GPR33 (G protein-coupled receptor 33) - Rat Genome Database

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Gene: GPR33 (G protein-coupled receptor 33) Homo sapiens
Analyze
Symbol: GPR33
Name: G protein-coupled receptor 33
RGD ID: 1351733
HGNC Page HGNC:4489
Description: Predicted to enable G protein-coupled receptor activity and complement receptor activity. Predicted to be involved in several processes, including complement receptor mediated signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of cytosolic calcium ion concentration. Predicted to be located in membrane. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 33 (gene/pseudogene); G protein-coupled receptor 33 pseudogene; probable G-protein coupled receptor 33
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381431,482,875 - 31,488,039 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1431,482,875 - 31,488,039 (-)EnsemblGRCh38hg38GRCh38
GRCh371431,952,081 - 31,957,245 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361431,021,971 - 31,022,961 (-)NCBINCBI36Build 36hg18NCBI36
Celera1411,817,510 - 11,818,500 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef1412,069,653 - 12,074,565 (-)NCBIHuRef
CHM1_11431,951,505 - 31,956,507 (-)NCBICHM1_1
T2T-CHM13v2.01425,680,197 - 25,685,200 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9653656   PMID:15987686   PMID:20399748   PMID:21873635  


Genomics

Comparative Map Data
GPR33
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381431,482,875 - 31,488,039 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1431,482,875 - 31,488,039 (-)EnsemblGRCh38hg38GRCh38
GRCh371431,952,081 - 31,957,245 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361431,021,971 - 31,022,961 (-)NCBINCBI36Build 36hg18NCBI36
Celera1411,817,510 - 11,818,500 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef1412,069,653 - 12,074,565 (-)NCBIHuRef
CHM1_11431,951,505 - 31,956,507 (-)NCBICHM1_1
T2T-CHM13v2.01425,680,197 - 25,685,200 (-)NCBIT2T-CHM13v2.0
Gpr33
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391252,069,786 - 52,074,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1252,069,786 - 52,074,846 (-)EnsemblGRCm39 Ensembl
GRCm381252,023,003 - 52,028,063 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1252,023,003 - 52,028,063 (-)EnsemblGRCm38mm10GRCm38
MGSCv371253,123,990 - 53,129,050 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361252,944,623 - 52,949,682 (-)NCBIMGSCv36mm8
Celera1253,329,509 - 53,338,104 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1222.11NCBI
Gpr33-ps1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8675,209,776 - 75,210,781 (-)NCBIGRCr8
mRatBN7.2669,474,435 - 69,475,440 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl669,474,435 - 69,475,440 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx669,898,988 - 69,899,993 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0670,205,627 - 70,206,632 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0669,645,152 - 69,646,157 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0672,804,843 - 72,805,848 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl672,804,843 - 72,805,848 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0682,366,716 - 82,367,721 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4672,176,407 - 72,177,412 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1672,179,532 - 72,180,538 (-)NCBI
Celera668,350,056 - 68,351,061 (-)NCBICelera
Cytogenetic Map6q23NCBI
Gpr33
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540929,124,200 - 29,130,823 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540929,124,200 - 29,130,823 (+)NCBIChiLan1.0ChiLan1.0
GPR33
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21532,812,104 - 32,817,827 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11432,028,607 - 32,034,331 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01412,259,566 - 12,264,971 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11430,456,768 - 30,461,762 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1430,456,788 - 30,457,789 (-)Ensemblpanpan1.1panPan2
GPR33
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1810,718,470 - 10,720,029 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl810,719,010 - 10,720,029 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha810,580,837 - 10,586,848 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0810,820,874 - 10,826,875 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl810,821,555 - 10,822,574 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1810,502,761 - 10,508,762 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0810,579,758 - 10,585,757 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0810,864,470 - 10,870,467 (-)NCBIUU_Cfam_GSD_1.0
Gpr33
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864042,567,993 - 42,572,866 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364946,074,140 - 6,078,747 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364946,074,140 - 6,078,747 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR33
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl768,084,248 - 68,088,895 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1768,084,248 - 68,088,895 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2772,965,166 - 72,969,813 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Gpr33
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624820839,284 - 840,276 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624820839,284 - 840,276 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GPR33
14 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q11.2-21.2(chr14:20196945-45284802)x1 copy number loss See cases [RCV000051485] Chr14:20196945..45284802 [GRCh38]
Chr14:20665104..45754005 [GRCh37]
Chr14:19734944..44823755 [NCBI36]
Chr14:14q11.2-21.2
pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:23548960-41983402)x1 copy number loss See cases [RCV000051490] Chr14:23548960..41983402 [GRCh38]
Chr14:24018169..42452605 [GRCh37]
Chr14:23088009..41522355 [NCBI36]
Chr14:14q11.2-21.1
pathogenic
GRCh38/hg38 14q12-21.2(chr14:30670314-44990595)x3 copy number gain See cases [RCV000052292] Chr14:30670314..44990595 [GRCh38]
Chr14:31139520..45459798 [GRCh37]
Chr14:30209271..44529548 [NCBI36]
Chr14:14q12-21.2
pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20000611-38984415)x3 copy number gain See cases [RCV000053803] Chr14:20000611..38984415 [GRCh38]
Chr14:20468770..39453619 [GRCh37]
Chr14:19538610..38523370 [NCBI36]
Chr14:14q11.2-21.1
pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20150949-39746154)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|See cases [RCV000053806] Chr14:20150949..39746154 [GRCh38]
Chr14:20619108..40215358 [GRCh37]
Chr14:19688948..39285109 [NCBI36]
Chr14:14q11.2-21.1
pathogenic
NC_000014.9:g.(31394019_31414809)_(31654321_31655889)del deletion Mitochondrial complex 1 deficiency, nuclear type 21 [RCV000000018] Chr14:31414809..31654321 [GRCh38]
Chr14:31884015..32123527 [GRCh37]
Chr14:30953766..31193278 [NCBI36]
Chr14:14q12
pathogenic
GRCh38/hg38 14q12-21.1(chr14:30382554-37712341)x1 copy number loss See cases [RCV000135334] Chr14:30382554..37712341 [GRCh38]
Chr14:30851760..38181546 [GRCh37]
Chr14:29921511..37251297 [NCBI36]
Chr14:14q12-21.1
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q12(chr14:31402452-31648460)x1 copy number loss See cases [RCV000140699] Chr14:31402452..31648460 [GRCh38]
Chr14:31871658..32117666 [GRCh37]
Chr14:30941409..31187417 [NCBI36]
Chr14:14q12
uncertain significance
GRCh38/hg38 14q12(chr14:31404152-31654707)x1 copy number loss See cases [RCV000141982] Chr14:31404152..31654707 [GRCh38]
Chr14:31873358..32123913 [GRCh37]
Chr14:30943109..31193664 [NCBI36]
Chr14:14q12
uncertain significance
GRCh38/hg38 14q12-13.1(chr14:28803988-33234266)x1 copy number loss See cases [RCV000142290] Chr14:28803988..33234266 [GRCh38]
Chr14:29273194..33703472 [GRCh37]
Chr14:28342945..32773223 [NCBI36]
Chr14:14q12-13.1
pathogenic
GRCh38/hg38 14q12-21.2(chr14:30792271-44685131)x1 copy number loss See cases [RCV000143063] Chr14:30792271..44685131 [GRCh38]
Chr14:31261477..45154334 [GRCh37]
Chr14:30331228..44224084 [NCBI36]
Chr14:14q12-21.2
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20022693-44093672)x3 copy number gain See cases [RCV000143186] Chr14:20022693..44093672 [GRCh38]
Chr14:20490852..44562875 [GRCh37]
Chr14:19560692..43632625 [NCBI36]
Chr14:14q11.2-21.2
pathogenic
GRCh38/hg38 14q11.2-21.3(chr14:20043513-48642042)x3 copy number gain See cases [RCV000143748] Chr14:20043513..48642042 [GRCh38]
Chr14:20511672..49111245 [GRCh37]
Chr14:19581512..48180995 [NCBI36]
Chr14:14q11.2-21.3
pathogenic
Single allele deletion Mitochondrial complex I deficiency [RCV000678000] Chr14:31012250..32193706 [GRCh38]
Chr14:31481456..32662912 [GRCh37]
Chr14:14q12
uncertain significance
GRCh37/hg19 14q11.2-22.2(chr14:23164384-54733411)x3 copy number gain See cases [RCV000447658] Chr14:23164384..54733411 [GRCh37]
Chr14:14q11.2-22.2
pathogenic
GRCh37/hg19 14q12(chr14:31916124-32101969)x1 copy number loss See cases [RCV000446865] Chr14:31916124..32101969 [GRCh37]
Chr14:14q12
uncertain significance
GRCh37/hg19 14q12(chr14:31822348-32154043)x3 copy number gain See cases [RCV000447234] Chr14:31822348..32154043 [GRCh37]
Chr14:14q12
likely benign
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-13.1(chr14:19794561-34049214)x3 copy number gain See cases [RCV000448273] Chr14:19794561..34049214 [GRCh37]
Chr14:14q11.2-13.1
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
NM_001197184.3(GPR33):c.400G>C (p.Val134Leu) single nucleotide variant Inborn genetic diseases [RCV003259387] Chr14:31483566 [GRCh38]
Chr14:31952772 [GRCh37]
Chr14:14q12
uncertain significance
GRCh37/hg19 14q12(chr14:31784406-32027900)x3 copy number gain not provided [RCV000683593] Chr14:31784406..32027900 [GRCh37]
Chr14:14q12
likely benign
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33
pathogenic
GRCh37/hg19 14q12-13.1(chr14:30448939-35017859)x1 copy number loss not provided [RCV000849105] Chr14:30448939..35017859 [GRCh37]
Chr14:14q12-13.1
pathogenic
GRCh37/hg19 14q12(chr14:31873358-32123957)x1 copy number loss not provided [RCV000849736] Chr14:31873358..32123957 [GRCh37]
Chr14:14q12
uncertain significance
GRCh37/hg19 14q12(chr14:31881150-32123495)x3 copy number gain not provided [RCV000846399] Chr14:31881150..32123495 [GRCh37]
Chr14:14q12
uncertain significance
GRCh37/hg19 14q11.2-21.1(chr14:20511672-42881888)x3 copy number gain not provided [RCV001249358] Chr14:20511672..42881888 [GRCh37]
Chr14:14q11.2-21.1
not provided
NM_001197184.3(GPR33):c.812C>T (p.Thr271Met) single nucleotide variant Inborn genetic diseases [RCV003247449] Chr14:31483154 [GRCh38]
Chr14:31952360 [GRCh37]
Chr14:14q12
uncertain significance
NM_001197184.3(GPR33):c.896A>G (p.Tyr299Cys) single nucleotide variant Inborn genetic diseases [RCV003252093] Chr14:31483070 [GRCh38]
Chr14:31952276 [GRCh37]
Chr14:14q12
uncertain significance
GRCh37/hg19 14q11.2-21.2(chr14:20511672-44829030)x3 copy number gain not provided [RCV001006605] Chr14:20511672..44829030 [GRCh37]
Chr14:14q11.2-21.2
pathogenic
NM_001197184.3(GPR33):c.845T>C (p.Ile282Thr) single nucleotide variant Epidermolysis bullosa simplex with nail dystrophy [RCV001089667] Chr14:31483121 [GRCh38]
Chr14:31952327 [GRCh37]
Chr14:14q12
uncertain significance
NUBPL, 240-KB DEL AND 130-KB DUP complex Mitochondrial complex 1 deficiency, nuclear type 21 [RCV000000018]|Parkinson disease, late-onset [RCV001256005] Chr14:31867179..32280475 [GRCh37]
Chr14:14q12
pathogenic
GRCh37/hg19 14q12(chr14:31822348-32145517)x3 copy number gain not provided [RCV001259655] Chr14:31822348..32145517 [GRCh37]
Chr14:14q12
uncertain significance
GRCh37/hg19 14q11.2-21.3(chr14:20511672-47481203) copy number gain Seizure [RCV002280625] Chr14:20511672..47481203 [GRCh37]
Chr14:14q11.2-21.3
pathogenic
NC_000014.8:g.(21162263_36986276)_(36987308_50713602)del deletion Brain-lung-thyroid syndrome [RCV002221171] Chr14:36986276..36987308 [GRCh37]
Chr14:14q11.2-21.3
pathogenic
GRCh37/hg19 14q12-13.1(chr14:24959823-33415359)x1 copy number loss not provided [RCV002475721] Chr14:24959823..33415359 [GRCh37]
Chr14:14q12-13.1
pathogenic
NM_001197184.3(GPR33):c.637G>A (p.Gly213Ser) single nucleotide variant Inborn genetic diseases [RCV002906126] Chr14:31483329 [GRCh38]
Chr14:31952535 [GRCh37]
Chr14:14q12
uncertain significance
NM_001197184.3(GPR33):c.389C>T (p.Thr130Ile) single nucleotide variant Inborn genetic diseases [RCV002873131] Chr14:31483577 [GRCh38]
Chr14:31952783 [GRCh37]
Chr14:14q12
uncertain significance
NM_001197184.3(GPR33):c.427C>T (p.Arg143Cys) single nucleotide variant Inborn genetic diseases [RCV002850427] Chr14:31483539 [GRCh38]
Chr14:31952745 [GRCh37]
Chr14:14q12
uncertain significance
NM_001197184.3(GPR33):c.359C>T (p.Ser120Leu) single nucleotide variant Inborn genetic diseases [RCV002703481] Chr14:31483607 [GRCh38]
Chr14:31952813 [GRCh37]
Chr14:14q12
uncertain significance
NM_001197184.3(GPR33):c.892C>G (p.Leu298Val) single nucleotide variant Inborn genetic diseases [RCV002673216] Chr14:31483074 [GRCh38]
Chr14:31952280 [GRCh37]
Chr14:14q12
uncertain significance
NM_001197184.3(GPR33):c.846A>G (p.Ile282Met) single nucleotide variant Inborn genetic diseases [RCV003183954] Chr14:31483120 [GRCh38]
Chr14:31952326 [GRCh37]
Chr14:14q12
uncertain significance
NM_001197184.3(GPR33):c.66G>T (p.Gln22His) single nucleotide variant Inborn genetic diseases [RCV003220413] Chr14:31483900 [GRCh38]
Chr14:31953106 [GRCh37]
Chr14:14q12
likely benign
NM_001197184.3(GPR33):c.197T>C (p.Leu66Ser) single nucleotide variant Inborn genetic diseases [RCV003210063] Chr14:31483769 [GRCh38]
Chr14:31952975 [GRCh37]
Chr14:14q12
uncertain significance
NM_001197184.3(GPR33):c.377G>A (p.Arg126His) single nucleotide variant Inborn genetic diseases [RCV003361452] Chr14:31483589 [GRCh38]
Chr14:31952795 [GRCh37]
Chr14:14q12
uncertain significance
NM_001197184.3(GPR33):c.878T>C (p.Ile293Thr) single nucleotide variant Inborn genetic diseases [RCV003384866] Chr14:31483088 [GRCh38]
Chr14:31952294 [GRCh37]
Chr14:14q12
uncertain significance
GRCh37/hg19 14q12(chr14:31796875-32027900)x3 copy number gain not provided [RCV003485026] Chr14:31796875..32027900 [GRCh37]
Chr14:14q12
uncertain significance
GRCh37/hg19 14q11.2-23.1(chr14:20511673-61826023)x3 copy number gain not provided [RCV003485022] Chr14:20511673..61826023 [GRCh37]
Chr14:14q11.2-23.1
pathogenic
GRCh37/hg19 14q12(chr14:31841456-32165895)x3 copy number gain not provided [RCV003485028] Chr14:31841456..32165895 [GRCh37]
Chr14:14q12
uncertain significance
GRCh37/hg19 14q12-21.2(chr14:29190489-45325177)x1 copy number loss not specified [RCV003987053] Chr14:29190489..45325177 [GRCh37]
Chr14:14q12-21.2
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:63
Interacting mature miRNAs:65
Transcripts:ENST00000399285
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium
Low 2 1 1 44 1 7 10 3
Below cutoff 238 249 235 95 297 73 487 125 245 84 339 234 24 135 279 1

Sequence


RefSeq Acc Id: ENST00000399285   ⟹   ENSP00000421557
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1431,482,875 - 31,488,039 (-)Ensembl
RefSeq Acc Id: NM_001197184   ⟹   NP_001184113
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381431,482,875 - 31,488,039 (-)NCBI
Sequence:
RefSeq Acc Id: NR_036675
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01425,680,197 - 25,685,200 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001184113 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAR98754 (Get FASTA)   NCBI Sequence Viewer  
  ADJ17324 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000421557
  ENSP00000421557.1
GenBank Protein Q49SQ1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001184113   ⟸   NM_001197184
- UniProtKB: Q49SQ1 (UniProtKB/Swiss-Prot),   D8VER1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000421557   ⟸   ENST00000399285
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q49SQ1-F1-model_v2 AlphaFold Q49SQ1 1-333 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4489 AgrOrtholog
COSMIC GPR33 COSMIC
Ensembl Genes ENSG00000214943 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000399285 ENTREZGENE
  ENST00000399285.5 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000214943 GTEx
HGNC ID HGNC:4489 ENTREZGENE
Human Proteome Map GPR33 Human Proteome Map
InterPro Formyl_rcpt-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2856 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2856 ENTREZGENE
OMIM 610118 OMIM
PANTHER G-PROTEIN COUPLED RECEPTOR 33-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28877 PharmGKB
PRINTS FMETLEUPHER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D8VER1 ENTREZGENE, UniProtKB/TrEMBL
  GPR33_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-05-11 GPR33  G protein-coupled receptor 33  GPR33  G protein-coupled receptor 33 (gene/pseudogene)  Symbol and/or name change 19259463 PROVISIONAL