Gene: Nubpl (nucleotide binding protein-like) Rattus norvegicus
Analyze
Symbol:
Nubpl
Name:
nucleotide binding protein-like
Description:
Predicted to have 4 iron, 4 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly; mitochondrial respiratory chain complex I assembly; and mitochondrion morphogenesis. Predicted to localize to the mitochondrion and plasma membrane. Human ortholog(s) of this gene implicated in mitochondrial complex I deficiency. Orthologous to human NUBPL (nucleotide binding protein like); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
iron-sulfur protein NUBPL; LOC299008; nucleotide-binding protein-like; RGD1307232; similar to hypothetical protein FLJ12660
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
NUBPL (nucleotide binding protein like) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Nubpl (nucleotide binding protein-like) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Nubpl (nucleotide binding protein like) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
NUBPL (nucleotide binding protein like) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
NUBPL (nucleotide binding protein like) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Nubpl (nucleotide binding protein like) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
NUBPL (nucleotide binding protein like) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
NUBPL (nucleotide binding protein like)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Nubpl (nucleotide binding protein-like)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
nubpl (nucleotide binding protein-like)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
CG3262
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 6 72,891,758 - 73,147,837 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 72,891,725 - 73,148,536 (+) Ensembl Rnor_5.0 6 82,557,115 - 82,709,215 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 Rnor_5.0 6 82,453,631 - 82,517,904 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 72,264,459 - 72,306,567 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 6 72,267,584 - 72,479,338 (+) NCBI Celera 6 68,435,325 - 68,646,422 (+) NCBI Celera Cytogenetic Map 6 q23 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
genetic disease ISO RGD:1343672 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10214753 more ... genetic disease ISO RGD:1343672 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10214753 more ... genetic disease ISO RGD:1343672 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:24088041 more ... mitochondrial complex I deficiency ISO RGD:1343672 8554872 ClinVar Annotator: match by OMIM:252010 ClinVar PMID:23553477 mitochondrial complex I deficiency ISO RGD:1343672 8554872 ClinVar Annotator: match by term: Mitochondrial complex I deficiency ClinVar PMID:10214753 more ... mitochondrial complex I deficiency ISO RGD:1343672 8554872 ClinVar Annotator: match by term: Mitochondrial complex I deficiency ClinVar PMID:24088041 more ... mitochondrial complex I deficiency ISO RGD:1343672 8554872 ClinVar Annotator: match by term: Mitochondrial complex I deficiency ClinVar PMID:20818383 , PMID:22072591 mitochondrial complex I deficiency ISO RGD:1343672 8554872 ClinVar Annotator: match by term: Mitochondrial complex I deficiency ClinVar PMID:21681106 mitochondrial complex I deficiency ISO RGD:1343672 8554872 ClinVar Annotator: match by term: Mitochondrial complex I deficiency ClinVar PMID:10214753 more ... mitochondrial complex I deficiency ISO RGD:1343672 8554872 ClinVar Annotator: match by term: Mitochondrial oxidative phosphorylation disorder ClinVar PMID:24033266 mitochondrial complex I deficiency ISO RGD:1343672 8554872 ClinVar Annotator: match by term: Mitochondrial complex I deficiency ClinVar PMID:25741868 mitochondrial complex I deficiency ISO RGD:1343672 8554872 ClinVar Annotator: match by OMIM:252010 ClinVar Mitochondrial Complex I Deficiency, Nuclear Type 21 ISO RGD:1343672 8554872 ClinVar Annotator: match by term: MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 21 ClinVar PMID:10214753 more ... Mitochondrial Complex I Deficiency, Nuclear Type 21 ISO RGD:1343672 8554872 ClinVar Annotator: match by term: MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 21 ClinVar PMID:24088041 more ... Mitochondrial Complex I Deficiency, Nuclear Type 21 ISO RGD:1343672 8554872 ClinVar Annotator: match by term: MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 21 ClinVar PMID:25741868 Mitochondrial Complex I Deficiency, Nuclear Type 21 ISO RGD:1343672 8554872 ClinVar Annotator: match by term: MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 21 ClinVar PMID:20818383 , PMID:22072591 Mitochondrial Complex I Deficiency, Nuclear Type 21 ISO RGD:1343672 8554872 ClinVar Annotator: match by term: MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 21 ClinVar PMID:23553477
