Gpr33-ps1 (G protein-coupled receptor 33, pseudogene 1) - Rat Genome Database

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Gene: Gpr33-ps1 (G protein-coupled receptor 33, pseudogene 1) Rattus norvegicus
Analyze
Symbol: Gpr33-ps1
Name: G protein-coupled receptor 33, pseudogene 1
RGD ID: 1306830
Description: Predicted to enable G protein-coupled receptor activity and complement receptor activity. Predicted to be involved in several processes, including complement receptor mediated signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of cytosolic calcium ion concentration. Predicted to be active in plasma membrane. Orthologous to human GPR33 (G protein-coupled receptor 33); INTERACTS WITH amphetamine; bisphenol A; vinclozolin.
Type: pseudo (Ensembl: protein-coding)
RefSeq Status: INFERRED
Previously known as: G protein-coupled receptor 33; Gpr33; LOC299007; probable G-protein coupled receptor 33
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8675,209,776 - 75,210,781 (-)NCBIGRCr8
mRatBN7.2669,474,435 - 69,475,440 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl669,474,435 - 69,475,440 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx669,898,988 - 69,899,993 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0670,205,627 - 70,206,632 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0669,645,152 - 69,646,157 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0672,804,843 - 72,805,848 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl672,804,843 - 72,805,848 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0682,366,716 - 82,367,721 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4672,176,407 - 72,177,412 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1672,179,532 - 72,180,538 (-)NCBI
Celera668,350,056 - 68,351,061 (-)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15987686   PMID:20399748  


Genomics

Comparative Map Data
Gpr33-ps1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8675,209,776 - 75,210,781 (-)NCBIGRCr8
mRatBN7.2669,474,435 - 69,475,440 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl669,474,435 - 69,475,440 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx669,898,988 - 69,899,993 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0670,205,627 - 70,206,632 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0669,645,152 - 69,646,157 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0672,804,843 - 72,805,848 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl672,804,843 - 72,805,848 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0682,366,716 - 82,367,721 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4672,176,407 - 72,177,412 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1672,179,532 - 72,180,538 (-)NCBI
Celera668,350,056 - 68,351,061 (-)NCBICelera
Cytogenetic Map6q23NCBI
GPR33
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381431,482,875 - 31,488,039 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1431,482,875 - 31,488,039 (-)EnsemblGRCh38hg38GRCh38
GRCh371431,952,081 - 31,957,245 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361431,021,971 - 31,022,961 (-)NCBINCBI36Build 36hg18NCBI36
Celera1411,817,510 - 11,818,500 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef1412,069,653 - 12,074,565 (-)NCBIHuRef
CHM1_11431,951,505 - 31,956,507 (-)NCBICHM1_1
T2T-CHM13v2.01425,680,197 - 25,685,200 (-)NCBIT2T-CHM13v2.0
Gpr33
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391252,069,786 - 52,074,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1252,069,786 - 52,074,846 (-)EnsemblGRCm39 Ensembl
GRCm381252,023,003 - 52,028,063 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1252,023,003 - 52,028,063 (-)EnsemblGRCm38mm10GRCm38
MGSCv371253,123,990 - 53,129,050 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361252,944,623 - 52,949,682 (-)NCBIMGSCv36mm8
Celera1253,329,509 - 53,338,104 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1222.11NCBI
Gpr33
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540929,124,200 - 29,130,823 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540929,124,200 - 29,130,823 (+)NCBIChiLan1.0ChiLan1.0
GPR33
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21532,812,104 - 32,817,827 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11432,028,607 - 32,034,331 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01412,259,566 - 12,264,971 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11430,456,768 - 30,461,762 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1430,456,788 - 30,457,789 (-)Ensemblpanpan1.1panPan2
GPR33
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1810,718,470 - 10,720,029 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl810,719,010 - 10,720,029 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha810,580,837 - 10,586,848 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0810,820,874 - 10,826,875 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl810,821,555 - 10,822,574 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1810,502,761 - 10,508,762 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0810,579,758 - 10,585,757 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0810,864,470 - 10,870,467 (-)NCBIUU_Cfam_GSD_1.0
Gpr33
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864042,567,993 - 42,572,866 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364946,074,140 - 6,078,747 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364946,074,140 - 6,078,747 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR33
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl768,084,248 - 68,088,895 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1768,084,248 - 68,088,895 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2772,965,166 - 72,969,813 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Gpr33
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624820839,284 - 840,276 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624820839,284 - 840,276 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr33-ps1
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:94
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000009040
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)66304056271636266Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system musculoskeletal system renal system reproductive system respiratory system
High
Medium
Low 6 2
Below cutoff 2 9 1 13 1 1 1 9 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009040   ⟹   ENSRNOP00000058988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl669,474,435 - 69,475,440 (-)Ensembl
Rnor_6.0 Ensembl672,804,843 - 72,805,848 (-)Ensembl
RefSeq Acc Id: NM_001031823   ⟹   NP_001026993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2669,474,435 - 69,475,440 (-)NCBI
Rnor_6.0672,804,843 - 72,805,848 (-)NCBI
Rnor_5.0682,366,716 - 82,367,721 (-)NCBI
RGSC_v3.4672,176,407 - 72,177,412 (-)RGD
Celera668,350,056 - 68,351,061 (-)RGD
Sequence:
Protein Sequences
GenBank Protein AAR98755 (Get FASTA)   NCBI Sequence Viewer  
  AAR98756 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058988.1
Reference Protein Sequences
RefSeq Acc Id: NP_001026993   ⟸   NM_001031823
- Sequence:
RefSeq Acc Id: ENSRNOP00000058988   ⟸   ENSRNOT00000009040
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q49SQ0-F1-model_v2 AlphaFold Q49SQ0 1-309 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306830 AgrOrtholog
BioCyc Gene G2FUF-37578 BioCyc
Ensembl Genes ENSRNOG00000038990 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009040.6 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  Formyl_pep_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
KEGG Report rno:299007 UniProtKB/TrEMBL
NCBI Gene 299007 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR 33-RELATED UniProtKB/TrEMBL
  PTHR24225 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Gpr33-ps1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038990 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt Q49SP9_RAT UniProtKB/TrEMBL
  Q49SQ0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-18 Gpr33-ps1  G protein-coupled receptor 33, pseudogene 1  Gpr33  G protein-coupled receptor 33  Name and Symbol changed 629549 APPROVED
2022-10-18 Gpr33  G protein-coupled receptor 33  Gpr33  G protein-coupled receptor 33  Type changed (type changed from [protein-coding] to [pseudogene]) 629549 APPROVED
2008-04-30 Gpr33  G protein-coupled receptor 33   Gpr33_predicted  G protein-coupled receptor 33 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Gpr33_predicted  G protein-coupled receptor 33 (predicted)      Symbol and Name status set to approved 70820 APPROVED