Gene: Aurka (aurora kinase A) Rattus norvegicus
Analyze
Symbol:
Aurka
Name:
aurora kinase A
Description:
Exhibits protein serine/threonine kinase activity. Involved in protein phosphorylation and response to estradiol. Localizes to the centrosome and spindle. Human ortholog(s) of this gene implicated in ovarian cancer and uterine cancer. Orthologous to human AURKA (aurora kinase A); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 2-methoxyethanol.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
ARK-1; aurora 2; aurora-A; aurora-related kinase 1; aurora/IPL1-related kinase 1; MGC124935; ratAurA; serine/threonine kinase 6; serine/threonine protein kinase 6; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A; Stk6
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
AURKA (aurora kinase A) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):
Aurka (aurora kinase A) HGNC
EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Aurka (aurora kinase A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
AURKA (aurora kinase A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
AURKA (aurora kinase A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Aurka (aurora kinase A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
AURKA (aurora kinase A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
AURKA (aurora kinase A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Aurka (aurora kinase A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
AURKA (aurora kinase A)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Aurka (aurora kinase A)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
aurka (aurora kinase A)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
IPL1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
air-1
Alliance
DIOPT (OMA, OrthoFinder, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
air-2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
aurA
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 3 170,364,177 - 170,380,278 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 3 170,364,181 - 170,378,210 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 3 176,437,310 - 176,456,036 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 3 163,270,479 - 163,284,506 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 3 163,177,671 - 163,190,537 (-) NCBI Celera 3 160,328,562 - 160,342,589 (-) NCBI Celera Cytogenetic Map 3 q42 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
multiple myeloma ISO RGD:1353168 8554872 ClinVar Annotator: match by term: Multiple myeloma ClinVar
Imported Annotations - CTD
Aneuploidy ISO RGD:1353168 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24976383 Breast Neoplasms ISO RGD:1353168 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18497064 Chromosomal Instability ISO RGD:1353168 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24976383 Colorectal Neoplasms ISO RGD:1353168 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24976383 hepatocellular carcinoma ISO RGD:1353168 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28284560 Kidney Neoplasms ISO RGD:1353168 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18497064 Mammary Neoplasms, Experimental ISO RGD:1353168 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12124350 melanoma ISO RGD:1353168 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22535842 neuroblastoma ISO RGD:1353168 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22588779 peripheral nervous system disease ISO RGD:1353168 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20864405 Prostatic Neoplasms ISO RGD:1353168 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17898866 Imported Annotations - OMIM
colorectal cancer ISO RGD:1353168 7240710 OMIM
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1353168 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AURKA mRNA CTD PMID:22079256 1,1-dichloroethene increases expression ISO RGD:1552819 6480464 vinylidene chloride results in increased expression of AURKA mRNA CTD PMID:26682919 17beta-estradiol increases expression ISO RGD:1552819 6480464 Estradiol results in increased expression of AURKA mRNA CTD PMID:25210133 17beta-estradiol increases expression ISO RGD:1353168 6480464 Estradiol results in increased expression of AURKA mRNA CTD PMID:16474171 more ... 17beta-estradiol multiple interactions ISO RGD:1552819 6480464 ESR1 protein promotes the reaction [Estradiol results in increased expression of AURKA mRNA] CTD PMID:25210133 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:1552819 6480464 [2 more ... CTD PMID:25510870 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO RGD:1552819 6480464 2 more ... CTD PMID:30294300 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO RGD:1353168 6480464 2 more ... CTD PMID:30796839 2,2',4,4'-Tetrabromodiphenyl ether multiple interactions ISO RGD:1353168 6480464 [2 more ... CTD PMID:30796839 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:1552819 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1353168 6480464 Tetrachlorodibenzodioxin results in decreased expression of AURKA mRNA CTD PMID:21802500 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1552819 6480464 Tetrachlorodibenzodioxin affects the expression of AURKA mRNA CTD PMID:21570461 2,3-dimethoxynaphthalene-1,4-dione increases expression ISO RGD:1353168 6480464 2 more ... CTD PMID:19031421 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of AURKA mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of AURKA mRNA CTD PMID:21346803 2-methoxyethanol decreases expression EXP 6480464 methyl cellosolve results in decreased expression of AURKA mRNA CTD PMID:19643169 2-methylcholine affects expression ISO RGD:1353168 6480464 beta-methylcholine affects the expression of AURKA mRNA CTD PMID:21179406 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:23196670 3-methylcholanthrene increases expression ISO RGD:1552819 6480464 Methylcholanthrene results in increased expression of AURKA mRNA CTD PMID:20713471 4,4'-sulfonyldiphenol increases expression ISO RGD:1353168 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of AURKA mRNA CTD PMID:27685785 4-hydroxyphenyl retinamide increases expression ISO RGD:1552819 6480464 Fenretinide results in increased expression of AURKA mRNA CTD PMID:28973697 4-hydroxyphenyl retinamide decreases expression ISO RGD:1552819 6480464 Fenretinide results in decreased expression of AURKA mRNA CTD PMID:28973697 5-azacytidine multiple interactions ISO RGD:1353168 6480464 [Azacitidine co-treated with Thalidomide] affects the expression of AURKA mRNA CTD PMID:18720364 5-fluorouracil decreases expression ISO RGD:1353168 6480464 Fluorouracil results in decreased expression of AURKA mRNA CTD PMID:15205334 more ... 5-fluorouracil decreases expression ISO RGD:1552819 6480464 Fluorouracil results in decreased expression of AURKA mRNA CTD PMID:19272435 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of AURKA mRNA CTD PMID:24780913 acetylsalicylic acid increases expression ISO RGD:1353168 6480464 Aspirin results in increased expression of AURKA mRNA CTD PMID:11906190 afimoxifene decreases expression ISO RGD:1353168 6480464 afimoxifene results in decreased expression of AURKA mRNA CTD PMID:16514628 afimoxifene decreases response to substance ISO RGD:1353168 6480464 AURKA results in decreased susceptibility to afimoxifene CTD PMID:21233418 aflatoxin B1 affects expression ISO RGD:1353168 6480464 Aflatoxin B1 affects the expression of AURKA protein CTD PMID:20106945 aldehydo-D-glucose increases expression ISO RGD:1552819 6480464 Glucose results in increased expression of AURKA mRNA CTD PMID:17178593 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of AURKA mRNA CTD PMID:16483693 arsane multiple interactions ISO RGD:1353168 6480464 Arsenic results in increased phosphorylation of and results in increased activity of AURKA protein, E2F1 protein affects the reaction [Arsenic results in increased expression of AURKA protein] CTD PMID:23174854 arsane increases expression ISO RGD:1353168 6480464 Arsenic results in increased expression of AURKA mRNA, Arsenic results in increased expression of AURKA protein CTD PMID:23174854 arsenic atom multiple interactions ISO RGD:1353168 6480464 Arsenic results in increased phosphorylation of and results in increased activity of AURKA protein, E2F1 protein affects the reaction [Arsenic results in increased expression of AURKA protein] CTD PMID:23174854 arsenic atom increases expression ISO RGD:1353168 6480464 Arsenic results in increased expression of AURKA mRNA, Arsenic results in increased expression of AURKA protein CTD PMID:23174854 arsenite(3-) decreases expression ISO RGD:1552819 6480464 arsenite results in decreased expression of AURKA mRNA CTD PMID:18929588 arsenous acid increases expression ISO RGD:1353168 6480464 Arsenic Trioxide results in increased expression of AURKA protein CTD PMID:16338065 azathioprine decreases expression ISO RGD:1353168 6480464 Azathioprine results in decreased expression of AURKA mRNA CTD PMID:22623647 belinostat decreases expression ISO RGD:1353168 6480464 belinostat results in decreased expression of AURKA mRNA, belinostat results in decreased expression of AURKA protein CTD PMID:19606018 belinostat decreases activity ISO RGD:1353168 6480464 belinostat results in decreased activity of AURKA protein CTD PMID:19606018 benzo[a]pyrene decreases expression ISO RGD:1552819 6480464 Benzo(a)pyrene results in decreased expression of AURKA mRNA CTD PMID:19770486 , PMID:22228805 benzo[a]pyrene decreases expression ISO RGD:1353168 6480464 Benzo(a)pyrene results in decreased expression of AURKA mRNA, Benzo(a)pyrene results in decreased expression of AURKA protein CTD PMID:21632981 more ... benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1353168 6480464 7 more ... CTD PMID:19150397 more ... benzo[b]fluoranthene increases expression ISO RGD:1552819 6480464 benzo(b)fluoranthene results in increased expression of AURKA mRNA CTD PMID:26377693 bis(2-chloroethyl) sulfide decreases expression ISO RGD:1353168 6480464 Mustard Gas results in decreased expression of AURKA mRNA CTD PMID:25102026 bis(2-chloroethyl) sulfide increases expression ISO RGD:1552819 6480464 Mustard Gas results in increased expression of AURKA mRNA CTD PMID:26392148 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1353168 6480464 Diethylhexyl Phthalate results in increased expression of AURKA protein CTD PMID:31163220 bisphenol A increases expression ISO RGD:1353168 6480464 bisphenol A results in increased expression of AURKA mRNA CTD PMID:16474171 more ... bisphenol A decreases expression ISO RGD:1353168 6480464 bisphenol A results in decreased expression of AURKA mRNA CTD PMID:29275510 bisphenol A increases phosphorylation ISO RGD:1353168 6480464 bisphenol A results in increased phosphorylation of AURKA protein CTD PMID:30980863 bisphenol A increases methylation ISO RGD:1552819 6480464 bisphenol A results in increased methylation of AURKA promoter CTD PMID:27312807 bisphenol A multiple interactions ISO RGD:1353168 6480464 bisphenol A inhibits the reaction [Doxorubicin results in increased expression of AURKA mRNA] CTD PMID:26320837 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of AURKA mRNA CTD PMID:25181051 , PMID:30816183 cadmium atom decreases expression ISO RGD:1353168 6480464 Cadmium results in decreased expression of AURKA mRNA CTD PMID:21120746 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of AURKA mRNA CTD PMID:25993096 calcitriol decreases expression ISO RGD:1353168 6480464 Calcitriol results in decreased expression of AURKA mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1353168 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of AURKA mRNA CTD PMID:21592394 carbon nanotube increases expression ISO RGD:1552819 6480464 Nanotubes, Carbon analog results in increased expression of AURKA mRNA, Nanotubes, Carbon results in increased expression of AURKA mRNA CTD PMID:25554681 chlorambucil increases expression ISO RGD:1552819 6480464 Chlorambucil results in increased expression of AURKA protein CTD PMID:22025197 chloroprene increases expression ISO RGD:1552819 6480464 Chloroprene results in increased expression of AURKA mRNA CTD PMID:23125180 cisplatin multiple interactions ISO RGD:1353168 6480464 MYC protein promotes the reaction [AURKA protein results in decreased susceptibility to Cisplatin] CTD PMID:20890087 cisplatin decreases expression ISO RGD:1552819 6480464 Cisplatin results in decreased expression of AURKA mRNA CTD PMID:25270620 cisplatin decreases response to substance ISO RGD:1353168 6480464 AURKA protein results in decreased susceptibility to Cisplatin CTD PMID:20890087 cisplatin increases expression ISO RGD:1552819 6480464 Cisplatin results in increased expression of AURKA mRNA CTD PMID:21151649 cobalt dichloride decreases expression ISO RGD:1353168 6480464 cobaltous chloride results in decreased expression of AURKA mRNA CTD PMID:19320972 , PMID:19376846 copper atom multiple interactions ISO RGD:1353168 6480464 [NSC 689534 binds to Copper] which results in decreased expression of AURKA mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:1353168 6480464 [NSC 689534 binds to Copper] which results in decreased expression of AURKA mRNA CTD PMID:20971185 copper(II) sulfate decreases expression ISO RGD:1353168 6480464 Copper Sulfate results in decreased expression of AURKA mRNA CTD PMID:19549813 coumestrol multiple interactions ISO RGD:1353168 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:18310284 , PMID:19167446 coumestrol increases expression ISO RGD:1353168 6480464 Coumestrol results in increased expression of AURKA mRNA CTD PMID:19167446 CU-O LINKAGE decreases expression ISO RGD:1353168 6480464 cupric oxide results in decreased expression of AURKA mRNA CTD PMID:22077320 curcumin decreases expression ISO RGD:1353168 6480464 Curcumin analog results in decreased expression of AURKA mRNA CTD PMID:26409325 cyclosporin A decreases expression ISO RGD:1353168 6480464 Cyclosporine results in decreased expression of AURKA mRNA CTD PMID:19159671 more ... cyclosporin A increases methylation ISO RGD:1353168 6480464 Cyclosporine results in increased methylation of AURKA promoter CTD PMID:27989131 D-glucose increases expression ISO RGD:1552819 6480464 Glucose results in increased expression of AURKA mRNA CTD PMID:17178593 daunorubicin decreases expression ISO RGD:1353168 6480464 Daunorubicin results in decreased expression of AURKA protein CTD PMID:23872705 diarsenic trioxide increases expression ISO RGD:1353168 6480464 Arsenic Trioxide results in increased expression of AURKA protein CTD PMID:16338065 diazinon affects expression EXP 6480464 Diazinon affects the expression of AURKA mRNA CTD PMID:22546817 dibenz[a,h]anthracene increases expression ISO RGD:1552819 6480464 1 more ... CTD PMID:26377693 dieldrin affects expression EXP 6480464 Dieldrin affects the expression of AURKA mRNA CTD PMID:22546817 dieldrin increases expression EXP 6480464 Dieldrin results in increased expression of AURKA mRNA CTD PMID:23153324 diethyl maleate decreases expression ISO RGD:1552819 6480464 diethyl maleate results in decreased expression of AURKA mRNA CTD PMID:25270620 diethyl maleate increases expression EXP 6480464 diethyl maleate results in increased expression of AURKA mRNA CTD PMID:21161181 diethylstilbestrol increases expression ISO RGD:1552819 6480464 Diethylstilbestrol results in increased expression of AURKA mRNA CTD PMID:15149470 dioxygen decreases expression ISO RGD:1353168 6480464 Oxygen deficiency results in decreased expression of AURKA mRNA CTD PMID:26516004 dorsomorphin multiple interactions ISO RGD:1353168 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1353168 6480464 Doxorubicin results in decreased expression of AURKA mRNA CTD PMID:15205334 , PMID:29803840 doxorubicin multiple interactions ISO RGD:1353168 6480464 bisphenol A inhibits the reaction [Doxorubicin results in increased expression of AURKA mRNA] CTD PMID:26320837 doxorubicin increases expression ISO RGD:1353168 6480464 Doxorubicin results in increased expression of AURKA mRNA CTD PMID:26320837 Enterolactone multiple interactions ISO RGD:1353168 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of AURKA mRNA CTD PMID:19167446 ethanol multiple interactions ISO RGD:1552819 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of AURKA mRNA CTD PMID:30517762 etoposide decreases expression ISO RGD:1552819 6480464 Etoposide results in decreased expression of AURKA mRNA CTD PMID:25270620 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of AURKA mRNA CTD PMID:18035473 flutamide increases expression EXP 6480464 Flutamide results in increased expression of AURKA mRNA CTD PMID:24793618 folic acid multiple interactions ISO RGD:1353168 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of AURKA mRNA CTD PMID:24657277 formaldehyde decreases expression ISO RGD:1353168 6480464 Formaldehyde results in decreased expression of AURKA mRNA CTD PMID:23649840 fulvestrant decreases expression ISO RGD:1353168 6480464 fulvestrant results in decreased expression of AURKA mRNA CTD PMID:16514628 gamma-tocopherol increases expression ISO RGD:1552819 6480464 Tocopherols results in increased expression of AURKA mRNA CTD PMID:17056531 gefitinib decreases response to substance ISO RGD:1353168 6480464 AURKA results in decreased susceptibility to gefitinib CTD PMID:21216229 gefitinib multiple interactions ISO RGD:1353168 6480464 [AURKA results in increased degradation of NFKBIA protein] which results in decreased susceptibility to Gefitinib, [TP53 protein results in decreased expression of AURKA protein] which results in increased susceptibility to Gefitinib CTD PMID:21216229 genistein increases expression ISO RGD:1353168 6480464 Genistein results in increased expression of AURKA mRNA CTD PMID:16474171 glucose increases expression ISO RGD:1552819 6480464 Glucose results in increased expression of AURKA mRNA CTD PMID:17178593 hydrogen peroxide affects expression ISO RGD:1353168 6480464 Hydrogen Peroxide affects the expression of AURKA mRNA CTD PMID:20044591 lead diacetate increases expression ISO RGD:1552819 6480464 lead acetate results in increased expression of AURKA mRNA CTD PMID:20542052 leflunomide decreases expression ISO RGD:1353168 6480464 leflunomide results in decreased expression of AURKA mRNA CTD PMID:28988120 lucanthone decreases expression ISO RGD:1353168 6480464 Lucanthone results in decreased expression of AURKA mRNA CTD PMID:21148553 melphalan increases expression ISO RGD:1552819 6480464 Melphalan results in increased expression of AURKA protein CTD PMID:22025197 methotrexate decreases expression ISO RGD:1353168 6480464 Methotrexate results in decreased expression of AURKA mRNA CTD PMID:24657277 methotrexate multiple interactions ISO RGD:1353168 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of AURKA mRNA CTD PMID:24657277 methyl isocyanate affects expression ISO RGD:1552819 6480464 methyl isocyanate affects the expression of AURKA mRNA CTD PMID:22223508 methyl methanesulfonate decreases expression ISO RGD:1353168 6480464 Methyl Methanesulfonate results in decreased expression of AURKA mRNA CTD PMID:23649840 methylseleninic acid affects expression ISO RGD:1353168 6480464 methylselenic acid affects the expression of AURKA mRNA CTD PMID:14617803 methylseleninic acid decreases expression ISO RGD:1353168 6480464 methylselenic acid results in decreased expression of AURKA mRNA CTD PMID:12517777 mitomycin C decreases expression ISO RGD:1552819 6480464 Mitomycin results in decreased expression of AURKA mRNA CTD PMID:25270620 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1353168 6480464 [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased expression of and results in increased phosphorylation of AURKA protein, MLN8054 inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased phosphorylation of AURKA protein] CTD PMID:24976383 N-methyl-N-nitrosourea multiple interactions EXP 6480464 [Estrogens co-treated with Progesterone] inhibits the reaction [Methylnitrosourea results in increased expression of AURKA mRNA] CTD PMID:12124350 N-methyl-N-nitrosourea increases expression EXP 6480464 Methylnitrosourea results in increased expression of AURKA mRNA CTD PMID:12124350 N-nitrosodiethylamine multiple interactions ISO RGD:1552819 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AURKA mRNA more ... CTD PMID:17854601 more ... N-nitrosodiethylamine increases expression ISO RGD:1552819 6480464 Diethylnitrosamine results in increased expression of AURKA mRNA CTD PMID:17854601 , PMID:18506893 naphthalene increases expression ISO RGD:1552819 6480464 naphthalene results in increased expression of AURKA mRNA CTD PMID:18978301 nickel atom increases expression ISO RGD:1353168 6480464 Nickel results in increased expression of AURKA mRNA CTD PMID:19031421 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of AURKA mRNA CTD PMID:22546817 nocodazole multiple interactions ISO RGD:1353168 6480464 [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased expression of and results in increased phosphorylation of AURKA protein, MLN8054 inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased phosphorylation of AURKA protein] CTD PMID:24976383 O-methyleugenol decreases expression EXP 6480464 methyleugenol results in decreased expression of AURKA mRNA CTD PMID:26011634 ochratoxin A multiple interactions ISO RGD:1552819 6480464 TRP53 gene mutant form promotes the reaction [ochratoxin A results in increased expression of AURKA mRNA] CTD PMID:25636497 ochratoxin A increases expression ISO RGD:1552819 6480464 ochratoxin A results in increased expression of AURKA mRNA CTD PMID:25636497 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of AURKA mRNA CTD PMID:25729387 oxaliplatin decreases expression ISO RGD:1353168 6480464 oxaliplatin results in decreased expression of AURKA mRNA CTD PMID:17762391 ozone multiple interactions ISO RGD:1552819 6480464 [NOTCH3 gene mutant form affects the susceptibility to Ozone] which results in increased expression of AURKA mRNA CTD PMID:25658374 p-chloromercuribenzoic acid decreases expression ISO RGD:1353168 6480464 p-Chloromercuribenzoic Acid results in decreased expression of AURKA mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:1353168 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AURKA mRNA CTD PMID:27188386 paclitaxel increases expression ISO RGD:1353168 6480464 Paclitaxel results in increased expression of AURKA mRNA CTD PMID:17374387 palbociclib decreases expression ISO RGD:1353168 6480464 palbociclib results in decreased expression of AURKA mRNA CTD PMID:22869556 paracetamol affects expression ISO RGD:1552819 6480464 Acetaminophen affects the expression of AURKA mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:1353168 6480464 Acetaminophen results in decreased expression of AURKA mRNA CTD PMID:26690555 , PMID:29067470 paraquat affects expression ISO RGD:1552819 6480464 Paraquat affects the expression of AURKA mRNA CTD PMID:26345256 phenethyl isothiocyanate decreases expression ISO RGD:1353168 6480464 phenethyl isothiocyanate results in decreased expression of AURKA mRNA CTD PMID:26678675 phenobarbital multiple interactions ISO RGD:1552819 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AURKA mRNA, NR1I3 protein affects the reaction [Phenobarbital results in increased expression of AURKA mRNA] CTD PMID:19482888 , PMID:24535843 phenobarbital increases expression ISO RGD:1552819 6480464 Phenobarbital results in increased expression of AURKA mRNA CTD PMID:19482888 more ... phenylmercury acetate decreases expression ISO RGD:1353168 6480464 Phenylmercuric Acetate results in decreased expression of AURKA mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1353168 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AURKA mRNA CTD PMID:27188386 phorbol 13-acetate 12-myristate increases expression ISO RGD:1353168 6480464 Tetradecanoylphorbol Acetate results in increased expression of AURKA mRNA CTD PMID:19031421 pirinixic acid decreases expression ISO RGD:1552819 6480464 pirinixic acid results in decreased expression of AURKA mRNA CTD PMID:17426115 pirinixic acid increases expression ISO RGD:1552819 6480464 pirinixic acid results in increased expression of AURKA mRNA CTD PMID:17950772 , PMID:23811191 pirinixic acid multiple interactions ISO RGD:1552819 6480464 PPARA protein promotes the reaction [pirinixic acid results in increased expression of AURKA mRNA] CTD PMID:17950772 piroxicam decreases expression ISO RGD:1353168 6480464 Piroxicam results in decreased expression of AURKA mRNA CTD PMID:21858171 potassium chromate decreases expression ISO RGD:1353168 6480464 potassium chromate(VI) results in decreased expression of AURKA mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:1353168 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AURKA mRNA CTD PMID:22079256 progesterone increases expression ISO RGD:1353168 6480464 Progesterone results in increased expression of AURKA mRNA CTD PMID:16888808 progesterone decreases expression ISO RGD:1353168 6480464 Progesterone results in decreased expression of AURKA mRNA CTD PMID:21795739 progesterone increases expression EXP 6480464 Progesterone results in increased expression of AURKA mRNA CTD PMID:12124350 progesterone multiple interactions EXP 6480464 [Estrogens co-treated with Progesterone] inhibits