Imported Annotations - CTD
mitochondrial metabolism disease ISO RGD:1343672 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20818383
Imported Annotations - OMIM
Mitochondrial Complex I Deficiency, Nuclear Type 21 ISO RGD:1343672 7240710 OMIM
Gene-Chemical Interaction Annotations
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of NUBPL mRNA] CTD PMID:31150632 1,1-dichloroethene decreases expression ISO RGD:1552806 6480464 vinylidene chloride results in decreased expression of NUBPL mRNA CTD PMID:26682919 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of NUBPL mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of NUBPL mRNA CTD PMID:21346803 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1552806 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of NUBPL mRNA CTD PMID:26251327 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one decreases expression EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of NUBPL mRNA CTD PMID:22484513 aflatoxin B1 decreases expression ISO RGD:1552806 6480464 Aflatoxin B1 results in decreased expression of NUBPL mRNA CTD PMID:19770486 aflatoxin B1 affects expression ISO RGD:1343672 6480464 Aflatoxin B1 affects the expression of NUBPL protein CTD PMID:20106945 Aroclor 1254 increases expression ISO RGD:1552806 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of NUBPL mRNA CTD PMID:23650126 arsane affects methylation ISO RGD:1343672 6480464 Arsenic affects the methylation of NUBPL gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1343672 6480464 Arsenic affects the methylation of NUBPL gene CTD PMID:25304211 benzo[a]pyrene decreases expression ISO RGD:1552806 6480464 Benzo(a)pyrene results in decreased expression of NUBPL mRNA CTD PMID:19770486 benzo[a]pyrene decreases expression ISO RGD:1343672 6480464 Benzo(a)pyrene results in decreased expression of NUBPL mRNA CTD PMID:20064835 more ... benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1343672 6480464 7 more ... CTD PMID:20018196 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1552806 6480464 Diethylhexyl Phthalate results in increased expression of NUBPL mRNA CTD PMID:28085963 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of NUBPL mRNA CTD PMID:25181051 butanal decreases expression ISO RGD:1343672 6480464 butyraldehyde results in decreased expression of NUBPL mRNA CTD PMID:26079696 cadmium dichloride increases expression ISO RGD:1343672 6480464 Cadmium Chloride results in increased expression of NUBPL mRNA CTD PMID:26472689 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of NUBPL mRNA CTD PMID:22023808 cisplatin decreases expression ISO RGD:1343672 6480464 Cisplatin results in decreased expression of NUBPL mRNA CTD PMID:27594783 cobalt dichloride increases expression ISO RGD:1552806 6480464 cobaltous chloride results in increased expression of NUBPL mRNA CTD PMID:21139344 cobalt dichloride decreases expression ISO RGD:1343672 6480464 cobaltous chloride results in decreased expression of NUBPL mRNA CTD PMID:19376846 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of NUBPL mRNA CTD PMID:24386269 copper(II) sulfate decreases expression ISO RGD:1343672 6480464 Copper Sulfate results in decreased expression of NUBPL mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:1552806 6480464 Cyclosporine results in decreased expression of NUBPL mRNA CTD PMID:19770486 cyclosporin A decreases expression ISO RGD:1343672 6480464 Cyclosporine results in decreased expression of NUBPL mRNA CTD PMID:20106945 , PMID:25562108 dibutyl phthalate decreases expression ISO RGD:1552806 6480464 Dibutyl Phthalate results in decreased expression of NUBPL mRNA CTD PMID:21266533 dicrotophos decreases expression ISO RGD:1343672 6480464 dicrotophos results in decreased expression of NUBPL mRNA CTD PMID:28302478 disodium selenite decreases expression ISO RGD:1343672 6480464 Sodium Selenite results in decreased expression of NUBPL mRNA CTD PMID:18175754 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of NUBPL mRNA CTD PMID:29391264 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of NUBPL mRNA CTD PMID:24136188 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of NUBPL mRNA CTD PMID:24136188 glyphosate increases methylation EXP 6480464 glyphosate results in increased methylation of NUBPL gene CTD PMID:31011160 hydrogen peroxide affects expression ISO RGD:1343672 6480464 Hydrogen Peroxide affects the expression of NUBPL mRNA CTD PMID:21179406 methylmercury chloride decreases expression ISO RGD:1343672 6480464 methylmercuric chloride results in decreased expression of NUBPL mRNA CTD PMID:28001369 nitrofen increases expression EXP 6480464 nitrofen results in increased expression of NUBPL mRNA CTD PMID:26720608 paracetamol affects expression ISO RGD:1552806 6480464 Acetaminophen affects the expression of NUBPL mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:1343672 6480464 Acetaminophen results in decreased expression of NUBPL mRNA CTD PMID:29067470 perfluorooctanoic acid increases expression ISO RGD:1343672 6480464 perfluorooctanoic acid results in increased expression of NUBPL protein CTD PMID:26879310 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of NUBPL mRNA CTD PMID:19162173 quercetin decreases expression ISO RGD:1343672 6480464 Quercetin results in decreased expression of NUBPL mRNA CTD PMID:21632981 silicon dioxide increases expression ISO RGD:1343672 6480464 Silicon Dioxide analog results in increased expression of NUBPL mRNA CTD PMID:23806026 sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of NUBPL mRNA CTD PMID:22110744 sodium fluoride increases expression ISO RGD:1552806 6480464 Sodium Fluoride results in increased expression of NUBPL protein CTD PMID:28918527 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of NUBPL mRNA] CTD PMID:31150632 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of NUBPL mRNA CTD PMID:31150632 valproic acid increases expression ISO RGD:1343672 6480464 Valproic Acid results in increased expression of NUBPL mRNA CTD PMID:23179753 , PMID:29154799
Gene Ontology Annotations
Molecular Pathway Annotations
4145119 Mcs25 Mammary carcinoma susceptibility QTL 25 0.0001 mammary gland integrity trait (VT:0010552) percentage of deaths in a study population during a period of time (CMO:0001024) 6 7009971 115379601 Rat 4889848 Pur25 Proteinuria QTL 25 14 0.003 total urine protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 6 59803065 94001333 Rat 6893332 Cm74 Cardiac mass QTL 74 0.4 0.64 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 6 60606431 108154445 Rat 6893340 Cm77 Cardiac mass QTL 77 0.26 0.57 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 6 36260288 84763275 Rat 731173 Uae22 Urinary albumin excretion QTL 22 10.1 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 68781170 147991367 Rat 9590290 Uminl2 Urine mineral level QTL 2 3.96 0.001 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) 6 41679046 86679046 Rat 9590306 Scort18 Serum corticosterone level QTL 18 2.88 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 6 41679046 86679046 Rat 634307 Bp141 Blood pressure QTL 141 4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 6 38106308 83106308 Rat 634330 Pia16 Pristane induced arthritis QTL 16 3.9 joint integrity trait (VT:0010548) arthritic paw count (CMO:0001460) 6 48432758 108268790 Rat 1300143 Rf14 Renal function QTL 14 2.92 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) 6 34367436 80490628 Rat 9590140 Scort4 Serum corticosterone level QTL 4 14.49 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 6 41679046 86679046 Rat 1331779 Rf38 Renal function QTL 38 2.876 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) 6 34995656 75623393 Rat 1354632 Scl29 Serum cholesterol level QTL 29 3.74 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 6 37608980 75023446 Rat 1354664 Slep2 Serum leptin concentration QTL 2 4.49 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) 6 1120393 75023446 Rat 1558641 Cm47 Cardiac mass QTL 47 2.9 0.001 heart mass (VT:0007028) heart wet weight (CMO:0000069) 6 60606431 108154445 Rat 1641904 Alcrsp4 Alcohol response QTL 4 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 6 71206251 116206251 Rat 1576309 Emca7 Estrogen-induced mammary cancer QTL 7 4 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 6 2537030 111715717 Rat 1578665 Bss16 Bone structure and strength QTL 16 4.4 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) 6 6161722 76002731 Rat 1578668 Bmd14 Bone mineral density QTL 14 3.8 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) 6 6161722 76002731 Rat 70176 Mcsm1 Mammary carcinoma susceptibility modifier QTL 1 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 6 62263348 107263348 Rat 2290393 Uae37 Urinary albumin excretion QTL 37 0.0001 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 68781170 147991367 Rat 2293088 Iddm28 Insulin dependent diabetes mellitus QTL 28 5.21 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 6 66222612 75023308 Rat 2293839 Kiddil2 Kidney dilation QTL 2 4.8 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) 6 22042854 84763421 Rat 2293841 Kiddil4 Kidney dilation QTL 4 4.4 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) 6 22042854 84763421 Rat 12801471 Schws9 Schwannoma susceptibility QTL 9 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) 6 66129520 111129520 Rat 2301972 Bp325 Blood pressure QTL 325 4.8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 6 1 75623393 Rat
Predicted Target Of
Count of predictions: 26 Count of miRNA genes: 25 Interacting mature miRNAs: 25 Transcripts: ENSRNOT00000038074 Prediction methods: Miranda, Rnahybrid Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
