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Gene: NOTCH3 (notch receptor 3) Canis lupus familiaris

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Symbol:

NOTCH3

Name:

notch receptor 3

RGD ID:

12408777

Description:

ENCODES a protein that exhibits enzyme binding (ortholog); INVOLVED IN artery morphogenesis (ortholog); cellular response to platelet-derived growth factor stimulus (ortholog); forebrain development (ortholog); PARTICIPATES IN altered Notch signaling pathway involving the main players; CADASIL pathway; Notch signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); Auditory Neuropathy (ortholog); autism spectrum disorder (ortholog); FOUND IN membrane (inferred); nucleoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

neurogenic locus notch homolog protein 3; notch 3; Notch homolog 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NOTCH3 (notch receptor 3)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Notch3 (notch 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Notch3 (notch receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Notch3 (notch receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NOTCH3 (notch receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Notch3 (notch receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NOTCH3 (notch receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NOTCH3 (notch receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Notch3 (notch receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	46,946,654 - 46,978,821 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	46,937,485 - 46,978,219 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	46,794,145 - 46,827,285 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	47,433,115 - 47,466,250 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	47,432,263 - 47,465,239 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	46,667,867 - 46,700,947 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	47,084,556 - 47,117,682 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	47,358,143 - 47,391,299 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
NOTCH3	Dog	Carotid Artery Injuries		ISO	Notch3 (Rattus norvegicus)	9068941	mRNA:decreased expression:carotid artery	RGD	PMID:11971902 and REF_RGD_ID:625426

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
NOTCH3	Dog	Auditory Neuropathy		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:25741868
NOTCH3	Dog	breast ductal carcinoma		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Ductal breast carcinoma	ClinVar
NOTCH3	Dog	CADASIL		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:10227618 more ...
NOTCH3	Dog	CADASIL 1		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:33942994 more ...
NOTCH3	Dog	CADASIL 1		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:10227618 more ...
NOTCH3	Dog	CADASIL2		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2	ClinVar	PMID:28492532
NOTCH3	Dog	cerebral cavernous malformation		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Cerebral cavernous malformation	ClinVar	PMID:25741868 and PMID:28492532
NOTCH3	Dog	cerebral infarction		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Ischemic stroke	ClinVar	PMID:10371548 more ...
NOTCH3	Dog	depressive disorder		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Depression	ClinVar	PMID:15364702 more ...
NOTCH3	Dog	genetic disease		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:14714274 more ...
NOTCH3	Dog	Infantile Myofibromatosis 1		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Myofibromatosis more ...	ClinVar	PMID:23731542
NOTCH3	Dog	Infantile Myofibromatosis 2		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Myofibromatosis more ...	ClinVar	PMID:10227618 more ...
NOTCH3	Dog	invasive ductal carcinoma		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Breast cancer and invasive ductal	ClinVar
NOTCH3	Dog	lateral meningocele syndrome		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:10227618 more ...
NOTCH3	Dog	migraine		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Migraine	ClinVar	PMID:25741868
NOTCH3	Dog	migraine with aura		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Migraine with aura	ClinVar	PMID:32581362
NOTCH3	Dog	migraine without aura		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Migraine without aura	ClinVar	PMID:12754354 more ...
NOTCH3	Dog	Progressive Psychomotor Deterioration		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Progressive psychomotor deterioration	ClinVar	PMID:32581362
NOTCH3	Dog	prostate cancer		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Malignant tumor of prostate	ClinVar	PMID:15364702 more ...
NOTCH3	Dog	Pulmonary Arterial Hypertension		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Pulmonary arterial hypertension	ClinVar	PMID:22006983 more ...
NOTCH3	Dog	Sneddon syndrome		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Idiopathic livedo reticularis with systemic involvement	ClinVar	PMID:17879445 more ...
NOTCH3	Dog	Stroke		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Stroke	ClinVar	PMID:12754354 more ...
NOTCH3	Dog	vascular dementia		ISO	NOTCH3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Vascular dementia	ClinVar	PMID:14714274 more ...

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
NOTCH3	Dog	autism spectrum disorder		ISO	NOTCH3 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:35663546
NOTCH3	Dog	Breast Neoplasms		ISO	NOTCH3 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:21036696
NOTCH3	Dog	esophagus squamous cell carcinoma		ISO	NOTCH3 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:25151357
NOTCH3	Dog	glioblastoma		ISO	NOTCH3 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:21127729
NOTCH3	Dog	hepatocellular carcinoma		ISO	NOTCH3 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:28284560
NOTCH3	Dog	infantile myofibromatosis		ISO	NOTCH3 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD
NOTCH3	Dog	Lung Neoplasms		ISO	NOTCH3 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:17804716
NOTCH3	Dog	lung non-small cell carcinoma		ISO	NOTCH3 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:21994468
NOTCH3	Dog	pancreatic ductal carcinoma		ISO	NOTCH3 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:19208345
NOTCH3	Dog	Skin Neoplasms		ISO	NOTCH3 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:27923803
NOTCH3	Dog	squamous cell carcinoma		ISO	NOTCH3 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:27923803

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
NOTCH3	Dog	acute lymphoblastic leukemia		ISO	Notch3 (Mus musculus)	9068941	OMIM:247640 more ...	MouseDO

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
NOTCH3	Dog	CADASIL 1		ISO	NOTCH3 (Homo sapiens)	7240710		OMIM
NOTCH3	Dog	Infantile Myofibromatosis 2		ISO	NOTCH3 (Homo sapiens)	7240710		OMIM
NOTCH3	Dog	lateral meningocele syndrome		ISO	NOTCH3 (Homo sapiens)	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
NOTCH3	Dog	artery morphogenesis	acts_upstream_of_or_within	ISO	MGI:2687010	9068941	PMID:23117660	MGI	PMID:23117660
NOTCH3	Dog	cell differentiation	involved_in	IEA	InterPro:IPR008297 more ...	150520179		InterPro	GO_REF:0000002
NOTCH3	Dog	cell differentiation	involved_in	IEA	UniProtKB-KW:KW-0221	150520179		UniProt	GO_REF:0000043
NOTCH3	Dog	cellular response to platelet-derived growth factor stimulus		ISO	Notch3 (Rattus norvegicus)	9068941		RGD	PMID:11971902 and REF_RGD_ID:625426
NOTCH3	Dog	forebrain development	acts_upstream_of_or_within	ISO	MGI:97363	9068941	PMID:16120638	MGI	PMID:16120638
NOTCH3	Dog	glomerular capillary formation	involved_in	ISO	Notch3 (Mus musculus)	9068941	PMID:15821257	UniProt	PMID:15821257
NOTCH3	Dog	negative regulation of cell differentiation	acts_upstream_of_or_within	ISO	Notch3 (Mus musculus)	9068941	PMID:15064243	MGI	PMID:15064243
NOTCH3	Dog	negative regulation of neuron differentiation	acts_upstream_of_or_within	ISO	Notch3 (Mus musculus)	9068941	PMID:15064243	MGI	PMID:15064243
NOTCH3	Dog	negative regulation of transcription by RNA polymerase II	acts_upstream_of_or_within	ISO	MGI:2687010	9068941	PMID:23117660	MGI	PMID:23117660
NOTCH3	Dog	neuroblast differentiation	acts_upstream_of	ISO	Notch3 (Mus musculus)	9068941	PMID:15064243	MGI	PMID:15064243
NOTCH3	Dog	neuron differentiation	acts_upstream_of	ISO	Notch3 (Mus musculus)	9068941	PMID:15064243	MGI	PMID:15064243
NOTCH3	Dog	neuron fate commitment	acts_upstream_of_or_within	ISO	MGI:97363	9068941	PMID:16120638	MGI	PMID:16120638
NOTCH3	Dog	Notch signaling pathway		ISO	Notch3 (Rattus norvegicus)	9068941		RGD	PMID:11925448 and REF_RGD_ID:632418
NOTCH3	Dog	Notch signaling pathway	involved_in	IEA	UniProtKB-KW:KW-0914	150520179		UniProt	GO_REF:0000043
NOTCH3	Dog	Notch signaling pathway	involved_in	IEA	InterPro:IPR008297 more ...	150520179		InterPro	GO_REF:0000002
NOTCH3	Dog	positive regulation of miRNA transcription	involved_in	IEA	UniProtKB:Q9UM47 and ensembl:ENSP00000263388	150520179		Ensembl	GO_REF:0000107
NOTCH3	Dog	positive regulation of smooth muscle cell proliferation	involved_in	ISO	Notch3 (Mus musculus)	9068941	PMID:19855400	UniProt	PMID:19855400
NOTCH3	Dog	positive regulation of transcription by RNA polymerase II	acts_upstream_of_or_within	ISO	MGI:2687010	9068941	PMID:23117660	MGI	PMID:23117660
NOTCH3	Dog	regulation of developmental process	involved_in	IEA	InterPro:IPR008297	150520179		InterPro	GO_REF:0000002
NOTCH3	Dog	regulation of DNA-templated transcription	involved_in	IEA	InterPro:IPR022331	150520179		InterPro	GO_REF:0000002
NOTCH3	Dog	tissue regeneration		ISO	Notch3 (Rattus norvegicus)	9068941		RGD	PMID:16118793 and REF_RGD_ID:1581404
NOTCH3	Dog	wound healing	involved_in	ISO	Notch3 (Rattus norvegicus)	9068941	PMID:11549580	UniProt	PMID:11549580 and REF_RGD_ID:13506277

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
NOTCH3	Dog	membrane	located_in	IEA	InterPro:IPR008297 more ...	150520179		InterPro	GO_REF:0000002
NOTCH3	Dog	membrane	located_in	IEA	UniProtKB-KW:KW-0472	150520179		UniProt	GO_REF:0000043
NOTCH3	Dog	nucleoplasm	located_in	IEA	UniProtKB:Q9UM47 and ensembl:ENSP00000263388	150520179		Ensembl	GO_REF:0000107
NOTCH3	Dog	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	150520179		UniProt	GO_REF:0000043
NOTCH3	Dog	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	150520179		UniProt	GO_REF:0000044
NOTCH3	Dog	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	150520179		UniProt	GO_REF:0000043
NOTCH3	Dog	plasma membrane	located_in	IEA	ARBA:ARBA00027801	150520179		UniProt	GO_REF:0000117
NOTCH3	Dog	plasma membrane	located_in	IEA	UniProtKB:Q9UM47 and ensembl:ENSP00000263388	150520179		Ensembl	GO_REF:0000107
NOTCH3	Dog	plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0039	150520179		UniProt	GO_REF:0000044
NOTCH3	Dog	receptor complex	part_of	IEA	UniProtKB:Q9UM47 and ensembl:ENSP00000263388	150520179		Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
NOTCH3	Dog	calcium ion binding	enables	IEA	InterPro:IPR001881 and InterPro:IPR018097	150520179		InterPro	GO_REF:0000002
NOTCH3	Dog	enzyme binding	enables	ISO	UniProtKB:Q9NWT6	9068941	PMID:17573339	UniProt	PMID:17573339
NOTCH3	Dog	identical protein binding	enables	IEA	UniProtKB:Q9UM47 and ensembl:ENSP00000263388	150520179		Ensembl	GO_REF:0000107
NOTCH3	Dog	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	150520179		UniProt	GO_REF:0000043
NOTCH3	Dog	protein binding	enables	ISO	UniProtKB:Q9R1P4	9068941	PMID:17292860	IntAct	PMID:17292860
NOTCH3	Dog	protein binding	enables	ISO	UniProtKB:Q77CA8	9068941	PMID:21191019	AgBase	PMID:21191019
NOTCH3	Dog	protein binding	enables	ISO	PR:P31266	9068941	PMID:9111338	MGI	PMID:9111338
NOTCH3	Dog	protein binding	enables	ISO	UniProtKB:Q9QXX0	9068941	PMID:10551863	UniProt	PMID:10551863
NOTCH3	Dog	protein binding	enables	ISO	UniProtKB:O00548 and UniProtKB:P78504	9068941	PMID:11006133	UniProt	PMID:11006133
NOTCH3	Dog	protein binding	enables	ISO	UniProtKB:P86480	9068941	PMID:32296183	IntAct	PMID:32296183
NOTCH3	Dog	protein binding	enables	ISO	UniProtKB:Q92585	9068941	PMID:11101851	UniProt	PMID:11101851
NOTCH3	Dog	protein binding	enables	ISO	UniProtKB:P25786	9068941	PMID:17292860	UniProt	PMID:17292860
NOTCH3	Dog	signaling receptor activity	enables	IEA	UniProtKB:Q9UM47 and ensembl:ENSP00000263388	150520179		Ensembl	GO_REF:0000107
NOTCH3	Dog	signaling receptor activity	enables	IEA	InterPro:IPR022331	150520179		InterPro	GO_REF:0000002

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
NOTCH3	Dog	altered Notch signaling pathway involving the main players		ISO	NOTCH3 (Homo sapiens)	9068941	Mutations are predominantly found in the EGF repeats and clustered within the first five	RGD	PMID:9388399 and REF_RGD_ID:1334441
NOTCH3	Dog	CADASIL pathway		ISO	NOTCH3 (Homo sapiens)	9068941	Mutations are predominantly found in the EGF repeats and clustered within the first five	RGD	PMID:9388399 and REF_RGD_ID:1334441
NOTCH3	Dog	Notch signaling pathway		ISO	Notch3 (Mus musculus)	9068941		RGD	PMID:11971902 and REF_RGD_ID:625426
NOTCH3	Dog	Notch signaling pathway		ISO	Notch3 (Rattus norvegicus)	9068941		RGD	PMID:15247148 and REF_RGD_ID:2306423
NOTCH3	Dog	Notch signaling pathway		ISO	NOTCH3 (Homo sapiens)	9068941		RGD	PMID:17761886 and REF_RGD_ID:2302204

Imported Annotations - PID (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
NOTCH3	Dog	Notch signaling pathway		ISO	NOTCH3 (Homo sapiens)	9068941		PID	PID:200015

PMID:22301074	PMID:30032202

NOTCH3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	46,946,654 - 46,978,821 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	46,937,485 - 46,978,219 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	46,794,145 - 46,827,285 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	47,433,115 - 47,466,250 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	47,432,263 - 47,465,239 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	46,667,867 - 46,700,947 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	47,084,556 - 47,117,682 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	47,358,143 - 47,391,299 (+)	NCBI		UU_Cfam_GSD_1.0

NOTCH3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	15,159,038 - 15,200,995 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	15,159,038 - 15,200,995 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	15,269,849 - 15,311,806 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	15,131,444 - 15,172,792 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	15,131,444 - 15,172,792	NCBI
Celera	19	15,166,185 - 15,207,451 (-)	NCBI		Celera
Cytogenetic Map	19	p13.12	NCBI
HuRef	19	14,838,304 - 14,879,920 (-)	NCBI		HuRef
CHM1_1	19	15,269,920 - 15,311,263 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	15,283,989 - 15,325,912 (-)	NCBI		T2T-CHM13v2.0

Notch3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	32,339,794 - 32,385,869 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	32,339,794 - 32,385,826 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	32,120,820 - 32,166,896 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	32,120,820 - 32,166,852 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	32,257,838 - 32,303,797 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	31,849,599 - 31,895,558 (-)	NCBI		MGSCv36	mm8
Celera	17	33,039,371 - 33,085,333 (-)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	17.37	NCBI

Notch3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	11,783,550 - 11,834,585 (-)	NCBI		GRCr8
mRatBN7.2	7	11,132,984 - 11,184,025 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	11,133,706 - 11,184,025 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	13,952,392 - 14,002,867 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	15,829,787 - 15,880,272 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	13,701,326 - 13,751,735 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	14,138,495 - 14,189,688 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	14,138,495 - 14,189,688 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	14,294,587 - 14,345,774 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	12,688,267 - 12,740,015 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	12,688,266 - 12,740,015 (-)	NCBI
Celera	7	9,246,229 - 9,296,285 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

Notch3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	8,012,502 - 8,047,710 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	8,012,370 - 8,048,616 (+)	NCBI	ChiLan1.0	ChiLan1.0

NOTCH3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	20,073,377 - 20,114,601 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	19,075,966 - 19,117,408 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	14,692,571 - 14,733,758 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	15,677,649 - 15,715,703 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	15,678,674 - 15,715,080 (-)	Ensembl	panpan1.1		panPan2

Notch3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	205,716,842 - 205,752,291 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	5,265,999 - 5,300,429 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	5,265,984 - 5,301,430 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NOTCH3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	62,364,501 - 62,402,344 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	62,364,507 - 62,402,348 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	61,891,971 - 61,909,274 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NOTCH3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	13,762,570 - 13,803,676 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	13,761,512 - 13,793,359 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	5,702,583 - 5,746,374 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Notch3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624901	2,292,640 - 2,328,433 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624901	2,292,257 - 2,328,433 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in NOTCH3
404 total Variants

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10


RefSeq Transcripts	XM_022407359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038428355	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038503997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038567021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038631166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000025565 ⟹ ENSCAFP00000023739

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	20	46,937,485 - 46,978,219 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845032981 ⟹ ENSCAFP00845025808

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	20	47,432,263 - 47,465,239 (+)	Ensembl

RefSeq Acc Id:

XM_022407359 ⟹ XP_022263067

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	20	46,946,654 - 46,978,821 (+)	NCBI
Dog10K_Boxer_Tasha	20	46,794,145 - 46,827,285 (+)	NCBI

Sequence:

show sequence

CTGTCGGCCGTGAGGGGGCTGTCTCTCTTGCTACTGCTAGCGGGGCCCGGGGCTGCAGCACCCCCTTGCCTGGACGGAAGCCCGTGTATGAATGGAGGTCGCTGCACCCAGTTGCCCTCCCGGGAGGC
TGCCTGCCTGTGCCCGCCGGGATGGGTGGGCGAGCGGTGCCAGCTGGAGGACCCCTGCCATTCGGGCCCCTGCGCTGGCCGTGGCGTCTGCCAGAGTTCCGTGGTGGCAGGCGCCGCCCGCTTCTCCT
GCCGGTGCCCCCGTGGCTTCCGAGGTCCCGACTGCTCCCTGCCGGACCCCTGCCTCAGCAGCCCTTGTACCCCATGGGCCCGCTGCTCGNGTGGGCCCGATGGTCGCTACATCTGCTCCTGCCCNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGCCCCCTCGCCGTCCGG
TATCGGGGGACATGCAAGACAGAGTGGCGTTCTCTCTTATGACTGCGCCTGCCTTCCTGGGTTCGAGGGCCAGAACTGTGAAGTGAATGTGGATGACTGTCCAGGGCACCGATGTCTAAATGGGGGGA
CGTGTGTGGATGGCGTCAACACCTACAACTGCCAGTGTCCTCCTGAATGGACAGGCCAATTCTGCACGGAGGACGTGGATGAATGCCAGCTGCAGCCCAACGCTTGCCACAATGGGGGCACCTGCTTC
AACACTCTGGGTGGCCACAGCTGTGTGTGTGTCAATGGCTGGACAGGCGAGAGCTGCAGTCAGAATATCGATGACTGTGCCACGGCTGTGTGCTTCCACGGGGCCACCTGCCATGACCGTGTGGCCTC
GTTCTACTGTGCCTGTCCCATGGGAAAGACTGGACTTCTGTGTCATCTGGATGATGCCTGTGTCAGCAACCCCTGTCACGAGGATGCTATCTGTGACACGAACCCTGTGAATGGCCGGGCCATCTGCA
CCTGTCCACCAGGCTTTACTGGCGGGGCATGTGACCAGGATGTGGATGAGTGCTCCATTGGCGCCAACCCATGTGAGCACCTGGGCCGGTGCGTGAACACACAGGGCTCATTCCTGTGCCAGTGTGGC
CGTGGCTACACTGGCCCGCGCTGCGAAACTGATGTCAACGAGTGCCTATCCGGGCCCTGCCGCAACCAGGCCACGTGCCTCGACCGTATTGGCCAGTTCACCTGTATCTGCATGGCAGGCTTTACAGG
CACCTACTGTGAGGTGGACATGGATGAGTGTCAGAGTAGCCCATGTGTCAACGGTGGGATCTGCAAAGACAGAGTCAACGGCTTCAGCTGCACCTGCCCCTCAGGCTTCAGCGGGGCCATGTGTCAGC
TGGATGTGGATGAGTGTGCAAGCACACCCTGCCGGAATGGAGCCAAGTGTGTAGACCAGCCCGATGGCTACGAATGCCGCTGCGCAGAGGGCTTCGAGGGCACCCTGTGTGAGCGCAACGTGGATGAC
TGCTCCCCGGATCCGTGCCACCATGGGCGCTGTGTGGATGGTATCGCCAGCTTCTCGTGCGCCTGCGCCCCGGGATACACGGGCACACGCTGTGAGAGCCAGGTGGACGAGTGCCGCAGCCAGCCCTG
CCGCCACGGAGGCAAATGTTTAGACTTGGTGGACAAGTATCTGTGCCGCTGCCCTCCTGGCACTACAGGAGTGAACTGCGAGGTGAACATTGATGATTGTGCCAGCAACCCCTGCACCTTCGGAGTCT
GCCGGGATGGCATCAACCGCTATGACTGTGTCTGCCAGCCTGGCTTCACAGGGCCCCTTTGCAACGTGGAGATCAACGAGTGTGCGTCCAGCCCGTGCGGTGATGGAGGCTCCTGCGTGGATGGGGAA
AATGGATTCCGCTGCCTCTGCCCTCCTGGCTCCCTGCCCCCGCTCTGCCTCCCCCCGAGCCATCCCTGTGCCCAAGAACCTTGCAGTCACGGTGTCTGCCATGATGCGCCCGGAGGGTTCCGCTGCGT
GTGTGAGCCTGGCTGGAGTGGCCCCCGATGCAGCCAGAGCCTTGCTCCCGATGCCTGTGAATCCCAGCCCTGCCGGTCTGGCGGCACCTGCACCAGTGACGGGATGGGCTTCCACTGCACCTGTCCCC
CTGGTGTCCAGGGCCGCCAGTGTGAGCTGCCGTCTCCCTGTGTCCCGAACCCCTGTGAGCATGGGGGCCACTGCGAGGCTTCCCCCGGCCAGCTGCCTGTCTGTTCCTGCTCCCCCGGCTGGCAAGGT
CCACGATGCCAGCAGGATGTGGATGAATGTGCTGGTCCCTCACCCTGTGGTTCCCACGGTACCTGCACCAACCTGGAGGGAAGTTTCAGCTGTACCTGCCACAGGGGGTATAGTGGTCCTTCCTGTGA
TCAGGACATCGACGACTGTGACCCCAACCCCTGCCTGAATGGTGGCTCCTGTCAGGATGGCGTGGGCTCCTTTTCGTGCTCCTGCCTCCCTGGCTTTGCTGGTCCTCGCTGTGCCCGAGATGTGGATG
AGTGCCTGAGCAGCCCCTGTGGCCCGGGCACCTGCACGGACCACGTGGCCTCCTTTACCTGCACCTGCCCACCTGGTTATGGAGGCTTCCACTGTGAGCAGGACCTGCCCGACTGCAGCCCCAGCTCC
TGCTTCCACGGCGGGACCTGCGTGGACGGTGTGAACTCGTTCAGCTGCCAGTGCCGCCCTGGCTACACGGGCGCGCACTGCCAGCACGAGGCCGACCCCTGCCTCTCTCGGCCCTGCCTGCACGGGGG
AGTCTGCACCGCTGCCCACCCTGGCTACCGCTGCACCTGCCCAGAGGGCTTCACTGGCGCGCAGTGCCAGACGCTGGTAGACTGGTGCAGCCGTGCGCCCTGTCAGAACGGGGGTCGCTGTGCCCGGA
CCGGGGCGTCCTTCTACTGCCTTTGCCCTCCGGGGTGGAGCGGCCGCCTCTGTGACCTCCGGAGCGTGCCCTGCAGGGAGGCCGCAGCCCAGACCGGGGTGCGGCTGGAAGAGCTGTGTCAGACAGGT
GGGCAGTGCGTGGACAAGGACAATTCTCACTACTGCGTGTGCCCCGAAGGCCGCACGGGCAGCCACTGTGAGCAGGAGGTGGACCCCTGCTTGGCCCAGCCCTGCCAGCATGGGGGCACCTGTCAAGG
