Insl3 (insulin-like 3) - Rat Genome Database

Name: Insl3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Insl3 (insulin-like 3) Rattus norvegicus

Analyze

Symbol:

Insl3

Name:

insulin-like 3

RGD ID:

620117

Description:

Exhibits G protein-coupled receptor binding activity. Involved in several processes, including male gonad development; oocyte maturation; and positive regulation of cAMP-mediated signaling. Localizes to extracellular space and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human INSL3 (insulin like 3); INTERACTS WITH (+)-taxifolin; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

ley-I-L; Leydig insulin-like peptide; Leydig insulin-like peptide relaxin-like factor; Leydig insulin-like peptide, relaxin-like factor; MGC112595; relaxin-like factor; Rlf

Orthologs:

Homo sapiens (human) : INSL3 (insulin like 3) HGNC Alliance
Mus musculus (house mouse) : Insl3 (insulin-like 3) MGI Alliance
Chinchilla lanigera (long-tailed chinchilla) : Insl3 (insulin like 3)
Canis lupus familiaris (dog) : INSL3 (insulin like 3)
Sus scrofa (pig) : INSL3 (insulin like 3)
Chlorocebus sabaeus (African green monkey) : INSL3 (insulin like 3)
Heterocephalus glaber (naked mole-rat) : Insl3 (insulin like 3)

more info ...

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	INSL3 (insulin like 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Insl3 (insulin-like 3)	HGNC	Treefam, EggNOG, NCBI, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Insl3 (insulin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	INSL3 (insulin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	INSL3 (insulin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	INSL3 (insulin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Insl3 (insulin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Insl3 (insulin-like 3)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	INSL3 (insulin like 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	insl3 (insulin-like 3 (Leydig cell))	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	Ilp4	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	16	20,120,753 - 20,122,702 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,121,352 - 20,122,696 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	19,981,216 - 19,983,156 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	18,890,131 - 18,891,475 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	16	18,890,128 - 18,891,473 (+)	NCBI
Celera	16	18,601,812 - 18,603,156 (+)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cryptorchidism (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-taxifolin (EXP)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrobenzenesulfonic acid (EXP)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

androgen antagonist (EXP)

atrazine (EXP,ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

Bisphenol A diglycidyl ether (ISO)

Bisphenol B (ISO)

bucladesine (EXP)

buta-1,3-diene (ISO)

butanal (ISO)

Butylbenzyl phthalate (EXP)

carmustine (ISO)

cetrorelix (ISO)

copper(II) sulfate (ISO)

cypermethrin (ISO)

desogestrel (ISO)

Di-n-hexyl phthalate (EXP)

dibromoacetic acid (EXP)

dibutyl phthalate (EXP)

Dicyclohexyl phthalate (EXP)

diethyl phthalate (EXP)

diheptyl phthalate (EXP)

diisobutyl phthalate (EXP)

Diisodecyl phthalate (EXP)

diisononyl phthalate (EXP)

dipentyl phthalate (EXP)

flavonoids (EXP)

genistein (ISO)

levonorgestrel (ISO)

mono(2-ethylhexyl) phthalate (EXP,ISO)

Monobutylphthalate (EXP)

paracetamol (ISO)

pentanal (ISO)

perfluorooctanoic acid (ISO)

propanal (ISO)

pyridaben (ISO)

quercetin (EXP)

simvastatin (EXP)

tamoxifen (ISO)

testosterone (ISO)

testosterone enanthate (EXP,ISO)

testosterone undecanoate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

ziram (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (IBA,IDA)

in utero embryonic development (ISO)

male gonad development (IDA,ISO)

negative regulation of apoptotic process (IDA)

negative regulation of cell population proliferation (IDA)

oocyte maturation (IDA)

positive regulation of cAMP-mediated signaling (IDA)

positive regulation of cell population proliferation (IDA)

positive regulation of epithelial cell migration (ISO)

positive regulation of wound healing (ISO)

regulation of male gonad development (ISO)

Cellular Component

extracellular space (IBA,IDA)

perinuclear region of cytoplasm (IDA)

Molecular Function

G protein-coupled receptor binding (IBA,IPI)

hormone activity (IEA)

protease binding (ISO)

protein binding (ISO)

