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Gene: ANGPT2 (angiopoietin 2) Homo sapiens
Symbol: ANGPT2
Name: angiopoietin 2
Description: Exhibits receptor tyrosine kinase binding activity. Involved in several processes, including Tie signaling pathway; negative regulation of blood vessel endothelial cell migration; and negative regulation of positive chemotaxis. Localizes to extracellular space. Biomarker of endometrial adenocarcinoma; transitional cell carcinoma; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AGPT2; ANG-2; ANG2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; Tie2-ligand
Mus musculus (house mouse) : Angpt2 (angiopoietin 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Angpt2 (angiopoietin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Angpt2 (angiopoietin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ANGPT2 (angiopoietin 2)
Canis lupus familiaris (dog) : ANGPT2 (angiopoietin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Angpt2 (angiopoietin 2)
Sus scrofa (pig) : ANGPT2 (angiopoietin 2)
Chlorocebus sabaeus (African green monkey) : ANGPT2 (angiopoietin 2)
Heterocephalus glaber (naked mole-rat) : Angpt2 (angiopoietin 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl86,499,651 - 6,563,409 (-)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl86,499,632 - 6,563,409 (-)EnsemblGRCh38hg38GRCh38
GRCh3886,499,632 - 6,563,420 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3786,357,172 - 6,420,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3686,347,601 - 6,408,170 (-)NCBINCBI36hg18NCBI36
Build 3486,347,600 - 6,408,172NCBI
Celera86,334,650 - 6,398,296 (-)NCBI
Cytogenetic Map8p23.1NCBI
HuRef86,139,162 - 6,202,785 (-)NCBIHuRef
CHM1_186,445,906 - 6,509,954 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ANGPT2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730844
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-05-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.