Vav1 (vav guanine nucleotide exchange factor 1) - Rat Genome Database

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Gene: Vav1 (vav guanine nucleotide exchange factor 1) Rattus norvegicus
Analyze
Symbol: Vav1
Name: vav guanine nucleotide exchange factor 1
RGD ID: 3951
Description: Predicted to enable guanyl-nucleotide exchange factor activity; phosphorylation-dependent protein binding activity; and phosphotyrosine residue binding activity. Involved in immune response-regulating cell surface receptor signaling pathway. Predicted to be located in cell-cell junction. Predicted to be active in cytoplasm. Biomarker of endometriosis; hepatocellular carcinoma; lymphopenia; and type 1 diabetes mellitus. Orthologous to human VAV1 (vav guanine nucleotide exchange factor 1); PARTICIPATES IN interleukin-6 signaling pathway; B cell receptor signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: p95; proto-oncogene vav; Vav; vav 1 guanine nucleotide exchange factor; Vav 1 oncogene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Ciaa3 Eae4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr892,248,856 - 2,295,905 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl92,248,914 - 2,296,922 (+)EnsemblGRCr8
mRatBN7.292,161,985 - 2,209,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl92,157,900 - 2,208,937 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,589,440 - 2,636,410 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,938,822 - 7,985,803 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,894,673 - 6,941,653 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,617,551 - 9,675,167 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,617,786 - 9,675,110 (-)Ensemblrn6Rnor6.0
Rnor_5.098,626,445 - 8,655,152 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.098,682,235 - 8,682,495 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera96,313,197 - 6,360,060 (-)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-amanitin  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diuron  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
genistein  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (ISO)
methoxychlor  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
pirinixic acid  (EXP)
propanal  (ISO)
protein kinase inhibitor  (ISO)
purine-6-thiol  (ISO)
pyrethrins  (EXP)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
testosterone  (EXP)
thioacetamide  (EXP)
tipifarnib  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell-cell junction  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Differential expression of p95vav in primary lymphoid tissue of BB rats congenic for the lymphopenia gene. Bieg S Autoimmunity. 1999;30(1):37-42.
2. Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci Furuya T, etal., Hum Mol Genet 2000 Sep 22;9(15):2241-50
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
6. DNA methylation and oncogene expression in methapyrilene-induced rat liver tumors and in treated hepatocytes in culture. Hernandez L, etal., Mol Carcinog. 1991;4(3):203-9.
7. Gene expression profiling of the rat endometriosis model. Konno R, etal., Am J Reprod Immunol. 2007 Oct;58(4):330-43.
8. Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Margolis B, etal., Nature. 1992 Mar 5;356(6364):71-4.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway. Song JS, etal., J Immunol 1999 Jul 15;163(2):802-10.
Additional References at PubMed
PMID:8990121   PMID:11070165   PMID:12477932   PMID:15249579   PMID:15618286   PMID:15644420   PMID:15696170   PMID:16203968   PMID:17721087   PMID:20624904   PMID:20962259   PMID:21178006  
PMID:22467863   PMID:23793062   PMID:26163585   PMID:30361391   PMID:34147481  


Genomics

Comparative Map Data
Vav1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr892,248,856 - 2,295,905 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl92,248,914 - 2,296,922 (+)EnsemblGRCr8
mRatBN7.292,161,985 - 2,209,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl92,157,900 - 2,208,937 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,589,440 - 2,636,410 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,938,822 - 7,985,803 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,894,673 - 6,941,653 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,617,551 - 9,675,167 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,617,786 - 9,675,110 (-)Ensemblrn6Rnor6.0
Rnor_5.098,626,445 - 8,655,152 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.098,682,235 - 8,682,495 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera96,313,197 - 6,360,060 (-)NCBICelera
Cytogenetic Map9q11NCBI
VAV1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,772,708 - 6,857,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,772,708 - 6,857,366 (+)Ensemblhg38GRCh38
