Notch3 (notch receptor 3) - Rat Genome Database

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Gene: Notch3 (notch receptor 3) Rattus norvegicus
Analyze
Symbol: Notch3
Name: notch receptor 3
RGD ID: 620761
Description: Predicted to enable enzyme binding activity; identical protein binding activity; and signaling receptor activity. Involved in several processes, including Notch signaling pathway; tissue regeneration; and wound healing. Predicted to be located in nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Orthologous to human NOTCH3 (notch receptor 3); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; altered Notch signaling pathway involving the main players; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: neurogenic locus notch homolog protein 3; notch 3; Notch gene homolog 3; Notch gene homolog 3 (Drosophila); Notch homolog 3; Notch homolog 3 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,783,550 - 11,834,585 (-)NCBIGRCr8
mRatBN7.2711,132,984 - 11,184,025 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl711,133,706 - 11,184,025 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,952,392 - 14,002,867 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,829,787 - 15,880,272 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,701,326 - 13,751,735 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0714,138,495 - 14,189,688 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl714,138,495 - 14,189,688 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0714,294,587 - 14,345,774 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,688,267 - 12,740,015 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1712,688,266 - 12,740,015 (-)NCBI
Celera79,246,229 - 9,296,285 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
carbon nanotube  (ISO)
chloromethylisothiazolinone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumarin  (ISO)
coumestrol  (ISO)
DAPT  (EXP)
DDE  (EXP)
deguelin  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
Dodecyl gallate  (ISO)
elemental selenium  (ISO)
enzalutamide  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
ionomycin  (ISO)
iron dichloride  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
nitrofen  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picene  (ISO)
picoxystrobin  (ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
Salinomycin  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IBA)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO,ISS)
receptor complex  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Distribution pattern of Notch3 mutations suggests a gain-of-function mechanism for CADASIL. Donahue CP and Kosik KS, Genomics 2004 Jan;83(1):59-65.
2. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Lindner V, etal., Am J Pathol. 2001 Sep;159(3):875-83. doi: 10.1016/S0002-9440(10)61763-4.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Amyloid precursor protein interacts with notch receptors. Oh SY, etal., J Neurosci Res. 2005 Oct 1;82(1):32-42.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway. Sweeney C, etal., FASEB J. 2004 Sep;18(12):1421-3. Epub 2004 Jul 9.
15. Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation. Resistance to Fas ligand-induced apoptosis. Wang W, etal., J Biol Chem 2002 Jun 14;277(24):21723-9.
16. Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK. Wang W, etal., J Biol Chem 2002 Jun 28;277(26):23165-71.
Additional References at PubMed
PMID:11182080   PMID:11438922   PMID:15064243   PMID:15350543   PMID:15821257   PMID:16120638   PMID:17079689   PMID:17573339   PMID:17881497   PMID:17939118   PMID:19640841   PMID:19855400  
PMID:21191019   PMID:21330605   PMID:22680933   PMID:22806125   PMID:23117660   PMID:23382219   PMID:23918872   PMID:25468996   PMID:26051713   PMID:26317171   PMID:27791012   PMID:28759157  
PMID:28902129   PMID:29754932   PMID:30811836   PMID:30954415   PMID:35316462   PMID:37153858  


