Ppm1a (protein phosphatase, Mg2+/Mn2+ dependent, 1A) - Rat Genome Database

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Gene: Ppm1a (protein phosphatase, Mg2+/Mn2+ dependent, 1A) Rattus norvegicus
Analyze
Symbol: Ppm1a
Name: protein phosphatase, Mg2+/Mn2+ dependent, 1A
RGD ID: 3373
Description: Enables phosphoprotein phosphatase activity and transmembrane transporter binding activity. Predicted to be involved in dephosphorylation; positive regulation of DNA-templated transcription; and regulation of signal transduction. Predicted to act upstream of or within cellular response to transforming growth factor beta stimulus; negative regulation of BMP signaling pathway; and positive regulation of protein export from nucleus. Located in neuron projection. Orthologous to human PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IA; MGC114340; PP2C-alpha; Pp2c1; protein phosphatase 1A; protein phosphatase 1A, magnesium dependent, alpha isoform; protein phosphatase 2C isoform alpha; protein phosphatase IA; Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform; Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8697,174,955 - 97,216,585 (+)NCBIGRCr8
mRatBN7.2691,439,094 - 91,486,139 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl691,438,834 - 91,480,697 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx691,813,295 - 91,850,303 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0692,112,780 - 92,149,786 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0691,540,724 - 91,577,731 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0694,433,658 - 94,484,979 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl694,429,068 - 94,484,351 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06103,874,809 - 103,935,598 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4695,162,067 - 95,198,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1695,165,522 - 95,202,392 (+)NCBI
Celera689,903,080 - 89,939,925 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
haloperidol  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone enanthate  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triticonazole  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C. Li D, etal., J Neurosci. 2005 Feb 23;25(8):1914-23.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Mutational analysis of Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP). Tada Y, etal., Arch Biochem Biophys. 2006 Aug 15;452(2):174-85. Epub 2006 Jun 21.
12. Molecular cloning of rat type 2C (IA) protein phosphatase mRNA. Tamura S, etal., Proc Natl Acad Sci U S A 1989 Mar;86(6):1796-800.
Additional References at PubMed
PMID:10644691   PMID:11559703   PMID:12477932   PMID:12761501   PMID:14654243   PMID:14664809   PMID:14674259   PMID:16751101   PMID:18930133   PMID:20801214   PMID:21151953   PMID:21829547  
PMID:22019086   PMID:22384250   PMID:22926646   PMID:23088624   PMID:25100727  


Genomics

Comparative Map Data
Ppm1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8697,174,955 - 97,216,585 (+)NCBIGRCr8
mRatBN7.2691,439,094 - 91,486,139 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl691,438,834 - 91,480,697 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx691,813,295 - 91,850,303 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0692,112,780 - 92,149,786 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0691,540,724 - 91,577,731 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0694,433,658 - 94,484,979 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl694,429,068 - 94,484,351 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06103,874,809 - 103,935,598 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4695,162,067 - 95,198,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1695,165,522 - 95,202,392 (+)NCBI
Celera689,903,080 - 89,939,925 (+)NCBICelera
Cytogenetic Map6q24NCBI
PPM1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381460,245,750 - 60,299,087 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1460,245,752 - 60,299,087 (+)EnsemblGRCh38hg38GRCh38
GRCh371460,712,468 - 60,765,805 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361459,782,223 - 59,829,826 (+)NCBINCBI36Build 36hg18NCBI36
Build 341459,782,222 - 59,829,823NCBI
Celera1440,762,274 - 40,815,941 (+)NCBICelera
Cytogenetic Map14q23.1NCBI
HuRef1440,876,613 - 40,929,690 (+)NCBIHuRef
CHM1_11460,651,750 - 60,705,118 (+)NCBICHM1_1
T2T-CHM13v2.01454,452,043 - 54,505,381 (+)NCBIT2T-CHM13v2.0
Ppm1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391272,804,231 - 72,846,593 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1272,804,229 - 72,846,593 (+)EnsemblGRCm39 Ensembl
GRCm381272,761,211 - 72,799,819 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1272,757,455 - 72,799,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv371273,862,198 - 73,895,927 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361273,680,442 - 73,713,400 (+)NCBIMGSCv36mm8
Celera1273,877,430 - 73,911,618 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1230.26NCBI
Ppm1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554669,315,227 - 9,362,028 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554669,315,227 - 9,331,213 (-)NCBIChiLan1.0ChiLan1.0
PPM1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21561,383,205 - 61,436,054 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11460,599,719 - 60,650,493 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01440,853,227 - 40,906,044 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11459,117,020 - 59,169,524 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1459,117,020 - 59,162,928 (+)Ensemblpanpan1.1panPan2
PPM1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1835,336,055 - 35,384,249 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl835,336,140 - 35,377,551 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha835,089,958 - 35,138,127 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0835,569,192 - 35,617,610 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl835,569,135 - 35,612,853 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1835,181,328 - 35,229,483 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0835,258,261 - 35,306,410 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0835,618,239 - 35,666,378 (+)NCBIUU_Cfam_GSD_1.0
Ppm1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864069,633,876 - 69,685,180 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364954,542,464 - 4,553,944 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364954,542,576 - 4,560,603 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPM1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1189,207,577 - 189,291,345 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11189,248,974 - 189,296,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21210,387,426 - 210,406,136 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPM1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12437,474,371 - 37,522,956 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2437,506,914 - 37,516,414 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605325,721,273 - 25,769,924 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ppm1a
214 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:44
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000008238
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat

Markers in Region
D6Arb18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2691,478,956 - 91,480,045 (+)MAPPERmRatBN7.2
Rnor_6.0694,483,226 - 94,484,314NCBIRnor6.0
Rnor_5.06103,928,416 - 103,929,504UniSTSRnor5.0
RGSC_v3.4695,197,641 - 95,198,729UniSTSRGSC3.4
Celera689,938,630 - 89,939,718UniSTS
Cytogenetic Map6q24UniSTS
RH144473  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2691,471,814 - 91,472,005 (+)MAPPERmRatBN7.2
Rnor_6.0694,476,084 - 94,476,274NCBIRnor6.0
Rnor_5.06103,921,274 - 103,921,464UniSTSRnor5.0
RGSC_v3.4695,190,499 - 95,190,689UniSTSRGSC3.4
Celera689,931,492 - 89,931,682UniSTS
RH 3.4 Map6663.0UniSTS
Cytogenetic Map6q24UniSTS
RH140124  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2691,479,743 - 91,479,945 (+)MAPPERmRatBN7.2
Rnor_6.0694,484,013 - 94,484,214NCBIRnor6.0
Rnor_5.06103,929,203 - 103,929,404UniSTSRnor5.0
RGSC_v3.4695,198,428 - 95,198,629UniSTSRGSC3.4
Celera689,939,417 - 89,939,618UniSTS
RH 3.4 Map6658.9UniSTS
Cytogenetic Map6q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000008238   ⟹   ENSRNOP00000008238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl691,438,834 - 91,480,697 (+)Ensembl
Rnor_6.0 Ensembl694,429,068 - 94,484,351 (+)Ensembl
RefSeq Acc Id: NM_017038   ⟹   NP_058734
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8697,179,143 - 97,216,129 (+)NCBI
mRatBN7.2691,443,266 - 91,480,252 (+)NCBI
Rnor_6.0694,433,661 - 94,484,521 (+)NCBI
Rnor_5.06103,874,809 - 103,935,598 (+)NCBI
RGSC_v3.4695,162,067 - 95,198,936 (+)RGD
Celera689,903,080 - 89,939,925 (+)RGD
Sequence:
RefSeq Acc Id: XM_039111786   ⟹   XP_038967714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8697,174,955 - 97,216,585 (+)NCBI
mRatBN7.2691,439,094 - 91,486,139 (+)NCBI
RefSeq Acc Id: XM_039111787   ⟹   XP_038967715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8697,201,872 - 97,216,585 (+)NCBI
mRatBN7.2691,465,994 - 91,486,139 (+)NCBI
RefSeq Acc Id: XM_063261552   ⟹   XP_063117622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8697,201,852 - 97,216,585 (+)NCBI
RefSeq Acc Id: NP_058734   ⟸   NM_017038
- UniProtKB: P20650 (UniProtKB/Swiss-Prot),   A6HC44 (UniProtKB/TrEMBL),   A0A0H2UHE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008238   ⟸   ENSRNOT00000008238
RefSeq Acc Id: XP_038967714   ⟸   XM_039111786
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038967715   ⟸   XM_039111787
- Peptide Label: isoform X3
- UniProtKB: P20650 (UniProtKB/Swiss-Prot),   A6HC44 (UniProtKB/TrEMBL),   A0A0H2UHE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117622   ⟸   XM_063261552
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20650-F1-model_v2 AlphaFold P20650 1-382 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3373 AgrOrtholog
BioCyc Gene G2FUF-37132 BioCyc
Ensembl Genes ENSRNOG00000005916 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008238.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24666 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24666 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN PHOSPHATASE 1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppm1a PhenoGen
PROSITE PPM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005916 RatGTEx
SMART PP2Cc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81601 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHE5 ENTREZGENE, UniProtKB/TrEMBL
  A6HC44 ENTREZGENE, UniProtKB/TrEMBL
  A6HC45_RAT UniProtKB/TrEMBL
  P20650 ENTREZGENE, UniProtKB/Swiss-Prot
  Q4V8L2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-03 Ppm1a  protein phosphatase, Mg2+/Mn2+ dependent, 1A  Ppm1a  protein phosphatase 1A, magnesium dependent, alpha isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ppm1a  Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation requires Mg2+ for activity 729446