (insulin-like 3) Rattus norvegicus
Analyze
Symbol: Insl3
Name: insulin-like 3
RGD ID: 620117
Description: Enables G protein-coupled receptor binding activity. Involved in several processes, including male gonad development; oocyte maturation; and positive regulation of cAMP-mediated signaling. Located in extracellular space and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human INSL3 (insulin like 3); INTERACTS WITH (+)-taxifolin; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ley-I-L; Leydig insulin-like peptide; Leydig insulin-like peptide relaxin-like factor; Leydig insulin-like peptide, relaxin-like factor; MGC112595; relaxin-like factor; Rlf
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21618,398,682 - 18,400,566 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,384,829 - 18,400,560 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,449,855 - 18,451,198 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01619,582,466 - 19,583,809 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01618,502,794 - 18,504,137 (+)NCBIRnor_WKY
Rnor_6.01620,120,753 - 20,122,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,121,352 - 20,122,696 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,981,216 - 19,983,156 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,890,131 - 18,891,475 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,890,128 - 18,891,473 (+)NCBI
Celera1618,601,812 - 18,603,156 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
androgen antagonist  (EXP)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bucladesine  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carmustine  (ISO)
cetrorelix  (ISO)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
cypermethrin  (ISO)
DDE  (EXP)
desogestrel  (ISO)
dexamethasone  (EXP)
Di-n-hexyl phthalate  (EXP)
dibromoacetic acid  (EXP)
dibutyl phthalate  (EXP)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP)
diheptyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dipentyl phthalate  (EXP)
flavonoids  (EXP)
genistein  (ISO)
gentamycin  (EXP)
levonorgestrel  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (EXP)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluoroheptanoic acid  (EXP)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (EXP)
propanal  (ISO)
pyridaben  (ISO)
quercetin  (EXP)
simvastatin  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
testosterone enanthate  (EXP,ISO)
testosterone undecanoate  (ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
ziram  (EXP)

References

References - curated
# Reference Title Reference Citation
1. Relaxin-like factor (RLF) serum concentrations and gubernaculum RLF receptor display in relation to pre- and neonatal development of rats. Boockfor FR, etal., Reproduction. 2001 Dec;122(6):899-906.
2. A novel mutation of the insulin-like 3 gene in patients with cryptorchidism. Canto P, etal., J Hum Genet. 2003;48(2):86-90.
3. Detection, localization, and action of the INSL3 receptor, LGR8, in rat kidney. Fu P, etal., Ann N Y Acad Sci. 2005 May;1041:516-9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Paracrine regulation of mammalian oocyte maturation and male germ cell survival. Kawamura K, etal., Proc Natl Acad Sci U S A. 2004 May 11;101(19):7323-8. Epub 2004 May 3.
7. The role of insulin 3, testosterone, Mullerian inhibiting substance and relaxin in rat gubernacular growth. Kubota Y, etal., Mol Hum Reprod 2002 Oct;8(10):900-5.
8. INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. Kumagai J, etal., J Biol Chem 2002 Aug 30;277(35):31283-6.
9. Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate. McKinnell C, etal., Endocrinology. 2005 Oct;146(10):4536-44. Epub 2005 Jul 21.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Chemical synthesis and biological activity of rat INSL3. Smith KJ, etal., J Pept Sci. 2001 Sep;7(9):495-501.
17. Structure and expression of the rat relaxin-like factor (RLF) gene. Spiess AN, etal., Mol Reprod Dev 1999 Dec;54(4):319-25.
Additional References at PubMed
PMID:10319319   PMID:12477932   PMID:15956681   PMID:16338306   PMID:17400582   PMID:18772241   PMID:19420383   PMID:19493424   PMID:20082125   PMID:20631401   PMID:21633115   PMID:23539510  
PMID:24169563  


