Thpo (thrombopoietin) - Rat Genome Database

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Gene: Thpo (thrombopoietin) Rattus norvegicus
Analyze
Symbol: Thpo
Name: thrombopoietin
RGD ID: 621438
Description: Enables signaling receptor binding activity. Involved in cellular response to lipopolysaccharide and positive regulation of cell population proliferation. Located in extracellular region; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2 Ensembl1180,182,820 - 80,188,167 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01182,845,676 - 82,853,439 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1182,848,853 - 82,852,425 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,868,655 - 83,873,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01185,925,385 - 85,932,532 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,412,552 - 82,417,807NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1179,022,653 - 79,027,908 (+)NCBICelera
RH 3.4 Map11 RGD
Cytogenetic Map11q23NCBI


References

References - curated
# Reference Title Reference Citation
1. Lack of pathogenic mutations in the 5'-untranslated region of the thrombopoietin gene in patients with non-familial essential thrombocythaemia. Allen AJ, etal., Eur J Haematol. 2001 Oct;67(4):232-7.
2. Exome sequencing reveals a thrombopoietin ligand mutation in a Micronesian family with autosomal recessive aplastic anemia. Dasouki MJ, etal., Blood. 2013 Nov 14;122(20):3440-9. doi: 10.1182/blood-2012-12-473538. Epub 2013 Oct 1.
3. Familial thrombocytosis caused by the novel germ-line mutation p.Pro106Leu in the MPL gene. El-Harith el-HA, etal., Br J Haematol. 2009 Jan;144(2):185-94. doi: 10.1111/j.1365-2141.2008.07430.x. Epub 2008 Nov 19.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin gene. Ghilardi N, etal., Br J Haematol. 1999 Nov;107(2):310-6.
6. Thrombopoietin inside the pulmonary vessels in patients with and without pulmonary hypertension. Haznedaroglu IC, etal., Platelets. 2002 Nov;13(7):395-9.
7. Circulating levels of thrombopoietic and inflammatory cytokines in patients with acute myeloblastic leukemia and myelodysplastic syndrome. Hsu HC, etal., Oncology. 2002;63(1):64-9.
8. Dual effects of adenovirus-mediated thrombopoietin gene transfer on hepatic oval cell proliferation and platelet counts. Ichiba M, etal., Biochem Biophys Res Commun. 2005 Sep 30;335(3):723-9.
9. Reduced expression of thrombopoietin is involved in thrombocytopenia in human and rat liver cirrhosis. Ishikawa T, etal., J Gastroenterol Hepatol. 1998 Sep;13(9):907-13.
10. The effect of thrombopoietin on erythroid progenitors in Diamond-Blackfan anemia. Kawasaki H, etal., Int J Hematol. 2002 May;75(4):382-4.
11. Familial essential thrombocythemia associated with one-base deletion in the 5'-untranslated region of the thrombopoietin gene. Kondo T, etal., Blood. 1998 Aug 15;92(4):1091-6.
12. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
13. Plasma thrombopoietin levels in patients with chronic renal failure. Linthorst GE, etal., Hematol J. 2002;3(1):38-42.
14. Thrombopoietin modulates cardiac contractility in vitro and contributes to myocardial depressing activity of septic shock serum. Lupia E, etal., Basic Res Cardiol. 2010 Sep;105(5):609-20. doi: 10.1007/s00395-010-0103-6. Epub 2010 May 14.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Platelet-derived microparticles in patients with arteriosclerosis obliterans: enhancement of high shear-induced microparticle generation by cytokines. Nomura S, etal., Thromb Res. 2000 May 15;98(4):257-68.
18. The sequence of a rat cDNA encoding thrombopoietin. Ogami K, etal., Gene 1995 Jun 9;158(2):309-10.
19. Soluble P-selectin, interleukin 6, and thrombopoietin levels in children with acute and chronic idiopathic thrombocytopenic purpura and their relationship with mega-dose methylprednisolone therapy: a pilot study. Olcay L, etal., J Pediatr Hematol Oncol. 2002 Dec;24(9):742-5.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. Mutation in the THPO gene is not associated with aplastic anaemia in Japanese children. Wang X, etal., Br J Haematol. 2012 Aug;158(4):553-5. doi: 10.1111/j.1365-2141.2012.09185.x. Epub 2012 Jun 12.
26. An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia. Wiestner A, etal., Nat Genet. 1998 Jan;18(1):49-52.
27. Hepatic thrombopoietin mRNA is increased in acute inflammation. Wolber EM, etal., Thromb Haemost 2001 Dec;86(6):1421-4.
28. The physiological response of thrombopoietin (c-Mpl ligand) to thrombocytopenia in the rat. Yang C, etal., Br J Haematol. 1999 May;105(2):478-85.
29. Inflammation stimulates thrombopoietin (Tpo) expression in rat brain-derived microvascular endothelial cells, but suppresses Tpo in astrocytes and microglia. Zhang J, etal., J Interferon Cytokine Res. 2010 Jul;30(7):465-9. doi: 10.1089/jir.2009.0062.
Additional References at PubMed
PMID:12393382   PMID:15337790   PMID:18006272   PMID:18433726   PMID:21237210   PMID:21540074   PMID:22128142   PMID:26116151  


Genomics

Comparative Map Data
Thpo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2 Ensembl1180,182,820 - 80,188,167 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01182,845,676 - 82,853,439 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1182,848,853 - 82,852,425 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,868,655 - 83,873,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01185,925,385 - 85,932,532 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,412,552 - 82,417,807NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1179,022,653 - 79,027,908 (+)NCBICelera
RH 3.4 Map11 RGD
Cytogenetic Map11q23NCBI
THPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383184,371,935 - 184,379,688 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3184,371,935 - 184,381,968 (-)EnsemblGRCh38hg38GRCh38
GRCh373184,089,723 - 184,097,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,572,467 - 185,578,626 (-)NCBINCBI36Build 36hg18NCBI36
Build 343185,572,474 - 185,578,634NCBI
Celera3182,530,743 - 182,536,902 (-)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3181,496,308 - 181,502,467 (-)NCBIHuRef
CHM1_13184,054,230 - 184,060,389 (-)NCBICHM1_1
T2T-CHM13v2.03187,181,188 - 187,188,943 (-)NCBIT2T-CHM13v2.0
Thpo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,543,204 - 20,553,261 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,543,204 - 20,553,261 (-)EnsemblGRCm39 Ensembl
GRCm381620,724,454 - 20,734,511 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,724,454 - 20,734,511 (-)EnsemblGRCm38mm10GRCm38
MGSCv371620,724,527 - 20,734,584 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361620,637,997 - 20,648,054 (-)NCBIMGSCv36mm8
Celera1621,289,807 - 21,299,861 (-)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1612.51NCBI
THPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,260,215 - 122,267,860 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113122,259,654 - 122,267,860 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,750,641 - 131,757,108 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THPO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,040,684 - 5,048,387 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606313,818,626 - 13,825,957 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thpo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473072,212,423 - 72,219,485 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473072,210,880 - 72,218,615 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH94517  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,187,994 - 80,188,141 (+)MAPPERmRatBN7.2
Rnor_6.01182,852,507 - 82,852,653NCBIRnor6.0
Rnor_6.01183,873,738 - 83,873,884NCBIRnor6.0
Rnor_5.01186,945,656 - 86,945,802UniSTSRnor5.0
Rnor_5.01185,931,600 - 85,931,746UniSTSRnor5.0
RGSC_v3.41182,417,635 - 82,417,781UniSTSRGSC3.4
Celera1179,027,736 - 79,027,882UniSTS
RH 3.4 Map11658.0UniSTS
Cytogenetic Map11q23UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:90
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000072402, ENSRNOT00000073743
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_031133   ⟹   NP_112395
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01182,847,424 - 82,852,679 (+)NCBI
Rnor_5.01185,925,385 - 85,932,532 (+)NCBI
RGSC_v3.41182,412,552 - 82,417,807 (+)RGD
Celera1179,022,653 - 79,027,908 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248552   ⟹   XP_006248614
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01182,845,676 - 82,853,439 (+)NCBI
Rnor_5.01185,925,385 - 85,932,532 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248553   ⟹   XP_006248615
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01182,845,676 - 82,853,439 (+)NCBI
Rnor_5.01185,925,385 - 85,932,532 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598078   ⟹   XP_017453567
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01182,848,704 - 82,853,439 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112395   ⟸   NM_031133
- Peptide Label: precursor
- UniProtKB: P49745 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006248614   ⟸   XM_006248552
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006248615   ⟸   XM_006248553
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017453567   ⟸   XM_017598078
- Peptide Label: isoform X3
- UniProtKB: P49745 (UniProtKB/Swiss-Prot)
- Sequence:

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49745-F1-model_v2 AlphaFold P49745 1-326 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-20756 BioCyc
Ensembl Genes ENSRNOG00000046850 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000050172 Ensembl, ENTREZGENE
Ensembl Protein ENSRNOP00000065517 ENTREZGENE
  ENSRNOP00000067269.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072402.2 UniProtKB/TrEMBL
  ENSRNOT00000073743 ENTREZGENE
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  EPO/TPO_CS UniProtKB/Swiss-Prot
  EPO_TPO UniProtKB/Swiss-Prot
  Thrombopoeitin UniProtKB/Swiss-Prot
KEGG Report rno:81811 UniProtKB/Swiss-Prot
NCBI Gene 81811 ENTREZGENE
PANTHER PTHR10560 UniProtKB/Swiss-Prot
Pfam EPO_TPO UniProtKB/Swiss-Prot
PhenoGen Thpo PhenoGen
PRINTS THROMBOPTN UniProtKB/Swiss-Prot
PROSITE EPO_TPO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A0A8L2QZ16_RAT UniProtKB/TrEMBL
  P49745 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Thpo  thrombopoietin      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Thpo  thrombopoietin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation hepatic mRNA expresion upregulated by acute inflammation induced by lipopolysaccharide injection 730050