Nrg1 (neuregulin 1) - Rat Genome Database

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Gene: Nrg1 (neuregulin 1) Rattus norvegicus
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Symbol: Nrg1
Name: neuregulin 1
RGD ID: 621341
Description: Enables receptor tyrosine kinase binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; cellular response to organonitrogen compound; and positive regulation of cell population proliferation. Located in several cellular components, including dendrite; extracellular space; and neuronal cell body. Used to study sciatic neuropathy. Biomarker of diabetic neuropathy; median neuropathy; overactive bladder syndrome; schizophrenia; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glial growth factor; neuregulin 1 type III beta 3; pro-neuregulin-1, membrane-bound isoform; pro-NRG1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nrg1Tn(sb-T2/Bart3)2.183Mcwi  
Genetic Models: F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81665,954,084 - 67,007,484 (+)NCBIGRCr8
mRatBN7.21659,250,658 - 60,304,519 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1659,250,854 - 60,296,884 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1664,587,755 - 65,638,290 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01668,001,434 - 69,052,009 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01663,221,979 - 64,273,342 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01662,969,573 - 64,065,063 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1663,837,216 - 64,057,434 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01662,632,432 - 63,718,738 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41663,937,796 - 64,126,183 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11663,937,870 - 64,126,262 (+)NCBI
Celera1657,283,140 - 58,311,856 (+)NCBICelera
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alcohol use disorder  (ISO)
Alzheimer's disease  (IDA,ISO)
amblyopia  (IEP)
amphetamine abuse  (ISO)
amyotrophic lateral sclerosis  (ISO)
bipolar disorder  (IEP,ISO)
Breast Neoplasms  (ISO)
cannabis abuse  (ISO)
cannabis dependence  (ISO)
Cardiotoxicity  (ISO)
cerebral malaria  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease type 1A  (ISO)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
COVID-19  (ISO)
dementia  (ISO)
demyelinating disease  (ISO)
Diabetic Cardiomyopathies  (IEP)
diabetic neuropathy  (IEP)
epilepsy  (IEP)
Experimental Liver Cirrhosis  (ISO)
Febrile Seizures  (ISO)
gastric ulcer  (ISO)
hepatocellular carcinoma  (ISO)
hereditary spastic paraplegia  (ISO)
Hirschsprung's disease  (ISO)
Hyperalgesia  (IEP)
influenza  (ISO)
interstitial cystitis  (IEP)
juvenile rheumatoid arthritis  (ISO)
Lung Neoplasms  (ISO)
major depressive disorder  (ISO)
median neuropathy  (IEP)
middle cerebral artery infarction  (ISO)
movement disease  (ISO)
myocardial infarction  (IEP,ISO)
Neointima  (IEP)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
Nerve Degeneration  (IEP)
neuropathy  (IEP)
obstructive sleep apnea  (ISO)
ovarian cancer  (ISO)
overactive bladder syndrome  (IEP)
Pain  (ISO)
polycystic ovary syndrome  (ISO)
psychotic disorder  (ISO)
schizophrenia  (IEP,ISO,ISS)
schizophrenia 6  (ISO)
sciatic neuropathy  (IMP)
skin papilloma  (ISO)
Spinal Cord Injuries  (IDA,ISO)
stress-related disorder  (IEP,IMP)
Subarachnoid Hemorrhage  (ISO)
substance abuse  (ISO)
Tobacco Use Disorder  (ISO)
transient cerebral ischemia  (ISO)
tuberculosis  (ISO)
Viral Myocarditis  (ISO)
visual epilepsy  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-D  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
AACOCF3  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
androgen antagonist  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylparaben  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (EXP,ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
etoposide  (ISO)
fenamidone  (ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
haloperidol  (EXP)
Heliotrine  (EXP)
hydrogen peroxide  (EXP)
indole-3-methanol  (EXP)
ketamine  (ISO)
L-methionine  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
LY294002  (EXP,ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP)
naphthalene  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
ochratoxin A  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
PCB138  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
propylparaben  (ISO)
prostaglandin E2  (ISO)
Ptaquiloside  (ISO)
pyrimidifen  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
risperidone  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
senecionine  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tephrosin  (ISO)
terbufos  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc sulfate  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IBA)
cardiac conduction system development  (ISO)
cardiac muscle cell apoptotic process  (IEP)
cardiac muscle cell differentiation  (ISO)
cardiac muscle cell myoblast differentiation  (IEA,ISO)
cardiac muscle tissue development  (ISO)
cell differentiation  (IBA)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (ISO)
cellular response to acetylcholine  (IEP)
cellular response to brain-derived neurotrophic factor stimulus  (IEP)
cellular response to ciliary neurotrophic factor  (IEP)
cellular response to L-glutamate  (IEP)
cellular response to mechanical stimulus  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to potassium ion  (IEP)
cellular response to serotonin  (IEP)
chemorepulsion involved in interneuron migration from the subpallium to the cortex  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
endocardial cell differentiation  (IEA,ISO)
ERBB signaling pathway  (ISO,ISS)
ERBB2-ERBB3 signaling pathway  (IEA,ISO)
ERBB2-ERBB4 signaling pathway  (IEA,ISO)
ERBB3 signaling pathway  (ISO)
ERBB4 signaling pathway  (ISO)
ERBB4-ERBB4 signaling pathway  (IEA,ISO)
female pregnancy  (IEP)
glial cell differentiation  (ISO)
glial cell fate commitment  (ISO)
heart development  (ISO)
intracellular signal transduction  (IBA)
locomotory behavior  (IDA,ISO)
MAPK cascade  (ISO)
memory  (IMP)
multicellular organismal response to stress  (IEP)
muscle organ development  (ISO)
myelination  (ISO)
myelination in peripheral nervous system  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of corticosterone secretion  (IMP)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of neuron migration  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of secretion  (IEA,ISO)
nervous system development  (IBA,IEA,ISO)
neuron fate commitment  (ISO)
neuron migration  (ISO)
oligodendrocyte differentiation  (ISO)
peripheral nervous system development  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of axon regeneration  (IDA)
positive regulation of calcineurin-NFAT signaling cascade  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell population proliferation  (IDA,IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO,ISS)
positive regulation of gene expression  (ISO)
positive regulation of membrane permeability  (IMP)
positive regulation of neural precursor cell proliferation  (IMP)
positive regulation of neuron projection development  (IDA)
positive regulation of peptidyl-tyrosine autophosphorylation  (IDA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein-containing complex assembly  (IEA,ISO)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of Schwann cell proliferation  (IMP)
positive regulation of striated muscle cell differentiation  (ISO)
postsynapse to nucleus signaling pathway  (ISO)
protein catabolic process  (ISO)
regulation of cell differentiation  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of presynapse assembly  (ISO)
response to dexamethasone  (IEP)
response to muscle activity  (IEP)
response to nutrient levels  (IEP)
response to progesterone  (IEP)
response to stress  (IEP)
response to vitamin D  (IEP)
Schwann cell development  (ISO)
Schwann cell differentiation  (ISO)
sensory perception of pain  (ISO)
sequestering of metal ion  (ISO)
signal transduction  (IEA)
synapse assembly  (ISO)
synaptic membrane adhesion  (ISO)
ventricular cardiac muscle cell differentiation  (ISO)
ventricular trabecula myocardium morphogenesis  (IEA,ISO)
wound healing  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Neonatal infection with neurotropic influenza A virus affects working memory and expression of type III Nrg1 in adult mice. Asp L, etal., Brain Behav Immun. 2009 Aug;23(6):733-41. doi: 10.1016/j.bbi.2009.04.004. Epub 2009 Apr 10.
2. Morphological and biomolecular characterization of the neonatal olfactory bulb ensheathing cell line. Audisio C, etal., J Neurosci Methods. 2009 Dec 15;185(1):89-98. doi: 10.1016/j.jneumeth.2009.09.021. Epub 2009 Sep 26.
3. Neuregulin-1 is increased in schizophrenia patients with chronic cannabis abuse: Preliminary results. Aukst Margetic B, etal., Schizophr Res. 2019 Jun;208:473-474. doi: 10.1016/j.schres.2019.02.007. Epub 2019 Feb 22.
4. Associations of Sleep Apnea, NRG1 Polymorphisms, Alcohol Consumption, and Cerebral White Matter Hyperintensities: Analysis with Genome-Wide Association Data. Baik I, etal., Sleep. 2015 Jul 1;38(7):1137-43. doi: 10.5665/sleep.4830.
5. Differential localization of neuregulin-1 type III in the central and peripheral nervous system. Bare DJ, etal., Brain Res. 2011 Jan 19;1369:10-20. doi: 10.1016/j.brainres.2010.10.092. Epub 2010 Oct 31.
6. Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury. Bartus K, etal., Brain. 2016 Mar 17. pii: aww039.
7. Heregulin-1ß and HER3 in hepatocellular carcinoma: status and regulation by insulin. Buta C, etal., J Exp Clin Cancer Res. 2016 Aug 11;35(1):126. doi: 10.1186/s13046-016-0402-3.
8. Exercise training activates neuregulin 1/ErbB signaling and promotes cardiac repair in a rat myocardial infarction model. Cai MX, etal., Life Sci. 2016 Mar 15;149:1-9. doi: 10.1016/j.lfs.2016.02.055. Epub 2016 Feb 15.
9. Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer disease brain and in a transgenic model of Alzheimer disease. Chaudhury AR, etal., J Neuropathol Exp Neurol. 2003 Jan;62(1):42-54.
10. Neuregulin-1-ErbB signaling promotes microglia activation contributing to mechanical allodynia of cyclophosphamide-induced cystitis. Chen JL, etal., Neurourol Urodyn. 2019 Jun;38(5):1250-1260. doi: 10.1002/nau.24005. Epub 2019 Apr 15.
11. Ranolazine protects against diabetic cardiomyopathy by activating the NOTCH1/NRG1 pathway. Chen X, etal., Life Sci. 2020 Nov 15;261:118306. doi: 10.1016/j.lfs.2020.118306. Epub 2020 Aug 21.
12. Interfering effect and mechanism of neuregulin on experimental dementia model in rats. Chen Y, etal., Behav Brain Res. 2011 Sep 23;222(2):321-5. doi: 10.1016/j.bbr.2011.03.063. Epub 2011 Apr 5.
13. Neuregulin-1 attenuates neointimal formation following vascular injury and inhibits the proliferation of vascular smooth muscle cells. Clement CM, etal., J Vasc Res. 2007;44(4):303-12. Epub 2007 Apr 16.
14. Unique properties of lamp2a compared to other lamp2 isoforms. Cuervo AM and Dice JF, J Cell Sci. 2000 Dec;113 Pt 24:4441-50.
15. Estrogen receptor alpha modulates Toll-like receptor signaling in murine lupus. Cunningham MA, etal., Clin Immunol. 2012 Jul;144(1):1-12. doi: 10.1016/j.clim.2012.04.001. Epub 2012 Apr 20.
16. Chronic administration of calcitriol enhanced neuregulin-1/ErbB signaling in rat myocardium. Dang R, etal., Pharmazie. 2016 Apr;71(4):192-5.
17. Chronic stress and excessive glucocorticoid exposure both lead to altered Neuregulin-1/ErbB signaling in rat myocardium. Dang R, etal., Steroids. 2016 Aug;112:47-53. doi: 10.1016/j.steroids.2016.04.011. Epub 2016 Apr 29.
18. Investigating the Role of Gene-Gene Interactions in TB Susceptibility. Daya M, etal., PLoS One. 2015 Apr 28;10(4):e0123970. doi: 10.1371/journal.pone.0123970. eCollection 2014.
19. Neuregulin 1 growth factors regulate proliferation but not apoptosis of a CNS neuronal progenitor cell line. Edwards JM and Bottenstein JE, Brain Res. 2006 Sep 7;1108(1):63-75. doi: 10.1016/j.brainres.2006.06.025. Epub 2006 Jul 21.
20. Exercise training and return to a well-balanced diet activate the neuregulin 1/ErbB pathway in skeletal muscle of obese rats. Ennequin G, etal., J Physiol. 2015 Jun 15;593(12):2665-77. doi: 10.1113/JP270026. Epub 2015 May 14.
21. Expressions of neuregulin 1beta and ErbB4 in prefrontal cortex and hippocampus of a rat schizophrenia model induced by chronic MK-801 administration. Feng Y, etal., J Biomed Biotechnol. 2010;2010:859516. doi: 10.1155/2010/859516. Epub 2010 May 4.
22. NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies. Fledrich R, etal., Nat Commun. 2019 Apr 1;10(1):1467. doi: 10.1038/s41467-019-09385-6.
23. Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A. Fledrich R, etal., Nat Med. 2014 Sep;20(9):1055-61. doi: 10.1038/nm.3664. Epub 2014 Aug 24.
24. Controlled delivery of fibroblast growth factor-1 and neuregulin-1 from biodegradable microparticles promotes cardiac repair in a rat myocardial infarction model through activation of endogenous regeneration. Formiga FR, etal., J Control Release. 2014 Jan 10;173:132-9. doi: 10.1016/j.jconrel.2013.10.034. Epub 2013 Nov 5.
25. Expression of ErbB3, ErbB4, and neuregulin-1 mRNA during tooth development. Fried K, etal., Dev Dyn 2002 Jul;224(3):356-60.
26. Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line. Frohnert PW, etal., Glia. 2003 Aug;43(2):104-18.
27. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
28. Neuregulin-1beta induces neurite extension and arborization in cultured hippocampal neurons. Gerecke KM, etal., Mol Cell Neurosci. 2004 Dec;27(4):379-93.
29. Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses. Go RC, etal., Am J Med Genet B Neuropsychiatr Genet. 2005 Nov 5;139B(1):28-32.
30. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
31. Cation-independent mannose 6-phosphate and 78 kDa receptors for lysosomal enzyme targeting are located in different cell compartments. Gonzalez-Noriega A, etal., Biochim Biophys Acta. 2005 Aug 15;1745(1):7-19. Epub 2005 Jan 26.
32. Neuregulin-1/ErbB signaling is impaired in the rat model of diabetic cardiomyopathy. Gui C, etal., Cardiovasc Pathol. 2012 Sep-Oct;21(5):414-20. doi: 10.1016/j.carpath.2011.12.006. Epub 2012 Jan 28.
33. Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans. Han S, etal., Biol Psychiatry. 2012 Oct 15;72(8):637-44. doi: 10.1016/j.biopsych.2012.02.038. Epub 2012 Apr 19.
34. Cleavage and Sub-Cellular Redistribution of Nuclear Pore Protein 98 by Coxsackievirus B3 Protease 2A Impairs Cardioprotection. Hanson PJ, etal., Front Cell Infect Microbiol. 2019 Jul 24;9:265. doi: 10.3389/fcimb.2019.00265. eCollection 2019.
35. Glial growth factor 2 promotes functional recovery with treatment initiated up to 7 days after permanent focal ischemic stroke. Iaci JF, etal., Neuropharmacology. 2010 Dec;59(7-8):640-9. doi: 10.1016/j.neuropharm.2010.07.017. Epub 2010 Aug 4.
36. Neuregulin-1 at synapses on phrenic motoneurons. Issa AN, etal., J Comp Neurol. 2010 Oct 15;518(20):4213-25. doi: 10.1002/cne.22449.
37. Glutamate-dependent ectodomain shedding of neuregulin-1 type II precursors in rat forebrain neurons. Iwakura Y, etal., PLoS One. 2017 Mar 28;12(3):e0174780. doi: 10.1371/journal.pone.0174780. eCollection 2017.
38. Changes of neuregulin-1 (NRG-1) expression in a rat model of overactive bladder induced by partial urethral obstruction: is NRG-1 a new biomarker of overactive bladder? Jang H, etal., BMC Urol. 2013 Oct 23;13:54. doi: 10.1186/1471-2490-13-54.
39. The Stress-Induced Transcription Factor NR4A1 Adjusts Mitochondrial Function and Synapse Number in Prefrontal Cortex. Jeanneteau F, etal., J Neurosci. 2018 Feb 7;38(6):1335-1350. doi: 10.1523/JNEUROSCI.2793-17.2017. Epub 2018 Jan 2.
40. Secretion of EGF-like domain of heregulinbeta promotes axonal growth and functional recovery of injured sciatic nerve. Joung I, etal., Mol Cells. 2010 Nov;30(5):477-84. doi: 10.1007/s10059-010-0137-5. Epub 2010 Oct 14.
41. Expression changes of the neuregulin 1 isoforms in neuropathic pain model rats. Kanzaki H, etal., Neurosci Lett. 2012 Feb 6;508(2):78-83. doi: 10.1016/j.neulet.2011.12.023. Epub 2011 Dec 28.
42. Analysis of gene-expression profiles by oligonucleotide microarray in children with influenza. Kawada J, etal., J Gen Virol. 2006 Jun;87(Pt 6):1677-83. doi: 10.1099/vir.0.81670-0.
43. Neuregulin 1 as an endogenous regulator of nicotinic acetylcholine receptors in adult major pelvic ganglion neurons. Kim HG, etal., Biochem Biophys Res Commun. 2015 Aug 7;463(4):632-7. doi: 10.1016/j.bbrc.2015.05.113. Epub 2015 Jun 2.
44. Linkage and association of schizophrenia with genetic variations in the locus of neuregulin 1 in Korean population. Kim JW, etal., 2006 Apr 5;141B(3):281-6. doi: 10.1002/ajmg.b.30209.
45. Neuregulin 1 regulates amyloid precursor protein cell surface expression and non-amyloidogenic processing. Kim YJ, etal., J Pharmacol Sci. 2018 May 29. pii: S1347-8613(18)30085-9. doi: 10.1016/j.jphs.2018.05.004.
46. Neuregulin 1 is a pronociceptive cytokine that is regulated by progesterone in the spinal cord: implications for sex specific pain modulation. Lacroix-Fralish ML, etal., Eur J Pain. 2008 Jan;12(1):94-103. Epub 2007 Apr 24.
47. Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle. Lebrasseur NK, etal., Am J Physiol Cell Physiol. 2003 May;284(5):C1149-55. Epub 2003 Jan 2.
48. Membrane-bound neuregulin1 type III actively promotes Schwann cell differentiation of multipotent Progenitor cells. Leimeroth R, etal., Dev Biol 2002 Jun 15;246(2):245-58.
49. Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy. Lemmens K, etal., Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H931-42. doi: 10.1152/ajpheart.00385.2010. Epub 2010 Dec 24.
50. Neuregulin 1 Attenuates Neuronal Apoptosis Induced by Deep Hypothermic Circulatory Arrest Through ErbB4 Signaling in Rats. Li P, etal., J Cardiovasc Pharmacol. 2015 Dec;66(6):551-7. doi: 10.1097/FJC.0000000000000303.
51. Insulin-regulated aminopeptidase marks an antigen-stimulated recycling compartment in mast cells. Liao H, etal., Traffic. 2006 Feb;7(2):155-67.
52. Linkage evidence of schizophrenia to loci near neuregulin 1 gene on chromosome 8p21 in Taiwanese families. Liu CM, etal., Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):79-83. doi: 10.1002/ajmg.b.20161.
53. Randomized Phase II Trial of Seribantumab in Combination With Paclitaxel in Patients With Advanced Platinum-Resistant or -Refractory Ovarian Cancer. Liu JF, etal., J Clin Oncol. 2016 Dec 20;34(36):4345-4353. doi: 10.1200/JCO.2016.67.1891. Epub 2016 Oct 23.
54. Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling. Liu M, etal., J Neuroinflammation. 2018 Apr 10;15(1):104. doi: 10.1186/s12974-018-1147-z.
55. The effects of neuregulin1 on brain function in controls and patients with schizophrenia and bipolar disorder. Mechelli A, etal., Neuroimage. 2008 Aug 15;42(2):817-26. doi: 10.1016/j.neuroimage.2008.05.025. Epub 2008 May 27.
56. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
57. No association between neuregulin 1 and psychotic symptoms in Alzheimer's disease patients. Middle F, etal., J Alzheimers Dis. 2010;20(2):561-7. doi: 10.3233/JAD-2010-1405.
58. Neuregulins and cancer. Montero JC, etal., Clin Cancer Res. 2008 Jun 1;14(11):3237-41. doi: 10.1158/1078-0432.CCR-07-5133.
59. Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1G93A ALS mice. Mòdol-Caballero G, etal., Neurobiol Dis. 2020 Apr;137:104793. doi: 10.1016/j.nbd.2020.104793. Epub 2020 Feb 4.
60. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
61. Denervation and reinnervation of adult skeletal muscle modulate mRNA expression of neuregulin-1 and ErbB receptors. Nicolino S, etal., Microsurgery. 2009;29(6):464-72. doi: 10.1002/micr.20636.
62. Overexpression of Neuregulin 1 Type III Confers Hippocampal mRNA Alterations and Schizophrenia-Like Behaviors in Mice. Olaya JC, etal., Schizophr Bull. 2018 Jun 6;44(4):865-875. doi: 10.1093/schbul/sbx122.
63. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
64. Expression of heregulin in human coronary atherosclerotic lesions. Panutsopulos D, etal., J Vasc Res. 2005 Nov-Dec;42(6):463-74. Epub 2005 Sep 6.
65. Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction. Parry TJ, etal., Eur J Pharmacol. 2017 Feb 5;796:76-89. doi: 10.1016/j.ejphar.2016.12.024. Epub 2016 Dec 16.
66. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
67. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
68. GOA pipeline RGD automated data pipeline
69. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
70. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
71. Comprehensive gene review and curation RGD comprehensive gene curation
72. Irreversible changes occurring in long-term denervated Schwann cells affect delayed nerve repair. Ronchi G, etal., J Neurosurg. 2017 Oct;127(4):843-856. doi: 10.3171/2016.9.JNS16140. Epub 2017 Jan 6.
73. Schwann cells express NDF and SMDF/n-ARIA mRNAs, secrete neuregulin, and show constitutive activation of erbB3 receptors: evidence for a neuregulin autocrine loop. Rosenbaum C, etal., Exp Neurol. 1997 Dec;148(2):604-15.
74. Therapeutic efficacy of neuregulin 1-expressing human adipose-derived mesenchymal stem cells for ischemic stroke. Ryu S, etal., PLoS One. 2019 Sep 27;14(9):e0222587. doi: 10.1371/journal.pone.0222587. eCollection 2019.
75. Neuregulin-1 attenuates mortality associated with experimental cerebral malaria. Solomon W, etal., J Neuroinflammation. 2014 Jan 17;11:9. doi: 10.1186/1742-2094-11-9.
76. Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. Tan GH, etal., Nat Neurosci. 2011 Dec 11;15(2):258-66. doi: 10.1038/nn.3005.
77. The involvement of Type II Neuregulin-1 in rat visuospatial learning and memory. Taylor AR, etal., Neurosci Lett. 2012 Dec 7;531(2):131-5. doi: 10.1016/j.neulet.2012.10.018. Epub 2012 Oct 23.
78. Sex-specific neuroendocrine and behavioral phenotypes in hypomorphic Type II Neuregulin 1 rats. Taylor SB, etal., Behav Brain Res. 2011 Oct 31;224(2):223-32. doi: 10.1016/j.bbr.2011.05.008. Epub 2011 May 19.
79. The interaction of disrupted type II neuregulin 1 and chronic adolescent stress on adult anxiety- and fear-related behaviors. Taylor SB, etal., Neuroscience. 2013 Sep 26;249:31-42. doi: 10.1016/j.neuroscience.2012.09.045. Epub 2012 Sep 25.
80. Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli. Taylor SB, etal., Physiol Behav. 2011 Aug 3;104(2):205-14. doi: 10.1016/j.physbeh.2010.11.015. Epub 2010 Nov 16.
81. Oxaliplatin induces hypomyelination and reduced neuregulin 1 expression in the rat sciatic nerve. Tsutsumi K, etal., Neurosci Res. 2014 Mar;80:86-90. doi: 10.1016/j.neures.2014.02.004. Epub 2014 Feb 14.
82. A functional neuregulin-1 gene variant and stressful life events: Effect on drug use in a longitudinal population-representative cohort study. Vaht M, etal., J Psychopharmacol. 2017 Jan;31(1):54-61. doi: 10.1177/0269881116655979. Epub 2016 Jul 10.
83. Rapid transient isoform-specific neuregulin1 transcription in motor neurons is regulated by neurotrophic factors and axon-target interactions. Wang J, etal., Mol Cell Neurosci. 2015 Sep;68:73-81. doi: 10.1016/j.mcn.2015.04.003. Epub 2015 Apr 22.
84. Neu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit. Wen D, etal., Cell 1992 May 1;69(3):559-72.
85. Structural and functional aspects of the multiplicity of Neu differentiation factors. Wen D, etal., Mol Cell Biol 1994 Mar;14(3):1909-19.
86. Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Wurmbach E, etal., Hepatology. 2007 Apr;45(4):938-47. doi: 10.1002/hep.21622.
87. Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model. Xu J, etal., Sci Rep. 2016 Aug 25;6:31692. doi: 10.1038/srep31692.
88. Effect of regulation of the NRG1/ErbB4 signaling pathway on the visual cortex synaptic plasticity of amblyopic adult rats. Xu L, etal., J Biochem Mol Toxicol. 2021 Sep;35(9):e22841. doi: 10.1002/jbt.22841. Epub 2021 Jul 17.
89. ErbB4 protects against neuronal apoptosis via activation of YAP/PIK3CB signaling pathway in a rat model of subarachnoid hemorrhage. Yan F, etal., Exp Neurol. 2017 Nov;297:92-100. doi: 10.1016/j.expneurol.2017.07.014. Epub 2017 Jul 27.
90. HER2 Signaling Implicated in Regulating Alveolar Epithelial Permeability with Cyclic Stretch. Yehya N, etal., Int J Mol Sci. 2019 Feb 22;20(4):948. doi: 10.3390/ijms20040948.
91. Functional and histological improvement of the injured spinal cord following transplantation of Schwann cells transfected with NRG1 gene. Zhang J, etal., Anat Rec (Hoboken). 2010 Nov;293(11):1933-46. doi: 10.1002/ar.21223.
92. Neuregulin-1β Plays a Neuroprotective Role by Inhibiting the Cdk5 Signaling Pathway after Cerebral Ischemia-Reperfusion Injury in Rats. Zhang R, etal., J Mol Neurosci. 2018 Oct;66(2):261-272. doi: 10.1007/s12031-018-1166-3. Epub 2018 Sep 11.
93. Prenatal dexamethasone exposure induces anxiety- and depressive-like behavior of male offspring rats through intrauterine programming of the activation of NRG1-ErbB4 signaling in hippocampal PV interneurons. Zhang S, etal., Cell Biol Toxicol. 2023 Jun;39(3):657-678. doi: 10.1007/s10565-021-09621-0. Epub 2021 Jun 29.
94. Traditional chinese medicine tang-luo-ning ameliorates sciatic nerve injuries in streptozotocin-induced diabetic rats. Zou DW, etal., Evid Based Complement Alternat Med. 2013;2013:989670. doi: 10.1155/2013/989670. Epub 2013 Oct 28.
Additional References at PubMed
PMID:1348215   PMID:7477375   PMID:7514177   PMID:7556068   PMID:7589796   PMID:7816098   PMID:8643489   PMID:8702723   PMID:8707830   PMID:9110980   PMID:9247262   PMID:9362461  
PMID:9553078   PMID:9685409   PMID:9789034   PMID:9852099   PMID:9892702   PMID:10559227   PMID:10597237   PMID:10686589   PMID:10707974   PMID:10762692   PMID:11116142   PMID:11389077  
PMID:11425901   PMID:11756753   PMID:12056846   PMID:12149465   PMID:12495620   PMID:12646923   PMID:12649319   PMID:12788100   PMID:12960782   PMID:14593214   PMID:14654373   PMID:14711829  
PMID:14733940   PMID:15044753   PMID:15073182   PMID:15132433   PMID:15155732   PMID:15212847   PMID:15219672   PMID:15355992   PMID:15494726   PMID:15519676   PMID:15952737   PMID:16036905  
PMID:16129398   PMID:16221846   PMID:16432850   PMID:16524373   PMID:16606832   PMID:16698793   PMID:17098736   PMID:17294200   PMID:17336907   PMID:17596863   PMID:17630047   PMID:17998937  
PMID:18080294   PMID:18410912   PMID:18458158   PMID:18465224   PMID:18596162   PMID:18633737   PMID:18819924   PMID:18830828   PMID:19179536   PMID:19781646   PMID:20220021   PMID:20360002  
PMID:20392965   PMID:20393464   PMID:20427670   PMID:20448149   PMID:20610754   PMID:20651836   PMID:20668675   PMID:20682778   PMID:21068328   PMID:21239627   PMID:21352860   PMID:21515322  
PMID:21539896   PMID:21690038   PMID:21802010   PMID:21919974   PMID:21962913   PMID:21991932   PMID:22269328   PMID:22357929   PMID:22376909   PMID:22496574   PMID:22659027   PMID:23097328  
PMID:23142316   PMID:23199222   PMID:23524246   PMID:23530877   PMID:23742124   PMID:23899995   PMID:24270810   PMID:24364879   PMID:24391468   PMID:24406781   PMID:24518229   PMID:24529326  
PMID:24530532   PMID:25177687   PMID:25266126   PMID:25337235   PMID:25453108   PMID:25978692   PMID:25988855   PMID:26061116   PMID:26092725   PMID:26183085   PMID:26235969   PMID:26574544  
PMID:27353365   PMID:27989735   PMID:27993557   PMID:28162790   PMID:29221474   PMID:29350067   PMID:29528383   PMID:29568012   PMID:29742506   PMID:29856744   PMID:30021123   PMID:30209718  
PMID:30940307   PMID:30989579   PMID:31115509   PMID:31799641   PMID:32492853   PMID:32798561   PMID:32920546   PMID:33470533   PMID:33705930   PMID:35370955   PMID:35416257   PMID:35883098  
PMID:36584915  


Genomics

Comparative Map Data
Nrg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81665,954,084 - 67,007,484 (+)NCBIGRCr8
mRatBN7.21659,250,658 - 60,304,519 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1659,250,854 - 60,296,884 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1664,587,755 - 65,638,290 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01668,001,434 - 69,052,009 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01663,221,979 - 64,273,342 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01662,969,573 - 64,065,063 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1663,837,216 - 64,057,434 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01662,632,432 - 63,718,738 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41663,937,796 - 64,126,183 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11663,937,870 - 64,126,262 (+)NCBI
Celera1657,283,140 - 58,311,856 (+)NCBICelera
Cytogenetic Map16q12.3NCBI
NRG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38831,639,245 - 32,774,046 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl831,639,222 - 32,855,666 (+)EnsemblGRCh38hg38GRCh38
GRCh37831,496,761 - 32,631,564 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36831,616,810 - 32,741,615 (+)NCBINCBI36Build 36hg18NCBI36
Build 34832,525,654 - 32,741,615NCBI
Celera830,430,833 - 31,581,276 (+)NCBICelera
Cytogenetic Map8p12NCBI
HuRef830,042,037 - 31,167,972 (+)NCBIHuRef
CHM1_1831,698,276 - 32,824,231 (+)NCBICHM1_1
T2T-CHM13v2.0831,920,455 - 33,055,399 (+)NCBIT2T-CHM13v2.0
Nrg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39832,299,493 - 33,381,858 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl832,408,601 - 32,408,786 (-)EnsemblGRCm39 Ensembl
GRCm39 Ensembl832,304,579 - 33,374,825 (-)EnsemblGRCm39 Ensembl
GRCm38831,807,452 - 32,891,609 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl831,814,551 - 32,884,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv37832,928,500 - 33,028,675 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36833,280,406 - 33,475,426 (-)NCBIMGSCv36mm8
Celera833,340,249 - 33,441,164 (-)NCBICelera
Cytogenetic Map8A3NCBI
cM Map818.75NCBI
Nrg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554638,009,530 - 9,037,116 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554638,009,436 - 9,037,116 (+)NCBIChiLan1.0ChiLan1.0
NRG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2750,214,732 - 51,343,176 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1826,509,393 - 27,059,005 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0830,954,852 - 32,084,411 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1829,049,787 - 29,267,531 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl829,050,222 - 29,263,977 (+)Ensemblpanpan1.1panPan2
NRG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11631,697,958 - 32,771,888 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1631,706,851 - 32,771,932 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1632,223,605 - 33,296,875 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01633,726,025 - 34,800,223 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1633,733,366 - 34,799,290 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11631,820,963 - 32,893,204 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01632,400,606 - 33,474,314 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01632,439,477 - 33,584,021 (-)NCBIUU_Cfam_GSD_1.0
Nrg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494354,835,543 - 55,046,030 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367661,104,728 - 1,305,972 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367661,104,841 - 1,306,368 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1552,630,679 - 52,839,505 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11552,625,550 - 53,688,003 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21559,915,458 - 59,983,046 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NRG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1829,745,984 - 30,862,140 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl830,635,803 - 30,856,487 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605211,219,877 - 12,342,139 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nrg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478011,301,182 - 12,424,066 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478011,297,306 - 11,525,236 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nrg1
8186 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1371
Count of miRNA genes:243
Interacting mature miRNAs:303
Transcripts:ENSRNOT00000013991, ENSRNOT00000014147, ENSRNOT00000014268, ENSRNOT00000038549, ENSRNOT00000058727
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
D16Rat109  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21660,148,243 - 60,148,445 (+)MAPPERmRatBN7.2
Rnor_6.01663,909,163 - 63,909,364NCBIRnor6.0
Rnor_5.01663,570,510 - 63,570,711UniSTSRnor5.0
RGSC_v3.41663,977,586 - 63,977,788RGDRGSC3.4
RGSC_v3.41663,977,587 - 63,977,788UniSTSRGSC3.4
RGSC_v3.11663,977,661 - 63,977,863RGD
Celera1658,163,324 - 58,163,525UniSTS
FHH x ACI Map1635.7999RGD
FHH x ACI Map1635.7999UniSTS
Cytogenetic Map16q12.3UniSTS
D16Rat60  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21660,252,081 - 60,252,231 (+)MAPPERmRatBN7.2
Rnor_6.01664,012,637 - 64,012,784NCBIRnor6.0
Rnor_5.01663,673,941 - 63,674,088UniSTSRnor5.0
RGSC_v3.41664,081,385 - 64,081,533RGDRGSC3.4
RGSC_v3.41664,081,386 - 64,081,533UniSTSRGSC3.4
RGSC_v3.11664,081,461 - 64,081,608RGD
Celera1658,267,033 - 58,267,180UniSTS
RH 3.4 Map16566.41UniSTS
RH 3.4 Map16566.41RGD
SHRSP x BN Map1626.13UniSTS
SHRSP x BN Map1626.13RGD
Cytogenetic Map16q12.3UniSTS
D16Wox14  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01664,056,787 - 64,056,995NCBIRnor6.0
Rnor_5.01663,718,091 - 63,718,299UniSTSRnor5.0
RGSC_v3.41664,125,536 - 64,125,744UniSTSRGSC3.4
Celera1658,311,209 - 58,311,417UniSTS
Cytogenetic Map16q12.3UniSTS
D16Wox15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21660,276,624 - 60,276,789 (+)MAPPERmRatBN7.2
Rnor_6.01664,037,178 - 64,037,342NCBIRnor6.0
Rnor_5.01663,698,482 - 63,698,646UniSTSRnor5.0
RGSC_v3.41664,105,927 - 64,106,091UniSTSRGSC3.4
Celera1658,291,600 - 58,291,764UniSTS
Cytogenetic Map16q12.3UniSTS
UniSTS:468010  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21659,251,365 - 59,251,565 (+)MAPPERmRatBN7.2
Rnor_6.01662,970,281 - 62,970,480NCBIRnor6.0
Rnor_5.01662,632,725 - 62,632,924UniSTSRnor5.0
RGSC_v3.41663,053,923 - 63,054,122UniSTSRGSC3.4
Celera1657,283,433 - 57,283,632UniSTS
Cytogenetic Map16q12.3UniSTS


Genetic Models
This gene Nrg1 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5
Low 3 31 35 19 18 19 1 1 69 35 37 11 1
Below cutoff 12 22 22 1 22 7 10 4 7

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF194438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF194439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF194440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF194441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF194442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF194443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF194993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF194995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF194996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF194997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY973241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY973242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY973243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY973244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY973245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY995221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY995222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY995223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ176766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M92430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000013991   ⟹   ENSRNOP00000013991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1660,197,448 - 60,296,884 (+)Ensembl
Rnor_6.0 Ensembl1663,958,645 - 64,057,434 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000014147   ⟹   ENSRNOP00000014147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1660,109,716 - 60,296,884 (+)Ensembl
Rnor_6.0 Ensembl1663,837,216 - 64,057,434 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000014268   ⟹   ENSRNOP00000014268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1660,109,716 - 60,296,884 (+)Ensembl
Rnor_6.0 Ensembl1663,837,216 - 64,057,434 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000038549   ⟹   ENSRNOP00000031467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1660,109,716 - 60,296,884 (+)Ensembl
Rnor_6.0 Ensembl1663,837,216 - 64,057,434 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000058727   ⟹   ENSRNOP00000055518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1659,250,854 - 60,296,884 (+)Ensembl
Rnor_6.0 Ensembl1663,880,428 - 64,057,434 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081522   ⟹   ENSRNOP00000072731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1660,197,448 - 60,296,884 (+)Ensembl
Rnor_6.0 Ensembl1663,958,645 - 64,057,434 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082355   ⟹   ENSRNOP00000071312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1660,197,448 - 60,296,884 (+)Ensembl
Rnor_6.0 Ensembl1663,958,645 - 64,057,434 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099919   ⟹   ENSRNOP00000077747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1660,197,448 - 60,296,884 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100344   ⟹   ENSRNOP00000081913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1660,197,448 - 60,295,929 (+)Ensembl
RefSeq Acc Id: NM_001271118   ⟹   NP_001258047
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,900,420 - 66,999,849 (+)NCBI
mRatBN7.21660,197,448 - 60,296,884 (+)NCBI
Rnor_6.01663,958,645 - 64,057,434 (+)NCBI
Rnor_5.01662,632,432 - 63,718,738 (+)NCBI
Celera1658,212,397 - 58,311,856 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271119   ⟹   NP_001258048
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,900,420 - 66,999,849 (+)NCBI
mRatBN7.21660,197,448 - 60,296,884 (+)NCBI
Rnor_6.01663,958,645 - 64,057,434 (+)NCBI
Rnor_5.01662,632,432 - 63,718,738 (+)NCBI
Celera1658,212,397 - 58,311,856 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271120   ⟹   NP_001258049
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,900,420 - 66,999,849 (+)NCBI
mRatBN7.21660,197,448 - 60,296,884 (+)NCBI
Rnor_6.01663,958,645 - 64,057,434 (+)NCBI
Rnor_5.01662,632,432 - 63,718,738 (+)NCBI
Celera1658,212,397 - 58,311,856 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271121   ⟹   NP_001258050
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,812,695 - 66,999,849 (+)NCBI
mRatBN7.21660,109,716 - 60,296,884 (+)NCBI
Rnor_6.01663,880,428 - 64,057,434 (+)NCBI
Rnor_5.01662,632,432 - 63,718,738 (+)NCBI
Celera1658,125,632 - 58,311,856 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271122   ⟹   NP_001258051
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,812,695 - 66,999,849 (+)NCBI
mRatBN7.21660,109,716 - 60,296,884 (+)NCBI
Rnor_6.01663,880,428 - 64,057,434 (+)NCBI
Rnor_5.01662,632,432 - 63,718,738 (+)NCBI
Celera1658,125,632 - 58,311,856 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271123   ⟹   NP_001258052
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,812,695 - 66,979,778 (+)NCBI
mRatBN7.21660,109,716 - 60,276,810 (+)NCBI
Rnor_6.01663,880,428 - 64,037,363 (+)NCBI
Rnor_5.01662,632,432 - 63,718,738 (+)NCBI
Celera1658,125,632 - 58,291,785 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271124   ⟹   NP_001258053
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,812,695 - 66,996,101 (+)NCBI
mRatBN7.21660,109,716 - 60,293,130 (+)NCBI
Rnor_6.01663,880,428 - 64,053,686 (+)NCBI
Rnor_5.01662,632,432 - 63,718,738 (+)NCBI
Celera1658,125,632 - 58,308,108 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271125   ⟹   NP_001258054
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,812,695 - 66,999,849 (+)NCBI
mRatBN7.21660,109,716 - 60,296,884 (+)NCBI
Rnor_6.01663,880,428 - 64,057,434 (+)NCBI
Rnor_5.01662,632,432 - 63,718,738 (+)NCBI
Celera1658,125,632 - 58,311,856 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271126   ⟹   NP_001258055
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,812,695 - 66,999,849 (+)NCBI
mRatBN7.21660,109,716 - 60,296,884 (+)NCBI
Rnor_6.01663,880,428 - 64,057,434 (+)NCBI
Rnor_5.01662,632,432 - 63,718,738 (+)NCBI
Celera1658,125,632 - 58,311,856 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271127   ⟹   NP_001258056
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,812,695 - 66,999,849 (+)NCBI
mRatBN7.21660,109,716 - 60,296,884 (+)NCBI
Rnor_6.01663,880,428 - 64,057,434 (+)NCBI
Rnor_5.01662,632,432 - 63,718,738 (+)NCBI
Celera1658,125,632 - 58,311,856 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271128   ⟹   NP_001258057
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,812,695 - 66,999,849 (+)NCBI
mRatBN7.21660,109,716 - 60,296,884 (+)NCBI
Rnor_6.01663,880,428 - 64,057,434 (+)NCBI
Rnor_5.01662,632,432 - 63,718,738 (+)NCBI
Celera1658,125,632 - 58,311,856 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271129   ⟹   NP_001258058
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,812,642 - 67,007,484 (+)NCBI
mRatBN7.21660,109,663 - 60,304,519 (+)NCBI
Rnor_6.01663,880,428 - 64,057,434 (+)NCBI
Rnor_5.01662,632,432 - 63,718,738 (+)NCBI
Celera1658,125,632 - 58,311,856 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271130   ⟹   NP_001258059
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81665,954,084 - 66,999,849 (+)NCBI
mRatBN7.21659,251,073 - 60,296,884 (+)NCBI
Rnor_6.01662,969,988 - 64,057,434 (+)NCBI
Rnor_5.01662,632,432 - 63,718,738 (+)NCBI
Celera1657,283,140 - 58,311,856 (+)NCBI
Sequence:
RefSeq Acc Id: NM_031588   ⟹   NP_113776
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,812,695 - 66,999,849 (+)NCBI
mRatBN7.21660,109,716 - 60,296,884 (+)NCBI
Rnor_6.01663,880,428 - 64,057,434 (+)NCBI
Rnor_5.01662,632,432 - 63,718,738 (+)NCBI
RGSC_v3.41663,937,796 - 64,126,183 (+)RGD
Celera1658,125,632 - 58,311,856 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599969   ⟹   XP_017455458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,900,819 - 67,007,484 (+)NCBI
mRatBN7.21660,189,884 - 60,303,024 (+)NCBI
Rnor_6.01663,958,222 - 64,065,063 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599971   ⟹   XP_017455460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,900,819 - 66,998,342 (+)NCBI
mRatBN7.21660,189,878 - 60,295,375 (+)NCBI
Rnor_6.01663,958,221 - 64,055,880 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094096   ⟹   XP_038950024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,900,819 - 66,998,342 (+)NCBI
mRatBN7.21660,189,878 - 60,295,375 (+)NCBI
RefSeq Acc Id: XM_063274978   ⟹   XP_063131048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,812,594 - 67,007,484 (+)NCBI
RefSeq Acc Id: XM_063274979   ⟹   XP_063131049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,812,591 - 66,998,342 (+)NCBI
RefSeq Acc Id: XM_063274980   ⟹   XP_063131050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,812,591 - 66,998,342 (+)NCBI
RefSeq Acc Id: XM_063274981   ⟹   XP_063131051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,967,530 - 67,007,484 (+)NCBI
RefSeq Acc Id: XM_063274982   ⟹   XP_063131052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81666,900,819 - 67,007,484 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001258047 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258048 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258049 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258050 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258051 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258052 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258053 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258054 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258055 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258056 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258057 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258058 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258059 (Get FASTA)   NCBI Sequence Viewer  
  NP_113776 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455458 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455460 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950024 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131048 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131049 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131050 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131051 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131052 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19940 (Get FASTA)   NCBI Sequence Viewer  
  AAA19941 (Get FASTA)   NCBI Sequence Viewer  
  AAA19942 (Get FASTA)   NCBI Sequence Viewer  
  AAA19943 (Get FASTA)   NCBI Sequence Viewer  
  AAA19944 (Get FASTA)   NCBI Sequence Viewer  
  AAA19945 (Get FASTA)   NCBI Sequence Viewer  
  AAA19946 (Get FASTA)   NCBI Sequence Viewer  
  AAA19947 (Get FASTA)   NCBI Sequence Viewer  
  AAA19948 (Get FASTA)   NCBI Sequence Viewer  
  AAA19949 (Get FASTA)   NCBI Sequence Viewer  
  AAG28427 (Get FASTA)   NCBI Sequence Viewer  
  AAG28428 (Get FASTA)   NCBI Sequence Viewer  
  AAG28429 (Get FASTA)   NCBI Sequence Viewer  
  AAG28430 (Get FASTA)   NCBI Sequence Viewer  
  AAG28431 (Get FASTA)   NCBI Sequence Viewer  
  AAG28432 (Get FASTA)   NCBI Sequence Viewer  
  AAG28433 (Get FASTA)   NCBI Sequence Viewer  
  AAG28449 (Get FASTA)   NCBI Sequence Viewer  
  AAG28450 (Get FASTA)   NCBI Sequence Viewer  
  AAG28451 (Get FASTA)   NCBI Sequence Viewer  
  AAX98677 (Get FASTA)   NCBI Sequence Viewer  
  AAX98678 (Get FASTA)   NCBI Sequence Viewer  
  AAX98679 (Get FASTA)   NCBI Sequence Viewer  
  AAY19481 (Get FASTA)   NCBI Sequence Viewer  
  ABA03059 (Get FASTA)   NCBI Sequence Viewer  
  EDM09117 (Get FASTA)   NCBI Sequence Viewer  
  EDM09118 (Get FASTA)   NCBI Sequence Viewer  
  EDM09119 (Get FASTA)   NCBI Sequence Viewer  
  EDM09120 (Get FASTA)   NCBI Sequence Viewer  
  EDM09121 (Get FASTA)   NCBI Sequence Viewer  
  EDM09122 (Get FASTA)   NCBI Sequence Viewer  
  EDM09123 (Get FASTA)   NCBI Sequence Viewer  
  EDM09124 (Get FASTA)   NCBI Sequence Viewer  
  EDM09125 (Get FASTA)   NCBI Sequence Viewer  
  EDM09126 (Get FASTA)   NCBI Sequence Viewer  
  EDM09127 (Get FASTA)   NCBI Sequence Viewer  
  EDM09128 (Get FASTA)   NCBI Sequence Viewer  
  EDM09129 (Get FASTA)   NCBI Sequence Viewer  
  EDM09130 (Get FASTA)   NCBI Sequence Viewer  
  EDM09131 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013991
  ENSRNOP00000013991.6
  ENSRNOP00000014147.5
  ENSRNOP00000014268
  ENSRNOP00000014268.5
  ENSRNOP00000031467
  ENSRNOP00000031467.6
  ENSRNOP00000055518.2
  ENSRNOP00000071312
  ENSRNOP00000071312.1
  ENSRNOP00000072731
  ENSRNOP00000072731.1
  ENSRNOP00000077747
  ENSRNOP00000077747.1
  ENSRNOP00000081913.1
  ENSRNOP00065002514
GenBank Protein P43322 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113776   ⟸   NM_031588
- Peptide Label: isoform 13
- UniProtKB: A6IVU6 (UniProtKB/TrEMBL),   Q52NV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258059   ⟸   NM_001271130
- Peptide Label: isoform 14
- UniProtKB: Q52NV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258057   ⟸   NM_001271128
- Peptide Label: isoform 11
- UniProtKB: A6IVU7 (UniProtKB/TrEMBL),   A6IVU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258058   ⟸   NM_001271129
- Peptide Label: isoform 12
- UniProtKB: A6IVU3 (UniProtKB/TrEMBL),   Q52NV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258054   ⟸   NM_001271125
- Peptide Label: isoform 8
- UniProtKB: Q52NV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258056   ⟸   NM_001271127
- Peptide Label: isoform 10 preproprotein
- UniProtKB: P43328 (UniProtKB/Swiss-Prot),   P43327 (UniProtKB/Swiss-Prot),   P43326 (UniProtKB/Swiss-Prot),   P43325 (UniProtKB/Swiss-Prot),   P43324 (UniProtKB/Swiss-Prot),   P43323 (UniProtKB/Swiss-Prot),   P43322 (UniProtKB/Swiss-Prot),   G3V7F0 (UniProtKB/TrEMBL),   A6IVU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258055   ⟸   NM_001271126
- Peptide Label: isoform 9
- UniProtKB: A6IVU5 (UniProtKB/TrEMBL),   Q52NV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258051   ⟸   NM_001271122
- Peptide Label: isoform 5
- UniProtKB: D3ZC94 (UniProtKB/TrEMBL),   Q52NV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258050   ⟸   NM_001271121
- Peptide Label: isoform 4
- UniProtKB: Q52NV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258053   ⟸   NM_001271124
- Peptide Label: isoform 7
- UniProtKB: A6IVU8 (UniProtKB/TrEMBL),   A6IVU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258052   ⟸   NM_001271123
- Peptide Label: isoform 6
- UniProtKB: A6IVV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258049   ⟸   NM_001271120
- Peptide Label: isoform 3
- UniProtKB: G3V7D6 (UniProtKB/TrEMBL),   A6IVV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258048   ⟸   NM_001271119
- Peptide Label: isoform 2
- UniProtKB: A0A0G2K057 (UniProtKB/TrEMBL),   A6IVV1 (UniProtKB/TrEMBL),   Q9ESB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258047   ⟸   NM_001271118
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K3Q3 (UniProtKB/TrEMBL),   A6IVV2 (UniProtKB/TrEMBL),   Q9ESB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455460   ⟸   XM_017599971
- Peptide Label: isoform X3
- UniProtKB: A6IVV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455458   ⟸   XM_017599969
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZKD3 (UniProtKB/TrEMBL),   A6IVV3 (UniProtKB/TrEMBL),   Q9ESB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071312   ⟸   ENSRNOT00000082355
RefSeq Acc Id: ENSRNOP00000031467   ⟸   ENSRNOT00000038549
RefSeq Acc Id: ENSRNOP00000014147   ⟸   ENSRNOT00000014147
RefSeq Acc Id: ENSRNOP00000014268   ⟸   ENSRNOT00000014268
RefSeq Acc Id: ENSRNOP00000072731   ⟸   ENSRNOT00000081522
RefSeq Acc Id: ENSRNOP00000055518   ⟸   ENSRNOT00000058727
RefSeq Acc Id: ENSRNOP00000013991   ⟸   ENSRNOT00000013991
RefSeq Acc Id: XP_038950024   ⟸   XM_039094096
- Peptide Label: isoform X4
- UniProtKB: A6IVV4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077747   ⟸   ENSRNOT00000099919
RefSeq Acc Id: ENSRNOP00000081913   ⟸   ENSRNOT00000100344
RefSeq Acc Id: XP_063131049   ⟸   XM_063274979
- Peptide Label: isoform X5
- UniProtKB: Q52NV1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131050   ⟸   XM_063274980
- Peptide Label: isoform X6
- UniProtKB: A6IVU9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131048   ⟸   XM_063274978
- Peptide Label: isoform X2
- UniProtKB: Q52NV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131052   ⟸   XM_063274982
- Peptide Label: isoform X8
- UniProtKB: Q9ESB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131051   ⟸   XM_063274981
- Peptide Label: isoform X7
Protein Domains
EGF-like   Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43322-F1-model_v2 AlphaFold P43322 1-662 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700145
Promoter ID:EPDNEW_R10668
Type:multiple initiation site
Name:Nrg1_1
Description:neuregulin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01663,880,382 - 63,880,442EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621341 AgrOrtholog
BioCyc Gene G2FUF-11099 BioCyc
Ensembl Genes ENSRNOG00000010392 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00065002671 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013991 ENTREZGENE
  ENSRNOT00000013991.9 UniProtKB/TrEMBL
  ENSRNOT00000014147.7 UniProtKB/TrEMBL
  ENSRNOT00000014268 ENTREZGENE
  ENSRNOT00000014268.9 UniProtKB/TrEMBL
  ENSRNOT00000038549 ENTREZGENE
  ENSRNOT00000038549.8 UniProtKB/TrEMBL
  ENSRNOT00000058727.5 UniProtKB/TrEMBL
  ENSRNOT00000081522 ENTREZGENE
  ENSRNOT00000081522.2 UniProtKB/TrEMBL
  ENSRNOT00000082355 ENTREZGENE
  ENSRNOT00000082355.2 UniProtKB/TrEMBL
  ENSRNOT00000099919.1 UniProtKB/TrEMBL
  ENSRNOT00000100344.1 UniProtKB/TrEMBL
  ENSRNOT00065003631 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuregulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuregulin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:112400 UniProtKB/TrEMBL
NCBI Gene 112400 ENTREZGENE
PANTHER PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuregulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nrg1 PhenoGen
PRINTS NEUREGULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010392 RatGTEx
  ENSRNOG00065002671 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K057 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K3Q3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZKD3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZSN5_RAT UniProtKB/TrEMBL
  A6IVT9_RAT UniProtKB/TrEMBL
  A6IVU0_RAT UniProtKB/TrEMBL
  A6IVU3 ENTREZGENE, UniProtKB/TrEMBL
  A6IVU4 ENTREZGENE, UniProtKB/TrEMBL
  A6IVU5 ENTREZGENE, UniProtKB/TrEMBL
  A6IVU6 ENTREZGENE, UniProtKB/TrEMBL
  A6IVU7 ENTREZGENE, UniProtKB/TrEMBL
  A6IVU8 ENTREZGENE, UniProtKB/TrEMBL
  A6IVU9 ENTREZGENE, UniProtKB/TrEMBL
  A6IVV0 ENTREZGENE, UniProtKB/TrEMBL
  A6IVV1 ENTREZGENE, UniProtKB/TrEMBL
  A6IVV2 ENTREZGENE, UniProtKB/TrEMBL
  A6IVV3 ENTREZGENE, UniProtKB/TrEMBL
  A6IVV4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZC94 ENTREZGENE, UniProtKB/TrEMBL
  D4ACB2_RAT UniProtKB/TrEMBL
  G3V7D6 ENTREZGENE, UniProtKB/TrEMBL
  G3V7F0 ENTREZGENE, UniProtKB/TrEMBL
  G3V9Q0_RAT UniProtKB/TrEMBL
  NRG1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P43323 ENTREZGENE
  P43324 ENTREZGENE
  P43325 ENTREZGENE
  P43326 ENTREZGENE
  P43327 ENTREZGENE
  P43328 ENTREZGENE
  Q3S2T6_RAT UniProtKB/TrEMBL
  Q52NV1 ENTREZGENE, UniProtKB/TrEMBL
  Q52NV2 ENTREZGENE, UniProtKB/TrEMBL
  Q52NV3 ENTREZGENE, UniProtKB/TrEMBL
  Q52R82_RAT UniProtKB/TrEMBL
  Q9ESA1_RAT UniProtKB/TrEMBL
  Q9ESA2_RAT UniProtKB/TrEMBL
  Q9ESA3_RAT UniProtKB/TrEMBL
  Q9ESA4_RAT UniProtKB/TrEMBL
  Q9ESA5_RAT UniProtKB/TrEMBL
  Q9ESA6_RAT UniProtKB/TrEMBL
  Q9ESA7_RAT UniProtKB/TrEMBL
  Q9ESA8_RAT UniProtKB/TrEMBL
  Q9ESA9_RAT UniProtKB/TrEMBL
  Q9ESB0 ENTREZGENE, UniProtKB/TrEMBL
  Q9ESB1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P43323 UniProtKB/Swiss-Prot
  P43324 UniProtKB/Swiss-Prot
  P43325 UniProtKB/Swiss-Prot
  P43326 UniProtKB/Swiss-Prot
  P43327 UniProtKB/Swiss-Prot
  P43328 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Nrg1  neuregulin 1      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Nrg1        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process involved in tooth development 727391
gene_process promotes both Schwann cell survival and differentiation 729365