Iddm28 QTL Report (Rattus norvegicus) - Rat Genome Database
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QTL: Iddm28 (Insulin dependent diabetes mellitus QTL 28) Rattus norvegicus

Symbol: Iddm28
Name: Insulin dependent diabetes mellitus QTL 28
RGD ID: 2293088
Also known as: Iddm
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: blood glucose level   (CMO:0000046)    
LOD Score: 5.21
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0666,222,612 - 75,023,308RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0675,798,693 - 84,567,798RGDRnor5.0
RGSC_v3.4665,393,789 - 74,436,856RGDRGSC3.4
Cross Type: intercross
Strains Crossed: ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

Related QTLs

Related QTL Description Reference
Iddm29 interacts with RGD:2303106


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
621345Nova1NOVA alternative splicing regulator 166696012667085836Rat
7725900LOC102556158uncharacterized LOC10255615866824934368268080Rat
1598277LOC366613similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) (Pendulin) (Pore targeting complex 58 kDa subunit) (PTAC58) (Importin alpha P1)66867292768674901Rat
7693265LOC102556377uncharacterized LOC10255637766871687368725462Rat
1334065Olr873-psolfactory receptor pseudogene 87366949762969498282Rat
2320031LOC100364934Leydig cell tumor 10 kDa protein-like66961929569619628Rat
2323500LOC100359740D-3-phosphoglycerate dehydrogenase-like66993708369938327Rat
7543646LOC102546336uncharacterized LOC10254633666993976269945424Rat
1559629RGD1559629similar to H+ ATP synthase66995012969951013Rat
2619Foxg1forkhead box G166997122769974037Rat
7619249LOC102546421uncharacterized LOC10254642166997556069994251Rat
7627887LOC102546496uncharacterized LOC10254649667021653970220854Rat
9219694LOC103692628uncharacterized LOC10369262867025830470343196Rat
6486816LOC100912520leydig cell tumor 10 kDa protein homolog67027622770276560Rat
1583294LOC685003similar to Leydig cell tumor 10 kDa protein67028946470289797Rat
9146736LOC103692629uncharacterized LOC10369262967096200770964521Rat
620964Prkd1protein kinase D167103501771349531Rat
11491233LOC108351231uncharacterized LOC10835123167167529871703445Rat
9182264LOC103692630uncharacterized LOC10369263067171201571733152Rat
7728058LOC102557478uncharacterized LOC10255747867173394471853649Rat
1310263G2e3G2/M-phase specific E3 ubiquitin protein ligase67209214872123878Rat
9079291LOC103692631uncharacterized LOC10369263167211317672114855Rat
619828Scfd1sec1 family domain containing 167212440872202703Rat
1587060LOC680823similar to Ubiquitin-conjugating enzyme E2 I (Ubiquitin-protein ligase I) (Ubiquitin carrier protein I) (SUMO-1-protein ligase) (SUMO-1-conjugating enzyme) (Ubiquitin-conjugating enzyme UbcE2A)67213301972133964Rat
7607530LOC102551044uncharacterized LOC10255104467218794872230834Rat
2323296LOC100359846hypothetical LOC10035984667226530672266267Rat
11497096LOC108351233uncharacterized LOC10835123367227091172359999Rat
9174726LOC103692632ADP-ribosylation factor-like protein 1 pseudogene67228870072290899Rat
11405764LOC108351234uncharacterized LOC10835123467231334072313928Rat
1308536Cochcochlin67235970272373710Rat
621827Strn3striatin 367237636072462676Rat
9229379LOC103692633uncharacterized LOC10369263367240361072409447Rat
1311990Ap4s1adaptor related protein complex 4 subunit sigma 167246197772502717Rat
1561653Hectd1HECT domain E3 ubiquitin protein ligase 167250965872596285Rat
1561116Heatr5aHEAT repeat containing 5A67264865472750202Rat
11421308LOC108351334vegetative cell wall protein gp1-like67274962172750307Rat
1309138Dtd2D-aminoacyl-tRNA deacylase 267278122972786835Rat
1306830Gpr33G protein-coupled receptor 3367280484372805848Rat
1307232Nubplnucleotide binding protein-like67289175873147837Rat
11440663LOC108351235tensin-2 pseudogene67293103972935120Rat
7536596LOC102552216tensin-like C1 domain-containing phosphatase-like67293141472932801Rat
1595110LOC685338similar to longevity assurance homolog 567319538973196416Rat
9358597LOC103692634uncharacterized LOC10369263467322460573225974Rat
9095294LOC103692641dynein assembly factor 3, axonemal homolog67334484273358025Rat
1308507Arhgap5Rho GTPase activating protein 567334512973408304Rat
7670615LOC102547541uncharacterized LOC10254754167344418873445547Rat
69412Akap6A-kinase anchoring protein 667355311173991992Rat
7709127LOC102547662uncharacterized LOC10254766267404979474058457Rat
9155261LOC103692635neuronal PAS domain-containing protein 3-like67408199574326992Rat
1307181Npas3neuronal PAS domain protein 367408199574913025Rat
7629096LOC102547735uncharacterized LOC10254773567424076474278309Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
42786D6Rat16920266622241166222612Ratregion
5055223RH14367713166678535266785482Ratregion
44094D6Got7627166688365666883926Ratregion
5503538NOVA1__606561366696350566964117Ratregion
5506409Nova154066696597766966516Ratregion
42784D6Rat20124366756527167565511Ratregion
42325D6Rat22123266845991468460143Ratregion
38608D6Rat10614266878117068781311Ratregion
44096D6Got8019666947267069472865Ratregion
5074224RH13789322966996089769961125Ratregion
7205942Foxg1066997015169971510Ratregion
7193005Foxg139666997269069973085Ratregion
5070420Foxg1100466997291369973916Ratregion
5507199UniSTS:22524316966997325669973424Ratregion
7192194Foxg145566997327769973731Ratregion
5028883RH14268818866998519969985386Ratregion
5062582BF40344618867006795670068143Ratregion
5501295D11S260514567013257170132720Ratregion
42791D6Rat19810367058570870585794Ratregion
5507147UniSTS:22484115467103556871035721Ratregion
5036454Prkcm20667103562071035825Ratregion
5085318BQ20993815067103793971038088Ratregion
44097D6Got7926867134110971341376Ratregion
44097D6Got7926867134110971341685Ratregion
44098D6Got8212467171253071712653Ratregion
44099D6Got8116267190091471901075Ratregion
5065568BI30340818567212223372122417Ratregion
5029341RH14442715767218701272187168Ratregion
5054369RH14318427067235795872358227Ratregion
5041570RH12893319667237348372373678Ratregion
5086879AI22830416367239691972397081Ratregion
41548D6Rat13016067244499972445149Ratregion
5030749BE10792715667246333872463493Ratregion
5033319RH13840015467247071072470863Ratregion
5083225BI27548219767250977772509973Ratregion
5077226RH13963520367251143572511637Ratregion
5053413RH14263410767255615372556259Ratregion
5070472AI84487613967256346772563605Ratregion
5047984RH13264220167264869672648896Ratregion
5034161RH14160018467271325972713442Ratregion
39340D6Rat7320067277947372779682Ratregion
5040426RH12827622067278077772780996Ratregion
5502186MARC_7649-7650:996688053:1067293390472934134Ratregion
42792D6Rat19922367314144473141654Ratregion
625778D6Got8918667330987973310064Ratregion
5064694BE10833915267339117773391328Ratregion
5057680BE10132115667340812873408283Ratregion
44100D6Got9022767364697473647200Ratregion
5085950BM38449618167367498773675167Ratregion
5031698AU04744818367367767873677860Ratregion
5047758RH13251119267367919573679387Ratregion
44103D6Got9122267370073873700956Ratregion
1638211D6Wox3618767399022873990414Ratregion
5032623RH13469019767399165173991847Ratregion
5066000BE11646517067399286573993034Ratregion
44105D6Got8810767405595274056058Ratregion
5059928BE10357015767421862874218784Ratregion
5026278RH13159921567479575974795973Ratregion
5507307fc03e11.x191767481462574815541Ratregion
5090827AU04998626767482354974823815Ratregion
5079998RH14132319767491333374913529Ratregion
5089041AU04891921567492737574927589Ratregion
44106D6Got8715467494706774947220Ratregion
36729D6Rat2313967502330875023446Ratregion
Position Markers

Flank 1: (D6Rat23)
Rat AssemblyChrPosition (strand)Source
Rnor_6.0675,023,308 - 75,023,446NCBI
Rnor_5.0684,567,798 - 84,567,936UniSTS
RGSC_v3.4674,436,856 - 74,436,995RGD
RGSC_v3.4674,436,857 - 74,436,995UniSTS
RGSC_v3.1674,439,982 - 74,440,121RGD
Celera670,485,804 - 70,485,940UniSTS
RH 2.0 Map6686.7RGD
SHRSP x BN Map646.6299RGD
FHH x ACI Map656.9299RGD
Peak: (D6Rat88)
Rat AssemblyChrPosition (strand)Source
Rnor_6.06100,716,550 - 100,716,766NCBI
Rnor_5.06110,101,561 - 110,101,777UniSTS
RGSC_v3.46100,193,176 - 100,193,393RGD
RGSC_v3.46100,193,177 - 100,193,393UniSTS
RGSC_v3.16100,196,633 - 100,196,849RGD
Celera694,768,859 - 94,769,075UniSTS
RH 3.4 Map6677.0UniSTS
RH 3.4 Map6677.0RGD
RH 2.0 Map6880.3RGD
SHRSP x BN Map657.8598RGD
FHH x ACI Map668.02RGD
Flank 2: (D6Rat169)
Rat AssemblyChrPosition (strand)Source
Rnor_6.0666,222,411 - 66,222,612NCBI
Rnor_5.0675,798,492 - 75,798,693UniSTS
RGSC_v3.4665,393,587 - 65,393,789RGD
RGSC_v3.4665,393,588 - 65,393,789UniSTS
RGSC_v3.1665,396,713 - 65,396,915RGD
Celera662,013,509 - 62,013,710UniSTS
SHRSP x BN Map643.1999UniSTS
SHRSP x BN Map643.1999RGD


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)67009971115379601Rat
4889848Pur25Proteinuria QTL 25140.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65980306594001333Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)660606431108154445Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63626028884763275Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64167904686679046Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64167904686679046Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63810630883106308Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)648432758108268790Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63436743680490628Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64167904686679046Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63499565675623393Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63760898075023446Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)6112039375023446Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)660606431108154445Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)671206251116206251Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)6616172276002731Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6616172276002731Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)662263348107263348Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)66622261275023308Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)666129520111129520Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6175623393Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercross  
qtl_gene measurement method: rats were tested three times a week for the presence of glycosuria and ketonuria. Once the animals became glycosuric, the diagnosis of type 1 diabetes was made on the basis of hyperglycemia (blood glucose: 16.7 mmol/l) for two consecutive days. 2293011
qtl_general susceptible allele comes from the BBDP 2293011
qtl_general this peak is distinct from other Iddm QTLs found in the same region 2293011
qtl_general software used: R/QTL and QTL Cartographer 2303106
qtl_general number of animals used: 574 animals which were negative for glycosuria until 165 days 2303106