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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cetrorelix
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Accession:CHEBI:59224 term browser browse the term
Definition:A synthetic ten-membered oligopeptide comprising N-acetyl-3-(naphthalen-2-yl)-D-alanyl, 4-chloro-D-phenylalanyl, 3-(pyridin-3-yl)-D-alanyl, L-seryl, L-tyrosyl, N(5)-carbamoyl-D-ornithyl, L-leucyl, L-arginyl, L-prolyl, and D-alaninamide residues coupled in sequence. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast.
Synonyms:exact_synonym: N-acetyl-3-(naphthalen-2-yl)-D-alanyl-4-chloro-D-phenylalanyl-3-(pyridin-3-yl)-D-alanyl-L-seryl-L-tyrosyl-N(5)-carbamoyl-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide
 related_synonym: Formula=C70H92ClN17O14;   InChI=1S/C70H92ClN17O14/c1-39(2)31-52(61(94)82-51(15-9-28-77-69(73)74)68(101)88-30-10-16-58(88)67(100)79-40(3)59(72)92)83-60(93)50(14-8-29-78-70(75)102)81-63(96)54(34-43-20-25-49(91)26-21-43)86-66(99)57(38-89)87-65(98)56(36-45-11-7-27-76-37-45)85-64(97)55(33-42-18-23-48(71)24-19-42)84-62(95)53(80-41(4)90)35-44-17-22-46-12-5-6-13-47(46)32-44/h5-7,11-13,17-27,32,37,39-40,50-58,89,91H,8-10,14-16,28-31,33-36,38H2,1-4H3,(H2,72,92)(H,79,100)(H,80,90)(H,81,96)(H,82,94)(H,83,93)(H,84,95)(H,85,97)(H,86,99)(H,87,98)(H4,73,74,77)(H3,75,78,102)/t40-,50-,51+,52+,53-,54+,55-,56-,57+,58+/m1/s1;   InChIKey=SBNPWPIBESPSIF-MHWMIDJBSA-N;   SMILES=CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O;   cetrorelixum
 xref: Beilstein:5860649;   CAS:120287-85-6;   DrugBank:DB00050;   Drug_Central:583;   KEGG:D07665
 xref_mesh: MESH:C062876
 xref: Patent:EP299402;   Patent:US4800191;   Wikipedia:Cetrorelix


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cetrorelix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO cetrorelix results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of APOE mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of APOE mRNA CTD PMID:18160741 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO
EXP
cetrorelix results in increased expression of BAX mRNA; cetrorelix results in increased expression of BAX protein CTD PMID:17268770, PMID:18829022 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO
EXP
cetrorelix results in decreased expression of BCL2 protein
cetrorelix results in decreased expression of BCL2 mRNA
CTD PMID:18829022, PMID:21062912 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO cetrorelix results in decreased expression of BCL2L1 protein CTD PMID:21062912 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 increases activity ISO
EXP
cetrorelix results in increased activity of CASP3 protein CTD PMID:17268770, PMID:21062912 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity ISO
EXP
cetrorelix results in increased activity of CASP9 protein CTD PMID:17268770 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccn5 cellular communication network factor 5 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CCN5 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CCN5 mRNA CTD PMID:18160741 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO cetrorelix results in increased expression of CDKN1A protein CTD PMID:21062912 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chga chromogranin A multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CHGA mRNA CTD PMID:18160741 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568
JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 decreases expression ISO cetrorelix results in decreased expression of CLCF1 mRNA CTD PMID:21062912 NCBI chr 1:219,468,866...219,472,445
Ensembl chr 1:219,468,675...219,472,654
JBrowse link
G Cst9l cystatin 9-like multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of CST9L mRNA; [cetrorelix co-treated with testosterone enanthate] results in increased expression of CST9L mRNA CTD PMID:18160741 NCBI chr 3:143,172,691...143,175,504
Ensembl chr 3:143,172,686...143,175,500
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO cetrorelix results in decreased expression of CXCL12 mRNA CTD PMID:21062912 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYB5A mRNA CTD PMID:18160741 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP11A1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYP11A1 mRNA CTD PMID:18160741 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP17A1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYP17A1 mRNA CTD PMID:18160741 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of DDR1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in increased expression of DDR1 mRNA CTD PMID:18160741 NCBI chr20:3,553,430...3,574,959
Ensembl chr20:3,552,929...3,575,780
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of DHCR24 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of DHCR24 mRNA CTD PMID:18160741 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Dpep3 dipeptidase 3 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of DPEP3 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of DPEP3 mRNA CTD PMID:18160741 NCBI chr19:37,946,516...37,955,199
Ensembl chr19:37,946,722...37,952,501
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO
EXP
cetrorelix results in increased expression of FAS mRNA; cetrorelix results in increased expression of FAS protein CTD PMID:17268770 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression ISO
EXP
cetrorelix results in decreased expression of FSHB protein CTD PMID:10077358, PMID:17638707 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of GSTA2 mRNA CTD PMID:18160741 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Hcrtr1 hypocretin receptor 1 decreases expression EXP cetrorelix results in decreased expression of HCRTR1 mRNA CTD PMID:17638707 NCBI chr 5:148,346,029...148,355,404
Ensembl chr 5:148,346,031...148,355,406
JBrowse link
G Hcrtr2 hypocretin receptor 2 decreases expression EXP cetrorelix results in decreased expression of HCRTR2 mRNA CTD PMID:17638707 NCBI chr 8:83,307,684...83,421,612
Ensembl chr 8:83,307,684...83,421,612
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of HMGCS2 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of HMGCS2 mRNA CTD PMID:18160741 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of HSD17B6 mRNA CTD PMID:18160741 NCBI chr 7:2,412,370...2,431,249
Ensembl chr 7:2,412,363...2,431,197
Ensembl chr13:2,412,363...2,431,197
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO cetrorelix results in decreased expression of IGF1 mRNA CTD PMID:21062912 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il6 interleukin 6 decreases expression ISO cetrorelix results in decreased expression of IL6 mRNA CTD PMID:21062912 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insl3 insulin-like 3 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of INSL3 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of INSL3 mRNA CTD PMID:18160741 NCBI chr16:20,120,753...20,122,702
Ensembl chr16:20,121,352...20,122,696
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
multiple interactions
decreases secretion
EXP
ISO
cetrorelix results in decreased expression of LHB protein
cypermethrin inhibits the reaction [cetrorelix results in decreased secretion of LHB protein]
CTD PMID:10077358, PMID:16914592, PMID:17638707, PMID:28731686 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO cetrorelix results in decreased phosphorylation of MAPK1 protein CTD PMID:21062912 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO cetrorelix results in decreased phosphorylation of MAPK3 protein CTD PMID:21062912 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Msmo1 methylsterol monooxygenase 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of MSMO1 mRNA CTD PMID:18160741 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PAPSS2 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of PAPSS2 mRNA CTD PMID:18160741 NCBI chr 1:251,145,264...251,230,716
Ensembl chr 1:251,145,253...251,230,715
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PGRMC1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of PGRMC1 mRNA CTD PMID:18160741 NCBI chr  X:123,205,869...123,213,880
Ensembl chr  X:123,205,869...123,213,882
JBrowse link
G Prl prolactin decreases expression EXP cetrorelix results in decreased expression of PRL protein CTD PMID:17638707 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prok1 prokineticin 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PROK1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of PROK1 mRNA CTD PMID:18160741 NCBI chr 2:209,986,503...209,994,438
Ensembl chr 2:209,987,992...209,993,250
JBrowse link
G Prps2 phosphoribosyl pyrophosphate synthetase 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of PRPS2 mRNA CTD PMID:18160741 NCBI chr  X:28,435,275...28,472,882
Ensembl chr  X:28,435,507...28,472,880
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO cetrorelix results in decreased phosphorylation of and results in decreased activity of RELA protein CTD PMID:21062912 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhob ras homolog family member B multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of RHOB mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of RHOB mRNA CTD PMID:18160741 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of STAR mRNA CTD PMID:18160741 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO cetrorelix results in decreased phosphorylation of STAT3 protein CTD PMID:21062912 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Sycp1 synaptonemal complex protein 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of SYCP1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of SYCP1 mRNA CTD PMID:18160741 NCBI chr 2:205,274,766...205,426,869
Ensembl chr 2:205,274,769...205,426,869
JBrowse link
G Taf4b TATA-box binding protein associated factor 4b multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of TAF4B mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of TAF4B mRNA CTD PMID:18160741 NCBI chr18:6,206,939...6,338,794
Ensembl chr18:6,207,280...6,318,219
JBrowse link
G Tex19.2 testis expressed gene 19.2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of TEX19 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of TEX19 mRNA CTD PMID:18160741 NCBI chr10:110,305,926...110,308,514
Ensembl chr10:110,305,928...110,308,514
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO cetrorelix results in decreased expression of TGFB1 mRNA CTD PMID:21062912 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnfsf13 TNF superfamily member 13 decreases expression ISO cetrorelix results in decreased expression of TNFSF13 mRNA CTD PMID:21062912 NCBI chr10:56,286,964...56,290,680
Ensembl chr10:56,286,887...56,289,952
JBrowse link
G Tp53 tumor protein p53 increases expression ISO cetrorelix results in increased expression of TP53 protein CTD PMID:21062912 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO cetrorelix results in decreased expression of VEGFA mRNA CTD PMID:21062912 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            antineoplastic agent 17001
              cetrorelix 49
                cetrorelix acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                peptide 9396
                                                  oligopeptide 1199
                                                    cetrorelix 49
                                                      cetrorelix acetate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.