Gstz1 (glutathione S-transferase zeta 1) - Rat Genome Database

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Gene: Gstz1 (glutathione S-transferase zeta 1) Rattus norvegicus
Analyze
Symbol: Gstz1
Name: glutathione S-transferase zeta 1
RGD ID: 1589363
Description: Predicted to enable glutathione transferase activity; maleylacetoacetate isomerase activity; and protein homodimerization activity. Involved in cellular detoxification. Is active in cytosol and mitochondrial matrix. Orthologous to human GSTZ1 (glutathione S-transferase zeta 1); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione S-transferase alpha 3; glutathione transferase zeta 1; GSTZ1-1; LOC681913; MAAI; maleylacetoacetate isomerase; similar to Maleylacetoacetate isomerase (MAAI) (Glutathione S-transferase zeta 1) (GSTZ1-1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86112,525,576 - 112,536,228 (+)NCBIGRCr8
mRatBN7.26106,794,594 - 106,805,284 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6106,794,074 - 106,805,284 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6106,962,390 - 106,973,018 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06107,261,228 - 107,271,856 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06106,630,899 - 106,641,529 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06111,176,798 - 111,187,246 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6111,176,798 - 111,187,244 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06120,460,963 - 120,471,411 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6104,615,943 - 104,626,563 (+)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstz1RatCOVID-19  ISOGSTZ1 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Object Symbol
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Term
Qualifier
Evidence
With
Reference
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Original Reference(s)
Gstz1Rathereditary sensory and autonomic neuropathy type 1C  ISOGSTZ1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neuropathy more ...ClinVarPMID:28492532
Gstz1RatMaleylacetoacetate Isomerase Deficiency  ISOGSTZ1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:27876694
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstz1Raturinary bladder cancer  ISOGSTZ1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22306368
Gstz1Ratvestibular disease  ISOGSTZ1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18776599
Object Symbol
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Original Reference(s)
Gstz1RatMaleylacetoacetate Isomerase Deficiency  ISOGSTZ1 (Homo sapiens)7240710 OMIM 

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Object Symbol
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Term
Qualifier
Evidence
With
Reference
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Source
Original Reference(s)
Gstz1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTZ1 mRNA]CTDPMID:31150632
Gstz1Rat(1->4)-beta-D-glucan multiple interactionsISOGstz1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of GSTZ1 mRNACTDPMID:36331819
Gstz1Rat(S)-naringenin increases expressionISOGSTZ1 (Homo sapiens)6480464naringenin results in increased expression of GSTZ1 mRNACTDPMID:24561720
Gstz1Rat(S)-naringenin multiple interactionsISOGSTZ1 (Homo sapiens)6480464Paraquat inhibits the reaction [naringenin results in increased expression of GSTZ1 mRNA]CTDPMID:24561720
Gstz1Rat1,1-dichloroethene decreases expressionISOGstz1 (Mus musculus)6480464vinylidene chloride results in decreased expression of GSTZ1 mRNACTDPMID:26682919
Gstz1Rat1-chloro-2,4-dinitrobenzene affects metabolic processingISOGSTZ1 (Homo sapiens)6480464GSTZ1 protein affects the metabolism of DinitrochlorobenzeneCTDPMID:1846734
Gstz1Rat17alpha-ethynylestradiol multiple interactionsISOGstz1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GSTZ1 mRNACTDPMID:17942748
Gstz1Rat17beta-estradiol decreases expressionISOGstz1 (Mus musculus)6480464Estradiol results in decreased expression of GSTZ1 mRNACTDPMID:39298647
Gstz1Rat17beta-estradiol decreases expressionISOGSTZ1 (Homo sapiens)6480464Estradiol results in decreased expression of GSTZ1 mRNACTDPMID:31614463
Gstz1Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:27291303
Gstz1Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionEXP 64804642 more ...CTDPMID:27291303
Gstz1Rat2,3,7,8-tetrabromodibenzodioxine increases expressionISOGstz1 (Mus musculus)64804642 more ...CTDPMID:27604104
Gstz1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOGstz1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GSTZ1 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GSTZ1 promoter]CTDPMID:17942748 and PMID:19654925
Gstz1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of GSTZ1 mRNACTDPMID:32109520
Gstz1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOGstz1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of GSTZ1 mRNACTDPMID:18163543
Gstz1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOGstz1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of GSTZ1 mRNACTDPMID:21570461
Gstz1Rat2,3,7,8-Tetrachlorodibenzofuran increases expressionEXP 64804642 more ...CTDPMID:32109520
Gstz1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOGstz1 (Mus musculus)64804642 more ...CTDPMID:38648751
Gstz1Rat4,4'-diaminodiphenylmethane decreases expressionISOGstz1 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of GSTZ1 mRNACTDPMID:18648102
Gstz1Rat4,4'-sulfonyldiphenol increases expressionISOGstz1 (Mus musculus)6480464bisphenol S results in increased expression of GSTZ1 mRNACTDPMID:39298647

