Gene: Cma1 (chymase 1) Rattus norvegicus
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Symbol: Cma1
Name: chymase 1
Description: Exhibits peptide binding activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to glucose stimulus; midbrain development; and positive regulation of angiogenesis. Localizes to the extracellular region. Human ortholog(s) of this gene implicated in asthma; atopic dermatitis; hypertrophic cardiomyopathy; and sarcoidosis. Orthologous to human CMA1 (chymase 1); PARTICIPATES IN angiotensin II signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: alpha-chymase; chymase; chymase 1 mast cell; chymase 1, mast cell; mast cell protease 3; mast cell protease 5; mast cell protease III; MCP3P; Mcpt5; rMCP-3; rMCP-5; rMCP-III
Orthologs:
Homo sapiens (human) : CMA1 (chymase 1)  HGNC  Alliance
Mus musculus (house mouse) : Cma1 (chymase 1, mast cell)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CMA1 (chymase 1)
Canis lupus familiaris (dog) : CMA1 (chymase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01534,601,037 - 34,603,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01538,490,971 - 38,493,753 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41534,083,202 - 34,084,387 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11534,098,901 - 34,102,176 (-)NCBI
Celera1528,991,244 - 28,994,014 (-)NCBICelera
Cytogenetic Map15p13NCBI
RH 3.4 Map15213.78RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cma1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2365
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.