Vav1 (vav guanine nucleotide exchange factor 1)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| FTP Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Vav1 (vav guanine nucleotide exchange factor 1) Rattus norvegicus

Analyze

Symbol:

Vav1

Name:

vav guanine nucleotide exchange factor 1

RGD ID:

3951

Description:

Predicted to have Rac guanyl-nucleotide exchange factor activity; phosphorylation-dependent protein binding activity; and phosphotyrosine residue binding activity. Involved in immune response-regulating cell surface receptor signaling pathway. Predicted to localize to cell-cell junction. Biomarker of endometriosis; hepatocellular carcinoma; lymphopenia; and type 1 diabetes mellitus. Orthologous to human VAV1 (vav guanine nucleotide exchange factor 1); PARTICIPATES IN interleukin-6 signaling pathway; B cell receptor signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; acetamide; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

p95; proto-oncogene vav; Vav; vav 1 guanine nucleotide exchange factor; Vav 1 oncogene

Orthologs:

Homo sapiens (human) : VAV1 (vav guanine nucleotide exchange factor 1) HGNC Alliance
Mus musculus (house mouse) : Vav1 (vav 1 oncogene) MGI Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vav1 (vav guanine nucleotide exchange factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : VAV1 (vav guanine nucleotide exchange factor 1)
Canis lupus familiaris (dog) : VAV1 (vav guanine nucleotide exchange factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vav1 (vav guanine nucleotide exchange factor 1)
Sus scrofa (pig) : VAV1 (vav guanine nucleotide exchange factor 1)
Chlorocebus sabaeus (African green monkey) : VAV1 (vav guanine nucleotide exchange factor 1)
Heterocephalus glaber (naked mole-rat) : Vav1 (vav guanine nucleotide exchange factor 1)

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

NCBI Annotation Information:

Annotation category: suggests misassembly; Annotation category: partial on reference assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	9	9,617,551 - 9,675,167 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	9,617,786 - 9,675,110 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	8,682,235 - 8,682,495 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	9	8,626,445 - 8,655,152 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	6,313,197 - 6,360,060 (-)	NCBI		Celera
Cytogenetic Map	9	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adult T-cell leukemia (ISO)

endometriosis (IEP)

Experimental Liver Cirrhosis (ISO)

hepatocellular carcinoma (IEP)

lung adenocarcinoma (ISO)

lymphopenia (IEP)

medulloblastoma (ISO)

type 1 diabetes mellitus (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,7-dihydropurine-6-thione (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acetylsalicylic acid (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

butanal (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

cisplatin (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

ethanol (ISO)

genistein (ISO)

lipopolysaccharide (ISO)

mercaptopurine (ISO)

N-formyl-L-methionyl-L-leucyl-L-phenylalanine (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

nickel atom (ISO)

paracetamol (ISO)

pentanal (ISO)

pirinixic acid (EXP)

propanal (ISO)

protein kinase inhibitor (ISO)

purine-6-thiol (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

tamibarotene (ISO)

tipifarnib (EXP)

titanium dioxide (ISO)

Tributyltin oxide (ISO)

trichloroethene (ISO)

tungsten (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell development (TAS)

G protein-coupled receptor signaling pathway (IEA,ISO)

immune response (IEA,ISO)

immune response-regulating cell surface receptor signaling pathway (IEP)

integrin-mediated signaling pathway (IEA,ISO)

intracellular signal transduction (ISO)

neutrophil chemotaxis (IEA,ISO)

phagocytosis (IEA,ISO)

positive regulation of cell adhesion (IEA,ISO)

positive regulation of GTPase activity (IEA,ISO)

positive regulation of natural killer cell mediated cytotoxicity (IEA,ISO)

reactive oxygen species metabolic process (IEA,ISO)

regulation of cell size (IEA,ISO)

regulation of GTPase activity (ISO)

small GTPase mediated signal transduction (IEA)

T cell activation (ISO)

T cell differentiation (IEA,ISO)

Cellular Component

cell-cell junction (IEA,ISO)

Molecular Function

guanyl-nucleotide exchange factor activity (ISO,TAS)

metal ion binding (IEA)

phosphorylation-dependent protein binding (IEA,ISO)

phosphotyrosine residue binding (IEA,ISO)

protein binding (ISO)

Rac guanyl-nucleotide exchange factor activity (IEA,ISO)

Ras guanyl-nucleotide exchange factor activity (ISO)

Rho guanyl-nucleotide exchange factor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

B cell receptor signaling pathway (IEA)

chemokine mediated signaling pathway (IEA)

Fc epsilon receptor mediated signaling pathway (IEA)

Fc gamma receptor mediated signaling pathway (IEA)

interleukin-6 signaling pathway (ISO)

T cell receptor signaling pathway (IEA)

References

References - curated


1.	Bieg S Autoimmunity. 1999;30(1):37-42.
2.	Furuya T, etal., Hum Mol Genet 2000 Sep 22;9(15):2241-50
3.	GOA data from the GO Consortium
4.	Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
5.	Hernandez L, etal., Mol Carcinog. 1991;4(3):203-9.
6.	Konno R, etal., Am J Reprod Immunol. 2007 Oct;58(4):330-43.
7.	Margolis B, etal., Nature. 1992 Mar 5;356(6364):71-4.
8.	MGD data from the GO Consortium
9.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	Pipeline to import KEGG annotations from KEGG into RGD
11.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12.	RGD automated data pipeline
13.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14.	RGD automated import pipeline for gene-chemical interactions
15.	Song JS, etal., J Immunol 1999 Jul 15;163(2):802-10.

Additional References at PubMed

PMID:8990121	PMID:11070165	PMID:12477932	PMID:15249579	PMID:15618286	PMID:15644420	PMID:15696170	PMID:16203968	PMID:17721087	PMID:20624904	PMID:20962259	PMID:21178006
PMID:22467863	PMID:23793062	PMID:26163585	PMID:30361391

Genomics

Candidate Gene Status

	Vav1 is a candidate Gene for QTL Ciaa3
	Vav1 is a candidate Gene for QTL Eae4

Comparative Map Data

Vav1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	9	9,617,551 - 9,675,167 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	9,617,786 - 9,675,110 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	8,682,235 - 8,682,495 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	9	8,626,445 - 8,655,152 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	6,313,197 - 6,360,060 (-)	NCBI		Celera
Cytogenetic Map	9	q12	NCBI

VAV1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	19	6,772,708 - 6,857,366 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	19	6,772,708 - 6,857,366 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	19	6,772,679 - 6,857,377 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	6,723,722 - 6,808,371 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	19	6,723,721 - 6,808,371	NCBI
Celera	19	6,714,968 - 6,799,596 (+)	NCBI
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	6,535,153 - 6,619,808 (+)	NCBI		HuRef
CHM1_1	19	6,772,530 - 6,857,195 (+)	NCBI		CHM1_1

Vav1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	57,586,080 - 57,636,236 (+)	NCBI
GRCm38	17	57,279,100 - 57,329,236 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	57,279,100 - 57,328,031 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	57,418,523 - 57,468,659 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	17	56,964,450 - 57,013,288 (+)	NCBI			mm8
Celera	17	61,628,185 - 61,678,969 (+)	NCBI		Celera
Cytogenetic Map	17	D	NCBI
cM Map	17	29.76	NCBI

Vav1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	2,695,730 - 2,755,824 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	2,697,508 - 2,755,468 (-)	NCBI	ChiLan1.0	ChiLan1.0

VAV1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	6,726,578 - 6,832,795 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	6,726,578 - 6,806,112 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	19	5,805,121 - 5,888,203 (+)	NCBI

VAV1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	20	53,482,498 - 53,531,296 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	20	53,482,239 - 53,532,399 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Vav1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936588	4,058,312 - 4,107,330 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

VAV1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	72,326,714 - 72,391,648 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	72,327,433 - 72,391,649 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	72,827,628 - 72,890,504 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

VAV1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	6,337,255 - 6,415,851 (+)	NCBI

Vav1
(Heterocephalus glaber - naked mole-rat)

No map positions available.

Position Markers

RH94621

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	9	9,617,573 - 9,617,721	NCBI	Rnor6.0
Rnor_5.0	9	8,626,467 - 8,626,615	UniSTS	Rnor5.0
Celera	9	6,313,219 - 6,313,367	UniSTS
Cytogenetic Map	9	q11-q12	UniSTS

RH141231

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	9	9,617,084 - 9,617,302	NCBI	Rnor6.0
Rnor_5.0	9	8,625,978 - 8,626,196	UniSTS	Rnor5.0
Celera	9	6,312,730 - 6,312,948	UniSTS
Cytogenetic Map	9	q11-q12	UniSTS

MARC_12285-12286:1005663674:1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Celera	9	6,331,629 - 6,332,509	UniSTS
Cytogenetic Map	9	q11-q12	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10054141	Gmadr4	Adrenal mass QTL 4	2.45	0.0074	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	9	1	16520166	Rat
70226	Eae4	Experimental allergic encephalomyelitis QTL 4			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	9	1	29467098	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	1	40383872	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	1	40383872	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	1	40383872	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	45029794	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1055222	93442944	Rat
1578675	Bss17	Bone structure and strength QTL 17	3.8		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	9	1907834	15555026	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	2355722	47355722	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	2355722	47355722	Rat
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	2880977	47375681	Rat
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	2880977	47880977	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	4986095	49986095	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	4986095	49986095	Rat
61450	Ciaa3	CIA Autoantibody QTL 3	6.5		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	9	5724254	25692342	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	122
Count of miRNA genes:	99
Interacting mature miRNAs:	111
Transcripts:	ENSRNOT00000073294
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2		22	14	19	14					1	7
Low	1	43	35	27		27	7	9	74	35	35	4	7
Below cutoff							1	2			5		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012759	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AABR07066495	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AABR07066496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AABR07066497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AABR07066498	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01057961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01057962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01057963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01057964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091160	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U39476	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000073294 ⟹ ENSRNOP00000064264

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	9	9,617,786 - 9,675,110 (-)	Ensembl

RefSeq Acc Id:

NM_012759 ⟹ NP_036891

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	9,617,551 - 9,675,167 (-)	NCBI
Rnor_5.0	9	8,626,445 - 8,655,152 (-)	NCBI
Rnor_5.0	9	8,682,235 - 8,682,495 (-)	NCBI
Celera	9	6,313,197 - 6,360,060 (-)	RGD

Sequence:

show sequence

AGGAACGAGGGTGCACGGGGCCTCCCCGAGGGGCCAAGGGAGAGGCAGGCAGCCACTATGGAGC
TCTGGCGACAGTGCACCCACTGGCTGATCCAGTGTCGGGTGCTGCCTCCCAGCCACCGTGTGAC
CTGGGAGGGGGCCCAGGTGTGTGAGCTGGCACAGGCACTGCGGGATGGTGTCCTCCTGTGTCAA
CTGCTTAACAACCTGCTCCCCCACGCCATCAATCTGCGGGAAGTTAACTTGTGGCCCCAGATGT
CCCAGTTCCTTTGTCTTAAGAACATCCGAACCTTCCTGTCTACTTGCTGTGAGAAATTCGGCCT
CAAGCGCAGCGAACTCTTTGAGGCTTTTGACCTCTTTGATGTGCAGGACTTTGGAAAGGTCATC
TACACCCTGTCTGCCCTGTCATGGACACCCATTGCCCAGAACAAAGGGATCATGCCCTTCCCAA
CAGAGGACAGCGCCCTGGGTGATGAAGATATTTACAGTGGCCTTTCAGACCAGATTGATGACAC
CGCAGAGGAAGATGAGGACCTTTATGACTGCGTGGAGAATGAGGAGGCAGAGGGGGACGAGATC
TACGAGGACCTAATGCGCTCGGAGTCGGTGCCCACACCTCCCAAGATGACAGAGTACGATAAGC
GCTGCTGCTGCCTGCGGGAGATCCAGCAGACTGAGGAGAAGTACACAGACACACTGGGCTCCAT
CCAGCAGCACTTCATGAAGCCCCTCCAGCGATTCCTCAAGCCTCAAGACATGGAGACCATCTTT
GTCAACATTGAGGAGCTGCTCTCTGTGCACACCCACTTCTTAAAGGAACTGAAGGATGCCCTGT
CTGGCCCGGGAGCAACGATGCTGTATCAGGTCTTCATCAAGTATAAGGAGAGGTTCCTTGTTTA
TGGCCGTTATTGCAGTCAGGTGGAGTCAGCCAGCAAGCACTTGGATCAAGTGGCCACAGCACGG
GAGGATGTGCAGATGAAGCTGGAGGAATGCTCTCAAAGAGCCAACAATGGCCGCTTCACCCTGC
GGGATCTGCTGATGGTGCCTATGCAGCGGGTGCTGAAGTATCACCTCCTCCTCCAGGAGCTAGT
GAAACACACACAGGATACTACAGAAAAGGAGAACCTGCGGTTGGCCCTGGACGCCATGAGGGAC
CTGGCGCAGTGTGTGAATGAGGTCAAGAGGGACAATGAAACCTTACGGCAGATCACAAACTTTC
AGCTGTCCATTGAGAACCTGGACCAGTCTCTGGCCAACTATGGCCGGCCTAAGATTGACGGTGA
GCTCAAGATTACCTCAGTGGAACGGCGCTCCAAGACAGACAGGTATGCCTTCCTGCTGGACAAA
GCACTGCTCATCTGTAAGCGCCGCGGGGACTCTTATGACCTCAAGGCCTCAGTGAACCTGCACA
GCTTCCAAGTTCGGGATGACTCTTCCGGGGAGCGGGACAACAAGAAGTGGAGCCACATGTTCCT
TCTGATTGAGGATCAAGGTGCCCAGGGGTATGAGCTGTTCTTCAAGACTCGGGAGCTAAAAAAG
AAGTGGATGGAACAGTTTGAAATGGCCATCTCCAACATCTACCCAGAAAATGCTACAGCCAATG
GACATGATTTTCAGATGTTCTCCTTTGAGGAGACCACTTCCTGCAAGGCCTGCCAGATGTTACT
CAGGGGCACATTCTACCAGGGATATCGCTGTTACAGGTGCCGTGCACCCGCACACAAGGAGTGT
CTGGGAAGGGTGCCTCCATGTGGCCGTCAAGATTTCTCAGGAACCATGAAGAAGGACAAGCTAC
ATCGAAGGGCCCAGGACAAGAAAAGGAATGAATTGGGCCTTCCTAAGATGGAGGTGTGTCAGGA
ATACTACGGGATCCCTCCTCCTCCCGGAGCCTTTGGGCCATTTCTGCGGCTCAACCCTGGGGAC
ATTGTGGAACTCACTAAGGCAGAGGCTGAACACAACTGGTGGGAGGGAAGAAATACAGCTACGA
ATGAAGTCGGCTGGTTTCCCTGTAACAGAGTTCGTCCCTACGTCCACGGCCCTCCCCAGGACCT
GTCTGTGCACCTCTGGTATGCGGGCCCCATGGAGCGAGCAGGCGCCGAGGGCATCCTCACCAAC
CGCTCTGATGGGACCTACCTGGTGCGGCAAAGGGTGAAAGATACAGCGGAATTCGCCATCAGCA
TTAAGTATAATGTGGAGGTCAAGCATATTAAAATCATGACGTCAGAGGGGTTGTACCGCATCAC
AGAGAAGAAGGCTTTCCGGGGCCTCCCGGAACTGGTAGAGTTTTATCAGCAGAATTCCCTAAAA
GATTGCTTCAAGTCGTTGGACACCACCTTGCAGTTTCCTTACAAGGAACCTGAGAGGAGAGCCA
TCAACAAGCCGCCGGTTGGAAGCACCAAGTATTTTGGCACTGCCAAAGCCCGCTACGACTTCTG
TGCCCGGGACCGATCGGAACTGTCCCTTAAGGAGGGTGACATCATCAAGATCCTCAACAAGAAG
GGACAGCAAGGCTGGTGGCGTGGGGAGATCTATGGCCGGATTGGCTGGTTTCCCTCTAACTATG
TGGAGGAAGACTATTCTGAATACTGCTGAGCCCGATGCCCTGCAGGACACAGAGAGAGGCAGAT
GATGGCTGAGCCCAGGATGCCAGCAGGGTTGAGGGGCTGTGAGCTGTTCTCATTGGCAGAGGAT
CTGGATGGAGCTCAGATGGCTAGTGGCCAGCTAGCAGGGTTCCCAGGATGAAGCCCAGAGATGG
TTAATTTATAGCACACTGATTTTTTCGAGTCCTCCAAGAAAGCTGATTCTAATAAAGTGAGGAC
AGCAGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_036891	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA98606	(Get FASTA)	NCBI Sequence Viewer
	AAH91160	(Get FASTA)	NCBI Sequence Viewer
	EDL83565	(Get FASTA)	NCBI Sequence Viewer
	P54100	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_036891 ⟸ NM_012759

- UniProtKB:

Q5BK91 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MELWRQCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLWP
QMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNKGIMP
FPTEDSALGDEDIYSGLSDQIDDTAEEDEDLYDCVENEEAEGDEIYEDLMRSESVPTPPKMTEY
DKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDMETIFVNIEELLSVHTHFLKELKD
ALSGPGATMLYQVFIKYKERFLVYGRYCSQVESASKHLDQVATAREDVQMKLEECSQRANNGRF
TLRDLLMVPMQRVLKYHLLLQELVKHTQDTTEKENLRLALDAMRDLAQCVNEVKRDNETLRQIT
NFQLSIENLDQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDKALLICKRRGDSYDLKASVN
LHSFQVRDDSSGERDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENAT
ANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVPPCGRQDFSGTMKKD
KLHRRAQDKKRNELGLPKMEVCQEYYGIPPPPGAFGPFLRLNPGDIVELTKAEAEHNWWEGRNT
ATNEVGWFPCNRVRPYVHGPPQDLSVHLWYAGPMERAGAEGILTNRSDGTYLVRQRVKDTAEFA
ISIKYNVEVKHIKIMTSEGLYRITEKKAFRGLPELVEFYQQNSLKDCFKSLDTTLQFPYKEPER
RAINKPPVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRIGWFPS
NYVEEDYSEYC

hide sequence

RefSeq Acc Id:

ENSRNOP00000064264 ⟸ ENSRNOT00000073294

Protein Domains

Calponin-homology (CH) DH PH Phorbol-ester/DAG-type SH2 SH3

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696432

Promoter ID:

EPDNEW_R6956

Type:

multiple initiation site

Name:

Vav1_1

Description:

vav guanine nucleotide exchange factor 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	9,675,192 - 9,675,252	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3951	AgrOrtholog
Ensembl Genes	ENSRNOG00000050430	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000064264	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000073294	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	1.10.418.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	1.20.900.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.505.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7373783	IMAGE-MGC_LOAD
InterPro	CAMSAP_CH	UniProtKB/Swiss-Prot
	CH-domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CH_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DBL_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DH-domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GDS_CDC24_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PE/DAG-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH_Vav	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM22_calponin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Vav1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VAV1_SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VAV1_SH3_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VAV1_SH3_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25156	UniProtKB/TrEMBL
MGC_CLONE	MGC:108735	IMAGE-MGC_LOAD
NCBI Gene	25156	ENTREZGENE
PANTHER	PTHR45818:SF2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	C1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CAMSAP_CH	UniProtKB/Swiss-Prot
	PF00169	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PF00307	UniProtKB/TrEMBL
	RhoGEF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Vav1	PhenoGen
PRINTS	SH2DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM22CALPONIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	DH_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DH_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH_DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PS50021	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_DAG_PE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_DAG_PE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	RhoGEF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00033	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00109	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00233	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47576	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF48065	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF50044	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55550	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene	Rn.48861	ENTREZGENE
UniProt	M0R4H8_RAT	UniProtKB/TrEMBL
	P54100	ENTREZGENE
	Q5BK91	ENTREZGENE, UniProtKB/TrEMBL
	VAV_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-02	Vav1	vav guanine nucleotide exchange factor 1	Vav1	vav 1 guanine nucleotide exchange factor	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-12-15	Vav1	vav 1 guanine nucleotide exchange factor	Vav1	vav 1 oncogene	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2003-04-09	Vav1	vav 1 oncogene		Vav 1 oncogene	Name updated	629478	APPROVED
2002-06-10	Vav1	Vav 1 oncogene			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_pathway	can activate the c-Jun N-terminal kinase-1 (JNK1) pathway	727273
gene_product	member of the Db1 subfamily of the Rho family of GTP binding proteins	727273

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)