References

References - curated


1.	Boockfor FR, etal., Reproduction. 2001 Dec;122(6):899-906.
2.	Canto P, etal., J Hum Genet. 2003;48(2):86-90.
3.	Fu P, etal., Ann N Y Acad Sci. 2005 May;1041:516-9.
4.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	GOA data from the GO Consortium
6.	Kawamura K, etal., Proc Natl Acad Sci U S A. 2004 May 11;101(19):7323-8. Epub 2004 May 3.
7.	Kubota Y, etal., Mol Hum Reprod 2002 Oct;8(10):900-5.
8.	Kumagai J, etal., J Biol Chem 2002 Aug 30;277(35):31283-6.
9.	McKinnell C, etal., Endocrinology. 2005 Oct;146(10):4536-44. Epub 2005 Jul 21.
10.	MGD data from the GO Consortium
11.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
12.	OMIM Disease Annotation Pipeline
13.	RGD automated data pipeline
14.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	RGD automated import pipeline for gene-chemical interactions
16.	Smith KJ, etal., J Pept Sci. 2001 Sep;7(9):495-501.
17.	Spiess AN, etal., Mol Reprod Dev 1999 Dec;54(4):319-25.

Additional References at PubMed

PMID:10319319	PMID:12477932	PMID:15956681	PMID:16338306	PMID:17400582	PMID:18772241	PMID:19420383	PMID:19493424	PMID:20082125	PMID:20631401	PMID:21633115	PMID:23539510
PMID:24169563

Genomics

Comparative Map Data

Insl3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	16	20,120,753 - 20,122,702 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,121,352 - 20,122,696 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	19,981,216 - 19,983,156 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	18,890,131 - 18,891,475 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	16	18,890,128 - 18,891,473 (+)	NCBI
Celera	16	18,601,812 - 18,603,156 (+)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

INSL3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	19	17,816,512 - 17,821,574 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	19	17,816,512 - 17,821,519 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	19	17,927,322 - 17,932,383 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	17,788,322 - 17,793,320 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	19	17,788,321 - 17,793,320	NCBI
Celera	19	17,829,042 - 17,834,041 (-)	NCBI
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	17,492,756 - 17,497,784 (-)	NCBI		HuRef
CHM1_1	19	17,926,865 - 17,931,926 (-)	NCBI		CHM1_1

Insl3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	72,141,896 - 72,143,221 (+)	NCBI
GRCm38	8	71,689,252 - 71,690,577 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	71,689,214 - 71,690,575 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	74,213,151 - 74,214,474 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	74,618,241 - 74,619,564 (+)	NCBI			mm8
Celera	8	74,203,798 - 74,205,121 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.43	NCBI

Insl3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955524	3,413,764 - 3,415,691 (+)	NCBI	ChiLan1.0	ChiLan1.0

INSL3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	20	45,050,526 - 45,072,805 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	20	45,071,128 - 45,072,446 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

INSL3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	59,929,581 - 59,931,343 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	59,929,591 - 59,931,220 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	59,499,023 - 59,500,652 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	2	q12-q13	NCBI

INSL3
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	16,291,220 - 16,296,705 (-)	NCBI

Insl3
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624908	1,368,660 - 1,369,740 (-)	NCBI

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	24228366	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	27556253	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	27556253	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	27556253	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	31816439	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	33160624	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	34465490	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	41240937	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	41240937	Rat
631561	Hcuc2	Hepatic copper content QTL 2	2.8		hepatic copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	41240957	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	244593	45244593	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	1090054	86162972	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1340741	46340741	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	1550187	49247447	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	1550187	63210301	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1550187	63210301	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	1550187	63210301	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	1550187	63210301	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1728297	46728297	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	4136355	23105837	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4136355	45905331	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	16	5013802	45905331	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	5013802	45905331	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	5013802	45905331	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	5013802	50013802	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	5013802	50169318	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	5013802	52144919	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	5013802	64012784	Rat
631517	Scl9	Serum cholesterol level QTL 9	3.3		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	16	17309396	22744540	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	19398187	70590230	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	19398187	70590230	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	19398187	70590230	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	19398187	70590230	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	138
Count of miRNA genes:	105
Interacting mature miRNAs:	118
Transcripts:	ENSRNOT00000025347
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High											1
Medium					1						19
Low	3		12	3	18	3	1	1	1	6	10	7	1
Below cutoff		28	34	28		28	2	4	38	24	11	3	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053680	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006252820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AABR07024869	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01086833	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF139918	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF139920	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098653	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000025347 ⟹ ENSRNOP00000025349

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	20,121,352 - 20,122,696 (+)	Ensembl

RefSeq Acc Id:

NM_053680 ⟹ NP_446132

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	20,121,352 - 20,122,696 (+)	NCBI
Rnor_5.0	16	19,981,216 - 19,983,156 (+)	NCBI
RGSC_v3.4	16	18,890,131 - 18,891,475 (+)	RGD
Celera	16	18,601,812 - 18,603,156 (+)	RGD

Sequence:

show sequence

ATGCACGCACTGCTGCTACTGCTGCTCCTGGCTCTAGGGTCCGCGCTGCGCTCCCCGCAGCCCC
CGGAGGCGCGCGCCAAGCTCTGTGGTCACCACCTGGTGCGTGCGCTGGTGCGGGTGTGCGGTGG
CCCGCGTTGGTCACCCGAGGCCACGCAGCCTGTGGACACCCGCGACCGGGAGCTGCTGCAGTGG
CTGGAGCAACGACATCTCCTGCACGCGCTCGTGGCCGATGCGGATCCCGCGCTAGACCCGGACC
CCGCGCTGGACCCGCAGCTTCCTCACCAGGCTTCTCAGCGCCAGCGCCGCAGTGTGGCCACCAA
CGCTGTGCACCGCTGCTGTCTCACTGGCTGCACCCAGCAAGACCTTTTGGGTCTGTGTCCCCAC
TGAAGGATTGTAGGGCTCAGGTGGTGTGTGTCAATTATTCCCCACCTNACAGCTGTGCCAATGA
AACACCCCCGGATTGCCTTGGAGGATCCCTAGTTTATTCATAGATCCCAGAAACCAAGGACCAC
AGGTCCTGTCCCCAGGGAGCCCCATCATGACCTGTGCCCACCTCCTCCCTGTGGGCCAACAGTC
TAAATAAAAAAGCAACTTG

hide sequence

RefSeq Acc Id:

XM_006252820 ⟹ XP_006252882

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	20,120,753 - 20,122,702 (+)	NCBI
Rnor_5.0	16	19,981,216 - 19,983,156 (+)	NCBI

Sequence:

show sequence

TGGGAGAGGAGAGGTCTTGGCCAGACCCCAAGGACACCCCCTTCCCTCCTGCCCAGCTGCATGC
AGTCCTTGGCTCGCCAGGGGAGCTGGTTCCGGGCAGAGGCAGTGCAAGGGGCAGAGGCCAAGGC
TGGAGCTAGGCTGAACCAGCCCTGTGCACCCCAGGACAGTGCCTGCAGTCACCCACCACAGTCA
GGAGGTAGAGGGACAGGAGAAGAACCATTTAGACTTATCCTCCCGTCTTCCAGCCTCAGTTTCC
CTCTTTGACAAAACCAAGTCATAAATACCTCCTCCCATCTCCTTCACAGCCCAAACTGCCTCCA
ACTTACAGCAATTCTCCTGCCTCAGCTTTTTCACTGCTAGCAAGACTGTCAACCTTACAAAAGG
GGAAGGGCACTTGGCTTGTTTTAAATGTTGGGGGGCGGCTCCTGGCACAGTGCTGCACCTGGGA
GAGGGACTTCAGGGTCCCAAGCTGGACACACAGCCCCTGACCGTGACCTGAGCCTCGACCTCCT
CGGTGCTGCTCGTCGTGTTCCCTCCAAGGCCCATGGGCGGCGCAAGGCGGCTATAAGGAGCGTC
CTTACCCGCTGCCTCCTGCCACCATGCACGCACTGCTGCTACTGCTGCTCCTGGCTCTAGGGTC
CGCGCTGCGCTCCCCGCAGCCCCCGGAGGCGCGCGCCAAGCTCTGTGGTCACCACCTGGTGCGT
GCGCTGGTGCGGGTGTGCGGTGGCCCGCGTTGGTCACCCGAGGCCACGCAGCCTGTGGACACCC
GCGACCGGACCTCACCCTTCCATGGCCACAAACTGGGGTGCACAGGAGGCAAACAGGCACACAG
AGTTGGAGGGGAGCTGCTGCAGTGGCTGGAGCAACGACATCTCCTGCACGCGCTCGTGGCCGAT
GCGGATCCCGCGCTAGACCCGGACCCCGCGCTGGACCCGCAGCTTCCTCACCAGGCTTCTCAGC
GCCAGCGCCGCAGTGTGGCCACCAACGCTGTGCACCGCTGCTGTCTCACTGGCTGCACCCAGCA
AGACCTTTTGGGTCTGTGTCCCCACTGAAGGATTGTAGGGCTCAGGTGGTGTGTGTCAATTATT
CCCCACCTCACAGCTGTGCCAATGAAACACCCCCGGATTGCCTTGGAGGATCCCTAGTTTATTC
ATAGATCCCAGAAACCAAGGACCACAGGTCCTGTCCCCAGGGAGCCCCATCATGACCTGTGCCC
ACCTCCTCCCTGTGGGCCAACAGTCTAAATAAAAAAGCAACTTGATGTTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_446132	(Get FASTA)	NCBI Sequence Viewer
	XP_006252882	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD33663	(Get FASTA)	NCBI Sequence Viewer
	AAD33851	(Get FASTA)	NCBI Sequence Viewer
	AAH98653	(Get FASTA)	NCBI Sequence Viewer
	EDL90760	(Get FASTA)	NCBI Sequence Viewer
	Q9WUK0	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_446132 ⟸ NM_053680
- Peptide Label:	precursor
- UniProtKB:	Q9WUK0 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MHALLLLLLLALGSALRSPQPPEARAKLCGHHLVRALVRVCGGPRWSPEATQPVDTRDRELLQW LEQRHLLHALVADADPALDPDPALDPQLPHQASQRQRRSVATNAVHRCCLTGCTQQDLLGLCPH hide sequence

