GPR33 (G protein-coupled receptor 33)

Gene: GPR33 (G protein-coupled receptor 33) Sus scrofa

Analyze

Symbol:

GPR33

Name:

G protein-coupled receptor 33

RGD ID:

14129736

Description:

ENCODES a protein that exhibits complement receptor activity (inferred); G protein-coupled receptor activity (inferred); INVOLVED IN G protein-coupled receptor signaling pathway (inferred); inflammatory response (inferred); phospholipase C-activating G protein-coupled receptor signaling pathway (inferred); ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); Epidermolysis Bullosa Simplex 5D with Nail Dystrophy (ortholog); genetic disease (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

probable G-protein coupled receptor 33

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	68,084,248 - 68,088,895 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	68,084,248 - 68,088,895 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	72,965,166 - 72,969,813 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brain-Lung-Thyroid Syndrome (ISO)

Epidermolysis Bullosa Simplex 5D with Nail Dystrophy (ISO)

genetic disease (ISO)

mitochondrial complex I deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

complement receptor mediated signaling pathway (IBA)

G protein-coupled receptor signaling pathway (IEA)

inflammatory response (IBA,IEA)

phospholipase C-activating G protein-coupled receptor signaling pathway (IBA,IEA)

positive regulation of cytosolic calcium ion concentration (IBA,IEA)

signal transduction (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IEA)

Molecular Function

complement receptor activity (IBA,IEA)

G protein-coupled receptor activity (IBA,IEA)

References

Additional References at PubMed

PMID:20399748	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

GPR33
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	68,084,248 - 68,088,895 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	68,084,248 - 68,088,895 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	72,965,166 - 72,969,813 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPR33
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	31,482,875 - 31,488,039 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	31,482,875 - 31,488,039 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	31,952,081 - 31,957,245 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	31,021,971 - 31,022,961 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	14	11,817,510 - 11,818,500 (-)	NCBI		Celera
Cytogenetic Map	14	q12	NCBI
HuRef	14	12,069,653 - 12,074,565 (-)	NCBI		HuRef
CHM1_1	14	31,951,505 - 31,956,507 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	25,680,197 - 25,685,200 (-)	NCBI		T2T-CHM13v2.0

Gpr33
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	52,069,786 - 52,074,887 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	52,069,786 - 52,074,846 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	52,023,003 - 52,028,063 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	52,023,003 - 52,028,063 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	53,123,990 - 53,129,050 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	52,944,623 - 52,949,682 (-)	NCBI		MGSCv36	mm8
Celera	12	53,329,509 - 53,338,104 (-)	NCBI		Celera
Cytogenetic Map	12	C1	NCBI
cM Map	12	22.11	NCBI

Gpr33-ps1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	75,209,776 - 75,210,781 (-)	NCBI		GRCr8
mRatBN7.2	6	69,474,435 - 69,475,440 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	69,474,435 - 69,475,440 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	69,898,988 - 69,899,993 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	70,205,627 - 70,206,632 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	69,645,152 - 69,646,157 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	72,804,843 - 72,805,848 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	72,804,843 - 72,805,848 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	82,366,716 - 82,367,721 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	72,176,407 - 72,177,412 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	72,179,532 - 72,180,538 (-)	NCBI
Celera	6	68,350,056 - 68,351,061 (-)	NCBI		Celera
Cytogenetic Map	6	q23	NCBI

Gpr33
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	29,124,200 - 29,130,823 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	29,124,200 - 29,130,823 (+)	NCBI	ChiLan1.0	ChiLan1.0

GPR33
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	32,812,104 - 32,817,827 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	32,028,607 - 32,034,331 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	12,259,566 - 12,264,971 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	30,456,768 - 30,461,762 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	30,456,788 - 30,457,789 (-)	Ensembl	panpan1.1		panPan2

GPR33
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	10,718,470 - 10,720,029 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	10,719,010 - 10,720,029 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	10,580,837 - 10,586,848 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	10,820,874 - 10,826,875 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	10,821,555 - 10,822,574 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	10,502,761 - 10,508,762 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	10,579,758 - 10,585,757 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	10,864,470 - 10,870,467 (-)	NCBI		UU_Cfam_GSD_1.0

Gpr33
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	42,567,993 - 42,572,866 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936494	6,074,140 - 6,078,747 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936494	6,074,140 - 6,078,747 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

Gpr33
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624820	839,284 - 840,276 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624820	839,284 - 840,276 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in GPR33
100 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium
Low	5		1	1		12		1	3
Below cutoff	5	3		3	1	8	2	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001190923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000056	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY490670	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY490671	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU407068	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP326712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GQ981325	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GQ981326	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000023087 ⟹ ENSSSCP00000027792

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	7	68,084,248 - 68,088,895 (+)	Ensembl

RefSeq Acc Id:

NM_001190923 ⟹ NP_001177852

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	7	68,084,248 - 68,088,895 (+)	NCBI

Sequence:

show sequence

AGTATCAGCAAGAAGAAAGGCAGGTGAAGTGAAGGCAAGTGTCGCTGACTTTTGCCTCTGTCCC
TGGAGAGAAGACTGCTGATGGAGTCCCTCTGGCCTTCCCAAGACAGTCTGTCATGAAGATGTAA
CTCCAAGTTTCTCACTCCAATTATGGATCTGCTCAACTCTACTGATTACCTGCTCAATGTCTCT
ACTTTAATAAGAAACAGCATTCACATTCCAACTTCTGCCTCAAAAATGACTGTTGTGCTTCTTT
TGCTCACATCATCTATAATTGGCACTATCACCAATGGTTTCTACCTATGGGTGCTAAAATTCAA
AATGAGAAAGACTGTCAATACTCTCTTATATTTTCATCTCATTCTCTCCTATTTTATTTCAACA
TTGTTTTTGCCATTTCTGGCCATCTCCCACCTTCAAGATGATCACTGGAGCTTTGGAATGGCCA
CGTGCAAGATGGTCTATGGCATTTTGTACACAGGGATGTTTGCGTCGGTTTTCTTCCTCTCGGC
CATCAGTGTTGATCGTTATCTTCTCACTCTTCACCCAGTGTGGTCGCAGCTGCACCGAACCCCA
CACTGGGCTTCCAGCATCATCTTGGGAGTCTGGATCTCTGCCACTGCCCTCAGCATACCCTATA
TGGTTTTCAGGGAGACACATGATGACCATAAAGGAATGGTGACCTGCCAAAATAATTACGCCAT
ATCTACCAACTGGGAAAGCAAAAAGATGCAAACATTAAGGCAATGGATTCATGTGGCCTGTTTT
AGCAGCCGCTTCTTGCTGTCCTTCCTTCTGCCTTTCTTCATCATCACCTTTTGTTATGAAAGAG
TAGCCAAAAAGATGAAAGCCAGGGGCCTGTTTAAATCCAACAAGCCCTTCAAGGTCATGATGAC
GGCAATTATCTCTTTCTTTGTGTGTTGGATGCCCTACCATGTATACCAAGGCTTAATTCTCACT
AAGAACAAATCACAATTTTTCCAGTTGACTCTGATACTCACAATGATAACTATTTCTTTCAATA
CTCTCTTTTCTCCCACACTCTATCTGTTTATTGGGGAGAACTTCAGAAAGGTTTTTAAGAAGTC
TGTTCTTAATCTTTTTGAGTTGACATTCAATGAGGATTCTTCAACAGAAAGGACACAAAACCTA
AATTCAGAAGGCTACATTTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001177852	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ADJ17326	(Get FASTA)	NCBI Sequence Viewer
	ADJ17327	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000027792
	ENSSSCP00000027792.1
	ENSSSCP00005003905.1
	ENSSSCP00025029747.1
	ENSSSCP00030000577.1
	ENSSSCP00035007275.1
	ENSSSCP00040033842.1
	ENSSSCP00045045282.1
	ENSSSCP00050028895.1
	ENSSSCP00055038282.1
	ENSSSCP00060035494.1
	ENSSSCP00065021972.1
	ENSSSCP00070010051.1

RefSeq Acc Id:

NP_001177852 ⟸ NM_001190923

- UniProtKB:

D8VER3 (UniProtKB/TrEMBL), A0A8D1W6X1 (UniProtKB/TrEMBL), A0A4X1T5A5 (UniProtKB/TrEMBL), A0A8D1BRB9 (UniProtKB/TrEMBL), A0A8D0HUR8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDLLNSTDYLLNVSTLIRNSIHIPTSASKMTVVLLLLTSSIIGTITNGFYLWVLKFKMRKTVNT
LLYFHLILSYFISTLFLPFLAISHLQDDHWSFGMATCKMVYGILYTGMFASVFFLSAISVDRYL
LTLHPVWSQLHRTPHWASSIILGVWISATALSIPYMVFRETHDDHKGMVTCQNNYAISTNWESK
KMQTLRQWIHVACFSSRFLLSFLLPFFIITFCYERVAKKMKARGLFKSNKPFKVMMTAIISFFV
CWMPYHVYQGLILTKNKSQFFQLTLILTMITISFNTLFSPTLYLFIGENFRKVFKKSVLNLFEL
TFNEDSSTERTQNLNSEGYI

hide sequence

RefSeq Acc Id:

ENSSSCP00000027792 ⟸ ENSSSCT00000023087

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000025131	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00005004575	UniProtKB/TrEMBL
	ENSSSCG00025050601	UniProtKB/TrEMBL
	ENSSSCG00030000977	UniProtKB/TrEMBL
	ENSSSCG00035015883	UniProtKB/TrEMBL
	ENSSSCG00040057847	UniProtKB/TrEMBL
	ENSSSCG00045037190	UniProtKB/TrEMBL
	ENSSSCG00050049497	UniProtKB/TrEMBL
	ENSSSCG00055024350	UniProtKB/TrEMBL
	ENSSSCG00060060035	UniProtKB/TrEMBL
	ENSSSCG00065037175	UniProtKB/TrEMBL
	ENSSSCG00070006389	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000023087	ENTREZGENE
	ENSSSCT00000023087.4	UniProtKB/TrEMBL
	ENSSSCT00005006763.1	UniProtKB/TrEMBL
	ENSSSCT00025069060.1	UniProtKB/TrEMBL
	ENSSSCT00030001300.1	UniProtKB/TrEMBL
	ENSSSCT00035020277.1	UniProtKB/TrEMBL
	ENSSSCT00040078461.1	UniProtKB/TrEMBL
	ENSSSCT00045064133.1	UniProtKB/TrEMBL
	ENSSSCT00050067332.1	UniProtKB/TrEMBL
	ENSSSCT00055047961.1	UniProtKB/TrEMBL
	ENSSSCT00060081916.1	UniProtKB/TrEMBL
	ENSSSCT00065050709.1	UniProtKB/TrEMBL
	ENSSSCT00070012218.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	Formyl_rcpt-rel	UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
KEGG Report	ssc:100157823	UniProtKB/TrEMBL
NCBI Gene	GPR33	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR 33-RELATED	UniProtKB/TrEMBL
	PTHR24225	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	FMETLEUPHER	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A4X1T5A5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D0HUR8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1BRB9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1MYS7_PIG	UniProtKB/TrEMBL
	A0A8D1W6X1	ENTREZGENE, UniProtKB/TrEMBL
	D8VER3	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:99815	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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