Gene: Notch3 (notch receptor 3) Rattus norvegicus
Analyze
Symbol:
Notch3
Name:
notch receptor 3
Description:
Predicted to have enzyme binding activity; identical protein binding activity; and signaling receptor activity. Involved in Notch signaling pathway; regulation of transcription, DNA-templated; and tissue regeneration. Predicted to localize to several cellular components, including the actin cytoskeleton; cell surface; and nucleoplasm. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Orthologous to human NOTCH3 (notch receptor 3); PARTICIPATES IN Notch signaling pathway; altered Notch signaling pathway involving the main players; CADASIL pathway; INTERACTS WITH 3H-1,2-dithiole-3-thione; ammonium chloride; bis(2-chloroethyl) sulfide.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
neurogenic locus notch homolog protein 3; notch 3; Notch gene homolog 3; Notch gene homolog 3 (Drosophila); Notch homolog 3; Notch homolog 3 (Drosophila)
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
NOTCH3 (notch receptor 3) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Notch3 (notch 3) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Notch3 (notch receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
NOTCH3 (notch receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
NOTCH3 (notch receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Notch3 (notch receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
NOTCH3 (notch receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
NOTCH2 (notch receptor 2) HGNC
OrthoMCL
Homo sapiens (human):
NOTCH4 (notch receptor 4) HGNC
OrthoMCL
Alliance orthologs 3
Homo sapiens (human):
NOTCH3 (notch receptor 3)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Notch3 (notch 3)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
notch3 (notch receptor 3)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
N
Alliance
DIOPT (Ensembl Compara, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
lin-12
Alliance
DIOPT (OrthoInspector, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 7 14,138,495 - 14,189,688 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 7 14,138,495 - 14,189,688 (-) Ensembl Rnor_5.0 7 14,294,587 - 14,345,774 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 7 12,688,267 - 12,740,015 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 7 12,688,266 - 12,740,015 (-) NCBI Celera 7 9,246,229 - 9,296,285 (-) NCBI Celera Cytogenetic Map 7 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
breast ductal carcinoma ISO RGD:732750 8554872 ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:19576955 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: CASIL ClinVar PMID:10227618 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:16717210 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:10371548 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:19542611 , PMID:25741868 CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:11102981 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:11102981 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:10371548 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:11102981 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:10371548 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:12754354 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:20301673 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:20038773 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:22159056 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:22006983 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by OMIM:125310 ClinVar CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by OMIM:125310 ClinVar PMID:25741868 CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:17879447 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:10854111 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:10712431 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:12196662 