RefSeq Acc Id:	XP_006252882 ⟸ XM_006252820
- Peptide Label:	isoform X1
- Sequence:	show sequence MHALLLLLLLALGSALRSPQPPEARAKLCGHHLVRALVRVCGGPRWSPEATQPVDTRDRTSPFH GHKLGCTGGKQAHRVGGELLQWLEQRHLLHALVADADPALDPDPALDPQLPHQASQRQRRSVAT NAVHRCCLTGCTQQDLLGLCPH hide sequence

RefSeq Acc Id:

ENSRNOP00000025349 ⟸ ENSRNOT00000025347

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700009

Promoter ID:

EPDNEW_R10532

Type:

multiple initiation site

Name:

Insl3_1

Description:

insulin-like 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	20,121,360 - 20,121,420	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620117	AgrOrtholog
Ensembl Genes	ENSRNOG00000018757	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000025349	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000025347	ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7386551	IMAGE-MGC_LOAD
InterPro	INSL3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	INSL3/INSL4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Insulin-like	UniProtKB/Swiss-Prot
	Insulin-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Insulin_CS	UniProtKB/Swiss-Prot
	Insulin_family	UniProtKB/Swiss-Prot
KEGG Report	rno:114215	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112595	IMAGE-MGC_LOAD
NCBI Gene	114215	ENTREZGENE
PANTHER	PTHR10423	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10423:SF4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Insulin	UniProtKB/Swiss-Prot
PhenoGen	Insl3	PhenoGen
PRINTS	INSULINFAMLY	UniProtKB/Swiss-Prot
PROSITE	INSULIN	UniProtKB/Swiss-Prot
SMART	IlGF	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56994	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene	Rn.48700	ENTREZGENE
UniProt	INSL3_RAT	UniProtKB/Swiss-Prot
	Q4KMB3_RAT	UniProtKB/TrEMBL
	Q9WUK0	ENTREZGENE
UniProt Secondary	Q9WUK1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-26	Insl3	insulin-like 3			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Insl3	insulin-like 3			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_disease	mutated protein is found in patients with cryptorchidism or defective testis due to abnormal gubernaculum development	633070
gene_expression	expressed in the testis Leydig cells, ovarian theca and luteal cells	633070
gene_function	binds to gubernacular homogenates and induces growth of gubernaculum	633070
gene_mutations_overexpression	overexpression in females leads to ovary descent	633070
gene_product	member of the relaxin family	633070

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM