Glutathione ethyl ester - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	Glutathione ethyl ester	go back to main search page
Accession:	CHEBI:183921	browse the term
Synonyms:	exact_synonym:	(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-ethylsulanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
	related_synonym:	Formula=C12H21N3O6S; InChI=1S/C12H21N3O6S/c1-2-22-6-8(11(19)14-5-10(17)18)15-9(16)4-3-7(13)12(20)21/h7-8H,2-6,13H2,1H3,(H,14,19)(H,15,16)(H,17,18)(H,20,21)/t7-,8-/m0/s1; InChIKey=HMFDVPSBWOHOAP-YUMQZZPRSA-N; SMILES=S(C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)CC
	xref:	CAS:24425-52-3; Chemspider:96831
	xref_mesh:	MESH:C042431

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Rat (38) Mouse (38) Human (39) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (38)

Glutathione ethyl ester

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcium/calmodulin-dependent protein kinase II alpha

multiple interactions

S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CAMK2A mRNA]

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

CART prepropeptide

multiple interactions

S-ethyl glutathione inhibits the reaction [Amphetamine results in decreased expression of CARTPT protein]; S-ethyl glutathione inhibits the reaction [Amphetamine results in increased expression of CARTPT mRNA]

NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713

G

catalase

multiple interactions

S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of CAT mRNA]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

multiple interactions

S-ethyl glutathione inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased phosphorylation of CAV1 protein]

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

CASP8 and FADD-like apoptosis regulator

multiple interactions

S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

C-X-C motif chemokine ligand 12

multiple interactions

S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CXCL12 mRNA]

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

S-ethyl glutathione inhibits the reaction [[CYP2E1 protein co-treated with Paraquat] results in increased expression of KLF6 protein]; S-ethyl glutathione inhibits the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein]; S-ethyl glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]

PMID:16872732 PMID:22486562

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

estrogen receptor 1

multiple interactions

S-ethyl glutathione inhibits the reaction [Benzo(a)pyrene results in decreased expression of ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

fibroblast growth factor 18

multiple interactions

S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of FGF18 mRNA]

NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818

G

fibronectin 1

multiple interactions

[S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

glucose-6-phosphate dehydrogenase

multiple interactions

S-ethyl glutathione inhibits the reaction [Cadmium Chloride results in increased expression of G6PD mRNA]; S-ethyl glutathione inhibits the reaction [Oxygen deficiency results in increased expression of G6PD mRNA]

PMID:12717738 PMID:15225644

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

S-ethyl glutathione inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

multiple interactions

S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GCLM mRNA]

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glycogen synthase kinase 3 beta

increases phosphorylation
multiple interactions

S-ethyl glutathione results in increased phosphorylation of GSK3B protein
S-ethyl glutathione inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione synthetase

multiple interactions

S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSS mRNA]

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

glutathione S-transferase alpha 1

multiple interactions

S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of GSTA1 mRNA]

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

heme oxygenase 1

multiple interactions

S-ethyl glutathione inhibits the reaction [Fenretinide results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 2

increases expression

S-ethyl glutathione results in increased expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

multiple interactions

S-ethyl glutathione inhibits the reaction [Mercuric Chloride results in increased expression of IL4 mRNA]; S-ethyl glutathione inhibits the reaction [Mercuric Chloride results in increased expression of IL4 protein]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

KLF transcription factor 6

multiple interactions

S-ethyl glutathione inhibits the reaction [[CYP2E1 protein co-treated with Paraquat] results in increased expression of KLF6 protein]; S-ethyl glutathione inhibits the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein]

NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570

G

lysyl oxidase

decreases expression
decreases activity

S-ethyl glutathione results in decreased expression of LOX mRNA
S-ethyl glutathione results in decreased activity of LOX protein

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

G

mitogen activated protein kinase 1

multiple interactions

S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK1 protein]
S-ethyl glutathione inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK1 protein]

PMID:24307199 PMID:24814887

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK3 protein]
S-ethyl glutathione inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK3 protein]

PMID:24307199 PMID:24814887

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

NFE2 like bZIP transcription factor 2

multiple interactions

S-ethyl glutathione inhibits the reaction [Hypochlorous Acid results in increased expression of NFE2L2 mRNA]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nitric oxide synthase 2

multiple interactions

S-ethyl glutathione inhibits the reaction [Acetaminophen inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]]
S-ethyl glutathione inhibits the reaction [Potassium Cyanide results in increased expression of NOS2 protein]

PMID:12774022 PMID:16933320

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

neuropeptide Y

multiple interactions

S-ethyl glutathione inhibits the reaction [Amphetamine results in decreased expression of NPY mRNA]; S-ethyl glutathione inhibits the reaction [Amphetamine results in decreased expression of NPY protein]; S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY mRNA]

PMID:24792324 PMID:25825358

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

nuclear receptor subfamily 2, group E, member 3

multiple interactions

S-ethyl glutathione inhibits the reaction [Benzo(a)pyrene results in decreased expression of NR2E3 protein]

NCBI chr 8:60,365,581...60,373,383
Ensembl chr 8:60,366,124...60,373,163

G

poly (ADP-ribose) polymerase 1

multiple interactions

S-ethyl glutathione inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [wedelolactone results in increased cleavage of PARP1 protein]

PMID:22733624 PMID:25246272 PMID:25619640

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

paired box 3

multiple interactions

S-ethyl glutathione inhibits the reaction [Glucose results in decreased expression of PAX3 mRNA]

NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042

G

platelet derived growth factor subunit B

multiple interactions

S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of PDGFB mRNA]

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

proopiomelanocortin

multiple interactions

S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of POMC mRNA]

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

peroxisome proliferator-activated receptor gamma

multiple interactions

S-ethyl glutathione inhibits the reaction [Buthionine Sulfoximine results in increased expression of PPARG mRNA]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

superoxide dismutase 1

multiple interactions

S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of SOD1 mRNA]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

signal transducer and activator of transcription 3

multiple interactions

S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of STAT3 mRNA]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transforming growth factor, beta 2

multiple interactions

S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of TGFB2 mRNA]

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

tumor necrosis factor

multiple interactions

S-ethyl glutathione inhibits the reaction [Acetaminophen inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 10

multiple interactions

S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

tumor protein p53

multiple interactions

S-ethyl glutathione inhibits the reaction [Camptothecin results in increased expression of TP53 protein modified form]; S-ethyl glutathione inhibits the reaction [tert-Butylhydroperoxide results in increased expression of TP53 protein modified form]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19838
chemical entity	19836
group	19795
organic group	18962
amino-acid residue	11129
peptide	11129
oligopeptide	1341
Glutathione ethyl ester	38
Path 2
Term	Annotations
CHEBI ontology	19838
subatomic particle	19836
composite particle	19836
hadron	19836
baryon	19836
nucleon	19836
atomic nucleus	19836
atom	19836
main group element atom	19786
p-block element atom	19786
carbon group element atom	19734
carbon atom	19731
organic molecular entity	19731
heteroorganic entity	19488
organochalcogen compound	19251
organooxygen compound	19168
carbon oxoacid	18637
carboxylic acid	18634
carboacyl group	17696
univalent carboacyl group	17696
carbamoyl group	17546
carboxamide	17546
peptide	11129
oligopeptide	1341
Glutathione ethyl ester	38

paths to the root