Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Notch3 (notch receptor 3) Rattus norvegicus
Analyze
Symbol: Notch3
Name: notch receptor 3
Description: Predicted to have enzyme binding activity; identical protein binding activity; and signaling receptor activity. Involved in Notch signaling pathway; regulation of transcription, DNA-templated; and tissue regeneration. Predicted to localize to several cellular components, including the actin cytoskeleton; cell surface; and nucleoplasm. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Orthologous to human NOTCH3 (notch receptor 3); PARTICIPATES IN Notch signaling pathway; altered Notch signaling pathway involving the main players; CADASIL pathway; INTERACTS WITH 3H-1,2-dithiole-3-thione; ammonium chloride; bis(2-chloroethyl) sulfide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: neurogenic locus notch homolog protein 3; notch 3; Notch gene homolog 3; Notch gene homolog 3 (Drosophila); Notch homolog 3; Notch homolog 3 (Drosophila)
Orthologs:
Homo sapiens (human) : NOTCH3 (notch receptor 3)  HGNC  Alliance
Mus musculus (house mouse) : Notch3 (notch 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Notch3 (notch receptor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NOTCH3 (notch receptor 3)
Canis lupus familiaris (dog) : NOTCH3 (notch receptor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Notch3 (notch receptor 3)
Sus scrofa (pig) : NOTCH3 (notch receptor 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0714,138,495 - 14,189,688 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl714,138,495 - 14,189,688 (-)Ensembl
Rnor_5.0714,294,587 - 14,345,774 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,688,267 - 12,740,015 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1712,688,266 - 12,740,015 (-)NCBI
Celera79,246,229 - 9,296,285 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Notch3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620761
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.