Slc22a17 (solute carrier family 22, member 17) - Rat Genome Database

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Gene: Slc22a17 (solute carrier family 22, member 17) Rattus norvegicus
Analyze
Symbol: Slc22a17
Name: solute carrier family 22, member 17
RGD ID: 631405
Description: Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in siderophore transport. Predicted to be located in organelle membrane and plasma membrane. Orthologous to human SLC22A17 (solute carrier family 22 member 17); INTERACTS WITH (+)-schisandrin B; 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 24p3 receptor; 24p3R; Boct; brain-specific organic ion transporter; brain-type organic cation transporter; lipocalin-2 receptor; MGC116043; rBOCT; solute carrier family 22 (organic cation transporter), member 17; solute carrier family 22 member 17
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21528,382,285 - 28,389,435 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,382,292 - 28,388,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,227,996 - 30,234,484 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01531,375,198 - 31,381,686 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01529,617,888 - 29,624,383 (-)NCBIRnor_WKY
Rnor_6.01533,569,824 - 33,576,972 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,569,843 - 33,576,331 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,456,770 - 37,463,918 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,008,690 - 33,015,184 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,024,383 - 33,030,880 (-)NCBI
Celera1527,960,106 - 27,966,600 (-)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16377569   PMID:17253959   PMID:21359964   PMID:22084236   PMID:30404645   PMID:31211866   PMID:32627017  


Genomics

Comparative Map Data
Slc22a17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21528,382,285 - 28,389,435 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,382,292 - 28,388,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,227,996 - 30,234,484 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01531,375,198 - 31,381,686 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01529,617,888 - 29,624,383 (-)NCBIRnor_WKY
Rnor_6.01533,569,824 - 33,576,972 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,569,843 - 33,576,331 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,456,770 - 37,463,918 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,008,690 - 33,015,184 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,024,383 - 33,030,880 (-)NCBI
Celera1527,960,106 - 27,966,600 (-)NCBICelera
Cytogenetic Map15p13NCBI
SLC22A17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,346,311 - 23,352,887 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1423,346,314 - 23,352,912 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,815,520 - 23,822,096 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,885,367 - 22,891,920 (-)NCBINCBI36Build 36hg18NCBI36
Build 341422,885,367 - 22,891,319NCBI
Celera143,678,238 - 3,684,791 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,931,941 - 3,938,494 (-)NCBIHuRef
CHM1_11423,814,199 - 23,820,752 (-)NCBICHM1_1
T2T-CHM13v2.01417,547,327 - 17,553,903 (-)NCBIT2T-CHM13v2.0
Slc22a17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,144,184 - 55,154,527 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,143,761 - 55,150,589 (-)EnsemblGRCm39 Ensembl
GRCm381454,906,727 - 54,913,132 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,906,304 - 54,913,132 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,525,564 - 55,531,969 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,860,950 - 53,867,287 (-)NCBIMGSCv36mm8
Celera1452,713,032 - 52,719,445 (-)NCBICelera
Cytogenetic Map14C3NCBI
SLC22A17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11422,260,079 - 22,266,666 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,260,079 - 22,266,667 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0144,165,419 - 4,172,002 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC22A17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,594,572 - 3,600,380 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,594,572 - 3,600,286 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,542,906 - 3,549,350 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,702,403 - 3,708,849 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,702,410 - 3,708,852 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,394,004 - 3,400,445 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,455,276 - 3,461,720 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,717,453 - 3,723,900 (-)NCBIUU_Cfam_GSD_1.0
Slc22a17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,359,508 - 35,365,963 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367221,022,971 - 1,029,672 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049367221,023,026 - 1,029,484 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,734,871 - 75,741,112 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,734,724 - 75,741,115 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,999,765 - 81,006,145 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,717,829 - 23,724,439 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605922,693,398 - 22,700,769 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc22a17
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248209,209,864 - 9,220,087 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248209,210,015 - 9,216,620 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc22a17
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:47
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000021851
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
RH131172  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,382,382 - 28,382,591 (+)MAPPERmRatBN7.2
Rnor_6.01533,569,922 - 33,570,130NCBIRnor6.0
Rnor_5.01537,456,868 - 37,457,076UniSTSRnor5.0
RGSC_v3.41533,008,775 - 33,008,983UniSTSRGSC3.4
Celera1527,960,191 - 27,960,399UniSTS
Cytogenetic Map15p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 34 24 15 16 15 1 1 74 29 38 11 1
Low 2 9 33 26 3 26 7 10 6 3 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021851   ⟹   ENSRNOP00000021851
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1528,382,293 - 28,388,799 (-)Ensembl
Rnor_6.0 Ensembl1533,569,843 - 33,576,331 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102200   ⟹   ENSRNOP00000082506
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1528,382,293 - 28,388,208 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104533   ⟹   ENSRNOP00000096057
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1528,382,292 - 28,388,794 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111642   ⟹   ENSRNOP00000083004
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1528,382,293 - 28,388,799 (-)Ensembl
RefSeq Acc Id: NM_177421   ⟹   NP_803156
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21528,382,298 - 28,388,794 (-)NCBI
Rnor_6.01533,569,837 - 33,576,331 (-)NCBI
Rnor_5.01537,456,770 - 37,463,918 (-)NCBI
RGSC_v3.41533,008,690 - 33,015,184 (-)RGD
Celera1527,960,106 - 27,966,600 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251965   ⟹   XP_006252027
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21528,382,285 - 28,389,435 (-)NCBI
Rnor_6.01533,569,824 - 33,576,972 (-)NCBI
Rnor_5.01537,456,770 - 37,463,918 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_803156   ⟸   NM_177421
- UniProtKB: Q4KLP1 (UniProtKB/Swiss-Prot),   Q9P290 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006252027   ⟸   XM_006251965
- Peptide Label: isoform X1
- UniProtKB: Q4KLP1 (UniProtKB/Swiss-Prot),   Q9P290 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021851   ⟸   ENSRNOT00000021851
RefSeq Acc Id: ENSRNOP00000082506   ⟸   ENSRNOT00000102200
RefSeq Acc Id: ENSRNOP00000096057   ⟸   ENSRNOT00000104533
RefSeq Acc Id: ENSRNOP00000083004   ⟸   ENSRNOT00000111642
Protein Domains
MFS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9P290-F1-model_v2 AlphaFold Q9P290 1-520 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699664
Promoter ID:EPDNEW_R10186
Type:multiple initiation site
Name:Slc22a17_1
Description:solute carrier family 22, member 17
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01533,576,336 - 33,576,396EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631405 AgrOrtholog
BioCyc Gene G2FUF-13767 BioCyc
Ensembl Genes ENSRNOG00000016414 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021851 ENTREZGENE
  ENSRNOP00000021851.6 UniProtKB/TrEMBL
  ENSRNOP00000082506.1 UniProtKB/TrEMBL
  ENSRNOP00000083004 ENTREZGENE
  ENSRNOP00000083004.1 UniProtKB/TrEMBL
  ENSRNOP00000096057.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021851 ENTREZGENE
  ENSRNOT00000021851.7 UniProtKB/TrEMBL
  ENSRNOT00000102200.1 UniProtKB/TrEMBL
  ENSRNOT00000104533.1 UniProtKB/TrEMBL
  ENSRNOT00000111642 ENTREZGENE
  ENSRNOT00000111642.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7312276 IMAGE-MGC_LOAD
InterPro MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:305886 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116043 IMAGE-MGC_LOAD
NCBI Gene 305886 ENTREZGENE
Pfam Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc22a17 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZTM9_RAT UniProtKB/TrEMBL
  A0A8I5ZZ20_RAT UniProtKB/TrEMBL
  A0A8I6GLF6_RAT UniProtKB/TrEMBL
  A0A8L2QB08_RAT UniProtKB/TrEMBL
  Q4KLP1 ENTREZGENE
  Q9P290 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q4KLP1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-19 Slc22a17  solute carrier family 22, member 17  Slc22a17  solute carrier family 22 (organic cation transporter), member 17  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Slc22a17  solute carrier family 22 (organic cation transporter), member 17  Boct  brain-specific organic ion transporter  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED