Angpt2 (angiopoietin 2) - Rat Genome Database

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Gene: Angpt2 (angiopoietin 2) Rattus norvegicus
Symbol: Angpt2
Name: angiopoietin 2
RGD ID: 621861
Description: Predicted to enable receptor tyrosine kinase binding activity. Involved in several processes, including blood vessel development; maternal process involved in female pregnancy; and positive regulation of angiogenesis. Located in cell projection and extracellular space. Used to study several diseases, including ischemia (multiple); membranoproliferative glomerulonephritis; portal hypertension; retinal disease (multiple); and uremia. Biomarker of several diseases, including Caroli disease; artery disease (multiple); gastric ulcer; glomerulonephritis (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human ANGPT2 (angiopoietin 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 3,7-dihydropurine-6-thione.
Type: protein-coding
Previously known as: Agpt2; Ang-2; angiopoietin-2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81677,790,760 - 77,841,241 (+)NCBIGRCr8
mRatBN7.21671,088,364 - 71,138,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1671,088,364 - 71,138,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1676,365,217 - 76,415,702 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,811,900 - 79,862,566 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01675,061,325 - 75,111,991 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,966,480 - 76,016,147 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,966,352 - 76,016,195 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01675,572,301 - 75,621,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,891,757 - 75,942,255 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11675,934,743 - 75,941,749 (+)NCBI
Celera1668,933,847 - 68,984,314 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
atorvastatin calcium  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
BQ 123  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
Curcumol  (EXP)
daunorubicin  (EXP)
diarsenic trioxide  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
dorsomorphin  (ISO)
enalapril  (EXP)
epoxiconazole  (ISO)
furosemide  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
iloprost  (ISO)
indometacin  (EXP)
isoprenaline  (EXP)
letrozole  (ISO)
lidocaine  (EXP)
LY294002  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mercaptopurine  (EXP)
methamphetamine  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotinic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
palytoxin  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PD123319  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propranolol  (ISO)
purine-6-thiol  (EXP)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
simvastatin  (EXP)
streptozocin  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vorinostat  (ISO)


References - curated
# Reference Title Reference Citation
1. Spatiotemporal analysis of the protein expression of angiogenic factors and their related receptors during folliculogenesis in rats with and without hormonal treatment. Abramovich D, etal., Reproduction. 2009 Feb;137(2):309-20. Epub 2008 Nov 7.
2. Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model. Ardelt AA, etal., Stroke. 2005 Feb;36(2):337-41. Epub 2005 Jan 6.
3. Mechanical load induced by glass microspheres releases angiogenic factors from neonatal rat ventricular myocytes cultures and causes arrhythmias. Barac DY, etal., J Cell Mol Med. 2008 Oct;12(5B):2037-51. doi: 10.1111/j.1582-4934.2008.00193.x.
4. Alteration of gene expression in rat colon mucosa after exercise. Buehlmeyer K, etal., Ann Anat. 2008;190(1):71-80. Epub 2007 May 23.
5. Angiopoietin 1 and 2 gene and protein expression is differentially regulated in acute anti-Thy1.1 glomerulonephritis. Campean V, etal., Am J Physiol Renal Physiol. 2008 May;294(5):F1174-84. Epub 2008 Feb 13.
6. Temporal changes of angiopoietins and Tie2 expression in rat lungs after monocrotaline-induced pulmonary hypertension. Cho YJ, etal., Comp Med. 2009 Aug;59(4):350-6.
7. Compensatory growth of coronary arterioles in postinfarcted heart: regional differences in DNA synthesis and growth factor/receptor expression patterns. Dedkov EI, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1686-93. Epub 2006 May 19.
8. Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases. Fabris L, etal., Hepatology. 2006 May;43(5):1001-12.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy. Hammes HP, etal., Diabetes. 2004 Apr;53(4):1104-10.
12. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Holash J, etal., Science. 1999 Jun 18;284(5422):1994-8.
13. Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2. Hu B, etal., Proc Natl Acad Sci U S A 2003 Jul 22;100(15):8904-9. Epub 2003 Jul 14.
14. Angiogenesis-related biomarkers in patients with alcoholic liver disease: their association with liver disease complications and outcome. Kasztelan-Szczerbinska B, etal., Mediators Inflamm. 2014;2014:673032. doi: 10.1155/2014/673032. Epub 2014 May 18.
15. The effect of recombinant human erythropoietin on neurovasculature repair after focal ischemic stroke in neonatal rats. Keogh CL, etal., J Pharmacol Exp Ther. 2007 Aug;322(2):521-8. Epub 2007 May 9.
16. Angiopoietin/tie receptors system may play a role during reconstruction and capillarization of the hepatic sinusoids after partial hepatectomy and liver necrosis in rats. Kimura H, etal., Hepatol Res. 2004 May;29(1):51-59.
17. Pathological but not physiological retinal neovascularization is altered in TNF-Rp55-receptor-deficient mice. Kociok N, etal., Invest Ophthalmol Vis Sci. 2006 Nov;47(11):5057-65.
18. Angiopoietin-1 and angiopoietin-2 in diabetes mellitus: relationship to VEGF, glycaemic control, endothelial damage/dysfunction and atherosclerosis. Lim HS, etal., Atherosclerosis. 2005 May;180(1):113-8. Epub 2004 Dec 21.
19. Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy. Lin J, etal., Diabetologia. 2006 May;49(5):1089-96. Epub 2006 Mar 7.
20. Angiopoietic factors and retinopathy in pregnancies complicated with Type 1 diabetes. Loukovaara S, etal., Diabet Med. 2004 Jul;21(7):697-704.
21. Expressions of Angiopoietin-1, Angiopoietin-2, and Tie2 and their roles in rat renal allografts with chronic allograft nephropathy. Ma X, etal., Transplant Proc. 2008 Oct;40(8):2795-9.
22. Rapamycin and cyclosporine have different effects on expression of Ang-1 and Ang-2 and Tie2 in rat renal allograft with chronic allograft nephropathy. Ma X, etal., Transplant Proc. 2008 Oct;40(8):2804-7.
23. Angiotensin II promotes development of the renal microcirculation through AT1 receptors. Madsen K, etal., J Am Soc Nephrol. 2010 Mar;21(3):448-59. doi: 10.1681/ASN.2009010045. Epub 2010 Jan 7.
24. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Mandriota SJ and Pepper MS, Circ Res 1998 Oct 19;83(8):852-9.
25. Effects of atorvastatin on angiogenesis in hindlimb ischemia and endothelial progenitor cell formation in rats. Matsumura M, etal., J Atheroscler Thromb. 2009 Aug;16(4):319-26. Epub 2009 Aug 11.
26. Changes in vascular leakage and expression of angiopoietins in the corpus luteum during pregnancy in rats. Matsuoka-Sakata A, etal., Reproduction. 2006 Feb;131(2):351-60.
27. Vascular endothelial growth factor and angiopoietin-2 play a major role in the pathogenesis of vascular leakage in cirrhotic rats. Melgar-Lesmes P, etal., Gut. 2009 Feb;58(2):285-92. Epub 2008 Oct 31.
28. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
29. Increased 5-lipoxygenase activating protein in immune-mediated experimental nephritis. Montero A, etal., J Nephrol. 2003 Sep-Oct;16(5):682-90.
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. Expression of angiopoietin-1 and -2, and its clinical significance in human bladder cancer. Oka N, etal., BJU Int. 2005 Mar;95(4):660-3.
32. Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Oliner J, etal., Cancer Cell. 2004 Nov;6(5):507-16.
33. Immunohistochemical study of VEGF, angiopoietin 2 and their receptors in the neovascularization following microinjection of C6 glioma cells into rat brain. Peoch M, etal., Anticancer Res 2002 Jul-Aug;22(4):2147-51.
34. Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells. Phelps ED, etal., Am J Physiol Cell Physiol. 2006 Feb;290(2):C352-61. Epub 2005 Sep 21.
35. Angiopoietin-2 and rat brain capillary remodeling during adaptation and deadaptation to prolonged mild hypoxia. Pichiule P and LaManna JC, J Appl Physiol 2002 Sep;93(3):1131-9.
36. GOA pipeline RGD automated data pipeline
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Comprehensive gene review and curation RGD comprehensive gene curation
40. Temporal renal expression of angiogenic growth factors and their receptors in experimental diabetes: role of the renin-angiotensin system. Rizkalla B, etal., J Hypertens. 2005 Jan;23(1):153-64.
41. Downregulation of angiogenic factors and their downstream target molecules affects the deterioration of erectile function in a rat model of hypercholesterolemia. Ryu JK, etal., Urology. 2006 Jun;67(6):1329-34.
42. Angiogenic factors in normal endometrium and endometrial adenocarcinoma. Saito M, etal., Pathol Int. 2007 Mar;57(3):140-7.
43. Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats. Shimizu H, etal., World J Gastroenterol. 2005 Dec 14;11(46):7254-60.
44. Increased expression of angiopoietin-2 and Tie2 receptor in a rat model of myocardial ischaemia/reperfusion. Shyu KG, etal., Clin Sci (Lond). 2003 Sep;105(3):287-94.
45. Vascular factors altered in glucose-treated mesangial cells and diabetic glomeruli. Changes in vascular factors impair endothelial cell growth and matrix. Singh AK, etal., Lab Invest. 2004 May;84(5):597-606.
46. Insulin-like growth factors, angiopoietin-2, and pigment epithelium-derived growth factor in the hypoxic retina. Sivakumar V, etal., J Neurosci Res. 2008 Feb 15;86(3):702-11.
47. Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients. Smadja DM, etal., Angiogenesis. 2020 May 27. pii: 10.1007/s10456-020-09730-0. doi: 10.1007/s10456-020-09730-0.
48. Infusion of angiotensin II reduces loss of glomerular capillary area in the early phase of anti-Thy-1.1 nephritis possibly via regulating angiogenesis-associated factors. Takazawa Y, etal., Kidney Int. 2005 Aug;68(2):704-22.
49. Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2. Tepper OM, etal., FASEB J. 2004 Aug;18(11):1231-3. Epub 2004 Jun 18.
50. Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension. Tiani C, etal., J Hepatol. 2009 Feb;50(2):296-305. Epub 2008 Dec 4.
51. Zone-specific remodeling of tumor blood vessels affects tumor growth. Tilki D, etal., Cancer. 2007 Nov 15;110(10):2347-62.
52. Gene array analysis of a rat model of pulmonary arteriovenous malformations after superior cavopulmonary anastomosis. Tipps RS, etal., J Thorac Cardiovasc Surg. 2008 Aug;136(2):283-9.
53. Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2. Vajkoczy P, etal., J Clin Invest 2002 Mar;109(6):777-85.
54. Assessment of blood volume, vessel size, and the expression of angiogenic factors in two rat glioma models: a longitudinal in vivo and ex vivo study. Valable S, etal., NMR Biomed. 2008 Nov;21(10):1043-56.
55. Kinetics of strain-dependent differential gene expression in oxygen-induced retinopathy in the rat. van Wijngaarden P, etal., Exp Eye Res. 2007 Oct;85(4):508-17. Epub 2007 Jul 10.
56. Postischemic angiogenic factor expression in stroke-prone rats. Wang MM, etal., Exp Neurol 2002 Feb;173(2):283-8.
57. Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing. Wen CY, etal., J Gastroenterol. 2003;38(5):431-5.
58. Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2. White RR, etal., Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5028-33. Epub 2003 Apr 11.
59. Regulation of angiopoietin and Tie-2 receptor expression in non-reproductive tissues by estrogen. Ye F, etal., Steroids 2002 Mar;67(3-4):305-10.
60. Peritoneal morphologic changes in a peritoneal dialysis rat model correlate with angiopoietin/Tie-2. Yuan J, etal., Pediatr Nephrol. 2009 Jan;24(1):163-70. Epub 2008 Aug 28.
61. Proangiogenic effects of protease-activated receptor 2 are tumor necrosis factor-alpha and consecutively Tie2 dependent. Zhu T, etal., Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):744-50. Epub 2006 Jan 26.
Additional References at PubMed
PMID:9204896   PMID:9660821   PMID:9846489   PMID:12477932   PMID:12580449   PMID:12773423   PMID:12937129   PMID:14966366   PMID:15509526   PMID:15579434   PMID:16056241   PMID:16778080  
PMID:19168695   PMID:19573435   PMID:19900368   PMID:19922791   PMID:20562294   PMID:20969813   PMID:21515377   PMID:22020092   PMID:22336210   PMID:22869617   PMID:23049737   PMID:23378030  
PMID:24006456   PMID:24612347   PMID:25759532   PMID:26781077   PMID:28179430   PMID:28637680   PMID:32720664   PMID:35289235  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81677,790,760 - 77,841,241 (+)NCBIGRCr8
mRatBN7.21671,088,364 - 71,138,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1671,088,364 - 71,138,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1676,365,217 - 76,415,702 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,811,900 - 79,862,566 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01675,061,325 - 75,111,991 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,966,480 - 76,016,147 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,966,352 - 76,016,195 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01675,572,301 - 75,621,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,891,757 - 75,942,255 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11675,934,743 - 75,941,749 (+)NCBI
Celera1668,933,847 - 68,984,314 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3886,499,632 - 6,563,245 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl86,499,632 - 6,563,409 (-)EnsemblGRCh38hg38GRCh38
GRCh3786,357,153 - 6,420,766 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3686,347,601 - 6,408,170 (-)NCBINCBI36Build 36hg18NCBI36
Build 3486,347,600 - 6,408,172NCBI
Celera86,334,650 - 6,398,296 (-)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef86,139,162 - 6,202,785 (-)NCBIHuRef
CHM1_186,445,906 - 6,509,954 (-)NCBICHM1_1
T2T-CHM13v2.086,254,102 - 6,317,682 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39818,740,279 - 18,791,578 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl818,740,279 - 18,791,578 (-)EnsemblGRCm39 Ensembl
GRCm38818,690,263 - 18,741,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl818,690,263 - 18,741,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv37818,691,337 - 18,741,551 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36818,691,314 - 18,741,528 (-)NCBIMGSCv36mm8
Celera818,824,534 - 18,875,113 (-)NCBICelera
Cytogenetic Map8A1.3NCBI
cM Map810.3NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540354,139,823 - 54,195,032 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540354,139,823 - 54,193,740 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2721,294,413 - 21,380,483 (-)NCBINHGRI_mPanPan1-v2
Mhudiblu_PPA_v08718,367 - 782,534 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.186,506,012 - 6,566,915 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl86,506,014 - 6,566,915 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11658,404,049 - 58,458,344 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1658,405,259 - 58,457,701 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1653,935,215 - 53,987,886 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01657,592,625 - 57,645,271 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1657,592,730 - 57,645,741 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11658,549,239 - 58,616,758 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01655,601,814 - 55,654,409 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01655,977,188 - 56,030,293 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244049434,473,275 - 4,524,605 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366154,472,247 - 4,524,556 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366154,472,261 - 4,524,537 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1537,544,707 - 37,599,041 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11537,544,177 - 37,600,925 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21542,687,923 - 42,787,653 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.186,283,619 - 6,345,320 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl86,280,584 - 6,344,729 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605448,397,826 - 48,458,677 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248614,457,158 - 4,509,623 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248614,457,519 - 4,510,035 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Angpt2
