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Gene: Nrg1 (neuregulin 1) Rattus norvegicus
Symbol: Nrg1
Name: neuregulin 1
Description: Exhibits receptor tyrosine kinase binding activity. Involved in several processes, including negative regulation of corticosterone secretion; positive regulation of neurogenesis; and response to progesterone. Localizes to extracellular space and synapse. Used to study sciatic neuropathy. Biomarker of diabetic neuropathy; median neuropathy; and visual epilepsy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; dementia; middle cerebral artery infarction; myocardial infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: neuregulin 1 type III beta 3; pro-neuregulin-1, membrane-bound isoform; pro-NRG1
Homo sapiens (human) : NRG1 (neuregulin 1)  HGNC  Alliance
Mus musculus (house mouse) : Nrg1 (neuregulin 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nrg1 (neuregulin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NRG1 (neuregulin 1)
Canis lupus familiaris (dog) : NRG1 (neuregulin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nrg1 (neuregulin 1)
Sus scrofa (pig) : NRG1 (neuregulin 1)
Chlorocebus sabaeus (African green monkey) : NRG1 (neuregulin 1)
Heterocephalus glaber (naked mole-rat) : Nrg1 (neuregulin 1)
more info ...
Allele / Splice: Nrg1Tn(sb-T2/Bart3)2.183Mcwi  
Genetic Models: F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01662,969,573 - 64,065,063 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1663,837,216 - 64,057,434 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01662,632,432 - 63,718,738 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41663,937,796 - 64,126,183 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11663,937,870 - 64,126,262 (+)NCBI
Celera1657,283,140 - 58,311,856 (+)NCBICelera
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nrg1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621341
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.