Acaa1a (acetyl-CoA acyltransferase 1A) - Rat Genome Database
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Gene: Acaa1a (acetyl-CoA acyltransferase 1A) Rattus norvegicus
Analyze
Symbol: Acaa1a
Name: acetyl-CoA acyltransferase 1A
RGD ID: 67379
Description: Exhibits acetyl-CoA C-acyltransferase activity; acetyl-CoA C-myristoyltransferase activity; and palmitoyl-CoA oxidase activity. Involved in several processes, including monocarboxylic acid metabolic process; response to nutrient; and response to steroid hormone. Localizes to peroxisome. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; unsaturated fatty acid biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 3-ketoacyl-CoA thiolase A, peroxisomal; Acaa; Acaa1; acetyl-CoA acyltransferase 1; acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A; Acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A 1 peroxisomal; Acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A peroxisomal; acetyl-CoA acyltransferase A; acetyl-CoA acyltransferase, 3-oxo acyl-CoA thiolase A; acetyl-CoA C-myristoyltransferase; acetyl-Coenzyme A acyltransferase 1; acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase); acetyl-Coenzyme A acyltransferase 1A; beta-ketothiolase A; MGC108766; peroxisomal 3-oxoacyl-CoA thiolase A; Pktaa; thiolase A
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   BpQTLcluster8  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28119,079,401 - 119,088,624 (+)NCBI
Rnor_6.0 Ensembl8128,027,958 - 128,036,236 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08128,027,880 - 128,036,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08127,234,641 - 127,243,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,305,097 - 124,313,887 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,324,833 - 124,333,624 (+)NCBI
Celera8118,231,008 - 118,239,798 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
aflatoxin B1  (ISO)
aspartame  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
capecitabine  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
ciglitazone  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (EXP)
ethanol  (EXP)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
glafenine  (EXP)
GW 7647  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
isotretinoin  (ISO)
leflunomide  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nafenopin  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
oleic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (EXP)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
pyrazinecarboxamide  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
scopoletin  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
tamoxifen  (EXP)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (TAS)
peroxisome  (IBA,IDA,ISO)

References

Additional References at PubMed
PMID:1347505   PMID:1680677   PMID:2318981   PMID:2365812   PMID:2895531   PMID:9053548   PMID:11734571   PMID:12477932   PMID:15489334   PMID:17881773   PMID:18614015   PMID:19479899  
PMID:19946888  


Genomics

Comparative Map Data
Acaa1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28119,079,401 - 119,088,624 (+)NCBI
Rnor_6.0 Ensembl8128,027,958 - 128,036,236 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08128,027,880 - 128,036,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08127,234,641 - 127,243,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,305,097 - 124,313,887 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,324,833 - 124,333,624 (+)NCBI
Celera8118,231,008 - 118,239,798 (+)NCBICelera
Cytogenetic Map8q32NCBI
ACAA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl338,103,129 - 38,137,242 (-)EnsemblGRCh38hg38GRCh38
GRCh38338,122,710 - 38,137,127 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37338,164,206 - 38,178,618 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,139,211 - 38,153,619 (-)NCBINCBI36hg18NCBI36
Build 34338,139,210 - 38,153,619NCBI
Celera338,100,002 - 38,114,534 (-)NCBI
Cytogenetic Map3p22.2ENTREZGENE
HuRef338,205,163 - 38,219,695 (-)NCBIHuRef
CHM1_1338,116,181 - 38,130,713 (-)NCBICHM1_1
Acaa1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,170,094 - 119,179,361 (+)NCBIGRCm39mm39
GRCm39 Ensembl9119,168,742 - 119,179,365 (+)Ensembl
GRCm389119,341,028 - 119,350,296 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,339,676 - 119,350,299 (+)EnsemblGRCm38mm10GRCm38
MGSCv379119,250,412 - 119,259,413 (+)NCBIGRCm37mm9NCBIm37
MGSCv369119,189,992 - 119,198,993 (+)NCBImm8
Celera9119,810,424 - 119,819,473 (+)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
ACAA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1338,302,976 - 38,317,009 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0338,020,439 - 38,035,341 (-)NCBIMhudiblu_PPA_v0panPan3
ACAA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl237,889,500 - 7,901,229 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1237,889,481 - 7,901,324 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ACAA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1322,964,875 - 23,020,143 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11322,964,844 - 23,020,138 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,168,888 - 25,179,542 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACAA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,282,556 - 1,297,154 (+)NCBI
ChlSab1.1 Ensembl151,282,650 - 1,297,832 (+)Ensembl
Acaa1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247312,665,228 - 2,677,248 (-)NCBI

Position Markers
D8Wox10  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.08128,032,912 - 128,033,050NCBIRnor6.0
Rnor_5.08127,239,673 - 127,239,811UniSTSRnor5.0
RGSC_v3.48124,310,080 - 124,310,219RGDRGSC3.4
RGSC_v3.48124,310,081 - 124,310,219UniSTSRGSC3.4
RGSC_v3.18124,329,817 - 124,329,956RGD
Celera8118,235,992 - 118,236,130UniSTS
RH 3.4 Map81312.6UniSTS
RH 3.4 Map81312.6RGD
RH 2.0 Map81012.2RGD
Cytogenetic Map8q32UniSTS
D8Arb22  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.08128,032,837 - 128,033,168NCBIRnor6.0
Rnor_5.08127,239,598 - 127,239,929UniSTSRnor5.0
RGSC_v3.48124,310,006 - 124,310,337UniSTSRGSC3.4
RGSC_v3.18124,329,742 - 124,330,074RGD
Celera8118,235,917 - 118,236,248UniSTS
Cytogenetic Map8q32UniSTS
BI274607  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.08128,036,329 - 128,036,479NCBIRnor6.0
Rnor_5.08127,243,090 - 127,243,240UniSTSRnor5.0
RGSC_v3.48124,313,745 - 124,313,895UniSTSRGSC3.4
Celera8118,239,656 - 118,239,806UniSTS
RH 3.4 Map81287.3UniSTS
Cytogenetic Map8q32UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)850529480128036471Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)865717449128033050Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)883894304128894304Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)889058229132243842Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102051964133307652Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8104682575133307652Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)8104682575133307652Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8107769005129956433Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:295
Count of miRNA genes:197
Interacting mature miRNAs:218
Transcripts:ENSRNOT00000045049, ENSRNOT00000055919
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 57 41 19 41 3 72 35 41 11
Low 8 8 8 2 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000045049   ⟹   ENSRNOP00000050691
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8128,027,958 - 128,036,236 (+)Ensembl
RefSeq Acc Id: NM_012489   ⟹   NP_036621
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28119,079,807 - 119,088,597 (+)NCBI
Rnor_6.08128,027,880 - 128,036,471 (+)NCBI
Rnor_5.08127,234,641 - 127,243,232 (+)NCBI
RGSC_v3.48124,305,097 - 124,313,887 (+)RGD
Celera8118,231,008 - 118,239,798 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080786   ⟹   XP_038936714
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28119,079,401 - 119,088,623 (+)NCBI
RefSeq Acc Id: XM_039080787   ⟹   XP_038936715
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28119,079,680 - 119,088,624 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036621   ⟸   NM_012489
- UniProtKB: P21775 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000050691   ⟸   ENSRNOT00000045049
RefSeq Acc Id: XP_038936714   ⟸   XM_039080786
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038936715   ⟸   XM_039080787
- Peptide Label: isoform X2
Protein Domains
Thiolase_C   Thiolase_N

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696370
Promoter ID:EPDNEW_R6895
Type:initiation region
Name:Acaa1a_1
Description:acetyl-CoA acyltransferase 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08128,027,875 - 128,027,935EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:67379 AgrOrtholog
Ensembl Genes ENSRNOG00000032908 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000050691 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045049 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7122340 IMAGE-MGC_LOAD
  IMAGE:7128867 IMAGE-MGC_LOAD
InterPro Thiolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_acyl_enz_int_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24157 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108766 IMAGE-MGC_LOAD
  MGC:93661 IMAGE-MGC_LOAD
NCBI Gene 24157 ENTREZGENE
Pfam Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acaa1a PhenoGen
PIRSF Ac-CoA_Ac_transf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOLASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204651
TIGRFAMs AcCoA-C-Actrans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LPD6_RAT UniProtKB/TrEMBL
  P21775 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5FVR9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-24 Acaa1a  acetyl-CoA acyltransferase 1A  Acaa1  acetyl-CoA acyltransferase 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-08-22 Acaa1  acetyl-CoA acyltransferase 1A  Acaa1a  acetyl-CoA acyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-18 Acaa1a  acetyl-CoA acyltransferase 1  Acaa1  acetyl-CoA acyltransferase 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-11 Acaa1  acetyl-CoA acyltransferase 1A  Acaa1a  acetyl-CoA acyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-23 Acaa1a  acetyl-CoA acyltransferase 1  Acaa1  acetyl-CoA acyltransferase 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-18 Acaa1  acetyl-CoA acyltransferase 1A  Acaa1a  acetyl-Coenzyme A acyltransferase 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Acaa1  acetyl-Coenzyme A acyltransferase 1  Acaa1  acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase)  Name updated 1299863 APPROVED
2003-01-28 Acaa1  acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase)  Acaa  acetyl-CoA acyltransferase, 3-oxo acyl-CoA thiolase A  Data Merged 628472 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process functions in peroxisomal beta-oxidation of fatty acids 1299138
gene_protein mature enzyme is composed of 398 amino acids and the molecular weight is 41,074 1299140