Thpo (thrombopoietin) - Rat Genome Database

Name: Thpo
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Thpo (thrombopoietin) Rattus norvegicus

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Symbol:

Thpo (Ensembl: Thpol1)

Name:

thrombopoietin (Ensembl:thrombopoietin like 1)

RGD ID:

621438

Description:

Enables signaling receptor binding activity. Involved in cellular response to lipopolysaccharide and positive regulation of cell population proliferation. Located in extracellular region; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; ammonium chloride.

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2 Ensembl	11	80,182,820 - 80,188,167 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	11	82,845,676 - 82,853,439 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	82,848,853 - 82,852,425 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	11	83,868,655 - 83,873,910 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	85,925,385 - 85,932,532 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	82,412,552 - 82,417,807	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	11	79,022,653 - 79,027,908 (+)	NCBI		Celera
RH 3.4 Map	11		RGD
Cytogenetic Map	11	q23	NCBI

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-methylcrotonyl-CoA carboxylase 1 deficiency (ISO)

aplastic anemia (ISO)

arteriosclerosis obliterans (ISO)

cardiomyopathy (ISO)

Chemical and Drug Induced Liver Injury (ISO)

congenital amegakaryocytic thrombocytopenia 2 (ISO)

congenital disorder of glycosylation Id (ISO)

Currarino syndrome (ISO)

essential thrombocythemia (ISO)

Experimental Liver Cirrhosis (IEP)

genetic disease (ISO)

hemorrhagic disease (ISO)

liver cirrhosis (ISO)

pulmonary hypertension (ISO)

thrombocytopenia (ISO)

Thrombocytopenia 9 (ISO)

thrombocytosis (ISO)

toxic shock syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,4-dinitrotoluene (EXP)

2,6-di-tert-butyl-4-methylphenol (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

ammonium chloride (EXP)

anagrelide (ISO)

anthra[1,9-cd]pyrazol-6(2H)-one (ISO)

asperuloside (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

CGP 52608 (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclophosphamide (ISO)

dibenziodolium (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (EXP)

entinostat (ISO)

epoxiconazole (ISO)

flavonoids (EXP)

furan (EXP)

gemcitabine (ISO)

genistein (ISO)

glutathione (EXP)

glycidol (EXP)

lipopolysaccharide (ISO)

LY294002 (ISO)

methamphetamine (ISO)

monocrotaline (ISO)

N-acetyl-L-cysteine (ISO)

N-methyl-N-nitrosourea (ISO)

nickel dichloride (ISO)

paracetamol (ISO)

PCB138 (ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

reactive oxygen species (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

StemRegenin 1 (ISO)

testosterone undecanoate (ISO)

thimerosal (ISO)

thioacetamide (EXP)

triclosan (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell population proliferation (IEA)

cell surface receptor signaling pathway via STAT (IEA,ISO)

cellular response to lipopolysaccharide (IEP)

megakaryocyte development (IEA,ISO)

megakaryocyte differentiation (ISO,ISS)

myeloid cell differentiation (ISO)

positive regulation of cell population proliferation (IDA,ISO)

positive regulation of ERK1 and ERK2 cascade (IBA,ISO,ISS)

positive regulation of hematopoietic stem cell proliferation (IBA,IEA,ISO)

positive regulation of MAPK cascade (IEA,ISO)

positive regulation of megakaryocyte differentiation (ISO,ISS)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA,ISO,ISS)

positive regulation of protein phosphorylation (ISO,ISS)

response to lipopolysaccharide (IEP)

thrombopoietin-mediated signaling pathway (IBA,IEA,ISO,ISS)

Cellular Component

extracellular region (IBA,IDA,IEA)

extracellular space (IEA,ISO)

Molecular Function

cytokine activity (IEA,ISO)

hormone activity (IEA)

signaling receptor binding (IBA,IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Lack of pathogenic mutations in the 5'-untranslated region of the thrombopoietin gene in patients with non-familial essential thrombocythaemia.	Allen AJ, etal., Eur J Haematol. 2001 Oct;67(4):232-7.
2.	Exome sequencing reveals a thrombopoietin ligand mutation in a Micronesian family with autosomal recessive aplastic anemia.	Dasouki MJ, etal., Blood. 2013 Nov 14;122(20):3440-9. doi: 10.1182/blood-2012-12-473538. Epub 2013 Oct 1.
3.	Familial thrombocytosis caused by the novel germ-line mutation p.Pro106Leu in the MPL gene.	El-Harith el-HA, etal., Br J Haematol. 2009 Jan;144(2):185-94. doi: 10.1111/j.1365-2141.2008.07430.x. Epub 2008 Nov 19.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin gene.	Ghilardi N, etal., Br J Haematol. 1999 Nov;107(2):310-6.
6.	Thrombopoietin inside the pulmonary vessels in patients with and without pulmonary hypertension.	Haznedaroglu IC, etal., Platelets. 2002 Nov;13(7):395-9.
7.	Circulating levels of thrombopoietic and inflammatory cytokines in patients with acute myeloblastic leukemia and myelodysplastic syndrome.	Hsu HC, etal., Oncology. 2002;63(1):64-9.
8.	Dual effects of adenovirus-mediated thrombopoietin gene transfer on hepatic oval cell proliferation and platelet counts.	Ichiba M, etal., Biochem Biophys Res Commun. 2005 Sep 30;335(3):723-9.
9.	Reduced expression of thrombopoietin is involved in thrombocytopenia in human and rat liver cirrhosis.	Ishikawa T, etal., J Gastroenterol Hepatol. 1998 Sep;13(9):907-13.
10.	The effect of thrombopoietin on erythroid progenitors in Diamond-Blackfan anemia.	Kawasaki H, etal., Int J Hematol. 2002 May;75(4):382-4.
11.	Familial essential thrombocythemia associated with one-base deletion in the 5'-untranslated region of the thrombopoietin gene.	Kondo T, etal., Blood. 1998 Aug 15;92(4):1091-6.
12.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
13.	Plasma thrombopoietin levels in patients with chronic renal failure.	Linthorst GE, etal., Hematol J. 2002;3(1):38-42.
14.	Thrombopoietin modulates cardiac contractility in vitro and contributes to myocardial depressing activity of septic shock serum.	Lupia E, etal., Basic Res Cardiol. 2010 Sep;105(5):609-20. doi: 10.1007/s00395-010-0103-6. Epub 2010 May 14.
15.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
16.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
17.	Platelet-derived microparticles in patients with arteriosclerosis obliterans: enhancement of high shear-induced microparticle generation by cytokines.	Nomura S, etal., Thromb Res. 2000 May 15;98(4):257-68.
18.	The sequence of a rat cDNA encoding thrombopoietin.	Ogami K, etal., Gene 1995 Jun 9;158(2):309-10.
19.	Soluble P-selectin, interleukin 6, and thrombopoietin levels in children with acute and chronic idiopathic thrombocytopenic purpura and their relationship with mega-dose methylprednisolone therapy: a pilot study.	Olcay L, etal., J Pediatr Hematol Oncol. 2002 Dec;24(9):742-5.
20.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
21.	GOA pipeline	RGD automated data pipeline
22.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
24.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25.	Mutation in the THPO gene is not associated with aplastic anaemia in Japanese children.	Wang X, etal., Br J Haematol. 2012 Aug;158(4):553-5. doi: 10.1111/j.1365-2141.2012.09185.x. Epub 2012 Jun 12.
26.	An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia.	Wiestner A, etal., Nat Genet. 1998 Jan;18(1):49-52.
27.	Hepatic thrombopoietin mRNA is increased in acute inflammation.	Wolber EM, etal., Thromb Haemost 2001 Dec;86(6):1421-4.
28.	The physiological response of thrombopoietin (c-Mpl ligand) to thrombocytopenia in the rat.	Yang C, etal., Br J Haematol. 1999 May;105(2):478-85.
29.	Inflammation stimulates thrombopoietin (Tpo) expression in rat brain-derived microvascular endothelial cells, but suppresses Tpo in astrocytes and microglia.	Zhang J, etal., J Interferon Cytokine Res. 2010 Jul;30(7):465-9. doi: 10.1089/jir.2009.0062.

Additional References at PubMed

PMID:12393382	PMID:15337790	PMID:18006272	PMID:18433726	PMID:21237210	PMID:21540074	PMID:22128142	PMID:26116151

Genomics

Comparative Map Data

Thpo
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2 Ensembl	11	80,182,820 - 80,188,167 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	11	82,845,676 - 82,853,439 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	82,848,853 - 82,852,425 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	11	83,868,655 - 83,873,910 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	85,925,385 - 85,932,532 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	82,412,552 - 82,417,807	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	11	79,022,653 - 79,027,908 (+)	NCBI		Celera
RH 3.4 Map	11		RGD
Cytogenetic Map	11	q23	NCBI

THPO
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	184,371,935 - 184,379,688 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	184,371,935 - 184,381,968 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	184,089,723 - 184,097,476 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	185,572,467 - 185,578,626 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	185,572,474 - 185,578,634	NCBI
Celera	3	182,530,743 - 182,536,902 (-)	NCBI		Celera
Cytogenetic Map	3	q27.1	NCBI
HuRef	3	181,496,308 - 181,502,467 (-)	NCBI		HuRef
CHM1_1	3	184,054,230 - 184,060,389 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	187,181,188 - 187,188,943 (-)	NCBI		T2T-CHM13v2.0

Thpo
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	20,543,204 - 20,553,261 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	20,543,204 - 20,553,261 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	20,724,454 - 20,734,511 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	20,724,454 - 20,734,511 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	20,724,527 - 20,734,584 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	20,637,997 - 20,648,054 (-)	NCBI		MGSCv36	mm8
Celera	16	21,289,807 - 21,299,861 (-)	NCBI		Celera
Cytogenetic Map	16	B1	NCBI
cM Map	16	12.51	NCBI

THPO
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	122,260,215 - 122,267,860 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	122,259,654 - 122,267,860 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	131,750,641 - 131,757,108 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

THPO
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	5,040,684 - 5,048,387 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666063	13,818,626 - 13,825,957 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Thpo
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	72,212,423 - 72,219,485 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	72,210,880 - 72,218,615 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	171
Count of miRNA genes:	90
Interacting mature miRNAs:	104
Transcripts:	ENSRNOT00000072402, ENSRNOT00000073743
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

RH94517

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	80,187,994 - 80,188,141 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	82,852,507 - 82,852,653	NCBI	Rnor6.0
Rnor_6.0	11	83,873,738 - 83,873,884	NCBI	Rnor6.0
Rnor_5.0	11	86,945,656 - 86,945,802	UniSTS	Rnor5.0
Rnor_5.0	11	85,931,600 - 85,931,746	UniSTS	Rnor5.0
RGSC_v3.4	11	82,417,635 - 82,417,781	UniSTS	RGSC3.4
Celera	11	79,027,736 - 79,027,882	UniSTS
RH 3.4 Map	11	658.0	UniSTS
Cytogenetic Map	11	q23	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248552	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248553	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AABR07034658	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01070267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D32207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

NM_031133 ⟹ NP_112395

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	82,847,424 - 82,852,679 (+)	NCBI
Rnor_5.0	11	85,925,385 - 85,932,532 (+)	NCBI
RGSC_v3.4	11	82,412,552 - 82,417,807 (+)	RGD
Celera	11	79,022,653 - 79,027,908 (+)	RGD

Sequence:

show sequence

GTGTACCTGGGTCCTGAAGCCCTTCTTCACCTGGATAGATTCCTTGGCCCACCTGTCCCCACCC
CACTCTGTGCAGAGGTACAAAAGCTCAAGCCGTCTCCATGGCCCCAGGAAAGATTCAGGGGAGA
GGCCCCACACAGGGAGCCACTGCAGTCAGACACCCTGGGCAGAATGGAGCTGACTGATTTGCTC
CTGGTGGCCATACTTCTCCTCACCGCAAGACTAACTCTGTCCAGCCCAGTTCCTCCCGCCTGTG
ACCCCAGACTCCTAAATAAACTGCTTCGTGACTCCTACCTCCTTCACAGCCGACTGAGTCAGTG
TCCTGACGTCAACCCTTTGTCTATCCCTGTCCTGCTGCCTGCTGTGGACTTTAGCCTGGGAGAA
TGGAAAACCCAGACGGAACAGAGCAAGGCACAGGACATTCTAGGGGCAGTGTCCCTTCTACTGG
AGGGGGTGATGGCAGCACGAGGACAGTTGGAACCCTCCTGCCTCTCATCCCTCCTGGGACAGCT
TTCTGGTCAGGTTCGCCTCCTCTTGGGAGCCCTGCAGGGCCTCCTAGGAACCCAGCTTCCTCCA
CAGGGCAGGACCACAGCTCACAAGGACCCCAGTGCCCTCTTCTTGAGCTTGCAACAACTGCTTC
GGGGAAAGGTGCGCTTCCTGCTGCTGGTAGAAGGTCCCGCCCTCTGTGTCAGACGGACCCTTCC
CACCACAGCTGTCCCAAGCAGAACCTCTCAACTCCTCACACTAAACAAGTTCCCAAACAGGACT
TCTGGATTGTTGGAGACGAACTTCAGTGTTGTAGCCAGAACTGCTGGCCCTGGACTTCTGAACA
GGCTTCAAGGATTCAGAGCCAAGATTATTCCTGGTCAGCTAAATCAAACCTCCGGGTCCTTAGA
CCAAATCCCTGGATACCTGAACGGGACACACGAACCTGTGAATGGAACTCATGGGCTCTTTGCT
GGGACCTCACTACAGACCCTGGAAGCCCCAGACGTTGTGCCAGGAGCTTTCAACAAAGGCTCCT
TGCCACTCAACCTCCAGAGTGGACTTCCTCCTATCCCAAGCCTTGCTGCTGATGGATACACACT
TTTCCCTCCTTCACCTACCTTCCCCACCCCTGGGTCTCCACCCCAGCTCCCCCCCGTTTCCTGA
CCCCTCCACCACCATACCTAACTCTACCAACCCTCATCCAGGACTTGGTCTCAGTAAGCGTCCC
GTGCACTGGCACGGAGAGCGATCGTCTGCAACATCTCTCAGGGGCAAGCTTCCTCAGGAAGGCT
CTGAGGCAGCTCACTAGACATCCTGCTCTCGCCTAACGGGCCCTGGGAAAGGGATACACAGGCC
AGGACACTGTACAACCTTAGGAGCGATTTTTTTCTTAACCTATCAACAATATTCATCAGAGC

hide sequence

RefSeq Acc Id:

XM_006248552 ⟹ XP_006248614

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	82,845,676 - 82,853,439 (+)	NCBI
Rnor_5.0	11	85,925,385 - 85,932,532 (+)	NCBI

Sequence:

show sequence

CACCCCCACACACACTCCTTGCGGCCACCCCTGGAGGTGGTGTCCATCCCAAGACCAGAGCCTC
GGGCTAGTGAAGGGTAGAGGCTGAGCCTCGGGCCTGTACCAGTGGTGAGCCGGATGGGCCGCTG
TAGGATGAGGGCTCGTCTTTGAAAAGGATACCGATCCTCCCCTACCTAGGACCCACAGCACCTC
CTTCCTTTCACTCTGGCTGTATTCCTATTTCCCTTCTGAGGTCTCTCCTCTTCCTTCAGTTCCC
AGGGTCAGGAACCTAGCTTGCGCTTCCCAGAATCAAGCAGTGCTTCCCCACGAGTGGACTCGTA
TTCCACCACCACCCCAACCTGTCCCCAAGTCCATCCAACTGTATCATCTATCACCTCTGACTGG
TGGTTTTCCTTCATCTGAGGGAGGACCTTATTCCTCTCCAGGTCATTCCCCACCTCCTTCGTCC
TGCTTTTCTAGACAAGCCTCCCCATCCTCTCCTACCCCCACCACTTCCCGCTATCCCAGCATCA
GGCTTCCTAATCTTAGGAGGTATCTCTTATTCAACTGGAGAATTCTGGGATCTGGGCCATACTC
CTTAATAGACAGTCCATCCTCAGAGGAGGCACGGGAGAAAGCCTGAGGAAGAACAAGGGAGAGA
GGGCAGGGTCAGGCCCCAGGGTCCCAGAGGACAGACTGTGGGGAGACAGGGACTGAGGAGAAAG
CACAGGAGCTAGAGCCAGGGCCAAAGGAAGAGAGAGAGGAGCCAGCAAAGAGGTATTTGTGGGG
GAGGCTCGGCAGCTGTCTTTCCTAAGACAGGAACAGATGGGCCTGGTTATTTCTCTCATCACAT
GTATAATGGTAGGACTGGAAGGGGACCATTGAGCAATCAACGGCAGGCTTGCCCACAGAGCTGA
GCTCTCCAGGTCCCTGTACCTCCAGGAGAAAGAAGGGTACCTAAGCCCAGTCAATCTATTTGTC
TGTCTCTCATTTTGAAACAGGTTCTCATTATGTAGCCCTGGCTGGCCTGTAGCTCACTAGGTAG
GCCAGGCTAGCCTCAAACTTCCTGAGATCCACCTGCCTCTGCCTCCCAAGTGCTGAGATTAAAG
AGGTGCTCTGGGCTCAGTCTTAACCAAACGCATATCCCTTCACTCCCCAGGTCCCACATATCGT
CCAAACCCTGTTTCCTGTAACATGATCATTCTCTCATATAGGCAATCCCTACATTGCCAGTTGG
AAAGGGGAAATACCAGGAAAGACACTCCTCTGGAGCAGGGGAATATGGAAGGGAACACAAGAAA
GCCAAAGTGCTGTCAGATTTCAGCCACAGGGATACTGTTCAGGGAAAAGAAATTTGGAGAGTCG
GGAACCAAAACGTCACCAATCTAAAACAAGACCTCTCTTTCCCAGGGACAAATGTATTCCGCCA
GATTTCTCCTGGACAAACCCCTTTCTCCTCTCTCTCACCCGGGCCTCAGGGTCTCATGTGCCCA
GGACATGAGACAGCTCCTGCTATTCAGATCCTCTCTAGAGCGTGTGTGGGTGGAGGGACCGGGC
TCCATTCACCGACCATGGTCCAGCCGTGGGCTCTAGGCCCGGTAGATAGGAAAAGAAGTCGTCA
TTTCCGGGGCCTTCACCAGGGCTTGGTGGCTCTCTGCTCTCTGATTGGGCGGAAGTGGCCTGGG
CAGGCTAGTGACCCTACTACAGAGGAGGGGCTGTACCCCAGCCAGTGTCTTCCTACCTACCTGC
TCCCCAGAGTGCTGCCTACTGTGTACCTGGGTCCTGAAGCCCTTCTTCACCTGGATAGATTCCT
TGGCCCACCTGTCCCCACCCCACTCTGTGCAGAGGTACAAAAGCTCAAGCCGTCTCCATGGCCC
CAGGAAAGATTCAGGGGAGAGGCCCCACACAGGGAGCCACTGCAGTCAGACACCCTGGGCAGAA
TGGAGCTGACTGATTTGCTCCTGGTGGCCATACTTCTCCTCACCGCAAGACTAACTCTGTCCAG
CCCAGTTCCTCCCGCCTGTGACCCCAGACTCCTAAATAAACTGCTTCGTGACTCCTACCTCCTT
CACAGCCGACTGAGTCAGTGTCCTGACGTCAACCCTTTGTCTATCCCTGTCCTGCTGCCTGCTG
TGGACTTTAGCCTGGGAGAATGGAAAACCCAGACGGAACAGAGCAAGGCACAGGACATTCTAGG
GGCAGTGTCCCTTCTACTGGAGGGGGTGATGGCAGCACGAGGACAGTTGGAACCCTCCTGCCTC
TCATCCCTCCTGGGACAGCTTTCTGGTCAGGTTCGCCTCCTCTTGGGAGCCCTGCAGGGCCTCC
TAGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGACCCCAGTGCCCTCTTCTT
GAGCTTGCAACAACTGCTTCGGGGAAAGGTGCGCTTCCTGCTGCTGGTAGAAGGTCCCGCCCTC
TGTGTCAGACGGACCCTTCCCACCACAGCTGTCCCAAGCAGAACCTCTCAACTCCTCACACTAA
ACAAGTTCCCAAACAGGACTTCTGGATTGTTGGAGACGAACTTCAGTGTTGTAGCCAGAACTGC
TGGCCCTGGACTTCTGAACAGGCTTCAAGGATTCAGAGCCAAGATTATTCCTGGTCAGCTAAAT
CAAACCTCCGGGTCCTTAGACCAAATCCCTGGATACCTGAACGGGACACACGAACCTGTGAATG
GAACTCATGGGCTCTTTGCTGGGACCTCACTACAGACCCTGGAAGCCCCAGACGTTGTGCCAGG
AGCTTTCAACAAAGGCTCCTTGCCACTCAACCTCCAGAGTGGACTTCCTCCTATCCCAAGCCTT
GCTGCTGATGGATACACACTTTTCCCTCCTTCACCTACCTTCCCCACCCCTGGGTCTCCACCCC
AGCTCCCCCCCGTTTCCTGACCCCTCCACCACCATACCTAACTCTACCAACCCTCATCCAGGAC
TTGGTCTCAGTAAGCGTCCCGTGCACTGGCACGGAGAGCGATCGTCTGCAACATCTCTCAGGGG
CAAGCTTCCTCAGGAAGGCTCTGAGGCAGCTCACTAGACATCCTGCTCTCGCCTAACGGGCCCT
GGGAAAGGGATACACAGGCCAGGACACTGTACAACCTTAGGAGCGATTTTTTTCTTAACCTATC
AACAATATTCATCAGAGCAGCTATCTTTGGTCTATTTCCTGTACAAATTTGAAAATGACGAATT
CTCTACATGTGCTTTCATACACTAAGTCTGCAAATGCCTAGACCGGTCTAGCCTTTCAACCCAG
GTAGAGACTAATACTGTATCAGAAAACGAAAGGGAACTCTTCTTTGCTTTCAAGTTTAAGTTCC
CTCCCAATGCCCTCATTCCCTTCACTGTGATTCCCAGTGAGAATGTTTGGTCCTCAAGATACTG
CTCTTGATAAAGGATTACCAGGTTAATCTCTGAGAAAGGCTGCCCCTACTTAGAGACAAAACTG
AACCTGTTTGAGAACGACAGCACCCAAAAGCCAATTAAAAACCAAGGGACCAATGTTCTTCACT
GGGACAACAGACCTCCCGGACCCTACCTCCCAAGAAAGCTAACAGGAAGCTTGGGGAACTCCAC
GCCCCAGGTAAGCTGTGCAGATGGTTCAGTAAAGACCAGACTTGGATGAGGCAGCTGAGCAAAC
AGCTCAGAGTATCAGCAGCTCAGCGGGAGCTTACGCAGGCCTGGGCTCCTGCTTCCCTCCTGTG
GAGGTCAGGCGGAAGTGCAGGAGTCAGGCTCCGTAGCTCACGCAGCAGGACAAGCAAAGAGCAG
TTGAAGGCTCTTTCTAGTTTCCACAAATGCATCTAAAAGGCAGTCCTGTGTGACCACCAGGAAG
TCTACTGGGAACCACCCTCCCCTGCAAATGAAGGCAGAGTTACGGGTTTTGCGAGTAAACGTGA
GTCTCTGCTT

hide sequence

RefSeq Acc Id:

XM_006248553 ⟹ XP_006248615

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	82,845,676 - 82,853,439 (+)	NCBI
Rnor_5.0	11	85,925,385 - 85,932,532 (+)	NCBI

Sequence:

show sequence

CACCCCCACACACACTCCTTGCGGCCACCCCTGGAGGTGGTGTCCATCCCAAGACCAGAGCCTC
GGGCTAGTGAAGGGTAGAGGCTGAGCCTCGGGCCTGTACCAGTGGTGAGCCGGATGGGCCGCTG
TAGGATGAGGGCTCGTCTTTGAAAAGGATACCGATCCTCCCCTACCTAGGACCCACAGCACCTC
CTTCCTTTCACTCTGGCTGTATTCCTATTTCCCTTCTGAGGTCTCTCCTCTTCCTTCAGTTCCC
AGGGTCAGGAACCTAGCTTGCGCTTCCCAGAATCAAGCAGTGCTTCCCCACGAGTGGACTCGTA
TTCCACCACCACCCCAACCTGTCCCCAAGTCCATCCAACTGTATCATCTATCACCTCTGACTGG
TGGTTTTCCTTCATCTGAGGGAGGACCTTATTCCTCTCCAGGTCATTCCCCACCTCCTTCGTCC
TGCTTTTCTAGACAAGCCTCCCCATCCTCTCCTACCCCCACCACTTCCCGCTATCCCAGCATCA
GGCTTCCTAATCTTAGGAGGTATCTCTTATTCAACTGGAGAATTCTGGGATCTGGGCCATACTC
CTTAATAGACAGTCCATCCTCAGAGGAGGCACGGGAGAAAGCCTGAGGAAGAACAAGGGAGAGA
GGGCAGGGTCAGGCCCCAGGGTCCCAGAGGACAGACTGTGGGGAGACAGGGACTGAGGAGAAAG
CACAGGAGCTAGAGCCAGGGCCAAAGGAAGAGAGAGAGGAGCCAGCAAAGAGGTATTTGTGGGG
GAGGCTCGGCAGCTGTCTTTCCTAAGACAGGAACAGATGGGCCTGGTTATTTCTCTCATCACAT
GTATAATGGTAGGACTGGAAGGGGACCATTGAGCAATCAACGGCAGGCTTGCCCACAGAGCTGA
GCTCTCCAGGTCCCTGTACCTCCAGGAGAAAGAAGGGTACCTAAGCCCAGTCAATCTATTTGTC
TGTCTCTCATTTTGAAACAGGTTCTCATTATGTAGCCCTGGCTGGCCTGTAGCTCACTAGGTAG
GCCAGGCTAGCCTCAAACTTCCTGAGATCCACCTGCCTCTGCCTCCCAAGTGCTGAGATTAAAG
AGGTGCTCTGGGCTCAGTCTTAACCAAACGCATATCCCTTCACTCCCCAGGTCCCACATATCGT
CCAAACCCTGTTTCCTGTAACATGATCATTCTCTCATATAGGCAATCCCTACATTGCCAGTTGG
AAAGGGGAAATACCAGGAAAGACACTCCTCTGGAGCAGGGGAATATGGAAGGGAACACAAGAAA
GCCAAAGTGCTGTCAGATTTCAGCCACAGGGATACTGTTCAGGGAAAAGAAATTTGGAGAGTCG
GGAACCAAAACGTCACCAATCTAAAACAAGACCTCTCTTTCCCAGGGACAAATGTATTCCGCCA
GATTTCTCCTGGACAAACCCCTTTCTCCTCTCTCTCACCCGGGCCTCAGGGTCTCATGTGCCCA
GGACATGAGACAGCTCCTGCTATTCAGATCCTCTCTAGAGCGTGTGTGGGTGGAGGGACCGGGC
TCCATTCACCGACCATGGTCCAGCCGTGGGCTCTAGGCCCGGTAGATAGGAAAAGAAGTCGTCA
TTTCCGGGGCCTTCACCAGGGCTTGGTGGCTCTCTGCTCTCTGATTGGGCGGAAGTGGCCTGGG
CAGGCTAGTGACCCTACTACAGAGGAGGGGCTGTACCCCAGCCAGTGTCTTCCTACCTACCTGC
TCCCCAGAGTGCTGCCTACTGTGTACCTGGGTCCTGAAGCCCTTCTTCACCTGGATAGATTCCT
TGGCCCACCTGTCCCCACCCCACTCTGTGCAGAGGTACAAAAGCTCAAGCCGTCTCCATGGCCC
CAGGAAAGATTCAGGGGAGAGGCCCCACACAGGGAGCCACTGCAGTCAGACACCCTGGGCAGAA
TGGAGCTGACTGATTTGCTCCTGGTGGCCATACTTCTCCTCACCGCAAGACTAACTCTGTCCAG
CCCAGTTCCTCCCGCCTGTGACCCCAGACTCCTAAATAAACTGCTTCGTGACTCCTACCTCCTT
CACAGCCGACTGAGTCAGTGTCCTGACGTCAACCCTTTGTCTATCCCTGTCCTGCTGCCTGCTG
TGGACTTTAGCCTGGGAGAATGGAAAACCCAGACGGAACAGAGCAAGGCACAGGACATTCTAGG
GGCAGTGTCCCTTCTACTGGAGGGGGTGATGGCAGCACGAGGACAGTTGGAACCCTCCTGCCTC
TCATCCCTCCTGGGACAGCTTTCTGGTCAGGTTCGCCTCCTCTTGGGAGCCCTGCAGGGCCTCC
TAGGAACCCAGGGCAGGACCACAGCTCACAAGGACCCCAGTGCCCTCTTCTTGAGCTTGCAACA
ACTGCTTCGGGGAAAGGTGCGCTTCCTGCTGCTGGTAGAAGGTCCCGCCCTCTGTGTCAGACGG
ACCCTTCCCACCACAGCTGTCCCAAGCAGAACCTCTCAACTCCTCACACTAAACAAGTTCCCAA
ACAGGACTTCTGGATTGTTGGAGACGAACTTCAGTGTTGTAGCCAGAACTGCTGGCCCTGGACT
TCTGAACAGGCTTCAAGGATTCAGAGCCAAGATTATTCCTGGTCAGCTAAATCAAACCTCCGGG
TCCTTAGACCAAATCCCTGGATACCTGAACGGGACACACGAACCTGTGAATGGAACTCATGGGC
TCTTTGCTGGGACCTCACTACAGACCCTGGAAGCCCCAGACGTTGTGCCAGGAGCTTTCAACAA
AGGCTCCTTGCCACTCAACCTCCAGAGTGGACTTCCTCCTATCCCAAGCCTTGCTGCTGATGGA
TACACACTTTTCCCTCCTTCACCTACCTTCCCCACCCCTGGGTCTCCACCCCAGCTCCCCCCCG
TTTCCTGACCCCTCCACCACCATACCTAACTCTACCAACCCTCATCCAGGACTTGGTCTCAGTA
AGCGTCCCGTGCACTGGCACGGAGAGCGATCGTCTGCAACATCTCTCAGGGGCAAGCTTCCTCA
GGAAGGCTCTGAGGCAGCTCACTAGACATCCTGCTCTCGCCTAACGGGCCCTGGGAAAGGGATA
CACAGGCCAGGACACTGTACAACCTTAGGAGCGATTTTTTTCTTAACCTATCAACAATATTCAT
CAGAGCAGCTATCTTTGGTCTATTTCCTGTACAAATTTGAAAATGACGAATTCTCTACATGTGC
TTTCATACACTAAGTCTGCAAATGCCTAGACCGGTCTAGCCTTTCAACCCAGGTAGAGACTAAT
ACTGTATCAGAAAACGAAAGGGAACTCTTCTTTGCTTTCAAGTTTAAGTTCCCTCCCAATGCCC
TCATTCCCTTCACTGTGATTCCCAGTGAGAATGTTTGGTCCTCAAGATACTGCTCTTGATAAAG
GATTACCAGGTTAATCTCTGAGAAAGGCTGCCCCTACTTAGAGACAAAACTGAACCTGTTTGAG
AACGACAGCACCCAAAAGCCAATTAAAAACCAAGGGACCAATGTTCTTCACTGGGACAACAGAC
CTCCCGGACCCTACCTCCCAAGAAAGCTAACAGGAAGCTTGGGGAACTCCACGCCCCAGGTAAG
CTGTGCAGATGGTTCAGTAAAGACCAGACTTGGATGAGGCAGCTGAGCAAACAGCTCAGAGTAT
CAGCAGCTCAGCGGGAGCTTACGCAGGCCTGGGCTCCTGCTTCCCTCCTGTGGAGGTCAGGCGG
AAGTGCAGGAGTCAGGCTCCGTAGCTCACGCAGCAGGACAAGCAAAGAGCAGTTGAAGGCTCTT
TCTAGTTTCCACAAATGCATCTAAAAGGCAGTCCTGTGTGACCACCAGGAAGTCTACTGGGAAC
CACCCTCCCCTGCAAATGAAGGCAGAGTTACGGGTTTTGCGAGTAAACGTGAGTCTCTGCTT

hide sequence

RefSeq Acc Id:

XM_017598078 ⟹ XP_017453567

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	82,848,704 - 82,853,439 (+)	NCBI

Sequence:

show sequence

GTCATTTTCAGGATAGATTCCTTGGCCCACCTGTCCCCACCCCACTCTGTGCAGAGGTACAAAA
GCTCAAGCCGTCTCCATGGCCCCAGGAAAGATTCAGGGGAGAGGCCCCACACAGGGAGCCACTG
CAGTCAGACACCCTGGGCAGAATGGAGCTGACTGATTTGCTCCTGGTGGCCATACTTCTCCTCA
CCGCAAGACTAACTCTGTCCAGCCCAGTTCCTCCCGCCTGTGACCCCAGACTCCTAAATAAACT
GCTTCGTGACTCCTACCTCCTTCACAGCCGACTGAGTCAGTGTCCTGACGTCAACCCTTTGTCT
ATCCCTGTCCTGCTGCCTGCTGTGGACTTTAGCCTGGGAGAATGGAAAACCCAGACGGAACAGA
GCAAGGCACAGGACATTCTAGGGGCAGTGTCCCTTCTACTGGAGGGGGTGATGGCAGCACGAGG
ACAGTTGGAACCCTCCTGCCTCTCATCCCTCCTGGGACAGCTTTCTGGTCAGGTTCGCCTCCTC
TTGGGAGCCCTGCAGGGCCTCCTAGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACA
AGGACCCCAGTGCCCTCTTCTTGAGCTTGCAACAACTGCTTCGGGGAAAGGTGCGCTTCCTGCT
GCTGGTAGAAGGTCCCGCCCTCTGTGTCAGACGGACCCTTCCCACCACAGCTGTCCCAAGCAGA
ACCTCTCAACTCCTCACACTAAACAAGTTCCCAAACAGGACTTCTGGATTGTTGGAGACGAACT
TCAGTGTTGTAGCCAGAACTGCTGGCCCTGGACTTCTGAACAGGCTTCAAGGATTCAGAGCCAA
GATTATTCCTGGTCAGCTAAATCAAACCTCCGGGTCCTTAGACCAAATCCCTGGATACCTGAAC
GGGACACACGAACCTGTGAATGGAACTCATGGGCTCTTTGCTGGGACCTCACTACAGACCCTGG
AAGCCCCAGACGTTGTGCCAGGAGCTTTCAACAAAGGCTCCTTGCCACTCAACCTCCAGAGTGG
ACTTCCTCCTATCCCAAGCCTTGCTGCTGATGGATACACACTTTTCCCTCCTTCACCTACCTTC
CCCACCCCTGGGTCTCCACCCCAGCTCCCCCCCGTTTCCTGACCCCTCCACCACCATACCTAAC
TCTACCAACCCTCATCCAGGACTTGGTCTCAGTAAGCGTCCCGTGCACTGGCACGGAGAGCGAT
CGTCTGCAACATCTCTCAGGGGCAAGCTTCCTCAGGAAGGCTCTGAGGCAGCTCACTAGACATC
CTGCTCTCGCCTAACGGGCCCTGGGAAAGGGATACACAGGCCAGGACACTGTACAACCTTAGGA
GCGATTTTTTTCTTAACCTATCAACAATATTCATCAGAGCAGCTATCTTTGGTCTATTTCCTGT
ACAAATTTGAAAATGACGAATTCTCTACATGTGCTTTCATACACTAAGTCTGCAAATGCCTAGA
CCGGTCTAGCCTTTCAACCCAGGTAGAGACTAATACTGTATCAGAAAACGAAAGGGAACTCTTC
TTTGCTTTCAAGTTTAAGTTCCCTCCCAATGCCCTCATTCCCTTCACTGTGATTCCCAGTGAGA
ATGTTTGGTCCTCAAGATACTGCTCTTGATAAAGGATTACCAGGTTAATCTCTGAGAAAGGCTG
CCCCTACTTAGAGACAAAACTGAACCTGTTTGAGAACGACAGCACCCAAAAGCCAATTAAAAAC
CAAGGGACCAATGTTCTTCACTGGGACAACAGACCTCCCGGACCCTACCTCCCAAGAAAGCTAA
CAGGAAGCTTGGGGAACTCCACGCCCCAGGTAAGCTGTGCAGATGGTTCAGTAAAGACCAGACT
TGGATGAGGCAGCTGAGCAAACAGCTCAGAGTATCAGCAGCTCAGCGGGAGCTTACGCAGGCCT
GGGCTCCTGCTTCCCTCCTGTGGAGGTCAGGCGGAAGTGCAGGAGTCAGGCTCCGTAGCTCACG
CAGCAGGACAAGCAAAGAGCAGTTGAAGGCTCTTTCTAGTTTCCACAAATGCATCTAAAAGGCA
GTCCTGTGTGACCACCAGGAAGTCTACTGGGAACCACCCTCCCCTGCAAATGAAGGCAGAGTTA
CGGGTTTTGCGAGTAAACGTGAGTCTCTGCTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_112395	(Get FASTA)	NCBI Sequence Viewer
	XP_006248614	(Get FASTA)	NCBI Sequence Viewer
	XP_006248615	(Get FASTA)	NCBI Sequence Viewer
	XP_017453567	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA06906	(Get FASTA)	NCBI Sequence Viewer
	EDL78026	(Get FASTA)	NCBI Sequence Viewer
	EDL78027	(Get FASTA)	NCBI Sequence Viewer
	EDL78028	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000065517
	ENSRNOP00000067269.2
GenBank Protein	P49745	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_112395 ⟸ NM_031133
- Peptide Label:	precursor
- UniProtKB:	P49745 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MELTDLLLVAILLLTARLTLSSPVPPACDPRLLNKLLRDSYLLHSRLSQCPDVNPLSIPVLLPA VDFSLGEWKTQTEQSKAQDILGAVSLLLEGVMAARGQLEPSCLSSLLGQLSGQVRLLLGALQGL LGTQLPPQGRTTAHKDPSALFLSLQQLLRGKVRFLLLVEGPALCVRRTLPTTAVPSRTSQLLTL NKFPNRTSGLLETNFSVVARTAGPGLLNRLQGFRAKIIPGQLNQTSGSLDQIPGYLNGTHEPVN GTHGLFAGTSLQTLEAPDVVPGAFNKGSLPLNLQSGLPPIPSLAADGYTLFPPSPTFPTPGSPP QLPPVS hide sequence

RefSeq Acc Id:

XP_006248614 ⟸ XM_006248552

- Peptide Label:

isoform X1

- Sequence:

show sequence

MCPGHETAPAIQILSRACVGGGTGLHSPTMVQPWALGPVDRKRSRHFRGLHQGLVALCSLIGRK
WPGQASDPTTEEGLYPSQCLPTYLLPRVLPTVYLGPEALLHLDRFLGPPVPTPLCAEVQKLKPS
PWPQERFRGEAPHREPLQSDTLGRMELTDLLLVAILLLTARLTLSSPVPPACDPRLLNKLLRDS
YLLHSRLSQCPDVNPLSIPVLLPAVDFSLGEWKTQTEQSKAQDILGAVSLLLEGVMAARGQLEP
SCLSSLLGQLSGQVRLLLGALQGLLGTQLPPQGRTTAHKDPSALFLSLQQLLRGKVRFLLLVEG
PALCVRRTLPTTAVPSRTSQLLTLNKFPNRTSGLLETNFSVVARTAGPGLLNRLQGFRAKIIPG
QLNQTSGSLDQIPGYLNGTHEPVNGTHGLFAGTSLQTLEAPDVVPGAFNKGSLPLNLQSGLPPI
PSLAADGYTLFPPSPTFPTPGSPPQLPPVS

hide sequence

RefSeq Acc Id:

XP_006248615 ⟸ XM_006248553

- Peptide Label:

isoform X2

- Sequence:

show sequence

MCPGHETAPAIQILSRACVGGGTGLHSPTMVQPWALGPVDRKRSRHFRGLHQGLVALCSLIGRK
WPGQASDPTTEEGLYPSQCLPTYLLPRVLPTVYLGPEALLHLDRFLGPPVPTPLCAEVQKLKPS
PWPQERFRGEAPHREPLQSDTLGRMELTDLLLVAILLLTARLTLSSPVPPACDPRLLNKLLRDS
YLLHSRLSQCPDVNPLSIPVLLPAVDFSLGEWKTQTEQSKAQDILGAVSLLLEGVMAARGQLEP
SCLSSLLGQLSGQVRLLLGALQGLLGTQGRTTAHKDPSALFLSLQQLLRGKVRFLLLVEGPALC
VRRTLPTTAVPSRTSQLLTLNKFPNRTSGLLETNFSVVARTAGPGLLNRLQGFRAKIIPGQLNQ
TSGSLDQIPGYLNGTHEPVNGTHGLFAGTSLQTLEAPDVVPGAFNKGSLPLNLQSGLPPIPSLA
ADGYTLFPPSPTFPTPGSPPQLPPVS

hide sequence

RefSeq Acc Id:	XP_017453567 ⟸ XM_017598078
- Peptide Label:	isoform X3
- UniProtKB:	P49745 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MELTDLLLVAILLLTARLTLSSPVPPACDPRLLNKLLRDSYLLHSRLSQCPDVNPLSIPVLLPA VDFSLGEWKTQTEQSKAQDILGAVSLLLEGVMAARGQLEPSCLSSLLGQLSGQVRLLLGALQGL LGTQLPPQGRTTAHKDPSALFLSLQQLLRGKVRFLLLVEGPALCVRRTLPTTAVPSRTSQLLTL NKFPNRTSGLLETNFSVVARTAGPGLLNRLQGFRAKIIPGQLNQTSGSLDQIPGYLNGTHEPVN GTHGLFAGTSLQTLEAPDVVPGAFNKGSLPLNLQSGLPPIPSLAADGYTLFPPSPTFPTPGSPP QLPPVS hide sequence

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P49745-F1-model_v2	AlphaFold	P49745	1-326	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-20756	BioCyc
Ensembl Genes	ENSRNOG00000046850	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00000050172	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000072402.2	UniProtKB/TrEMBL
	ENSRNOT00000073743	ENTREZGENE
Gene3D-CATH	1.20.1250.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	4_helix_cytokine-like_core	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EPO/TPO_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EPO_TPO	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Thrombopoeitin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:81811	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	81811	ENTREZGENE
PANTHER	PTHR10560	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	THROMBOPOIETIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	EPO_TPO	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Thpo	PhenoGen
PRINTS	THROMBOPTN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	EPO_TPO	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000046850	RatGTEx
	ENSRNOG00000050172	RatGTEx
Superfamily-SCOP	SSF47266	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2QZ16_RAT	UniProtKB/TrEMBL
	A6JS79_RAT	UniProtKB/TrEMBL
	A6JS80_RAT	UniProtKB/TrEMBL
	A6JS81_RAT	UniProtKB/TrEMBL
	P49745	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Thpo	thrombopoietin			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Thpo	thrombopoietin			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	hepatic mRNA expresion upregulated by acute inflammation induced by lipopolysaccharide injection	730050

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM