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Gene: Scnn1g (sodium channel epithelial 1 subunit gamma) Rattus norvegicus
Symbol: Scnn1g
Name: sodium channel epithelial 1 subunit gamma
RGD ID: 3641
Description: Exhibits WW domain binding activity and ligand-gated sodium channel activity. Predicted to contribute to sodium channel activity. Involved in response to hypoxia; sodium ion transport; and wound healing, spreading of epidermal cells. Localizes to apical plasma membrane and cell surface. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1G (sodium channel epithelial 1 subunit gamma); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3-isobutyl-1-methyl-7H-xanthine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: amiloride sensitive sodium channel gamma1 subunit; amiloride-sensitive sodium channel subunit gamma; ENaC; epithelial Na(+) channel subunit gamma; epithelial sodium channel gamma subunit; gamma-ENaC; gamma-NaCH; nonvoltage-gated sodium channel 1 subunit gamma; SCNEG; sodium channel epithelial 1 gamma subunit; Sodium channel nonvoltage-gated 1 gamma (epithelial); sodium channel, non-voltage-gated 1, gamma subunit; sodium channel, nonvoltage-gated 1 gamma; sodium channel, nonvoltage-gated 1, gamma; Sodium channel, nonvoltage-gated 1, gamma (epithelial); sodium channel, nonvoltage-gated, type I, gamma
Homo sapiens (human) : SCNN1G (sodium channel epithelial 1 subunit gamma)  HGNC  Alliance
Mus musculus (house mouse) : Scnn1g (sodium channel, nonvoltage-gated 1 gamma)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Scnn1g (sodium channel epithelial 1 gamma subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : SCNN1G (sodium channel epithelial 1 subunit gamma)
Canis lupus familiaris (dog) : SCNN1G (sodium channel epithelial 1 subunit gamma)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scnn1g (sodium channel epithelial 1 subunit gamma)
Sus scrofa (pig) : SCNN1G (sodium channel epithelial 1 subunit gamma)
Chlorocebus sabaeus (African green monkey) : SCNN1G (sodium channel epithelial 1 subunit gamma)
Heterocephalus glaber (naked mole-rat) : Scnn1g (sodium channel epithelial 1 subunit gamma)
more info ...
Is Marker For: Strains:   SHR.BN-(D1Mit3-Igf2)/Ipcv  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01191,704,397 - 191,738,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1191,704,311 - 191,738,268 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01198,620,974 - 198,655,013 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41180,555,660 - 180,589,534 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11180,695,574 - 180,729,447 (+)NCBI
Celera1174,023,130 - 174,057,000 (+)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Scnn1g
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3641
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.