Acaa1a (acetyl-CoA acyltransferase 1A) - Rat Genome Database

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Gene: Acaa1a (acetyl-CoA acyltransferase 1A) Rattus norvegicus
Analyze
Symbol: Acaa1a
Name: acetyl-CoA acyltransferase 1A
RGD ID: 67379
Description: Enables acetyl-CoA C-acyltransferase activity; acetyl-CoA C-myristoyltransferase activity; and palmitoyl-CoA oxidase activity. Involved in several processes, including monocarboxylic acid metabolic process; response to nutrient; and response to steroid hormone. Located in peroxisome. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; unsaturated fatty acid biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-ketoacyl-CoA thiolase A, peroxisomal; Acaa; Acaa1; acetyl-CoA acyltransferase 1; acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A; Acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A 1 peroxisomal; Acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A peroxisomal; acetyl-CoA acyltransferase A; acetyl-CoA acyltransferase, 3-oxo acyl-CoA thiolase A; acetyl-CoA C-myristoyltransferase; acetyl-Coenzyme A acyltransferase 1; acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase); acetyl-Coenzyme A acyltransferase 1A; beta-ketothiolase A; MGC108766; peroxisomal 3-oxoacyl-CoA thiolase A; Pktaa; thiolase A
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   BpQTLcluster8  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,956,126 - 127,966,348 (+)NCBIGRCr8
mRatBN7.28119,079,401 - 119,088,626 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,079,775 - 119,088,624 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,661,801 - 124,670,662 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,860,818 - 122,869,679 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,694,346 - 120,703,213 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,027,880 - 128,036,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,027,958 - 128,036,236 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,234,641 - 127,243,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,305,097 - 124,313,887 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,324,833 - 124,333,624 (+)NCBI
Celera8118,231,008 - 118,239,798 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
aspartame  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
capecitabine  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
ciglitazone  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
etomoxir  (EXP)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
glafenine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
GW 7647  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
leflunomide  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nafenopin  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
oleic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (EXP)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
pyrazinecarboxamide  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
scopoletin  (EXP)
senecionine  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
tamoxifen  (EXP)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Correlation between genetic and cytogenetic maps of the rat. Andoh Y, etal., Mamm Genome 1998 Apr;9(4):287-93.
2. Substrate specificities of 3-oxoacyl-CoA thiolase A and sterol carrier protein 2/3-oxoacyl-CoA thiolase purified from normal rat liver peroxisomes. Sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in the metabolism of 2-methyl-branched fatty acids and bile acid intermediates. Antonenkov VD, etal., J Biol Chem. 1997 Oct 10;272(41):26023-31. doi: 10.1074/jbc.272.41.26023.
3. Cloning and sequence determination of cDNA encoding a second rat liver peroxisomal 3-ketoacyl-CoA thiolase. Bodnar AG and Rachubinski RA, Gene. 1990 Jul 16;91(2):193-9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Structural analysis of cDNA for rat peroxisomal 3-ketoacyl-CoA thiolase. Hijikata M, etal., J Biol Chem 1987 Jun 15;262(17):8151-8.
7. Rat peroxisomal 3-ketoacyl-CoA thiolase gene. Occurrence of two closely related but differentially regulated genes. Hijikata M, etal., J Biol Chem 1990 Mar 15;265(8):4600-6.
8. Activity of hepatic fatty acid oxidation enzymes in rats fed alpha-linolenic acid. Kabir Y and Ide T, Biochim Biophys Acta. 1996 Nov 22;1304(2):105-19.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Effects of ubiquinone and mevalonic acid on hepatic peroxisomal enzymes induced by dehydroepiandrosterone. Khan SA and Nyce JW, Pharmacol Toxicol. 1997 Mar;80(3):118-21.
11. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. The effects of chronic trimetazidine treatment on mechanical function and fatty acid oxidation in diabetic rat hearts. Onay-Besikci A, etal., Can J Physiol Pharmacol. 2007 May;85(5):527-35.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Human peroxisomal 3-oxoacyl-coenzyme A thiolase deficiency. Schram AW, etal., Proc Natl Acad Sci U S A. 1987 Apr;84(8):2494-6.
18. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1347505   PMID:1680677   PMID:2318981   PMID:2365812   PMID:2895531   PMID:9053548   PMID:11734571   PMID:12477932   PMID:15489334   PMID:17881773   PMID:18614015   PMID:19479899  
PMID:19946888  


Genomics

Comparative Map Data
Acaa1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,956,126 - 127,966,348 (+)NCBIGRCr8
mRatBN7.28119,079,401 - 119,088,626 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,079,775 - 119,088,624 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,661,801 - 124,670,662 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,860,818 - 122,869,679 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,694,346 - 120,703,213 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,027,880 - 128,036,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,027,958 - 128,036,236 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,234,641 - 127,243,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,305,097 - 124,313,887 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,324,833 - 124,333,624 (+)NCBI
Celera8118,231,008 - 118,239,798 (+)NCBICelera
Cytogenetic Map8q32NCBI
ACAA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,122,715 - 38,137,127 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,103,129 - 38,137,242 (-)EnsemblGRCh38hg38GRCh38
GRCh37338,164,206 - 38,178,618 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,139,211 - 38,153,619 (-)NCBINCBI36Build 36hg18NCBI36
Build 34338,139,210 - 38,153,619NCBI
Celera338,100,002 - 38,114,534 (-)NCBICelera
Cytogenetic Map3p22.2ENTREZGENE
HuRef338,205,163 - 38,219,695 (-)NCBIHuRef
CHM1_1338,116,181 - 38,130,713 (-)NCBICHM1_1
T2T-CHM13v2.0338,128,384 - 38,142,796 (-)NCBIT2T-CHM13v2.0
Acaa1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,170,113 - 119,179,361 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,168,742 - 119,179,365 (+)EnsemblGRCm39 Ensembl
GRCm389119,341,028 - 119,350,296 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,339,676 - 119,350,299 (+)EnsemblGRCm38mm10GRCm38
MGSCv379119,250,412 - 119,259,413 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,189,992 - 119,198,993 (+)NCBIMGSCv36mm8
Celera9119,810,424 - 119,819,473 (+)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
ACAA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,075,928 - 38,090,823 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,080,692 - 38,095,705 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,020,439 - 38,035,341 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,302,976 - 38,317,009 (-)NCBIpanpan1.1PanPan1.1panPan2
ACAA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,889,481 - 7,901,324 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,889,500 - 7,901,229 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha237,931,439 - 7,943,297 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0238,179,036 - 8,190,917 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,179,041 - 8,190,806 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1237,992,930 - 8,004,823 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,134,083 - 8,145,938 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0238,126,342 - 8,138,206 (-)NCBIUU_Cfam_GSD_1.0
ACAA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1322,964,875 - 23,020,143 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11322,964,844 - 23,020,138 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,168,888 - 25,179,542 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACAA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,282,556 - 1,297,154 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl151,282,650 - 1,297,832 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606310,012,294 - 10,026,718 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acaa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247312,665,228 - 2,676,497 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247312,665,228 - 2,677,248 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acaa1a
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:295
Count of miRNA genes:197
Interacting mature miRNAs:218
Transcripts:ENSRNOT00000045049, ENSRNOT00000055919
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
D8Wox10  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr88127,962,512 - 127,962,651 (+)Marker Load Pipeline
mRatBN7.28119,084,790 - 119,084,929 (+)MAPPERmRatBN7.2
Rnor_6.08128,032,912 - 128,033,050NCBIRnor6.0
Rnor_5.08127,239,673 - 127,239,811UniSTSRnor5.0
RGSC_v3.48124,310,080 - 124,310,219RGDRGSC3.4
RGSC_v3.48124,310,081 - 124,310,219UniSTSRGSC3.4
RGSC_v3.18124,329,817 - 124,329,956RGD
Celera8118,235,992 - 118,236,130UniSTS
RH 3.4 Map81312.6UniSTS
RH 3.4 Map81312.6RGD
RH 2.0 Map81012.2RGD
Cytogenetic Map8q32UniSTS
D8Arb22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,084,715 - 119,085,047 (+)MAPPERmRatBN7.2
Rnor_6.08128,032,837 - 128,033,168NCBIRnor6.0
Rnor_5.08127,239,598 - 127,239,929UniSTSRnor5.0
RGSC_v3.48124,310,006 - 124,310,337UniSTSRGSC3.4
RGSC_v3.18124,329,742 - 124,330,074RGD
Celera8118,235,917 - 118,236,248UniSTS
Cytogenetic Map8q32UniSTS
BI274607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,088,454 - 119,088,605 (+)MAPPERmRatBN7.2
Rnor_6.08128,036,329 - 128,036,479NCBIRnor6.0
Rnor_5.08127,243,090 - 127,243,240UniSTSRnor5.0
RGSC_v3.48124,313,745 - 124,313,895UniSTSRGSC3.4
Celera8118,239,656 - 118,239,806UniSTS
RH 3.4 Map81287.3UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000045049   ⟹   ENSRNOP00000050691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8119,079,820 - 119,088,624 (+)Ensembl
Rnor_6.0 Ensembl8128,027,958 - 128,036,236 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103723   ⟹   ENSRNOP00000092329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8119,079,807 - 119,088,597 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107742   ⟹   ENSRNOP00000079249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8119,079,820 - 119,088,624 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112098   ⟹   ENSRNOP00000092720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8119,079,775 - 119,088,597 (+)Ensembl
RefSeq Acc Id: NM_001395662   ⟹   NP_001382591
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,957,481 - 127,966,348 (+)NCBI
mRatBN7.28119,079,759 - 119,088,626 (+)NCBI
RefSeq Acc Id: NM_012489   ⟹   NP_036621
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,957,481 - 127,966,348 (+)NCBI
mRatBN7.28119,079,759 - 119,088,626 (+)NCBI
Rnor_6.08128,027,880 - 128,036,471 (+)NCBI
Rnor_5.08127,234,641 - 127,243,232 (+)NCBI
RGSC_v3.48124,305,097 - 124,313,887 (+)RGD
Celera8118,231,008 - 118,239,798 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080786   ⟹   XP_038936714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,957,123 - 127,966,344 (+)NCBI
mRatBN7.28119,079,401 - 119,088,623 (+)NCBI
RefSeq Acc Id: XM_063264886   ⟹   XP_063120956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,956,126 - 127,966,344 (+)NCBI
RefSeq Acc Id: XM_063264887   ⟹   XP_063120957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,957,210 - 127,966,344 (+)NCBI
RefSeq Acc Id: XM_063264888   ⟹   XP_063120958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,957,240 - 127,966,344 (+)NCBI
RefSeq Acc Id: NP_036621   ⟸   NM_012489
- Peptide Label: isoform 1
- UniProtKB: Q5FVR9 (UniProtKB/Swiss-Prot),   P21775 (UniProtKB/Swiss-Prot),   A0A8I6AHC5 (UniProtKB/TrEMBL),   A6I3W1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050691   ⟸   ENSRNOT00000045049
RefSeq Acc Id: XP_038936714   ⟸   XM_039080786
- Peptide Label: isoform X1
- UniProtKB: Q5FVR9 (UniProtKB/Swiss-Prot),   P21775 (UniProtKB/Swiss-Prot),   A0A8I6AHC5 (UniProtKB/TrEMBL),   A6I3W1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092329   ⟸   ENSRNOT00000103723
Ensembl Acc Id: ENSRNOP00000079249   ⟸   ENSRNOT00000107742
Ensembl Acc Id: ENSRNOP00000092720   ⟸   ENSRNOT00000112098
RefSeq Acc Id: NP_001382591   ⟸   NM_001395662
- Peptide Label: isoform 2
- UniProtKB: A0A8I6G309 (UniProtKB/TrEMBL),   F1LPD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120956   ⟸   XM_063264886
- Peptide Label: isoform X1
- UniProtKB: Q5FVR9 (UniProtKB/Swiss-Prot),   P21775 (UniProtKB/Swiss-Prot),   A0A8I6AHC5 (UniProtKB/TrEMBL),   A6I3W1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120957   ⟸   XM_063264887
- Peptide Label: isoform X1
- UniProtKB: Q5FVR9 (UniProtKB/Swiss-Prot),   P21775 (UniProtKB/Swiss-Prot),   A0A8I6AHC5 (UniProtKB/TrEMBL),   A6I3W1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120958   ⟸   XM_063264888
- Peptide Label: isoform X1
- UniProtKB: Q5FVR9 (UniProtKB/Swiss-Prot),   P21775 (UniProtKB/Swiss-Prot),   A0A8I6AHC5 (UniProtKB/TrEMBL),   A6I3W1 (UniProtKB/TrEMBL)
Protein Domains
Thiolase C-terminal   Thiolase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21775-F1-model_v2 AlphaFold P21775 1-434 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696370
Promoter ID:EPDNEW_R6895
Type:initiation region
Name:Acaa1a_1
Description:acetyl-CoA acyltransferase 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08128,027,875 - 128,027,935EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:67379 AgrOrtholog
BioCyc Gene G2FUF-28790 BioCyc
Ensembl Genes ENSRNOG00000032908 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045049.6 UniProtKB/TrEMBL
  ENSRNOT00000103723.1 UniProtKB/TrEMBL
  ENSRNOT00000107742.1 UniProtKB/TrEMBL
  ENSRNOT00000112098.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7122340 IMAGE-MGC_LOAD
  IMAGE:7128867 IMAGE-MGC_LOAD
InterPro Thiolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase-like_sf_Thiolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_acyl_enz_int_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24157 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108766 IMAGE-MGC_LOAD
  MGC:93661 IMAGE-MGC_LOAD
NCBI Gene 24157 ENTREZGENE
PANTHER 3-KETOACYL-COA THIOLASE A, PEROXISOMAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3-KETOACYL-COA THIOLASE, PEROXISOMAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acaa1a PhenoGen
PIRSF Ac-CoA_Ac_transf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOLASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032908 RatGTEx
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204651
UniProt A0A8I6AHC5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AHJ8_RAT UniProtKB/TrEMBL
  A0A8I6G309 ENTREZGENE, UniProtKB/TrEMBL
  A6I3W1 ENTREZGENE, UniProtKB/TrEMBL
  F1LPD6 ENTREZGENE, UniProtKB/TrEMBL
  P21775 ENTREZGENE
  Q5FVR9 ENTREZGENE
  THIKA_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q5FVR9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-24 Acaa1a  acetyl-CoA acyltransferase 1A  Acaa1  acetyl-CoA acyltransferase 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-08-22 Acaa1  acetyl-CoA acyltransferase 1A  Acaa1a  acetyl-CoA acyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-18 Acaa1a  acetyl-CoA acyltransferase 1  Acaa1  acetyl-CoA acyltransferase 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-11 Acaa1  acetyl-CoA acyltransferase 1A  Acaa1a  acetyl-CoA acyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-23 Acaa1a  acetyl-CoA acyltransferase 1  Acaa1  acetyl-CoA acyltransferase 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-18 Acaa1  acetyl-CoA acyltransferase 1A  Acaa1a  acetyl-Coenzyme A acyltransferase 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Acaa1  acetyl-Coenzyme A acyltransferase 1  Acaa1  acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase)  Name updated 1299863 APPROVED
2003-01-28 Acaa1  acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase)  Acaa  acetyl-CoA acyltransferase, 3-oxo acyl-CoA thiolase A  Data merged from RGD:2010 628472 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process functions in peroxisomal beta-oxidation of fatty acids 1299138
gene_protein mature enzyme is composed of 398 amino acids and the molecular weight is 41,074 1299140