Gpr33 (G protein-coupled receptor 33) - Rat Genome Database

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Gene: Gpr33 (G protein-coupled receptor 33) Mus musculus
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Symbol: Gpr33
Name: G protein-coupled receptor 33
RGD ID: 1315667
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor activity and complement receptor activity. Predicted to be involved in several processes, including complement receptor mediated signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in testis. Orthologous to human GPR33 (G protein-coupled receptor 33).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: probable G-protein coupled receptor 33
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391252,069,786 - 52,074,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1252,069,786 - 52,074,846 (-)EnsemblGRCm39 Ensembl
GRCm381252,023,003 - 52,028,063 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1252,023,003 - 52,028,063 (-)EnsemblGRCm38mm10GRCm38
MGSCv371253,123,990 - 53,129,050 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361252,944,623 - 52,949,682 (-)NCBIMGSCv36mm8
Celera1253,329,509 - 53,338,104 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1222.11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9653656   PMID:12477932   PMID:15489334   PMID:15987686   PMID:16595170   PMID:20399748   PMID:21873635   PMID:24194600   PMID:25849460   PMID:27626380  


Genomics

Comparative Map Data
Gpr33
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391252,069,786 - 52,074,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1252,069,786 - 52,074,846 (-)EnsemblGRCm39 Ensembl
GRCm381252,023,003 - 52,028,063 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1252,023,003 - 52,028,063 (-)EnsemblGRCm38mm10GRCm38
MGSCv371253,123,990 - 53,129,050 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361252,944,623 - 52,949,682 (-)NCBIMGSCv36mm8
Celera1253,329,509 - 53,338,104 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1222.11NCBI
GPR33
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381431,482,875 - 31,488,039 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1431,482,875 - 31,488,039 (-)EnsemblGRCh38hg38GRCh38
GRCh371431,952,081 - 31,957,245 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361431,021,971 - 31,022,961 (-)NCBINCBI36Build 36hg18NCBI36
Celera1411,817,510 - 11,818,500 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef1412,069,653 - 12,074,565 (-)NCBIHuRef
CHM1_11431,951,505 - 31,956,507 (-)NCBICHM1_1
T2T-CHM13v2.01425,680,197 - 25,685,200 (-)NCBIT2T-CHM13v2.0
Gpr33-ps1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8675,209,776 - 75,210,781 (-)NCBIGRCr8
mRatBN7.2669,474,435 - 69,475,440 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl669,474,435 - 69,475,440 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx669,898,988 - 69,899,993 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0670,205,627 - 70,206,632 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0669,645,152 - 69,646,157 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0672,804,843 - 72,805,848 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl672,804,843 - 72,805,848 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0682,366,716 - 82,367,721 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4672,176,407 - 72,177,412 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1672,179,532 - 72,180,538 (-)NCBI
Celera668,350,056 - 68,351,061 (-)NCBICelera
Cytogenetic Map6q23NCBI
Gpr33
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540929,124,200 - 29,130,823 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540929,124,200 - 29,130,823 (+)NCBIChiLan1.0ChiLan1.0
GPR33
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21532,812,104 - 32,817,827 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11432,028,607 - 32,034,331 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01412,259,566 - 12,264,971 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11430,456,768 - 30,461,762 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1430,456,788 - 30,457,789 (-)Ensemblpanpan1.1panPan2
GPR33
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1810,718,470 - 10,720,029 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl810,719,010 - 10,720,029 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha810,580,837 - 10,586,848 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0810,820,874 - 10,826,875 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl810,821,555 - 10,822,574 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1810,502,761 - 10,508,762 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0810,579,758 - 10,585,757 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0810,864,470 - 10,870,467 (-)NCBIUU_Cfam_GSD_1.0
Gpr33
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864042,567,993 - 42,572,866 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364946,074,140 - 6,078,747 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364946,074,140 - 6,078,747 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR33
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl768,084,248 - 68,088,895 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1768,084,248 - 68,088,895 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2772,965,166 - 72,969,813 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Gpr33
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624820839,284 - 840,276 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624820839,284 - 840,276 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr33
233 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:115
Interacting mature miRNAs:118
Transcripts:ENSMUST00000040161
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
13524839Ppiq10_mprepulse inhibition QTL 10 (mouse)121304319554945798Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
1300870Ath18_matherosclerosis 18 (mouse)Not determined121825996652260067Mouse
12904956Edlmmq10_mextensor digitorum longus muscle mass QTL 10 (mouse)121973983353739833Mouse
1302172Skts5_mskin tumor susceptibility 5 (mouse)Not determined122214886656149016Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122916068563160884Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122916068563160884Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122980158463801733Mouse
14747008Mancz10_mmandible centroid size 10 (mouse)122986352263863522Mouse
10402492Dipa8_mdrug induced psychomotor activation 8 (mouse)Not determined123493387268934019Mouse
1300818Bbaa10_mB.burgdorferi-associated arthritis 10 (mouse)Not determined123509100465511019Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse

Markers in Region
AI327343  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381252,023,099 - 52,023,235UniSTSGRCm38
MGSCv371253,124,086 - 53,124,222UniSTSGRCm37
Celera1253,329,605 - 53,329,741UniSTS
Cytogenetic Map12C1UniSTS
Whitehead/MRC_RH12423.97UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC161114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF045766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY490626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY490628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY490629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY490630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY490635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY490636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY490637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY490638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY490639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY490640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ156954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ981323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ981327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000040161   ⟹   ENSMUSP00000048059
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1252,069,786 - 52,074,846 (-)Ensembl
GRCm38.p6 Ensembl1252,023,003 - 52,028,063 (-)Ensembl
RefSeq Acc Id: NM_008159   ⟹   NP_032185
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391252,069,786 - 52,074,887 (-)NCBI
GRCm381252,023,003 - 52,028,063 (-)ENTREZGENE
MGSCv371253,123,990 - 53,129,050 (-)RGD
Celera1253,329,509 - 53,338,104 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032185   ⟸   NM_008159
- UniProtKB: O88416 (UniProtKB/Swiss-Prot),   D8VER2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000048059   ⟸   ENSMUST00000040161
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88416-F1-model_v2 AlphaFold O88416 1-339 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1277106 AgrOrtholog
Ensembl Genes ENSMUSG00000035148 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000040161 ENTREZGENE
  ENSMUST00000040161.5 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Formyl_rcpt-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14762 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1277106 ENTREZGENE
NCBI Gene 14762 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR 33-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpr33 PhenoGen
PRINTS FMETLEUPHER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D8VER2 ENTREZGENE, UniProtKB/TrEMBL
  GPR33_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE