Iddm28 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Iddm28 (Insulin dependent diabetes mellitus QTL 28) Rattus norvegicus

Symbol: Iddm28
Name: Insulin dependent diabetes mellitus QTL 28
RGD ID: 2293088
Previously known as: Iddm
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: blood glucose level   (CMO:0000046)    
LOD Score: 5.21
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2663,040,562 - 71,636,266RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0666,222,612 - 75,023,308RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0675,798,693 - 84,567,798RGDRnor5.0
RGSC_v3.4665,393,789 - 74,436,856RGDRGSC3.4
Cross Type: intercross
Strains Crossed: ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Polygenic nature of spontaneous diabetes in the rat. Permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility. Colle E, etal., Diabetes. 1992 Dec;41(12):1617-23.
2. Unpublished observations for Iddm QTL Personal communication with Dr. Wallis
3. TYPE 1 DIABETES IN THE BB RAT: A POLYGENIC DISEASE. Wallis RH, etal., Diabetes. 2009 Apr;58(4):1007-17. Epub 2009 Jan 23
Related QTLs

Related QTL Description Reference
Iddm29 interacts with RGD:2303106


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
2619Foxg1forkhead box G166667479766677611Rat
621827Strn3striatin 366904777669134102Rat
621345Nova1NOVA alternative splicing regulator 166378010563905950Rat
620964Prkd1protein kinase D166772519368039002Rat
619828Scfd1sec1 family domain containing 166879581068874076Rat
1306830Gpr33G protein-coupled receptor 3366947443569475440Rat
1307232NubplNUBP iron-sulfur cluster assembly factor like66955927869781254Rat
69412Akap6A-kinase anchoring protein 667018410170624369Rat
1311990Ap4s1adaptor related protein complex 4 subunit sigma 166913340369174488Rat
1308507Arhgap5Rho GTPase activating protein 566997590470039299Rat
1309138Dtd2D-aminoacyl-tRNA deacylase 266945014669456430Rat
1310263G2e3G2/M-phase specific E3 ubiquitin protein ligase66876384768795305Rat
1308536Cochcochlin66903113969045124Rat
1307181Npas3neuronal PAS domain protein 367070277371527928Rat
1559629RGD1559629similar to H+ ATP synthase66665418766654763Rat
1561653Hectd1HECT domain E3 ubiquitin protein ligase 166918142969267803Rat
1561116Heatr5aHEAT repeat containing 5A66932186969419861Rat
1334065Olr873-psolfactory receptor pseudogene 87366621392966214582Rat
1587060Ube2i-ps3ubiquitin-conjugating enzyme E2I, pseudogene 366880406168805440Rat
1595110Cers5-ps1ceramide synthase 5, pseudogene 166982385169830063Rat
1598277Kpna1-ps3karyopherin subunit alpha 1, pseudogene 366542390965426151Rat
2320031LOC100364934Leydig cell tumor 10 kDa protein-like66633698966337899Rat
2323296Snrnp48-ps2small nuclear ribonucleoprotein U11/U12 subunit 48, pseudogene 266893614068948448Rat
2323500Phgdh-ps1phosphoglycerate dehydrogenase, pseudogene 166664132866642516Rat
7627887LOC102546496uncharacterized LOC10254649666690249166930836Rat
7629096LOC102547735uncharacterized LOC10254773567087483070899484Rat
7619249LOC102546421uncharacterized LOC10254642166668963566699336Rat
7725900LOC102556158uncharacterized LOC10255615866503448965134280Rat
7709127LOC102547662uncharacterized LOC10254766267067789370687394Rat
7728058LOC102557478uncharacterized LOC10255747866844343768505774Rat
9219694LOC103692628uncharacterized LOC10369262866696117167055411Rat
11440663LOC108351235tensin-2 pseudogene66959456869601783Rat
11405764LOC108351234uncharacterized LOC10835123466898468968985303Rat
41281687Arl1-ps1ADP-ribosylation factor like GTPase 1, pseudogene 166895551168962169Rat
41088753LOC120103535uncharacterized LOC12010353566916814369174099Rat
41089517LOC120093205uncharacterized LOC12009320567006935370091813Rat
41384656LOC120093424small nucleolar RNA SNORA2/SNORA34 family67109002471090159Rat
41172264LOC120103531uncharacterized LOC12010353166668467466685883Rat
41254020LOC120093508U6 spliceosomal RNA67081389370813999Rat
41328288LOC120093502U4 spliceosomal RNA66469570864695834Rat
41103385LOC120093278U6 spliceosomal RNA67006837370068479Rat
41195602LOC120093317small nucleolar RNA SNORA73 family66305535063055553Rat
41293354LOC120103536uncharacterized LOC12010353666919891369201280Rat
41350299LOC120093284U6 spliceosomal RNA66862788368627990Rat
41200290LOC120093485U2 spliceosomal RNA66451313164513345Rat
40945147LOC120093279U6 spliceosomal RNA67006906070069166Rat
40997044LOC120093455small nucleolar RNA SNORA1766684549766845624Rat
40947446LOC120093250uncharacterized LOC12009325066474904964779502Rat
40951447LOC120103529uncharacterized LOC12010352966495868964973053Rat
41004139LOC120093468small nucleolar RNA SNORA1766583512565835255Rat
41010064LOC120093251uncharacterized LOC12009325166856912168571922Rat
41076279LOC120103533uncharacterized LOC12010353366885816468862838Rat
41135267LOC120093458small nucleolar RNA SNORA1766688136966881496Rat
41257709LOC120103532uncharacterized LOC12010353266779498267868731Rat
41057606LOC120103530uncharacterized LOC12010353066546133865583973Rat
41302933Gapdh-ps90Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 9066739692267441051Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
36729D6Rat2313967163626671636405Ratregion
38608D6Rat10614266553155565531697Ratregion
39340D6Rat7320066944906769449277Ratregion
42784D6Rat20124366435743064357671Ratregion
42786D6Rat16920266304036063040562Ratregion
42791D6Rat19810366725990067259987Ratregion
42792D6Rat19922366977486069775071Ratregion
42325D6Rat22123266522321465223444Ratregion
41548D6Rat13016066911642069116571Ratregion
44094D6Got7627166370286263703133Ratregion
44096D6Got8019666618874866188944Ratregion
44097D6Got7926866803086568031133Ratregion
44097D6Got7926866803086568031246Ratregion
44098D6Got8212466838305268383176Ratregion
44099D6Got8116266856820268568366Ratregion
44100D6Got9022767027725770277484Ratregion
44103D6Got9122267033069070330909Ratregion
44105D6Got8810767068487670684985Ratregion
44106D6Got8715467156001271560166Ratregion
625778D6Got8918666994475369944939Ratregion
1638211D6Wox3618767061943170619618Ratregion
7193005Foxg139666667626366676659Ratregion
5036454Prkcm20666772579967726005Ratregion
5034161RH14160018466938647869386662Ratregion
5028883RH14268818866668877666688964Ratregion
5026278RH13159921567141037671410591Ratregion
5031698AU04744818367030784470308027Ratregion
5029341RH14442715766885837068858527Ratregion
5032623RH13469019767062085470621051Ratregion
5033319RH13840015466914249469142648Ratregion
5030749BE10792715666913476369134919Ratregion
5055223RH14367713166360251263602643Ratregion
5057680BE10132115667003912070039276Ratregion
5059928BE10357015767084549470845651Ratregion
5053413RH14263410766922765369227760Ratregion
5054369RH14318427066902933369029603Ratregion
5041570RH12893319666904489669045092Ratregion
5047758RH13251119267030936170309554Ratregion
5047984RH13264220166932191069322111Ratregion
7192194Foxg145566667685066677305Ratregion
5040426RH12827622066945037169450591Ratregion
5077226RH13963520366918320569183408Ratregion
5079998RH14132319767152628471526481Ratregion
5074224RH13789322966666469266664921Ratregion
5070420Foxg1100466667648666677490Ratregion
5070472AI84487613966923496669235105Ratregion
5065568BI30340818566879365968793844Ratregion
5062582BF40344618866677031066770498Ratregion
5066000BE11646517067062206870622238Ratregion
5064694BE10833915267002216870022320Ratregion
5086879AI22830416366906833569068498Ratregion
5089041AU04891921567154026271540477Ratregion
5083225BI27548219766918154769181744Ratregion
5090827AU04998626767143788971438156Ratregion
5085318BQ20993815066772811867728268Ratregion
5085950BM38449618167030524470305425Ratregion
5506409Nova154066378595563786495Ratregion
5507307fc03e11.x191767142896371429882Ratregion
5507199UniSTS:22524316966667682966676998Ratregion
5502186MARC_7649-7650:996688053:1066960056669600797Ratregion
5503538NOVA1__606561366378348363784096Ratregion
5501295D11S260514566684375066843900Ratregion
5507147UniSTS:22484115466772574767725901Ratregion
Position Markers