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:21616505 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:19006080 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:19006080 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:19006080 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:12136071 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:11559313 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by OMIM:125310 ClinVar PMID:11706120 CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by OMIM:125310 ClinVar PMID:16864835 CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by OMIM:125310 ClinVar PMID:11755616 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by OMIM:125310 ClinVar PMID:8878478 , PMID:9388399 CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by OMIM:125310 ClinVar PMID:20301673 , PMID:22664156 CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:24086431 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:18765654 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:22153900 more ... CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:26467025 CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:25741868 , PMID:26467025 CADASIL ISO RGD:732750 8554872 ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ClinVar PMID:22153900 more ... CADASIL 1 ISO RGD:732750 8554872 ClinVar Annotator: match by term: CEREBRAL ARTERIOPATHY, AUTOSOMAL DOMINANT, WITH SUBCORTICAL INFARCTS AND LEUKOENCEPHALOPATHY, TYPE 1 ClinVar PMID:10227618 more ... cerebral infarction ISO RGD:732750 8554872 ClinVar Annotator: match by term: Ischemic stroke ClinVar PMID:20301673 more ... genetic disease ISO RGD:732750 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:19539236 more ... Infantile Myofibromatosis 1 ISO RGD:732750 8554872 ClinVar Annotator: match by term: Infantile myofibromatosis 1 ClinVar PMID:23731542 Infantile Myofibromatosis 2 ISO RGD:732750 8554872 ClinVar Annotator: match by term: Infantile myofibromatosis 2 ClinVar PMID:23731542 lateral meningocele syndrome ISO RGD:732750 8554872 ClinVar Annotator: match by term: Lehman syndrome ClinVar PMID:21337686 more ... lateral meningocele syndrome ISO RGD:732750 8554872 ClinVar Annotator: match by term: Lehman syndrome ClinVar PMID:23696373 , PMID:25394726 lateral meningocele syndrome ISO RGD:732750 8554872 ClinVar Annotator: match by term: Lehman syndrome ClinVar PMID:15666314 , PMID:25394726 lateral meningocele syndrome ISO RGD:732750 8554872 ClinVar Annotator: match by term: Lehman syndrome ClinVar PMID:25394726 lateral meningocele syndrome ISO RGD:732750 8554872 ClinVar Annotator: match by term: Lehman syndrome ClinVar PMID:25394726 , PMID:9188658 lateral meningocele syndrome ISO RGD:732750 8554872 ClinVar Annotator: match by term: Lehman syndrome ClinVar PMID:26754023 migraine ISO RGD:732750 8554872 ClinVar Annotator: match by term: Migraine ClinVar PMID:25741868 prostate cancer ISO RGD:732750 8554872 ClinVar Annotator: match by term: Prostate cancer ClinVar PMID:23265383
Imported Annotations - CTD
Breast Neoplasms ISO RGD:732750 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21036696 CADASIL ISO RGD:732750 11554173 CTD Direct Evidence: marker/mechanism CTD glioblastoma multiforme ISO RGD:732750 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21127729 hepatocellular carcinoma ISO RGD:732750 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28284560 infantile myofibromatosis ISO RGD:732750 11554173 CTD Direct Evidence: marker/mechanism CTD Lung Neoplasms ISO RGD:732750 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17804716 lung non-small cell carcinoma ISO RGD:732750 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21994468 pancreatic ductal carcinoma ISO RGD:732750 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19208345 Skin Neoplasms ISO RGD:732750 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27923803 squamous cell carcinoma ISO RGD:732750 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27923803 Imported Annotations - MGI
