PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A) - Rat Genome Database

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Pathways
Gene: PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A) Chlorocebus sabaeus
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Symbol: PPM1A
Name: protein phosphatase, Mg2+/Mn2+ dependent 1A
RGD ID: 18572509
Description: ENCODES a protein that exhibits phosphoprotein phosphatase activity (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN cellular response to transforming growth factor beta stimulus (ortholog); N-terminal protein myristoylation (ortholog); negative regulation of BMP signaling pathway (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); lung cancer (ortholog); nonpapillary renal cell carcinoma (ortholog); FOUND IN neuron projection (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein phosphatase 1A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap12436,674,754 - 36,723,377 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366605325,721,273 - 25,769,924 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.12437,474,371 - 37,522,956 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2437,506,914 - 37,516,414 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
PPM1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap12436,674,754 - 36,723,377 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366605325,721,273 - 25,769,924 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.12437,474,371 - 37,522,956 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2437,506,914 - 37,516,414 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
PPM1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381460,245,750 - 60,299,087 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1460,245,752 - 60,299,223 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371460,712,468 - 60,765,805 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361459,782,223 - 59,829,826 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341459,782,222 - 59,829,823NCBI
Celera1440,762,274 - 40,815,941 (+)NCBICelera
Cytogenetic Map14q23.1NCBI
HuRef1440,876,613 - 40,929,690 (+)NCBIHuRef
CHM1_11460,651,750 - 60,705,118 (+)NCBICHM1_1
T2T-CHM13v2.01454,452,043 - 54,505,381 (+)NCBIT2T-CHM13v2.0
Ppm1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391272,804,231 - 72,846,593 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1272,788,165 - 72,846,593 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381272,761,211 - 72,799,819 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1272,757,455 - 72,799,819 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371273,862,198 - 73,895,927 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361273,680,442 - 73,713,400 (+)NCBIMGSCv36mm8
Celera1273,877,430 - 73,911,618 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1230.26NCBI
Ppm1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8697,174,955 - 97,216,585 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl697,174,916 - 97,216,574 (+)EnsemblGRCr8
mRatBN7.2691,439,094 - 91,486,139 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl691,438,834 - 91,480,697 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx691,813,295 - 91,850,303 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0692,112,780 - 92,149,786 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0691,540,724 - 91,577,731 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd698,699,578 - 98,736,584 (+)NCBI
Lyon_Normotensive698,106,622 - 98,143,630 (+)NCBI
Lyon_Hypertensive695,900,349 - 95,937,353 (+)NCBI
F344_StmMcwi695,047,995 - 95,085,022 (+)NCBI
Rnor_6.0694,433,658 - 94,484,979 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl694,429,068 - 94,484,351 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.06103,874,809 - 103,935,598 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4695,162,067 - 95,198,936 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera689,903,080 - 89,939,925 (+)NCBICelera
RGSC_v3.1695,165,522 - 95,202,392 (+)NCBI
Cytogenetic Map6q24NCBI
Ppm1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554669,315,227 - 9,362,028 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554669,315,227 - 9,331,213 (-)NCBIChiLan1.0ChiLan1.0
PPM1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21561,383,205 - 61,436,054 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11460,599,719 - 60,650,493 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01440,853,227 - 40,906,044 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11459,117,020 - 59,169,524 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1459,117,020 - 59,162,928 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
PPM1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1835,336,055 - 35,384,249 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl835,336,140 - 35,377,551 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha835,089,958 - 35,138,127 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0835,569,192 - 35,617,610 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl835,569,135 - 35,612,853 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1835,181,328 - 35,229,483 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0835,258,261 - 35,306,410 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0835,618,239 - 35,666,378 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppm1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1555,839,080 - 55,883,187 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440864069,633,876 - 69,685,180 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364954,542,464 - 4,553,944 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364954,542,576 - 4,560,603 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPM1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1189,207,577 - 189,291,345 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.11189,248,974 - 189,296,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21210,387,426 - 210,406,136 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Ppm1a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1787,030,936 - 87,069,267 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in PPM1A
688 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000012292   ⟹   ENSCSAP00000010335
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2437,506,914 - 37,516,414 (+)Ensembl
RefSeq Acc Id: XM_007986857   ⟹   XP_007985048
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap12436,674,754 - 36,723,377 (+)NCBI
Vero_WHO_p1.0NW_02366605325,721,285 - 25,769,924 (+)NCBI
ChlSab1.12437,474,371 - 37,522,956 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037984079   ⟹   XP_037840007
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap12436,674,768 - 36,723,377 (+)NCBI
Vero_WHO_p1.0NW_02366605325,721,273 - 25,769,924 (+)NCBI
RefSeq Acc Id: XM_037984080   ⟹   XP_037840008
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap12436,696,036 - 36,723,377 (+)NCBI
Vero_WHO_p1.0NW_02366605325,742,491 - 25,769,924 (+)NCBI
RefSeq Acc Id: XM_037984081   ⟹   XP_037840009
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap12436,702,043 - 36,723,377 (+)NCBI
Vero_WHO_p1.0NW_02366605325,748,476 - 25,769,924 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007985048 (Get FASTA)   NCBI Sequence Viewer  
  XP_037840007 (Get FASTA)   NCBI Sequence Viewer  
  XP_037840008 (Get FASTA)   NCBI Sequence Viewer  
  XP_037840009 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010335
  ENSCSAP00000010335.1
RefSeq Acc Id: XP_007985048   ⟸   XM_007986857
- UniProtKB: A0A0D9RNZ6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000010335   ⟸   ENSCSAT00000012292
RefSeq Acc Id: XP_037840007   ⟸   XM_037984079
- UniProtKB: A0A0D9RNZ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037840008   ⟸   XM_037984080
- UniProtKB: A0A0D9RNZ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037840009   ⟸   XM_037984081
- UniProtKB: A0A0D9RNZ6 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014198 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012292.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.430 UniProtKB/TrEMBL
  3.60.40.10 UniProtKB/TrEMBL
InterPro PP2C UniProtKB/TrEMBL
  PP2C_BS UniProtKB/TrEMBL
  PP2C_C UniProtKB/TrEMBL
  PP2C_C_sf UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/TrEMBL
KEGG Report csab:103229109 UniProtKB/TrEMBL
NCBI Gene PPM1A ENTREZGENE
PANTHER PROTEIN PHOSPHATASE UniProtKB/TrEMBL
Pfam PP2C UniProtKB/TrEMBL
  PP2C_C UniProtKB/TrEMBL
PROSITE PPM_1 UniProtKB/TrEMBL
  PPM_2 UniProtKB/TrEMBL
SMART PP2Cc UniProtKB/TrEMBL
Superfamily-SCOP SSF81601 UniProtKB/TrEMBL
  SSF81606 UniProtKB/TrEMBL
UniProt A0A0D9RNZ6 ENTREZGENE, UniProtKB/TrEMBL