Flank 1: (D6Rat23)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2671,636,266 - 71,636,405 (+)MAPPER
Rnor_6.0675,023,308 - 75,023,446NCBI
Rnor_5.0684,567,798 - 84,567,936UniSTS
RGSC_v3.4674,436,856 - 74,436,995RGD
RGSC_v3.4674,436,857 - 74,436,995UniSTS
RGSC_v3.1674,439,982 - 74,440,121RGD
Celera670,485,804 - 70,485,940UniSTS
RH 2.0 Map6686.7RGD
SHRSP x BN Map646.6299RGD
FHH x ACI Map656.9299RGD
Peak: (D6Rat88)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2696,356,417 - 96,356,634 (+)MAPPER
Rnor_6.06100,716,550 - 100,716,766NCBI
Rnor_5.06110,101,561 - 110,101,777UniSTS
RGSC_v3.46100,193,176 - 100,193,393RGD
RGSC_v3.46100,193,177 - 100,193,393UniSTS
RGSC_v3.16100,196,633 - 100,196,849RGD
Celera694,768,859 - 94,769,075UniSTS
RH 3.4 Map6677.0UniSTS
RH 3.4 Map6677.0RGD
RH 2.0 Map6880.3RGD
SHRSP x BN Map657.8598RGD
FHH x ACI Map668.02RGD
Flank 2: (D6Rat169)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2663,040,360 - 63,040,562 (+)MAPPER
Rnor_6.0666,222,411 - 66,222,612NCBI
Rnor_5.0675,798,492 - 75,798,693UniSTS
RGSC_v3.4665,393,587 - 65,393,789RGD
RGSC_v3.4665,393,588 - 65,393,789UniSTS
RGSC_v3.1665,396,713 - 65,396,915RGD
Celera662,013,509 - 62,013,710UniSTS
SHRSP x BN Map643.1999RGD
SHRSP x BN Map643.1999UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
4889848Pur25Proteinuria QTL 25140.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)66304056271636266Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercross  
qtl_gene measurement method: rats were tested three times a week for the presence of glycosuria and ketonuria. Once the animals became glycosuric, the diagnosis of type 1 diabetes was made on the basis of hyperglycemia (blood glucose: 16.7 mmol/l) for two consecutive days. 2293011
qtl_general susceptible allele comes from the BBDP 2293011
qtl_general this peak is distinct from other Iddm QTLs found in the same region 2293011
qtl_general software used: R/QTL and QTL Cartographer 2303106
qtl_general number of animals used: 574 animals which were negative for glycosuria until 165 days 2303106