Aurka (aurora kinase A) - Rat Genome Database

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Gene: Aurka (aurora kinase A) Rattus norvegicus
Analyze
Symbol: Aurka
Name: aurora kinase A
RGD ID: 628895
Description: Enables protein serine/threonine kinase activity. Involved in response to estradiol. Located in centrosome. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Orthologous to human AURKA (aurora kinase A); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ARK-1; aurora 2; aurora-A; aurora-related kinase 1; aurora/IPL1-related kinase 1; ipl1- and aurora-related kinase 1; MGC124935; ratAurA; serine/threonine kinase 6; serine/threonine protein kinase 6; serine/threonine-protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A; serine/threonine-protein kinase Ayk1; Stk6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83181,546,742 - 181,562,890 (-)NCBIGRCr8
mRatBN7.23161,128,309 - 161,144,524 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3161,128,313 - 161,144,390 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3164,937,768 - 164,951,932 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03173,436,787 - 173,450,951 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03171,178,603 - 171,192,767 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03170,364,177 - 170,380,278 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3170,364,181 - 170,378,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03176,437,310 - 176,456,036 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43163,270,479 - 163,284,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13163,177,671 - 163,190,537 (-)NCBI
Celera3160,328,562 - 160,342,589 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorambucil  (ISO)
Chloroacetonitrile  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
deguelin  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP,ISO)
diethylstilbestrol  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
etoposide  (ISO)
felodipine  (ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
genistein  (ISO)
glucose  (ISO)
gossypin  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
melphalan  (ISO)
methotrexate  (ISO)
methyl isocyanate  (ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
monocrotaline  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nocodazole  (ISO)
NORCANTHARIDIN  (ISO)
O-methyleugenol  (EXP,ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
progesterone  (EXP,ISO)
promethazine  (EXP)
propiconazole  (ISO)
pyrimidines  (ISO)
quercetin  (ISO)
quinazolines  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Aurora-A over-expression in high-grade PIN lesions and prostate cancer. Buschhorn HM, etal., Prostate. 2005 Sep 1;64(4):341-6.
2. Gene Expression Study of Aurora-A Reveals Implication During Bladder Carcinogenesis and Increasing Values in Invasive Urothelial Cancer. Comperat E, etal., Urology. 2008 May 14;.
3. STK15 polymorphisms and association with risk of invasive ovarian cancer. Dicioccio RA, etal., Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1589-94.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Centrosome amplification and overexpression of aurora a are early events in rat mammary carcinogenesis. Goepfert TM, etal., Cancer Res 2002 Jul 15;62(14):4115-22.
6. Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast. Hoque A, etal., Cancer Epidemiol Biomarkers Prev. 2003 Dec;12(12):1518-22.
7. Enhanced expression of lymphomagenesis-related genes in peripheral blood B cells of chronic hepatitis C patients. Ito M, etal., Clin Immunol. 2010 Jun;135(3):459-65. doi: 10.1016/j.clim.2010.02.002. Epub 2010 Mar 1.
8. Significance of Aurora-A expression in renal cell carcinoma. Kurahashi T, etal., Urol Oncol. 2007 Mar-Apr;25(2):128-33.
9. Expression of Aurora kinases A and B in normal, hyperplastic, and malignant human endometrium: Aurora B as a predictor for poor prognosis in endometrial carcinoma. Kurai M, etal., Hum Pathol. 2005 Dec;36(12):1281-8.
10. [Aurora-a is a predictive marker for stage III epithelial ovarian cancers] Lassmann S, etal., Verh Dtsch Ges Pathol. 2007;91:225-32.
11. Targeting Aurora kinases for the treatment of prostate cancer. Lee EC, etal., Cancer Res. 2006 May 15;66(10):4996-5002.
12. Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACI rats. Li JJ, etal., Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18123-8. Epub 2004 Dec 15.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. STK15 F31I polymorphism is associated with increased uterine cancer risk: a pilot study. Milam MR, etal., Gynecol Oncol. 2007 Oct;107(1):71-4. Epub 2007 Jun 27.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. The prognostic role of the STK15 T91A polymorphism and of STK15 mRNA expression in patients with urothelial cell carcinoma. Schultz IJ, etal., Anticancer Res. 2007 Mar-Apr;27(2):1025-30.
Additional References at PubMed
PMID:9245792   PMID:11413462   PMID:12477932   PMID:13678582   PMID:14580337   PMID:14695913   PMID:15793587   PMID:15987997   PMID:16962097   PMID:17060449   PMID:17726514   PMID:18345035  
PMID:18566290   PMID:18614302   PMID:18615013   PMID:18801727   PMID:19075002   PMID:19435814   PMID:19668197   PMID:19801554   PMID:19812038   PMID:20460379   PMID:20531406   PMID:20662813  
PMID:21274965   PMID:21399614   PMID:21600873   PMID:21761347   PMID:21807936   PMID:21820309   PMID:22832491   PMID:22939930   PMID:23213400   PMID:25657325   PMID:25912878   PMID:26030060  
PMID:28218735   PMID:30811038   PMID:33086033   PMID:35054947  


Genomics

Comparative Map Data
Aurka
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83181,546,742 - 181,562,890 (-)NCBIGRCr8
mRatBN7.23161,128,309 - 161,144,524 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3161,128,313 - 161,144,390 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3164,937,768 - 164,951,932 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03173,436,787 - 173,450,951 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03171,178,603 - 171,192,767 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03170,364,177 - 170,380,278 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3170,364,181 - 170,378,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03176,437,310 - 176,456,036 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43163,270,479 - 163,284,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13163,177,671 - 163,190,537 (-)NCBI
Celera3160,328,562 - 160,342,589 (-)NCBICelera
Cytogenetic Map3q42NCBI
AURKA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382056,369,390 - 56,392,215 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2056,369,389 - 56,392,337 (-)EnsemblGRCh38hg38GRCh38
GRCh372054,944,446 - 54,967,271 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362054,377,852 - 54,400,758 (-)NCBINCBI36Build 36hg18NCBI36
Celera2051,683,792 - 51,707,784 (-)NCBICelera
Cytogenetic Map20q13.2NCBI
HuRef2051,729,262 - 51,752,229 (-)NCBIHuRef
CHM1_12054,845,539 - 54,868,444 (-)NCBICHM1_1
T2T-CHM13v2.02058,146,836 - 58,169,709 (-)NCBIT2T-CHM13v2.0
Aurka
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392172,198,116 - 172,212,825 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2172,198,110 - 172,212,455 (-)EnsemblGRCm39 Ensembl
GRCm382172,356,190 - 172,370,886 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2172,356,190 - 172,370,535 (-)EnsemblGRCm38mm10GRCm38
MGSCv372172,181,696 - 172,196,006 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362172,047,401 - 172,061,711 (-)NCBIMGSCv36mm8
Celera2178,315,373 - 178,329,688 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map294.84NCBI
Aurka
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554452,831,157 - 2,853,357 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554452,831,073 - 2,853,151 (+)NCBIChiLan1.0ChiLan1.0
AURKA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22162,116,577 - 62,139,405 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12062,109,695 - 62,132,523 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02052,707,757 - 52,730,579 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12053,994,880 - 54,017,381 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2053,994,881 - 54,017,339 (-)Ensemblpanpan1.1panPan2
AURKA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12441,585,483 - 41,604,875 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2441,585,518 - 41,604,791 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2440,833,209 - 40,852,906 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02442,296,241 - 42,316,154 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2442,296,229 - 42,315,779 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12441,536,239 - 41,555,929 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02441,675,064 - 41,694,968 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02442,333,178 - 42,352,923 (-)NCBIUU_Cfam_GSD_1.0
Aurka
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640183,775,540 - 183,790,540 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936875295,238 - 310,457 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AURKA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11756,954,838 - 56,972,435 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21764,066,378 - 64,083,673 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AURKA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.127,730,060 - 7,753,167 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl27,734,128 - 7,752,395 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605055,804,778 - 55,827,848 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aurka
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624790147,149 - 161,344 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624790143,818 - 162,065 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aurka
73 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:410
Count of miRNA genes:231
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000055102
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat

Markers in Region
RH130500  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,129,117 - 161,129,299 (+)MAPPERmRatBN7.2
Rnor_6.03170,364,986 - 170,365,167NCBIRnor6.0
Rnor_5.03176,440,768 - 176,440,949UniSTSRnor5.0
RGSC_v3.43163,271,288 - 163,271,469UniSTSRGSC3.4
Celera3160,329,371 - 160,329,552UniSTS
Cytogenetic Map3q42UniSTS
RH138996  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,128,091 - 161,128,249 (+)MAPPERmRatBN7.2
Rnor_6.03170,363,960 - 170,364,117NCBIRnor6.0
Rnor_5.03176,439,742 - 176,439,899UniSTSRnor5.0
RGSC_v3.43163,270,262 - 163,270,419UniSTSRGSC3.4
Celera3160,328,345 - 160,328,502UniSTS
RH 3.4 Map31494.1UniSTS
Cytogenetic Map3q42UniSTS
RH140220  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,128,052 - 161,128,249 (+)MAPPERmRatBN7.2
Rnor_6.03170,363,921 - 170,364,117NCBIRnor6.0
Rnor_5.03176,439,703 - 176,439,899UniSTSRnor5.0
RGSC_v3.43163,270,223 - 163,270,419UniSTSRGSC3.4
Celera3160,328,306 - 160,328,502UniSTS
Cytogenetic Map3q42UniSTS
D19S915  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,130,658 - 161,131,690 (+)MAPPERmRatBN7.2
mRatBN7.21517,676,999 - 17,678,572 (+)MAPPERmRatBN7.2
Rnor_6.0983,379,567 - 83,381,139NCBIRnor6.0
Rnor_6.03170,366,527 - 170,367,558NCBIRnor6.0
Rnor_5.03176,442,309 - 176,443,340UniSTSRnor5.0
Rnor_5.0983,146,666 - 83,148,238UniSTSRnor5.0
RGSC_v3.43163,272,829 - 163,273,860UniSTSRGSC3.4
RGSC_v3.41519,688,890 - 19,690,462UniSTSRGSC3.4
Celera3160,330,912 - 160,331,943UniSTS
Cytogenetic Map15p14UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 39 24 18 24 35 19 41 11
Low 17 18 17 1 17 8 11 39 16 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000055102   ⟹   ENSRNOP00000051977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3161,128,313 - 161,141,283 (-)Ensembl
Rnor_6.0 Ensembl3170,364,181 - 170,378,210 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094630   ⟹   ENSRNOP00000091920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3161,129,084 - 161,144,390 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097745   ⟹   ENSRNOP00000084621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3161,128,313 - 161,140,478 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110792   ⟹   ENSRNOP00000095702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3161,129,074 - 161,144,323 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115626   ⟹   ENSRNOP00000081987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3161,128,904 - 161,144,386 (-)Ensembl
RefSeq Acc Id: NM_153296   ⟹   NP_695208
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83181,546,742 - 181,560,769 (-)NCBI
mRatBN7.23161,128,309 - 161,142,336 (-)NCBI
Rnor_6.03170,364,177 - 170,378,204 (-)NCBI
Rnor_5.03176,437,310 - 176,456,036 (-)NCBI
RGSC_v3.43163,270,479 - 163,284,506 (-)RGD
Celera3160,328,562 - 160,342,589 (-)RGD
Sequence:
RefSeq Acc Id: XM_006235675   ⟹   XP_006235737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83181,547,329 - 181,562,890 (-)NCBI
mRatBN7.23161,128,896 - 161,144,524 (-)NCBI
Rnor_6.03170,364,762 - 170,380,278 (-)NCBI
Rnor_5.03176,437,310 - 176,456,036 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235676   ⟹   XP_006235738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83181,547,329 - 181,562,809 (-)NCBI
mRatBN7.23161,128,896 - 161,144,524 (-)NCBI
Rnor_6.03170,364,762 - 170,380,216 (-)NCBI
Rnor_5.03176,437,310 - 176,456,036 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104394   ⟹   XP_038960322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83181,550,637 - 181,562,890 (-)NCBI
mRatBN7.23161,132,204 - 161,144,524 (-)NCBI
RefSeq Acc Id: NP_695208   ⟸   NM_153296
- UniProtKB: P59241 (UniProtKB/Swiss-Prot),   Q3MHU2 (UniProtKB/TrEMBL),   F1LN52 (UniProtKB/TrEMBL),   A0A8I5ZT82 (UniProtKB/TrEMBL),   A0A8I6APN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235737   ⟸   XM_006235675
- Peptide Label: isoform X1
- UniProtKB: P59241 (UniProtKB/Swiss-Prot),   Q3MHU2 (UniProtKB/TrEMBL),   F1LN52 (UniProtKB/TrEMBL),   A0A8I5ZT82 (UniProtKB/TrEMBL),   A0A8I6APN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235738   ⟸   XM_006235676
- Peptide Label: isoform X1
- UniProtKB: P59241 (UniProtKB/Swiss-Prot),   Q3MHU2 (UniProtKB/TrEMBL),   F1LN52 (UniProtKB/TrEMBL),   A0A8I5ZT82 (UniProtKB/TrEMBL),   A0A8I6APN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000051977   ⟸   ENSRNOT00000055102
RefSeq Acc Id: XP_038960322   ⟸   XM_039104394
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000081987   ⟸   ENSRNOT00000115626
RefSeq Acc Id: ENSRNOP00000091920   ⟸   ENSRNOT00000094630
RefSeq Acc Id: ENSRNOP00000095702   ⟸   ENSRNOT00000110792
RefSeq Acc Id: ENSRNOP00000084621   ⟸   ENSRNOT00000097745
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P59241-F1-model_v2 AlphaFold P59241 1-397 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628895 AgrOrtholog
BioCyc Gene G2FUF-46541 BioCyc
Ensembl Genes ENSRNOG00000004479 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055102.5 UniProtKB/TrEMBL
  ENSRNOT00000094630.1 UniProtKB/TrEMBL
  ENSRNOT00000097745 ENTREZGENE
  ENSRNOT00000097745.1 UniProtKB/TrEMBL
  ENSRNOT00000110792.1 UniProtKB/TrEMBL
  ENSRNOT00000115626.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7453115 IMAGE-MGC_LOAD
InterPro Aur UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AURKA UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:261730 UniProtKB/TrEMBL
MGC_CLONE MGC:124935 IMAGE-MGC_LOAD
NCBI Gene 261730 ENTREZGENE
PANTHER AURORA KINASE A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aurka PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004479 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZT82 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXM5_RAT UniProtKB/TrEMBL
  A0A8I6AEJ9_RAT UniProtKB/TrEMBL
  A0A8I6APN1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8YA08_RAT UniProtKB/TrEMBL
  AURKA_RAT UniProtKB/Swiss-Prot
  F1LN52 ENTREZGENE
  P59241 ENTREZGENE
  Q3MHU2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LN52 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-12-21 Aurka  aurora kinase A  Stk6  serine/threonine kinase 6  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Stk6  serine/threonine kinase 6      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Stk6  serine/threonine kinase 6      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization protein localized to the centrosome 619665
gene_expression protein expressed in the mammary gland 619665
gene_regulation may be regulated by sex steroids estrogen and/or progesterone 619665