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Biological Process
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Object Symbol
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Original Reference(s)
Gstz1Rataromatic amino acid metabolic process involved_inIEAInterPro:IPR0059551600115GO_REF:0000002InterProGO_REF:0000002
Gstz1Ratcellular detoxification involved_inIDA 407430016PMID:20884751FlyBase 
Gstz1Ratcellular detoxification involved_inISOGSTZ1 (Homo sapiens)1624291 PMID:20884751RGDPMID:20884751
Gstz1Ratglutathione metabolic process involved_inISOGSTZ1 (Homo sapiens)1624291 PMID:10739172RGDPMID:10739172
Gstz1Ratglutathione metabolic process involved_inIBAFB:FBgn0037696 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gstz1RatL-phenylalanine catabolic process involved_inIEAUniPathway:UPA001391600115GO_REF:0000041UniProtGO_REF:0000041
Gstz1RatL-phenylalanine catabolic process involved_inIBAPANTHER:PTN001344486 and UniProtKB:O431231600115GO_REF:0000033GO_CentralGO_REF:0000033
Gstz1RatL-phenylalanine catabolic process involved_inIEAUniProtKB-KW:KW-05851600115GO_REF:0000043UniProtGO_REF:0000043
Gstz1Rattyrosine catabolic process involved_inIEAUniProtKB-KW:KW-08281600115GO_REF:0000043UniProtGO_REF:0000043
1 to 9 of 9 rows

Cellular Component
1 to 9 of 9 rows

  
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Original Reference(s)
Gstz1Ratcytoplasm located_inIEAInterPro:IPR0059551600115GO_REF:0000002InterProGO_REF:0000002
Gstz1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Gstz1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Gstz1Ratcytosol is_active_inIDA 407430016PMID:20884751FlyBase 
Gstz1Ratcytosol is_active_inISOGSTZ1 (Homo sapiens)1624291 PMID:20884751RGDPMID:20884751
Gstz1Ratmitochondrial matrix is_active_inIDA 407430016PMID:20884751FlyBase 
Gstz1Ratmitochondrion is_active_inISOGSTZ1 (Homo sapiens)1624291 PMID:20884751RGDPMID:20884751
Gstz1Ratmitochondrion is_active_inIBAMGI:1341859 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gstz1Ratmitochondrion located_inISOGstz1 (Mus musculus)1624291 PMID:14651853RGDPMID:14651853
1 to 9 of 9 rows

Molecular Function
1 to 14 of 14 rows

  
Object Symbol
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Reference
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Original Reference(s)
Gstz1Ratcatalytic activity enablesIEAInterPro:IPR0059551600115GO_REF:0000002InterProGO_REF:0000002
Gstz1Ratcatalytic activity enablesIEAUniProtKB-KW:KW-05111600115GO_REF:0000043UniProtGO_REF:0000043
Gstz1Ratglutathione transferase activity enablesISOGSTZ1 (Homo sapiens)1624291 PMID:10739172RGDPMID:10739172
Gstz1Ratglutathione transferase activity enablesIEAEC:2.5.1.181600115GO_REF:0000003UniProtGO_REF:0000003
Gstz1Ratglutathione transferase activity enablesIBAFB:FBgn0037696 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gstz1Ratidentical protein binding enablesISOGSTZ1 (Homo sapiens)1624291UniProtKB:O43708 more ...RGDPMID:16189514 more ...
Gstz1Ratisomerase activity enablesIEAUniProtKB-KW:KW-04131600115GO_REF:0000043UniProtGO_REF:0000043
Gstz1Ratmaleylacetoacetate isomerase activity enablesIEAEC:5.2.1.21600115GO_REF:0000003UniProtGO_REF:0000003
Gstz1Ratmaleylacetoacetate isomerase activity enablesIEARHEA:148171600115GO_REF:0000116RHEAGO_REF:0000116
Gstz1Ratmaleylacetoacetate isomerase activity enablesIBAPANTHER:PTN001344486 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gstz1Ratmaleylacetoacetate isomerase activity enablesISOGSTZ1 (Homo sapiens)1624291 PMID:10739172RGDPMID:10739172
Gstz1Ratprotein binding enablesISOGSTZ1 (Homo sapiens)1624291UniProtKB:P16333 more ...RGDPMID:17474147 and PMID:32296183
Gstz1Ratprotein homodimerization activity enablesISOGSTZ1 (Homo sapiens)1624291UniProtKB:O43708 and PMID:10739172RGDPMID:10739172
Gstz1Rattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
1 to 14 of 14 rows