CTACATGGGGGGTTATGTGTGTGAGTGTCCAGCTGGCTACACTGGGGACAACTGTGAGGATGATGTGGATGAATGTGCCTCCCAGCCTTGCCAGCACGGGGGCTTCTGCATTGACCTTGTGGCCCGCT
ATCTCTGCTCCTGCCCCCCAGGAACACTGGGAGTGCTCTGTGAGATTAATGAGGACGACTGTGGCCCAGGCCCACCCCTGGACGGTGGCCCCCGGTGCCTGCACAACGGTACCTGCGTAGACCTAGTG
GGTGGCTTCCGCTGCACCTGTCCCCCGGGATACACCGGTCTGCGCTGTGAGGCAGACATCAATGAGTGTCGCCCGGGTGCCTGCCATGACGCACACACTCGGGACTGTCTGCAGGACCCAGGTGGGGG
CTTCCGCTGCATTTGTCGTACAGGCTTCACAGGTCCCCGCTGTCAGACCGTCCTGTCTCCCTGCGAGTCCCAGCCCTGCCAGCACGGAGGCCAGTGCCGTCCCAGCCCAGGCCCTGGGGGTGTGCTGA
CATTTACCTGTCACTGCATTCCGCCGTTCTGGGGCGCGCGCTGCGAGCGGGTGGCGCGCTCCTGCCGCGAGCTGCAGTGCCCGGCGGGCGTCCCGTGCCAGCAGACGGTGCGCGGGCCGCGCTGCGCC
TGTGCCCCCGGCCTGTCGGGGCCCGCCTGCCGGGGCGCGCGGGGGTCGCCGCCCGGGGCCGCCAACGCCAGCTGCGTGGCCTCGCCGTGCCTGCACGGGGGCTCCTGCCGCCCCGCGCCTCTCGCACC
CTTCTTCCGCTGCGCGTGCGCGCCGGGCTGGGCCGGACCGCGCTGCGAGGCGCCCGCGGCGGCGGCGCCGGAGGCCCCCGAGGAGCCGCTGTGCCCGAGCGCCGCCTGCGAGGCCAAGAGCGGGGACC
GGCGCTGCGACCGCGAGTGCAACAGCCCGGGCTGCGGCTGGGACGGCGGCGACTGCTCGCTGAGCGTGGGCGACCCCTGGCGGCAGTGCGCGGCGCTGCAGTGCTGGCGCCTCTTCAACAACAGCCGC
TGCGACCCCGCCTGCAGCTCGCCCGCCTGCCTCTACGACAACTTCGACTGCCGCGCGGGTGGCCGGGAGCGCGCCTGCAACCCAGTGTACGAGAAGTACTGTGCAGACCACTTTGCGGATGGCCGCTG
CGACCAGGGCTGCAATACCGAGGAGTGCGGCTGGGATGGACTGGACTGTGCGGGCGAGGTGCCGGCCCTGCTGGCCCGCGGTGTGCTGGTGGTCACCGTGCTGCTGCCGCCTGAGGAGCTGCTGCGGT
CCAGCGCCGACTTCCTGCAGCGGCTCAGCAGCATCCTGCGCACGTCGCTGCGCTTCCGCCTGGATGAGCACGGCCAGGCCATGGTCTTCCCTTACCACCGGCCGGGTCCTGGCTCCGAGTCCCGGAAC
CGGCGGGAGCTGGCCCCGGAGGTGATCGGCTCTGTGGTGATGCTGGAGATTGACAACCGGCTGTGCCTGCAGTCGCCGGAGAATGACCACTGCTTCCCCGATGCCCAGAGCGCGGCCGACTACCTGGG
AGCGCTGTCGGCGGTGGAGCGCCTTGACTTCCCGTACCCGCTGCGGGCTGTGCGCGGGGAGCCCCTGGAGCCGCCGGAGCCCAGCGTGCCGTTGCTTCCCCTGCTGGCTGCGAGCGCCGTCTTCCTGC
TGGTCATCCTCGTCCTGGGGGTCATGGTGGCCCGGCGCAAGCGGGAGCACAGCACCCTCTGGTTCCCCGAGGGCTTCGCGCTCCACAAGGACGTGGCTGCTGGTCACAAGGGCCGGCGGGAGCCCGTG
GGCCAGGATGCGCTGGGCATGAAGAACATGGCCAAGAGCGAGAGTCTGATGGGGGATGTGGCCACAGACTGGATGGACACGGAATGCCCAGAGGCTAAGCGGCTAAAGGTAGAGGAGCCCAGCGTGGG
GGCCGAGGATGCTGTGGATTGCCGCCAGTGGACTCAGCACCACCTGGTTGCTGCCGACATCCGTGTGGCACCAGCCATGGCATTGACACCCCCACAGGGCGACGTAGATGCTGATGGCATGGATGTCA
ATGTGCGCGGCCCAGATGGCTTCACCCCACTGATGCTGGCCTCCTTTTGTGGGGGGGCCCTGGAACCAATGCCCACTGAGGAGGACGAGGCGGAGGACACGTCAGCCAGCATCATCTCAGACCTGATC
TGCCAGGGAGCCCAGCTCGGGGCACGGACGGACCGCACAGGCGAGACGGCCCTGCACCTGGCTGCCCGTTACGCCCGGGCCGATGCAGCCAAGCGGCTGCTGGATGCTGGGGCAGACACCAATGCCCA
GGACCACTCAGGGCGCACTCCTTTGCACACTGCTGTCACCGCGGATGCCCAGGGTGTGTTCCAGATTCTCATCCGGAACCGCTCCACAGACCTGGATGCCCGCATGGCAGATGGCTCAACGGCGTTAA
TCCTGGCAGCCCGCCTGGCAGTGGAGGGCATGGTGGAAGAGCTCATTGCCAGCCATGCTGATGTTAATGCTGTGGATGAGCTTGGGAAATCAGCCTTACACTGGGCTGCAGCTGTCAACAATGTGGAG
GCCACCTTGGCCCTGCTCAAAAATGGAGCCAACAAAGACATGCAGGATAGCAAGGAGGAAACTCCACTGTTTCTGGCCGCCCGAGAGGGCAGCTACGAGGCTGCCAAGCTGCTTCTGGACCACTTTGC
CAACCGTGAGATCACAGACCACCTGGACAGGCTGCCACGGGATGTGGCCCAGGAGCGGCTGCACCAGGACATCGTGCGCCTGCTGGACCAGCCCAGTGGGCCCCGTAGCCCTCACGGCCCGCATGGCC
TGGGGCCCCTCCTCTGCCCACCTGGGGCCTTCCTCCCCGGCCTCAAGGTGGCACAGTCCGGAGGCAAGAAGAGCCGGAGGCCACCGGGGAAGGCGGGGCTGGGGCCGCAGGGCGCCCGGGGCCGGGGC
AAGAAGCTGACCCTGGCCTGCCCGGGTCCCCTGGCCGAGAGCTCGGTCACGCTGTCCCCCNGGGACTCGCTGGACTCCCCGCGGGCCAATGTGTGA

hide sequence

RefSeq Acc Id:

XM_038428355 ⟹ XP_038284283

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	20	47,433,115 - 47,466,250 (+)	NCBI

RefSeq Acc Id:

XM_038503997 ⟹ XP_038359925

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	20	46,667,867 - 46,700,947 (+)	NCBI

RefSeq Acc Id:

XM_038567021 ⟹ XP_038422949

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	20	47,358,143 - 47,391,299 (+)	NCBI

RefSeq Acc Id:

XM_038631166 ⟹ XP_038487094

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	20	47,084,556 - 47,117,682 (+)	NCBI


Protein RefSeqs	XP_022263067	(Get FASTA)	NCBI Sequence Viewer
	XP_038284283	(Get FASTA)	NCBI Sequence Viewer
	XP_038359925	(Get FASTA)	NCBI Sequence Viewer
	XP_038422949	(Get FASTA)	NCBI Sequence Viewer
	XP_038487094	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000023739.6
	ENSCAFP00030038787.1
	ENSCAFP00845025808
	ENSCAFP00845025808.1

RefSeq Acc Id:

XP_022263067 ⟸ XM_022407359

- UniProtKB:

A0A8C0K7F9 (UniProtKB/TrEMBL), A0A8C0PAF0 (UniProtKB/TrEMBL), A0A8P0SK77 (UniProtKB/TrEMBL), A0A8I3P150 (UniProtKB/TrEMBL)

- Sequence:

show sequence

LSAVRGLSLLLLLAGPGAAAPPCLDGSPCMNGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGAARFSCRCPRGFRGPDCSLPDPCLSSPCTPWARCSXGPDGRYICSCPX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAPSPSGIGGHARQSGVLSYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCF
NTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCG
RGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDMDECQSSPCVNGGICKDRVNGFSCTCPSGFSGAMCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCERNVDD
CSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPPGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGDGGSCVDGE
NGFRCLCPPGSLPPLCLPPSHPCAQEPCSHGVCHDAPGGFRCVCEPGWSGPRCSQSLAPDACESQPCRSGGTCTSDGMGFHCTCPPGVQGRQCELPSPCVPNPCEHGGHCEASPGQLPVCSCSPGWQG
PRCQQDVDECAGPSPCGSHGTCTNLEGSFSCTCHRGYSGPSCDQDIDDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSSPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSS
CFHGGTCVDGVNSFSCQCRPGYTGAHCQHEADPCLSRPCLHGGVCTAAHPGYRCTCPEGFTGAQCQTLVDWCSRAPCQNGGRCARTGASFYCLCPPGWSGRLCDLRSVPCREAAAQTGVRLEELCQTG
GQCVDKDNSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCQGYMGGYVCECPAGYTGDNCEDDVDECASQPCQHGGFCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDGGPRCLHNGTCVDLV
GGFRCTCPPGYTGLRCEADINECRPGACHDAHTRDCLQDPGGGFRCICRTGFTGPRCQTVLSPCESQPCQHGGQCRPSPGPGGVLTFTCHCIPPFWGARCERVARSCRELQCPAGVPCQQTVRGPRCA
CAPGLSGPACRGARGSPPGAANASCVASPCLHGGSCRPAPLAPFFRCACAPGWAGPRCEAPAAAAPEAPEEPLCPSAACEAKSGDRRCDRECNSPGCGWDGGDCSLSVGDPWRQCAALQCWRLFNNSR
CDPACSSPACLYDNFDCRAGGRERACNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCAGEVPALLARGVLVVTVLLPPEELLRSSADFLQRLSSILRTSLRFRLDEHGQAMVFPYHRPGPGSESRN
RRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERLDFPYPLRAVRGEPLEPPEPSVPLLPLLAASAVFLLVILVLGVMVARRKREHSTLWFPEGFALHKDVAAGHKGRREPV
GQDALGMKNMAKSESLMGDVATDWMDTECPEAKRLKVEEPSVGAEDAVDCRQWTQHHLVAADIRVAPAMALTPPQGDVDADGMDVNVRGPDGFTPLMLASFCGGALEPMPTEEDEAEDTSASIISDLI
CQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVE
ATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPHGPHGLGPLLCPPGAFLPGLKVAQSGGKKSRRPPGKAGLGPQGARGRG
KKLTLACPGPLAESSVTLSPXDSLDSPRANV

hide sequence

Ensembl Acc Id:

ENSCAFP00000023739 ⟸ ENSCAFT00000025565

RefSeq Acc Id:

XP_038359925 ⟸ XM_038503997

RefSeq Acc Id:

XP_038487094 ⟸ XM_038631166

RefSeq Acc Id:	XP_038284283 ⟸ XM_038428355
- UniProtKB:	A0A8C0K7F9 (UniProtKB/TrEMBL), A0A8C0PAF0 (UniProtKB/TrEMBL), A0A8P0SK77 (UniProtKB/TrEMBL), A0A8I3P150 (UniProtKB/TrEMBL)

Protein Domains

EGF-like LNR

RGD ID:

13686980

Promoter ID:

EPDNEW_C5048

Type:

multiple initiation site

Name:

NOTCH3_1

Description:

notch 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	20	46,946,498 - 46,946,558	EPDNEW

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000016107	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030024086	UniProtKB/TrEMBL
	ENSCAFG00845018638	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000025565.6	UniProtKB/TrEMBL
	ENSCAFT00030044441.1	UniProtKB/TrEMBL
	ENSCAFT00845032981	ENTREZGENE
	ENSCAFT00845032981.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.20	UniProtKB/TrEMBL
	3.30.300.320	UniProtKB/TrEMBL
	3.30.70.3310	UniProtKB/TrEMBL
	Laminin	UniProtKB/TrEMBL
InterPro	Ankyrin_rpt	UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/TrEMBL
	EGF-like_Ca-bd_dom	UniProtKB/TrEMBL
	EGF-like_CS	UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/TrEMBL
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/TrEMBL
	Growth_fac_rcpt_cys_sf	UniProtKB/TrEMBL
	Notch	UniProtKB/TrEMBL
	Notch-like_dom_sf	UniProtKB/TrEMBL
	NOTCH1_EGF-like	UniProtKB/TrEMBL
	Notch_3	UniProtKB/TrEMBL
	Notch_C	UniProtKB/TrEMBL
	Notch_Cell-Fate_Det	UniProtKB/TrEMBL
	Notch_dom	UniProtKB/TrEMBL
	Notch_NOD_dom	UniProtKB/TrEMBL
	Notch_NODP_dom	UniProtKB/TrEMBL
NCBI Gene	NOTCH3	ENTREZGENE
PANTHER	CRUMBS FAMILY MEMBER	UniProtKB/TrEMBL
	DROSOPHILA CRUMBS HOMOLOG	UniProtKB/TrEMBL
Pfam	Ank	UniProtKB/TrEMBL
	Ank_2	UniProtKB/TrEMBL
	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	hEGF	UniProtKB/TrEMBL
	NOD	UniProtKB/TrEMBL
	NODP	UniProtKB/TrEMBL
	Notch	UniProtKB/TrEMBL
PIRSF	Notch	UniProtKB/TrEMBL
PRINTS	EGFBLOOD	UniProtKB/TrEMBL
	LNOTCHREPEAT	UniProtKB/TrEMBL
	NOTCH	UniProtKB/TrEMBL
	NOTCH3	UniProtKB/TrEMBL
PROSITE	ANK_REP_REGION	UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/TrEMBL
	ASX_HYDROXYL	UniProtKB/TrEMBL
	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	LNR	UniProtKB/TrEMBL
SMART	ANK	UniProtKB/TrEMBL
	DUF3454	UniProtKB/TrEMBL
	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	NOD	UniProtKB/TrEMBL
	NODP	UniProtKB/TrEMBL
	SM00004	UniProtKB/TrEMBL
Superfamily-SCOP	EGF/Laminin	UniProtKB/TrEMBL
	SSF48403	UniProtKB/TrEMBL
	SSF57184	UniProtKB/TrEMBL
	SSF90193	UniProtKB/TrEMBL
UniProt	A0A8C0K7F9	ENTREZGENE
	A0A8C0PAF0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3P150	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0SK77	ENTREZGENE
UniProt Secondary	A0A8P0SK77	UniProtKB/TrEMBL
VGNC ID	VGNC:43899	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-01-15	NOTCH3	notch receptor 3		notch 3	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)