Genomics

Comparative Map Data
Insl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21618,398,682 - 18,400,566 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,384,829 - 18,400,560 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,449,855 - 18,451,198 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01619,582,466 - 19,583,809 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01618,502,794 - 18,504,137 (+)NCBIRnor_WKY
Rnor_6.01620,120,753 - 20,122,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,121,352 - 20,122,696 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,981,216 - 19,983,156 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,890,131 - 18,891,475 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,890,128 - 18,891,473 (+)NCBI
Celera1618,601,812 - 18,603,156 (+)NCBICelera
Cytogenetic Map16p14NCBI
INSL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,816,512 - 17,821,519 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1917,816,512 - 17,821,574 (-)EnsemblGRCh38hg38GRCh38
GRCh371917,927,321 - 17,932,328 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,788,322 - 17,793,320 (-)NCBINCBI36Build 36hg18NCBI36
Build 341917,788,321 - 17,793,320NCBI
Celera1917,829,042 - 17,834,041 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,492,756 - 17,497,784 (-)NCBIHuRef
CHM1_11917,926,865 - 17,931,926 (-)NCBICHM1_1
T2T-CHM13v2.01917,950,620 - 17,955,630 (-)NCBIT2T-CHM13v2.0
Insl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,141,896 - 72,143,221 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,141,858 - 72,143,219 (+)EnsemblGRCm39 Ensembl
GRCm38871,689,252 - 71,690,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,689,214 - 71,690,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,213,151 - 74,214,474 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36874,618,241 - 74,619,564 (+)NCBIMGSCv36mm8
Celera874,203,798 - 74,205,121 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
Insl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,413,246 - 3,416,025 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,413,764 - 3,415,691 (+)NCBIChiLan1.0ChiLan1.0
INSL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,071,128 - 45,072,446 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2045,050,526 - 45,072,805 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,983,087 - 44,984,405 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,556,269 - 45,557,587 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,535,982 - 45,557,946 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,792,679 - 44,793,993 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,202,958 - 45,204,276 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,478,927 - 45,480,245 (+)NCBIUU_Cfam_GSD_1.0
INSL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,929,584 - 59,931,219 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,929,591 - 59,931,220 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,499,023 - 59,500,652 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q12-q13NCBI
INSL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,291,220 - 16,296,705 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,291,563 - 16,296,643 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660743,092,222 - 3,097,819 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Insl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,368,660 - 1,369,740 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Insl3
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:105
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000025347
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 1 19
Low 3 12 3 18 3 1 1 1 6 10 7 1
Below cutoff 28 34 28 28 2 4 38 24 11 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025347   ⟹   ENSRNOP00000025349
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1620,121,352 - 20,122,696 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080146   ⟹   ENSRNOP00000073659
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,384,829 - 18,400,560 (+)Ensembl
RefSeq Acc Id: NM_053680   ⟹   NP_446132
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21618,399,216 - 18,400,560 (+)NCBI
Rnor_6.01620,121,352 - 20,122,696 (+)NCBI
Rnor_5.01619,981,216 - 19,983,156 (+)NCBI
RGSC_v3.41618,890,131 - 18,891,475 (+)RGD
Celera1618,601,812 - 18,603,156 (+)RGD
Sequence:
RefSeq Acc Id: XM_006252820   ⟹   XP_006252882
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21618,398,682 - 18,400,566 (+)NCBI
Rnor_6.01620,120,753 - 20,122,702 (+)NCBI
Rnor_5.01619,981,216 - 19,983,156 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_446132   ⟸   NM_053680
- Peptide Label: precursor
- UniProtKB: Q9WUK1 (UniProtKB/Swiss-Prot),   Q9WUK0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006252882   ⟸   XM_006252820
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000025349   ⟸   ENSRNOT00000025347
RefSeq Acc Id: ENSRNOP00000073659   ⟸   ENSRNOT00000080146
Protein Domains
FERM   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUK0-F1-model_v2 AlphaFold Q9WUK0 1-128 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700009
Promoter ID:EPDNEW_R10532
Type:multiple initiation site
Name:Insl3_1
Description:insulin-like 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01620,121,360 - 20,121,420EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620117 AgrOrtholog
BioCyc Gene G2FUF-11828 BioCyc
Ensembl Genes ENSRNOG00000018669 UniProtKB/TrEMBL
  ENSRNOG00000018757 Ensembl
  ENSRNOG00000068505 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000073659 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080146 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7386551 IMAGE-MGC_LOAD
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_F1 UniProtKB/TrEMBL
  FERM_F2 UniProtKB/TrEMBL
  INSL3/INSL4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like UniProtKB/Swiss-Prot
  Insulin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_CS UniProtKB/Swiss-Prot
  Insulin_family UniProtKB/Swiss-Prot
  Jak1_PHL_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Jak/Tyk2 UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Jak3 UniProtKB/TrEMBL
KEGG Report rno:114215 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112595 IMAGE-MGC_LOAD
NCBI Gene 114215 ENTREZGENE
PANTHER PTHR10423 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FERM_F1 UniProtKB/TrEMBL
  FERM_F2 UniProtKB/TrEMBL
  Insulin UniProtKB/Swiss-Prot
  Jak1_Phl UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PhenoGen Insl3 PhenoGen
PIRSF TyrPK_Jak UniProtKB/TrEMBL
PRINTS INSULINFAMLY UniProtKB/Swiss-Prot
  JANUSKINASE UniProtKB/TrEMBL
  JANUSKINASE3 UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/TrEMBL
  INSULIN UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  IlGF UniProtKB/Swiss-Prot
  SH2 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF56994 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K636_RAT UniProtKB/TrEMBL
  INSL3_RAT UniProtKB/Swiss-Prot
  Q4KMB3_RAT UniProtKB/TrEMBL
  Q9WUK0 ENTREZGENE
  Q9WUK1 ENTREZGENE
UniProt Secondary Q9WUK1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Insl3  insulin-like 3      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Insl3  insulin-like 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mutated protein is found in patients with cryptorchidism or defective testis due to abnormal gubernaculum development 633070
gene_expression expressed in the testis Leydig cells, ovarian theca and luteal cells 633070
gene_function binds to gubernacular homogenates and induces growth of gubernaculum 633070
gene_mutations_overexpression overexpression in females leads to ovary descent 633070
gene_product member of the relaxin family 633070