GRCh37196,772,719 - 6,857,372 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,723,722 - 6,808,371 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34196,723,721 - 6,808,371NCBI
Celera196,714,968 - 6,799,596 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,535,153 - 6,619,808 (+)NCBIHuRef
CHM1_1196,772,530 - 6,857,195 (+)NCBICHM1_1
T2T-CHM13v2.0196,762,101 - 6,846,684 (+)NCBIT2T-CHM13v2.0
Vav1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,586,080 - 57,636,236 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,586,100 - 57,635,031 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381757,279,100 - 57,329,236 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,279,100 - 57,328,031 (+)Ensemblmm10GRCm38
MGSCv371757,418,523 - 57,468,659 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361756,964,450 - 57,013,288 (+)NCBIMGSCv36mm8
Celera1761,628,185 - 61,678,969 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.76NCBI
Vav1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,695,730 - 2,755,824 (-)Ensembl
ChiLan1.0NW_0049554952,697,508 - 2,755,468 (-)NCBIChiLan1.0ChiLan1.0
VAV1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22011,185,888 - 11,272,029 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11910,411,972 - 10,494,172 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,805,121 - 5,888,203 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,726,578 - 6,832,795 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,726,578 - 6,806,112 (+)EnsemblpanPan2panpan1.1
VAV1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,482,239 - 53,532,399 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,482,498 - 53,531,296 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2053,231,024 - 53,280,874 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02054,137,307 - 54,187,259 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,137,311 - 54,193,863 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,204,407 - 53,254,232 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,652,377 - 53,702,224 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,881,726 - 53,931,647 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vav1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,727,422 - 213,748,901 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,058,343 - 4,107,109 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,058,312 - 4,107,330 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VAV1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,326,716 - 72,391,648 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1272,327,433 - 72,391,649 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,827,628 - 72,890,504 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VAV1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,337,255 - 6,415,851 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660811,571,908 - 1,654,139 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vav1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,838,706 - 3,897,080 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248283,838,464 - 3,896,698 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Vav1
374 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:99
Interacting mature miRNAs:111
Transcripts:ENSRNOT00000073294
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631533Iresp3Immunoglobin response QTL316.2blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)916094576Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat

Markers in Region
RH94621  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.292,208,768 - 2,208,917 (-)MAPPERmRatBN7.2
Rnor_6.099,617,573 - 9,617,721NCBIRnor6.0
Rnor_5.098,626,467 - 8,626,615UniSTSRnor5.0
Celera96,313,219 - 6,313,367UniSTS
Cytogenetic Map9q11-q12UniSTS
RH141231  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.292,209,187 - 2,209,406 (-)MAPPERmRatBN7.2
Rnor_6.099,617,084 - 9,617,302NCBIRnor6.0
Rnor_5.098,625,978 - 8,626,196UniSTSRnor5.0
Celera96,312,730 - 6,312,948UniSTS
Cytogenetic Map9q11-q12UniSTS
MARC_12285-12286:1005663674:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr892,276,535 - 2,277,415 (+)Marker Load Pipeline
Celera96,331,629 - 6,332,509UniSTS
Cytogenetic Map9q11-q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 158 91 90 59 92 59 6 356 192 11 134 81 92 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000073294   ⟹   ENSRNOP00000064264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl92,248,914 - 2,296,922 (+)Ensembl
mRatBN7.2 Ensembl92,161,985 - 2,208,937 (+)Ensembl
Rnor_6.0 Ensembl99,617,786 - 9,675,110 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094489   ⟹   ENSRNOP00000086561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl92,248,914 - 2,296,922 (+)Ensembl
mRatBN7.2 Ensembl92,161,985 - 2,208,937 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096076   ⟹   ENSRNOP00000077767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl92,248,914 - 2,289,900 (+)Ensembl
mRatBN7.2 Ensembl92,161,985 - 2,208,937 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111335   ⟹   ENSRNOP00000081960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl92,248,914 - 2,296,922 (+)Ensembl
mRatBN7.2 Ensembl92,157,900 - 2,208,937 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000173752   ⟹   ENSRNOP00000108863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl92,248,914 - 2,296,922 (+)Ensembl
RefSeq Acc Id: NM_012759   ⟹   NP_036891
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr892,248,955 - 2,295,905 (+)NCBI
mRatBN7.292,161,985 - 2,208,939 (+)NCBI
Rnor_6.099,617,551 - 9,675,167 (-)NCBI
Rnor_5.098,626,445 - 8,655,152 (-)NCBI
Rnor_5.098,682,235 - 8,682,495 (-)NCBI
Celera96,313,197 - 6,360,060 (-)RGD
Sequence:
RefSeq Acc Id: XM_063266662   ⟹   XP_063122732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr892,248,856 - 2,278,923 (+)NCBI
Protein Sequences
Protein RefSeqs NP_036891 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122732 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA98606 (Get FASTA)   NCBI Sequence Viewer  
  AAH91160 (Get FASTA)   NCBI Sequence Viewer  
  EDL83565 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000081960
GenBank Protein P54100 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036891   ⟸   NM_012759
- UniProtKB: P54100 (UniProtKB/Swiss-Prot),   Q5BK91 (UniProtKB/TrEMBL),   A0A8I5Y9Q8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064264   ⟸   ENSRNOT00000073294
Ensembl Acc Id: ENSRNOP00000086561   ⟸   ENSRNOT00000094489
Ensembl Acc Id: ENSRNOP00000077767   ⟸   ENSRNOT00000096076
Ensembl Acc Id: ENSRNOP00000081960   ⟸   ENSRNOT00000111335
RefSeq Acc Id: XP_063122732   ⟸   XM_063266662
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000108863   ⟸   ENSRNOT00000173752
Protein Domains
Calponin-homology (CH)   DH   PH   Phorbol-ester/DAG-type   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54100-F1-model_v2 AlphaFold P54100 1-843 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696432
Promoter ID:EPDNEW_R6956
Type:multiple initiation site
Name:Vav1_1
Description:vav guanine nucleotide exchange factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.099,675,192 - 9,675,252EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3951 AgrOrtholog
BioCyc Gene G2FUF-28479 BioCyc
Ensembl Genes ENSRNOG00000050430 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000111335 ENTREZGENE
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot
  1.20.900.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
  3.30.60.20 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7373783 IMAGE-MGC_LOAD
InterPro CAMSAP_CH UniProtKB/Swiss-Prot
  CH-domain UniProtKB/Swiss-Prot
  CH_dom_sf UniProtKB/Swiss-Prot
  DBL_dom_sf UniProtKB/Swiss-Prot
  DH-domain UniProtKB/Swiss-Prot
  GDS_CDC24_CS UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  PH_Vav UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  SM22_calponin UniProtKB/Swiss-Prot
  VAV1_SH2 UniProtKB/Swiss-Prot
  VAV1_SH3_1 UniProtKB/Swiss-Prot
  VAV1_SH3_2 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108735 IMAGE-MGC_LOAD
NCBI Gene 25156 ENTREZGENE
PANTHER PROTEIN VAV UniProtKB/Swiss-Prot
  PTHR45818:SF2 UniProtKB/Swiss-Prot
Pfam C1_1 UniProtKB/Swiss-Prot
  CAMSAP_CH UniProtKB/Swiss-Prot
  PF00169 UniProtKB/Swiss-Prot
  RhoGEF UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
  SH3_2 UniProtKB/Swiss-Prot
PhenoGen Vav1 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
  SM22CALPONIN UniProtKB/Swiss-Prot
PROSITE DH_1 UniProtKB/Swiss-Prot
  DH_2 UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  PS50021 UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000050430 RatGTEx
SMART RhoGEF UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  SM00033 UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF47576 UniProtKB/Swiss-Prot
  SSF48065 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt A0A8I5Y9Q8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZTA6_RAT UniProtKB/TrEMBL
  A0A8I6A1G3_RAT UniProtKB/TrEMBL
  M0R4H8_RAT UniProtKB/TrEMBL
  P54100 ENTREZGENE
  Q5BK91 ENTREZGENE, UniProtKB/TrEMBL
  VAV_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Vav1  vav guanine nucleotide exchange factor 1  Vav1  vav 1 guanine nucleotide exchange factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Vav1  vav 1 guanine nucleotide exchange factor  Vav1  vav 1 oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Vav1  vav 1 oncogene    Vav 1 oncogene  Name updated 629478 APPROVED
2002-06-10 Vav1  Vav 1 oncogene      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_pathway can activate the c-Jun N-terminal kinase-1 (JNK1) pathway 727273
gene_product member of the Db1 subfamily of the Rho family of GTP binding proteins 727273