291 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:344
Count of miRNA genes:201
Interacting mature miRNAs:238
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21671,138,572 - 71,138,771 (+)MAPPERmRatBN7.2
Rnor_6.01676,015,918 - 76,016,113NCBIRnor6.0
Rnor_5.01675,621,739 - 75,621,934UniSTSRnor5.0
RGSC_v3.41675,942,023 - 75,942,221UniSTSRGSC3.4
Celera1668,984,082 - 68,984,280UniSTS
RH 3.4 Map16694.1UniSTS
Cytogenetic Map16q12.5UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21671,138,553 - 71,138,738 (+)MAPPERmRatBN7.2
Rnor_6.01676,015,899 - 76,016,080NCBIRnor6.0
Rnor_5.01675,621,720 - 75,621,901UniSTSRnor5.0
RGSC_v3.41675,942,004 - 75,942,188UniSTSRGSC3.4
Celera1668,984,063 - 68,984,247UniSTS
RH 3.4 Map16697.0UniSTS
Cytogenetic Map16q12.5UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21671,089,708 - 71,089,894 (+)MAPPERmRatBN7.2
Rnor_6.01675,967,825 - 75,968,010NCBIRnor6.0
Rnor_5.01675,573,646 - 75,573,831UniSTSRnor5.0
RGSC_v3.41675,893,102 - 75,893,287UniSTSRGSC3.4
Celera1668,935,192 - 68,935,377UniSTS
RH 3.4 Map16704.71UniSTS
Cytogenetic Map16q12.5UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 5 10 28 11 6
Low 3 43 43 32 9 32 8 11 74 7 30 5 8
Below cutoff 9 9 9


RefSeq Acc Id: ENSRNOT00000022774   ⟹   ENSRNOP00000022774
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1671,088,364 - 71,138,804 (+)Ensembl
Rnor_6.0 Ensembl1675,966,352 - 76,016,195 (+)Ensembl
RefSeq Acc Id: NM_134454   ⟹   NP_604449
Rat AssemblyChrPosition (strand)Source
GRCr81677,790,760 - 77,841,241 (+)NCBI
mRatBN7.21671,088,364 - 71,138,805 (+)NCBI
Rnor_6.01675,966,480 - 76,016,147 (+)NCBI
Rnor_5.01675,572,301 - 75,621,968 (+)NCBI
RGSC_v3.41675,891,757 - 75,942,255 (+)RGD
Celera1668,933,847 - 68,984,314 (+)RGD
RefSeq Acc Id: NP_604449   ⟸   NM_134454
- Peptide Label: precursor
- UniProtKB: B1WBY0 (UniProtKB/Swiss-Prot),   Q548N5 (UniProtKB/Swiss-Prot),   O35462 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022774   ⟸   ENSRNOT00000022774
Protein Domains
Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35462-F1-model_v2 AlphaFold O35462 1-496 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700217
Promoter ID:EPDNEW_R10741
Type:single initiation site
Description:angiopoietin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01675,966,283 - 75,966,343EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621861 AgrOrtholog
BioCyc Gene G2FUF-10804 BioCyc
Ensembl Genes ENSRNOG00000016696 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055008284 UniProtKB/Swiss-Prot
  ENSRNOG00060021324 UniProtKB/Swiss-Prot
  ENSRNOG00065009041 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022774 ENTREZGENE
  ENSRNOT00000022774.7 UniProtKB/Swiss-Prot
  ENSRNOT00055014001 UniProtKB/Swiss-Prot
  ENSRNOT00060036958 UniProtKB/Swiss-Prot
  ENSRNOT00065014451 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot
  Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 UniProtKB/Swiss-Prot
InterPro Fibrinogen-like_C UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_C_dom UniProtKB/Swiss-Prot
  Fibrinogen_CS UniProtKB/Swiss-Prot
KEGG Report rno:89805 UniProtKB/Swiss-Prot
  PTHR19143:SF199 UniProtKB/Swiss-Prot
Pfam Fibrinogen_C UniProtKB/Swiss-Prot
PhenoGen Angpt2 PhenoGen
  FIBRINOGEN_C_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016696 RatGTEx
  ENSRNOG00055008284 RatGTEx
  ENSRNOG00060021324 RatGTEx
  ENSRNOG00065009041 RatGTEx
SMART FBG UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56496 UniProtKB/Swiss-Prot
UniProt ANGP2_RAT UniProtKB/Swiss-Prot
UniProt Secondary B1WBY0 UniProtKB/Swiss-Prot
  Q548N5 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Angpt2  angiopoietin 2  Agpt2    Symbol updated 1299863 APPROVED
2005-01-20 Agpt2  angiopoietin 2    angiopoietin-2  Name updated 1299863 APPROVED
2002-08-07 Agpt2  angiopoietin-2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression increased after stroke 704373
gene_process mediates initiation of vascular growth by angiogenic sprouting; plays a role in remodeling of the initial microvasculature 625690