Genomics

Comparative Map Data
Notch3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,783,550 - 11,834,585 (-)NCBIGRCr8
mRatBN7.2711,132,984 - 11,184,025 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl711,133,706 - 11,184,025 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,952,392 - 14,002,867 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,829,787 - 15,880,272 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,701,326 - 13,751,735 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0714,138,495 - 14,189,688 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl714,138,495 - 14,189,688 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0714,294,587 - 14,345,774 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,688,267 - 12,740,015 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1712,688,266 - 12,740,015 (-)NCBI
Celera79,246,229 - 9,296,285 (-)NCBICelera
Cytogenetic Map7q11NCBI
NOTCH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381915,159,038 - 15,200,995 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1915,159,038 - 15,200,995 (-)EnsemblGRCh38hg38GRCh38
GRCh371915,269,849 - 15,311,806 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361915,131,444 - 15,172,792 (-)NCBINCBI36Build 36hg18NCBI36
Build 341915,131,444 - 15,172,792NCBI
Celera1915,166,185 - 15,207,451 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1914,838,304 - 14,879,920 (-)NCBIHuRef
CHM1_11915,269,920 - 15,311,263 (-)NCBICHM1_1
T2T-CHM13v2.01915,283,989 - 15,325,912 (-)NCBIT2T-CHM13v2.0
Notch3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391732,339,794 - 32,385,869 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1732,339,794 - 32,385,826 (-)EnsemblGRCm39 Ensembl
GRCm381732,120,820 - 32,166,896 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1732,120,820 - 32,166,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371732,257,838 - 32,303,797 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361731,849,599 - 31,895,558 (-)NCBIMGSCv36mm8
Celera1733,039,371 - 33,085,333 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.37NCBI
Notch3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554958,012,502 - 8,047,710 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554958,012,370 - 8,048,616 (+)NCBIChiLan1.0ChiLan1.0
NOTCH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22020,073,377 - 20,114,601 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11919,075,966 - 19,117,408 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01914,692,571 - 14,733,758 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11915,677,649 - 15,715,703 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1915,678,674 - 15,715,080 (-)Ensemblpanpan1.1panPan2
NOTCH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12046,946,654 - 46,978,821 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2046,937,485 - 46,978,219 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2046,794,145 - 46,827,285 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02047,433,115 - 47,466,250 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2047,432,263 - 47,465,239 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12046,667,867 - 46,700,947 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02047,084,556 - 47,117,682 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02047,358,143 - 47,391,299 (+)NCBIUU_Cfam_GSD_1.0
Notch3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118205,716,842 - 205,752,291 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365965,265,999 - 5,300,429 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365965,265,984 - 5,301,430 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTCH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl262,364,501 - 62,402,344 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1262,364,507 - 62,402,348 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2261,891,971 - 61,909,274 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOTCH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,762,570 - 13,803,676 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl613,761,512 - 13,793,359 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660745,702,583 - 5,746,374 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Notch3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249012,292,640 - 2,328,433 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249012,292,257 - 2,328,433 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Notch3
423 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:213
Count of miRNA genes:125
Interacting mature miRNAs:138
Transcripts:ENSRNOT00000037456
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
D7Got3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2711,172,761 - 11,172,950 (+)MAPPERmRatBN7.2
Rnor_6.0714,178,426 - 14,178,614NCBIRnor6.0
Rnor_5.0714,334,512 - 14,334,700UniSTSRnor5.0
RGSC_v3.4712,728,752 - 12,728,941RGDRGSC3.4
RGSC_v3.4712,728,753 - 12,728,941UniSTSRGSC3.4
RGSC_v3.1712,728,753 - 12,728,941RGD
Celera79,285,023 - 9,285,211UniSTS
RH 3.4 Map766.3UniSTS
RH 3.4 Map766.3RGD
RH 2.0 Map70.0RGD
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 32 13 4 17 4 2 3 57 22 31 11 2
Low 3 11 40 33 2 33 6 8 17 13 10 6
Below cutoff 4 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000037456   ⟹   ENSRNOP00000037570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl711,133,706 - 11,184,025 (-)Ensembl
Rnor_6.0 Ensembl714,138,495 - 14,189,688 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112007   ⟹   ENSRNOP00000097528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl711,133,706 - 11,181,469 (-)Ensembl
RefSeq Acc Id: NM_020087   ⟹   NP_064472
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,784,272 - 11,834,585 (-)NCBI
mRatBN7.2711,133,706 - 11,184,025 (-)NCBI
Rnor_6.0714,138,495 - 14,189,688 (-)NCBI
Rnor_5.0714,294,587 - 14,345,774 (-)NCBI
RGSC_v3.4712,688,267 - 12,740,015 (-)RGD
Celera79,246,229 - 9,296,285 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079793   ⟹   XP_038935721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,783,550 - 11,834,583 (-)NCBI
mRatBN7.2711,132,984 - 11,184,023 (-)NCBI
RefSeq Acc Id: NP_064472   ⟸   NM_020087
- Peptide Label: precursor
- UniProtKB: Q9R172 (UniProtKB/Swiss-Prot),   F1LQX7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037570   ⟸   ENSRNOT00000037456
RefSeq Acc Id: XP_038935721   ⟸   XM_039079793
- Peptide Label: isoform X1
- UniProtKB: Q9R172 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000097528   ⟸   ENSRNOT00000112007
Protein Domains
EGF-like   LNR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R172-F1-model_v2 AlphaFold Q9R172 1-2319 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695065
Promoter ID:EPDNEW_R5590
Type:single initiation site
Name:Notch3_1
Description:notch 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0714,189,697 - 14,189,757EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620761 AgrOrtholog
BioCyc Gene G2FUF-34832 BioCyc
Ensembl Genes ENSRNOG00000004346 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055032239 UniProtKB/Swiss-Prot
  ENSRNOG00060027558 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000037456.5 UniProtKB/TrEMBL
  ENSRNOT00000112007.1 UniProtKB/TrEMBL
  ENSRNOT00055055785 UniProtKB/Swiss-Prot
  ENSRNOT00060048019 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.300.320 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.3310 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.470.20 UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3454_notch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_NOD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_NODP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56761 UniProtKB/Swiss-Prot
NCBI Gene 56761 ENTREZGENE
PANTHER CRUMBS FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DROSOPHILA CRUMBS HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 UniProtKB/TrEMBL
Pfam Ank UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NODP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Notch3 PhenoGen
PIRSF Notch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS EGFBLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LNOTCHREPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LNR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004346 RatGTEx
  ENSRNOG00055032239 RatGTEx
  ENSRNOG00060027558 RatGTEx
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NODP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90193 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AWG8_RAT UniProtKB/TrEMBL
  A6K938_RAT UniProtKB/TrEMBL
  A6K939_RAT UniProtKB/TrEMBL
  A6K940_RAT UniProtKB/TrEMBL
  F1LQX7 ENTREZGENE, UniProtKB/TrEMBL
  NOTC3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-04 Notch3  notch receptor 3  Notch3  notch 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Notch3  notch 3  Notch3  Notch homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Notch3  Notch homolog 3 (Drosophila)  Notch3  Notch gene homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Notch3  Notch gene homolog 3 (Drosophila)    Notch 3  Name updated 1299863 APPROVED
2002-08-07 Notch3  Notch 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mutations in human homolog are associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephelopathy (CADASIL) syndrome 632418
gene_process induces c-FLIP expression via ERK/MAPK activation 632418