acute lymphocytic leukemia ISS RGD:1552400 13592920 OMIM:247640 more ... MouseDO Imported Annotations - OMIM
CADASIL 1 ISO RGD:732750 7240710 OMIM Infantile Myofibromatosis 2 ISO RGD:732750 7240710 OMIM lateral meningocele syndrome ISO RGD:732750 7240710 OMIM
1,3-benzothiazole-2-thiol decreases expression ISO RGD:732750 6480464 captax results in decreased expression of NOTCH3 mRNA CTD PMID:20713136 17alpha-ethynylestradiol multiple interactions ISO RGD:1552400 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NOTCH3 mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO RGD:1552400 6480464 Ethinyl Estradiol affects the expression of NOTCH3 mRNA CTD PMID:17555576 17alpha-ethynylestradiol increases expression ISO RGD:1552400 6480464 Ethinyl Estradiol results in increased expression of NOTCH3 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:732750 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of NOTCH3 mRNA CTD PMID:30165855 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RGD:732750 6480464 2 more ... CTD PMID:19095052 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1552400 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NOTCH3 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1552400 6480464 Tetrachlorodibenzodioxin results in increased expression of NOTCH3 mRNA CTD PMID:16962184 3-phenylprop-2-enal increases expression ISO RGD:732750 6480464 cinnamic aldehyde results in increased expression of NOTCH3 mRNA CTD PMID:20713136 3H-1,2-dithiole-3-thione increases expression EXP 6480464 1, 2-dithiol-3-thione results in increased expression of NOTCH3 mRNA CTD PMID:19162173 4-hydroxyphenyl retinamide decreases expression ISO RGD:1552400 6480464 Fenretinide results in decreased expression of NOTCH3 mRNA CTD PMID:16467112 8-bromo-3',5'-cyclic AMP increases expression ISO RGD:732750 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of NOTCH3 mRNA CTD PMID:20147733 aflatoxin B1 increases expression ISO RGD:1552400 6480464 Aflatoxin B1 results in increased expression of NOTCH3 mRNA CTD PMID:19770486 aflatoxin B1 increases methylation ISO RGD:732750 6480464 Aflatoxin B1 results in increased methylation of NOTCH3 intron CTD PMID:30157460 aflatoxin B2 decreases methylation ISO RGD:732750 6480464 aflatoxin B2 results in decreased methylation of NOTCH3 intron CTD PMID:30157460 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of NOTCH3 mRNA CTD PMID:16483693 antirheumatic drug increases expression ISO RGD:732750 6480464 Antirheumatic Agents results in increased expression of NOTCH3 mRNA CTD PMID:24449571 benzo[a]pyrene increases expression ISO RGD:1552400 6480464 Benzo(a)pyrene results in increased expression of NOTCH3 mRNA CTD PMID:19770486 benzo[a]pyrene multiple interactions ISO RGD:1552400 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of NOTCH3 mRNA] CTD PMID:22228805 benzo[e]pyrene decreases methylation ISO RGD:732750 6480464 benzo(e)pyrene results in decreased methylation of NOTCH3 intron CTD PMID:30157460 bis(2-chloroethyl) sulfide decreases expression EXP 6480464 Mustard Gas results in decreased expression of NOTCH3 mRNA CTD PMID:28402575 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA CTD PMID:25607892 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of NOTCH3 mRNA CTD PMID:25181051 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of NOTCH3 gene CTD PMID:28505145 butanal decreases expression ISO RGD:732750 6480464 butyraldehyde results in decreased expression of NOTCH3 mRNA CTD PMID:26079696 carbon nanotube decreases expression ISO RGD:1552400 6480464 Nanotubes, Carbon results in decreased expression of NOTCH3 mRNA CTD PMID:25554681 chloromethylisothiazolinone increases expression ISO RGD:732750 6480464 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of NOTCH3 mRNA CTD PMID:20713136 cisplatin multiple interactions ISO RGD:732750 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of NOTCH3 mRNA CTD PMID:27392435 