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Gene: PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A) Homo sapiens
Symbol: PPM1A
Name: protein phosphatase, Mg2+/Mn2+ dependent 1A
Description: Exhibits R-SMAD binding activity and calmodulin-dependent protein phosphatase activity. Involved in peptidyl-threonine dephosphorylation; positive regulation of transcription, DNA-templated; and regulation of signal transduction. Localizes to the cytosol; nucleus; and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ42306; MGC9201; phosphatase 2C alpha; PP2C-ALPHA; PP2CA; PP2Calpha; protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; protein phosphatase 1a, magnesium dependent, alpha isoform; protein phosphatase 2C alpha isoform; protein phosphatase 2C isoform alpha; protein phosphatase IA
Mus musculus (house mouse) : Ppm1a (protein phosphatase 1A, magnesium dependent, alpha isoform)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ppm1a (protein phosphatase, Mg2+/Mn2+ dependent, 1A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppm1a (protein phosphatase, Mg2+/Mn2+ dependent 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A)
Canis lupus familiaris (dog) : PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppm1a (protein phosphatase, Mg2+/Mn2+ dependent 1A)
Sus scrofa (pig) : PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A)
more info ...
Related Pseudogenes: PPM1AP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381460,245,750 - 60,299,087 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371460,712,470 - 60,765,805 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361459,782,223 - 59,829,826 (+)NCBINCBI36hg18NCBI36
Build 341459,782,222 - 59,829,823NCBI
Celera1440,762,274 - 40,815,941 (+)NCBI
Cytogenetic Map14q23.1NCBI
HuRef1440,876,613 - 40,929,690 (+)NCBIHuRef
CHM1_11460,651,750 - 60,705,118 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PPM1A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731572
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.