Imported Annotations - SMPDB

1 to 9 of 9 rows
1 to 9 of 9 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Gstz1Ratglutathione metabolic pathway  IEA 6907045 KEGGrno:00480
Gstz1Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980
Gstz1Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00982
Gstz1Rattyrosine metabolic pathway  IEA 6907045 KEGGrno:00350

External Pathway Database Links

KEGG Pathway Glutathione metabolism


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1. Li W, etal., J Pharmacol Exp Ther. 2011 Jan;336(1):87-94. doi: 10.1124/jpet.110.173195. Epub 2010 Sep 30.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:9531472   PMID:10739172   PMID:11327815   PMID:12477932   PMID:14651853   PMID:16189514   PMID:25416956   PMID:29626439  



Gstz1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86112,525,576 - 112,536,228 (+)NCBIGRCr8
mRatBN7.26106,794,594 - 106,805,284 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6106,794,074 - 106,805,284 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6106,962,390 - 106,973,018 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06107,261,228 - 107,271,856 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06106,630,899 - 106,641,529 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06111,176,798 - 111,187,246 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6111,176,798 - 111,187,244 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06120,460,963 - 120,471,411 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6104,615,943 - 104,626,563 (+)NCBICelera
Cytogenetic Map6q31NCBI
GSTZ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381477,321,036 - 77,331,597 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1477,320,996 - 77,331,597 (+)EnsemblGRCh38hg38GRCh38
GRCh371477,787,379 - 77,797,940 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361476,857,107 - 76,867,693 (+)NCBINCBI36Build 36hg18NCBI36
Build 341476,857,106 - 76,867,692NCBI
Celera1457,825,806 - 57,836,516 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1457,953,339 - 57,964,018 (+)NCBIHuRef
CHM1_11477,726,689 - 77,737,398 (+)NCBICHM1_1
T2T-CHM13v2.01471,530,399 - 71,540,959 (+)NCBIT2T-CHM13v2.0
Gstz1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391287,192,102 - 87,211,497 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1287,193,939 - 87,211,497 (+)EnsemblGRCm39 Ensembl
GRCm381287,147,161 - 87,164,723 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1287,147,165 - 87,164,723 (+)EnsemblGRCm38mm10GRCm38
MGSCv371288,488,668 - 88,505,673 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361288,036,821 - 88,053,826 (+)NCBIMGSCv36mm8
Celera1288,612,223 - 88,629,231 (+)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1241.34NCBI
Gstz1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554381,219,018 - 1,231,287 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554381,218,990 - 1,231,407 (+)NCBIChiLan1.0ChiLan1.0
GSTZ1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21578,404,884 - 78,432,045 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11477,621,388 - 77,648,486 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01457,874,184 - 57,901,397 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11477,075,814 - 77,102,745 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1477,075,814 - 77,086,530 (+)Ensemblpanpan1.1panPan2
GSTZ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1850,133,496 - 50,143,487 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl850,133,714 - 50,143,439 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha849,821,231 - 49,831,169 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0850,367,085 - 50,377,034 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl850,367,124 - 50,377,028 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1850,029,935 - 50,039,870 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0850,052,790 - 50,063,232 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0850,450,973 - 50,460,913 (+)NCBIUU_Cfam_GSD_1.0
Gstz1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864025,910,957 - 25,927,021 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364886,141,317 - 6,154,075 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364886,141,913 - 6,153,591 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSTZ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7100,392,271 - 100,408,420 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17100,392,217 - 100,404,025 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27106,553,162 - 106,564,936 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSTZ1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12454,567,594 - 54,578,262 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2454,567,655 - 54,579,613 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605342,767,574 - 42,778,242 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gstz1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473424,575,540 - 24,595,784 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473424,575,009 - 24,595,944 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Gstz1
40 total Variants

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:145
Interacting mature miRNAs:162
Transcripts:ENSRNOT00000072215
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 29 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat

1 to 10 of 29 rows
RH137359  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26106,805,004 - 106,805,201 (+)MAPPERmRatBN7.2
Rnor_6.06111,186,972 - 111,187,168NCBIRnor6.0
Rnor_5.06120,471,137 - 120,471,333UniSTSRnor5.0
Celera6104,626,291 - 104,626,487UniSTS
RH 3.4 Map6748.89UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000072215   ⟹   ENSRNOP00000065390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6106,794,074 - 106,805,284 (+)Ensembl
Rnor_6.0 Ensembl6111,176,798 - 111,187,244 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082027   ⟹   ENSRNOP00000073813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6106,798,160 - 106,804,566 (+)Ensembl
Rnor_6.0 Ensembl6111,180,108 - 111,186,546 (+)Ensembl
RefSeq Acc Id: NM_001109445   ⟹   NP_001102915
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,525,606 - 112,536,226 (+)NCBI
mRatBN7.26106,794,656 - 106,805,277 (+)NCBI
Rnor_6.06111,176,798 - 111,187,244 (+)NCBI
Rnor_5.06120,460,963 - 120,471,411 (+)NCBI
Celera6104,615,943 - 104,626,563 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240399   ⟹   XP_006240461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,528,968 - 112,536,228 (+)NCBI
mRatBN7.26106,798,069 - 106,805,284 (+)NCBI
Rnor_6.06111,180,209 - 111,187,246 (+)NCBI
Rnor_5.06120,460,963 - 120,471,411 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112925   ⟹   XP_038968853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,525,576 - 112,533,586 (+)NCBI
mRatBN7.26106,794,594 - 106,802,606 (+)NCBI
RefSeq Acc Id: XM_063262472   ⟹   XP_063118542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,529,140 - 112,536,228 (+)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_001102915 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240461 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968853 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118542 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58834 (Get FASTA)   NCBI Sequence Viewer  
  ACI32127 (Get FASTA)   NCBI Sequence Viewer  
  EDL81627 (Get FASTA)   NCBI Sequence Viewer  
  EDL81629 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065390
  ENSRNOP00000073813
GenBank Protein P57113 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_001102915   ⟸   NM_001109445
- UniProtKB: B0BNI1 (UniProtKB/Swiss-Prot),   P57113 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006240461   ⟸   XM_006240399
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6H2 (UniProtKB/TrEMBL),   A6JE83 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073813   ⟸   ENSRNOT00000082027
Ensembl Acc Id: ENSRNOP00000065390   ⟸   ENSRNOT00000072215
RefSeq Acc Id: XP_038968853   ⟸   XM_039112925
- Peptide Label: isoform X2
GST C-terminal   GST N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-P57113-F1-model_v2 AlphaFold P57113 1-216 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694751
Promoter ID:EPDNEW_R5276
Type:multiple initiation site
Name:Gstz1_2
Description:glutathione S-transferase zeta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5278  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06111,176,846 - 111,176,906EPDNEW
RGD ID:13694753
Promoter ID:EPDNEW_R5278
Type:initiation region
Name:Gstz1_1
Description:glutathione S-transferase zeta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5276  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06111,180,288 - 111,180,348EPDNEW


1 to 38 of 38 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-36726 BioCyc
BioCyc Pathway TYRFUMCAT-PWY [L-tyrosine degradation I] BioCyc
BioCyc Pathway Image TYRFUMCAT-PWY BioCyc
Ensembl Genes ENSRNOG00000047708 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000072215 ENTREZGENE
  ENSRNOT00000082027 ENTREZGENE
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7381517 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  GST_Zeta UniProtKB/Swiss-Prot
  GST_Zeta_C UniProtKB/Swiss-Prot
  GST_Zeta_N UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:681913 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188285 IMAGE-MGC_LOAD
NCBI Gene 681913 ENTREZGENE
PANTHER MALEYLACETOACETATE ISOMERASE UniProtKB/Swiss-Prot
  MALEYLACETOACETATE ISOMERASE UniProtKB/Swiss-Prot
Pfam GST_C_3 UniProtKB/Swiss-Prot
  GST_N_2 UniProtKB/Swiss-Prot
PhenoGen Gstz1 PhenoGen
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047708 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
UniProt A0A0G2K6H2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QW65_RAT UniProtKB/TrEMBL
  A6JE83 ENTREZGENE, UniProtKB/TrEMBL
  A6JE85 ENTREZGENE, UniProtKB/TrEMBL
  B0BNI1 ENTREZGENE
  MAAI_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B0BNI1 UniProtKB/Swiss-Prot
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-16 Gstz1  glutathione S-transferase zeta 1  Gstz1  glutathione transferase zeta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-02 Gstz1  glutathione transferase zeta 1  LOC681913  similar to Maleylacetoacetate isomerase (MAAI) (Glutathione S-transferase zeta 1) (GSTZ1-1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC681913  similar to Maleylacetoacetate isomerase (MAAI) (Glutathione S-transferase zeta 1) (GSTZ1-1)      Symbol and Name status set to provisional 70820 PROVISIONAL