cisplatin increases expression ISO RGD:732750 6480464 Cisplatin results in increased expression of NOTCH3 mRNA CTD PMID:27392435 copper atom increases expression EXP 6480464 Copper results in increased expression of NOTCH3 mRNA CTD PMID:30556269 copper(0) increases expression EXP 6480464 Copper results in increased expression of NOTCH3 mRNA CTD PMID:30556269 coumestrol decreases expression ISO RGD:732750 6480464 Coumestrol results in decreased expression of NOTCH3 mRNA CTD PMID:19167446 DDE multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA CTD PMID:25607892 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of NOTCH3 mRNA CTD PMID:17379624 dibutyl phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA CTD PMID:25607892 dimethyl sulfoxide increases expression ISO RGD:732750 6480464 Dimethyl Sulfoxide results in increased expression of NOTCH3 mRNA CTD PMID:20713136 dimethylarsinic acid increases expression EXP 6480464 Cacodylic Acid results in increased expression of NOTCH3 mRNA CTD PMID:17720352 dioxygen increases expression ISO RGD:732750 6480464 Oxygen deficiency results in increased expression of NOTCH3 mRNA CTD PMID:26516004 elemental selenium increases expression ISO RGD:732750 6480464 Selenium results in increased expression of NOTCH3 mRNA CTD PMID:19244175 epoxiconazole multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA CTD PMID:25607892 ethanol increases expression ISO RGD:732750 6480464 Ethanol results in increased expression of NOTCH3 mRNA CTD PMID:20713136 ethanol increases expression ISO RGD:1552400 6480464 Ethanol results in increased expression of NOTCH3 mRNA CTD PMID:30319688 fenamidone increases expression ISO RGD:1552400 6480464 fenamidone results in increased expression of NOTCH3 mRNA CTD PMID:27029645 fenofibrate multiple interactions ISO RGD:1552400 6480464 Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH3 mRNA], Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH3 protein] CTD PMID:31241159 glycidol decreases expression EXP 6480464 glycidol results in decreased expression of NOTCH3 mRNA CTD PMID:24915197 ionomycin multiple interactions ISO RGD:732750 6480464 [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NOTCH3 mRNA, pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NOTCH3 mRNA] CTD PMID:15477007 linuron multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA CTD PMID:25607892 lipopolysaccharide increases expression ISO RGD:1552400 6480464 Lipopolysaccharides results in increased expression of NOTCH3 mRNA CTD PMID:12057914 methapyrilene decreases methylation ISO RGD:732750 6480464 Methapyrilene results in decreased methylation of NOTCH3 intron CTD PMID:30157460 methotrexate affects expression ISO RGD:1552400 6480464 Methotrexate affects the expression of NOTCH3 mRNA CTD PMID:18502557 ozone multiple interactions ISO RGD:1552400 6480464 [NOTCH3 gene mutant form affects the susceptibility to Ozone] which affects the expression of ADAMTS4 mRNA more ... CTD PMID:25658374 ozone decreases response to substance ISO RGD:1552400 6480464 NOTCH3 protein results in decreased susceptibility to Ozone CTD PMID:25658374 ozone increases expression ISO RGD:1552400 6480464 Ozone results in increased expression of NOTCH3 mRNA CTD PMID:25658374 paracetamol affects expression ISO RGD:1552400 6480464 Acetaminophen affects the expression of NOTCH3 mRNA CTD PMID:17562736 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:732750 6480464 [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NOTCH3 mRNA, pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NOTCH3 mRNA] CTD PMID:15477007 potassium dichromate increases expression ISO RGD:1552400 6480464 Potassium Dichromate results in increased expression of NOTCH3 mRNA CTD PMID:23608068 prochloraz multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA CTD PMID:25607892 procymidone multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA CTD PMID:25607892 pyrrolidine dithiocarbamate multiple interactions ISO RGD:732750 6480464 pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NOTCH3 mRNA] CTD PMID:15477007 raloxifene affects expression ISO RGD:732750 6480464 Raloxifene Hydrochloride affects the expression of NOTCH3 mRNA CTD PMID:14699072 Salinomycin decreases expression ISO RGD:732750 6480464 salinomycin results in decreased expression of NOTCH3 mRNA CTD PMID:19682730 selenium atom increases expression ISO RGD:732750 6480464 Selenium results in increased expression of NOTCH3 mRNA CTD PMID:19244175 silicon dioxide decreases expression ISO RGD:732750 6480464 Silicon Dioxide analog results in decreased expression of NOTCH3 mRNA CTD PMID:23806026 tamoxifen affects expression ISO RGD:1552400 6480464 Tamoxifen affects the expression of NOTCH3 mRNA CTD PMID:17555576 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of NOTCH3 mRNA CTD PMID:31150632 tetracycline decreases expression ISO RGD:732750 6480464 Tetracycline results in decreased expression of NOTCH3 mRNA CTD PMID:28882639 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of NOTCH3 mRNA CTD PMID:30012374 Triptolide increases expression ISO RGD:1552400 6480464 triptolide results in increased expression of NOTCH3 mRNA, triptolide results in increased expression of NOTCH3 protein CTD PMID:31241159 Triptolide multiple interactions ISO RGD:1552400 6480464 Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH3 mRNA], Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH3 protein] CTD PMID:31241159 tris(2-butoxyethyl) phosphate affects expression ISO RGD:732750 6480464 tris(2-butoxyethyl) phosphate affects the expression of NOTCH3 mRNA CTD PMID:29024780 troglitazone increases expression ISO RGD:1552400 6480464 troglitazone results in increased expression of NOTCH3 mRNA CTD PMID:17569031 vinclozolin multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA CTD PMID:25607892 zoledronic acid decreases expression ISO RGD:732750 6480464 zoledronic acid results in decreased expression of NOTCH3 mRNA CTD PMID:24714768
Biological Process artery morphogenesis ISO RGD:1552400 1624291 MGI:MGI:2687010 (MGI:MGI:5609934 , PMID:23117660) RGD MGI:MGI:5609934 , PMID:23117660 artery morphogenesis IEA UniProtKB:Q61982 , ensembl:ENSMUSP000000850161600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell differentiation IEA UniProtKB-KW:KW-0221 1600115 GO_REF:0000037 UniProt GO_REF:0000037 forebrain development ISO RGD:1552400 1624291 MGI:MGI:97363 (MGI:MGI:3604921 , PMID:16120638) RGD MGI:MGI:3604921 , PMID:16120638 forebrain development IEA UniProtKB:Q61982 , ensembl:ENSMUSP000000850161600115 GO_REF:0000107 Ensembl GO_REF:0000107 glomerular capillary formation IEA UniProtKB:Q61982 , ensembl:ENSMUSP000000850161600115 GO_REF:0000107 Ensembl GO_REF:0000107 glomerular capillary formation ISO RGD:1552400 1624291 (PMID:15821257) RGD PMID:15821257 multicellular organism development IEA UniProtKB-KW:KW-0217 1600115 GO_REF:0000037 UniProt GO_REF:0000037 negative regulation of cell differentiation ISO RGD:1552400 1624291 (MGI:MGI:3529381, PMID:15064243) RGD MGI:MGI:3529381 , PMID:15064243 negative regulation of neuron differentiation ISO RGD:1552400 1624291 (MGI:MGI:3529381, PMID:15064243) RGD MGI:MGI:3529381 , PMID:15064243 negative regulation of neuron differentiation IEA UniProtKB:Q61982 , ensembl:ENSMUSP000000850161600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II ISO RGD:1552400 1624291 MGI:MGI:2687010 (MGI:MGI:5609934 , PMID:23117660) RGD MGI:MGI:5609934 , PMID:23117660 negative regulation of transcription by RNA polymerase II IEA UniProtKB:Q61982 , ensembl:ENSMUSP000000850161600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuron fate commitment ISO RGD:1552400 1624291 MGI:MGI:97363 (MGI:MGI:3604921 , PMID:16120638) RGD MGI:MGI:3604921 , PMID:16120638 neuron fate commitment IEA UniProtKB:Q61982 , ensembl:ENSMUSP000000850161600115 GO_REF:0000107 Ensembl GO_REF:0000107 Notch signaling pathway IBA MGI:MGI:97363 more ... 13792537 PMID:21873635 GO_Central Notch signaling pathway ISO RGD:1552400 1624291 (MGI:MGI:4367619, PMID:19855400) RGD MGI:MGI:4367619 , PMID:19855400 Notch signaling pathway IEA UniProtKB:Q61982 , ensembl:ENSMUSP000000850161600115 GO_REF:0000107 Ensembl GO_REF:0000107 Notch signaling pathway IDA 632418 RGD positive regulation of smooth muscle cell proliferation IEA UniProtKB:Q61982 , ensembl:ENSMUSP000000850161600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of smooth muscle cell proliferation ISO RGD:1552400 1624291 (MGI:MGI:4367619, PMID:19855400) RGD MGI:MGI:4367619 , PMID:19855400 positive regulation of transcription by RNA polymerase II ISO RGD:1552400 1624291 MGI:MGI:2687010 (MGI:MGI:5609934 , PMID:23117660) RGD MGI:MGI:5609934 , PMID:23117660 positive regulation of transcription by RNA polymerase II IEA UniProtKB:Q61982 , ensembl:ENSMUSP000000850161600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of developmental process IEA InterPro:IPR008297 1600115 GO_REF:0000002 InterPro GO_REF:0000002 regulation of transcription, DNA-templated IDA 625426 RGD tissue regeneration IEP 1581404 RGD wound healing IEP 13506277 PMID:11549580 UniProt Cellular Component actin cytoskeleton ISO RGD:732750 1624291 RGD GO_REF:0000052 actin cytoskeleton IEA UniProtKB:Q9UM47 , ensembl:ENSP000002633881600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell surface IBA MGI:MGI:97363 more ... 13792537 PMID:21873635 GO_Central cytosol IEA UniProtKB:Q9UM47 , ensembl:ENSP000002633881600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:732750 1624291 RGD GO_REF:0000052 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000037 UniProt GO_REF:0000037 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000038 UniProt GO_REF:0000038 nucleoplasm ISO RGD:732750 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:Q9UM47 , ensembl:ENSP000002633881600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus IEA UniProtKB-SubCell:SL-0191 1600115 GO_REF:0000039 UniProt GO_REF:0000039 nucleus ISO RGD:1552400 1624291 (MGI:MGI:5693363, PMID:21191019) RGD MGI:MGI:5693363 , PMID:21191019 plasma membrane ISO RGD:1552400 1624291 (MGI:MGI:3689772, PMID:17079689) RGD MGI:MGI:3689772 , PMID:17079689 plasma membrane IBA MGI:MGI:97363 more ... 13792537 PMID:21873635 GO_Central plasma membrane ISO RGD:732750 1624291 (PMID:15350543) RGD PMID:15350543 plasma membrane IEA UniProtKB:Q9UM47 , ensembl:ENSP000002633881600115 GO_REF:0000107 Ensembl GO_REF:0000107 plasma membrane ISS UniProtKB:Q9UM47 1600115 GO_REF:0000024 UniProt GO_REF:0000024 plasma membrane IEA UniProtKB:Q61982 , ensembl:ENSMUSP000000850161600115 GO_REF:0000107 Ensembl GO_REF:0000107 receptor complex ISO RGD:732750 1624291 (PMID:23382219) RGD PMID:23382219 receptor complex IBA PANTHER:PTN001933897 more ... 13792537 PMID:21873635 GO_Central receptor complex IEA UniProtKB:Q9UM47 , ensembl:ENSP000002633881600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function calcium ion binding IEA InterPro:IPR001881 , InterPro:IPR018097 1600115 GO_REF:0000002 InterPro GO_REF:0000002 enzyme binding IEA UniProtKB:Q61982 , ensembl:ENSMUSP000000850161600115 GO_REF:0000107 Ensembl GO_REF:0000107 enzyme binding ISO RGD:1552400 1624291 UniProtKB:Q9NWT6 (MGI:MGI:5318027 , PMID:17573339) RGD MGI:MGI:5318027 , PMID:17573339 identical protein binding IEA UniProtKB:Q9UM47 , ensembl:ENSP000002633881600115 GO_REF:0000107 Ensembl GO_REF:0000107 identical protein binding ISO RGD:732750 1624291 UniProtKB:Q9UM47 (PMID:26051713) RGD PMID:26051713 protein binding ISO RGD:732750 1624291 UniProtKB:O00548 more ... RGD PMID:11006133 more ... protein binding ISO RGD:1552400 1624291 UniProtKB:P31266 more ... RGD MGI:MGI:1347427 more ... signaling receptor activity ISS UniProtKB:Q9UM47 1600115 GO_REF:0000024 UniProt GO_REF:0000024 signaling receptor activity ISO RGD:732750 1624291 (PMID:15350543) RGD PMID:15350543 signaling receptor activity IEA UniProtKB:Q9UM47 , ensembl:ENSP000002633881600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