the reaction [Methylnitrosourea results in increased expression of AURKA mRNA] CTD PMID:12124350 promethazine decreases expression EXP 6480464 Promethazine results in decreased expression of AURKA mRNA CTD PMID:26011634 propiconazole increases expression ISO RGD:1552819 6480464 propiconazole results in increased expression of AURKA mRNA CTD PMID:21278054 pyrimidines affects splicing ISO RGD:1353168 6480464 Pyrimidines affects the splicing of AURKA mRNA CTD PMID:25281741 quercetin decreases expression ISO RGD:1353168 6480464 Quercetin results in decreased expression of AURKA mRNA CTD PMID:21632981 quinazolines affects splicing ISO RGD:1353168 6480464 Quinazolines affects the splicing of AURKA mRNA CTD PMID:25281741 raloxifene decreases expression ISO RGD:1353168 6480464 Raloxifene Hydrochloride results in decreased expression of AURKA mRNA CTD PMID:16514628 resveratrol multiple interactions ISO RGD:1353168 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of AURKA mRNA CTD PMID:19167446 resveratrol increases expression ISO RGD:1353168 6480464 resveratrol results in increased expression of AURKA mRNA CTD PMID:19167446 SB 431542 multiple interactions ISO RGD:1353168 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide increases expression ISO RGD:1552819 6480464 Silicon Dioxide results in increased expression of AURKA mRNA CTD PMID:29341224 silver atom multiple interactions ISO RGD:1353168 6480464 CFL1 mRNA promotes the reaction [Silver results in increased expression of AURKA protein modified form] CTD PMID:28499611 silver atom increases expression ISO RGD:1353168 6480464 Silver results in increased expression of AURKA protein modified form CTD PMID:28499611 silver(0) multiple interactions ISO RGD:1353168 6480464 CFL1 mRNA promotes the reaction [Silver results in increased expression of AURKA protein modified form] CTD PMID:28499611 silver(0) increases expression ISO RGD:1353168 6480464 Silver results in increased expression of AURKA protein modified form CTD PMID:28499611 silver(1+) nitrate increases expression ISO RGD:1353168 6480464 Silver Nitrate results in increased expression of AURKA protein modified form CTD PMID:28499611 silver(1+) nitrate multiple interactions ISO RGD:1353168 6480464 CFL1 mRNA promotes the reaction [Silver Nitrate results in increased expression of AURKA protein modified form] CTD PMID:28499611 simvastatin decreases expression ISO RGD:1353168 6480464 Simvastatin results in decreased expression of AURKA mRNA CTD PMID:17428261 sodium arsenite decreases expression ISO RGD:1552819 6480464 sodium arsenite results in decreased expression of AURKA mRNA CTD PMID:17998272 sodium arsenite increases expression ISO RGD:1353168 6480464 sodium arsenite results in increased expression of AURKA mRNA CTD PMID:29301061 Soman increases expression EXP 6480464 Soman results in increased expression of AURKA mRNA CTD PMID:19281266 sulindac decreases expression ISO RGD:1353168 6480464 Sulindac results in decreased expression of AURKA mRNA CTD PMID:11906190 sulindac sulfide decreases expression ISO RGD:1353168 6480464 sulindac sulfide results in decreased expression of AURKA mRNA CTD PMID:12734198 sunitinib decreases expression ISO RGD:1353168 6480464 Sunitinib results in decreased expression of AURKA mRNA CTD PMID:31533062 tert-butyl hydroperoxide increases expression ISO RGD:1552819 6480464 tert-Butylhydroperoxide results in increased expression of AURKA mRNA CTD PMID:15003993 testosterone multiple interactions ISO RGD:1353168 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of AURKA mRNA CTD PMID:21592394 testosterone decreases expression ISO RGD:1353168 6480464 Testosterone results in decreased expression of AURKA mRNA CTD PMID:21592394 tetrachloromethane multiple interactions ISO RGD:1552819 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of AURKA mRNA more ... CTD PMID:16006527 more ... tetrachloromethane increases expression ISO RGD:1552819 6480464 Carbon Tetrachloride results in increased expression of AURKA mRNA CTD PMID:17484886 , PMID:27339419 thalidomide multiple interactions ISO RGD:1353168 6480464 [Azacitidine co-treated with Thalidomide] affects the expression of AURKA mRNA CTD PMID:18720364 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of AURKA mRNA CTD PMID:22659510 more ... titanium dioxide increases expression ISO RGD:1552819 6480464 titanium dioxide results in increased expression of AURKA mRNA CTD PMID:23557971 tocopherol increases expression ISO RGD:1552819 6480464 Tocopherols results in increased expression of AURKA mRNA CTD PMID:17056531 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of AURKA mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of AURKA mRNA CTD PMID:25729387 trichloroethene increases expression ISO RGD:1552819 6480464 Trichloroethylene results in increased expression of AURKA mRNA CTD PMID:25549359 trichostatin A decreases expression ISO RGD:1353168 6480464 trichostatin A results in decreased expression of AURKA mRNA CTD PMID:19606018 trichostatin A affects expression ISO RGD:1353168 6480464 trichostatin A affects the expression of AURKA mRNA CTD PMID:28542535 triclosan decreases expression ISO RGD:1353168 6480464 Triclosan results in decreased expression of AURKA mRNA CTD PMID:30510588 trimellitic anhydride increases expression ISO RGD:1552819 6480464 trimellitic anhydride results in increased expression of AURKA mRNA CTD PMID:19042947 tungsten increases expression ISO RGD:1552819 6480464 Tungsten results in increased expression of AURKA mRNA CTD PMID:30912803 tunicamycin decreases expression ISO RGD:1353168 6480464 Tunicamycin results in decreased expression of AURKA mRNA CTD PMID:22378314 , PMID:29453283 valproic acid decreases expression ISO RGD:1552819 6480464 Valproic Acid results in decreased expression of AURKA mRNA CTD PMID:21427059 valproic acid decreases expression ISO RGD:1353168 6480464 Valproic Acid results in decreased expression of AURKA mRNA CTD PMID:22083351 more ... vincristine increases response to substance ISO RGD:1353168 6480464 AURKA gene SNP results in increased susceptibility to Vincristine CTD PMID:20864405 vincristine increases expression ISO RGD:1353168 6480464 Vincristine results in increased expression of AURKA mRNA CTD PMID:17374387 zinc atom increases expression ISO RGD:1353168 6480464 Zinc deficiency results in increased expression of AURKA mRNA CTD PMID:22171008 zinc(0) increases expression ISO RGD:1353168 6480464 Zinc deficiency results in increased expression of AURKA mRNA CTD PMID:22171008
Biological Process anterior/posterior axis specification ISO RGD:1552819 1624291 MGI:MGI:3836420 (MGI:MGI:5449118 , PMID:22939930) RGD MGI:MGI:5449118 , PMID:22939930 anterior/posterior axis specification IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell division IEA UniProtKB-KW:KW-0132 1600115 GO_REF:0000043 UniProt GO_REF:0000043 centrosome cycle ISO RGD:1552819 1624291 MGI:MGI:1932915 (MGI:MGI:3697244 , PMID:17060449) RGD MGI:MGI:3697244 , PMID:17060449 centrosome localization ISO RGD:1552819 1624291 (MGI:MGI:5488573, PMID:22832491) RGD MGI:MGI:5488573 , PMID:22832491 centrosome localization IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107 histone-serine phosphorylation IEA GO:0035174 1600115 GO_REF:0000108 GOC GO_REF:0000108 liver regeneration IEA UniProtKB:O14965 , ensembl:ENSP000002169111600115 GO_REF:0000107 Ensembl GO_REF:0000107 liver regeneration ISO RGD:1353168 1624291 (PMID:19435814) RGD PMID:19435814 meiotic cell cycle ISO RGD:1552819 1624291 (MGI:MGI:4942235, PMID:21274965) RGD MGI:MGI:4942235 , PMID:21274965 meiotic spindle organization ISO RGD:1552819 1624291 (MGI:MGI:3045818, PMID:14695913) RGD MGI:MGI:3045818 , PMID:14695913 microtubule cytoskeleton organization ISO RGD:1552819 1624291 MGI:MGI:1932915 more ... RGD MGI:MGI:4438131 , PMID:19668197 mitotic cell cycle ISO RGD:1552819 1624291 (MGI:MGI:3575445 more ... RGD MGI:MGI:3575445 more ... mitotic centrosome separation ISO RGD:1552819 1624291 MGI:MGI:1932915 more ... RGD MGI:MGI:3697244 more ... mitotic centrosome separation IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitotic spindle organization ISO RGD:1552819 1624291 MGI:MGI:3826513 more ... RGD MGI:MGI:3822929 more ... mitotic spindle organization IBA MGI:MGI:894678 more ... 13792537 PMID:21873635 GO_Central mitotic spindle organization IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of apoptotic process ISO RGD:1552819 1624291 MGI:MGI:3836420 (MGI:MGI:5449118 , PMID:22939930) RGD MGI:MGI:5449118 , PMID:22939930 negative regulation of apoptotic process IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of gene expression ISO RGD:1353168 1624291 (PMID:28218735) RGD PMID:28218735 negative regulation of gene expression IEA UniProtKB:O14965 , ensembl:ENSP000002169111600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of protein binding ISO RGD:1353168 1624291 (PMID:21820309) RGD PMID:21820309 negative regulation of protein binding IEA UniProtKB:O14965 , ensembl:ENSP000002169111600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of spindle checkpoint ISO RGD:1552819 1624291 MGI:MGI:3836423 (MGI:MGI:3835913 , PMID:19075002) RGD MGI:MGI:3835913 , PMID:19075002 neuron projection extension ISO RGD:1552819 1624291 MGI:MGI:1919369 more ... RGD MGI:MGI:4438131 , PMID:19668197 neuron projection extension IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-serine phosphorylation ISO RGD:1353168 1624291 (PMID:28218735) RGD PMID:28218735 positive regulation of meiotic cell cycle process involved in oocyte maturation ISO RGD:13867865 1624291 (PMID:18614302), (PMID:20662813) RGD PMID:18614302 , PMID:20662813 positive regulation of oocyte maturation ISO RGD:1552819 1624291 (MGI:MGI:3045818, PMID:14695913) RGD MGI:MGI:3045818 , PMID:14695913 positive regulation of oocyte maturation IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO RGD:1552819 1624291 (MGI:MGI:3697244, PMID:17060449) RGD MGI:MGI:3697244 , PMID:17060449 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of translation ISO RGD:13867865 1624291 (PMID:18614302) RGD PMID:18614302 protein localization to centrosome ISO RGD:1552819 1624291 (MGI:MGI:3697244, PMID:17060449) RGD MGI:MGI:3697244 , PMID:17060449 protein localization to centrosome IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein phosphorylation IDA 619665 RGD protein phosphorylation ISO RGD:1353168 1624291 (PMID:21600873), (PMID:21820309) RGD PMID:21600873 , PMID:21820309 protein phosphorylation ISO RGD:1552819 1624291 MGI:MGI:101765 (MGI:MGI:3697244 , PMID:17060449) RGD MGI:MGI:3697244 , PMID:17060449 regulation of cytokinesis IBA PANTHER:PTN000681967 more ... 13792537 PMID:21873635 GO_Central regulation of protein stability ISO RGD:1353168 1624291 (PMID:15987997) RGD PMID:15987997 regulation of protein stability IEA UniProtKB:O14965 , ensembl:ENSP000002169111600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to estradiol IEP 1643347 RGD response to wounding IEA UniProtKB:O14965 , ensembl:ENSP000002169111600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to wounding ISO RGD:1353168 1624291 (PMID:19435814) RGD PMID:19435814 spindle assembly involved in female meiosis I ISO RGD:1552819 1624291 (MGI:MGI:4942235, PMID:21274965) RGD MGI:MGI:4942235 , PMID:21274965 spindle assembly involved in female meiosis I IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107 spindle organization ISO RGD:1353168 1624291 (PMID:21820309) RGD PMID:21820309 Cellular Component axon hillock ISO RGD:1552819 1624291 (MGI:MGI:4438131, PMID:19668197) RGD MGI:MGI:4438131 , PMID:19668197 axon hillock IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107 centriole IEA UniProtKB-SubCell:SL-0046 1600115 GO_REF:0000044 UniProt GO_REF:0000044 centrosome IDA 619665 RGD centrosome ISO RGD:1353168 1624291 (PMID:17726514), (PMID:21399614), (PMID:21600873), (PMID:23213400), (PMID:25657325) RGD GO_REF:0000052 more ... centrosome ISO RGD:1552819 1624291 (MGI:MGI:3831656, PMID:9245792) RGD MGI:MGI:3831656 , PMID:9245792 chromosome passenger complex IBA FB:FBgn0024227 more ... 13792537 PMID:21873635 GO_Central cilium IEA UniProtKB-KW:KW-0969 1600115 GO_REF:0000043 UniProt GO_REF:0000043 condensed nuclear chromosome, centromeric region IBA CGD:CAL0000183313 more ... 13792537 PMID:21873635 GO_Central cytosol IEA UniProtKB:O14965 , ensembl:ENSP000002169111600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:1353168 1624291 RGD GO_REF:0000052 germinal vesicle ISO RGD:1552819 1624291 (MGI:MGI:3045818, PMID:14695913) RGD MGI:MGI:3045818 , PMID:14695913 germinal vesicle IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107 meiotic spindle ISO RGD:1552819 1624291 (MGI:MGI:3045818, PMID:14695913) RGD MGI:MGI:3045818 , PMID:14695913 meiotic spindle IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107 microtubule cytoskeleton ISO RGD:1353168 1624291 (PMID:19801554) RGD PMID:19801554 microtubule organizing center ISO RGD:1552819 1624291 MGI:MGI:1932915 more ... RGD MGI:MGI:4438131 , PMID:19668197 mitotic spindle ISO RGD:1552819 1624291 (MGI:MGI:3831656, PMID:9245792) RGD MGI:MGI:3831656 , PMID:9245792 mitotic spindle pole ISO RGD:1353168 1624291 (PMID:25657325) RGD PMID:25657325 mitotic spindle pole ISS UniProtKB:O14965 1600115 GO_REF:0000024 UniProt GO_REF:0000024 mitotic spindle pole IEA UniProtKB:O14965 , ensembl:ENSP000002169111600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm ISO RGD:1353168 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:O14965 , ensembl:ENSP000002169111600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:1353168 1624291 (PMID:20531406) RGD PMID:20531406 perinuclear region of cytoplasm ISO RGD:1353168 1624291 (PMID:20531406) RGD PMID:20531406 perinuclear region of cytoplasm IEA UniProtKB:O14965 , ensembl:ENSP000002169111600115 GO_REF:0000107 Ensembl GO_REF:0000107 pronucleus ISO RGD:1552819 1624291 (MGI:MGI:3045818, PMID:14695913) RGD MGI:MGI:3045818 , PMID:14695913 pronucleus IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107 spindle IDA 619665 RGD spindle microtubule colocalizes_with ISO RGD:1353168 1624291 (PMID:19801554) RGD PMID:19801554 spindle microtubule IBA PANTHER:PTN000681967 more ... 13792537 PMID:21873635 GO_Central spindle microtubule IEA UniProtKB:O14965 , ensembl:ENSP000002169111600115 GO_REF:0000107 Ensembl GO_REF:0000107 spindle midzone IBA FB:FBgn0024227 more ... 13792537 PMID:21873635 GO_Central spindle pole centrosome ISO RGD:1353168 1624291 (PMID:19801554) RGD PMID:19801554 spindle pole centrosome IBA PANTHER:PTN000681967 more ... 13792537 PMID:21873635 GO_Central spindle pole centrosome IEA UniProtKB:O14965 , ensembl:ENSP000002169111600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function ATP binding IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000043 UniProt GO_REF:0000043 histone serine kinase activity ISO RGD:1552819 1624291 (MGI:MGI:4942235, PMID:21274965) RGD MGI:MGI:4942235 , PMID:21274965 histone serine kinase activity IBA MGI:MGI:107168 more ... 13792537 PMID:21873635 GO_Central histone serine kinase activity IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding ISO RGD:1552819 1624291 UniProtKB:A2APB8 more ... RGD MGI:MGI:3575445 more ... protein binding ISO RGD:1353168 1624291 UniProtKB:A2APB8 more ... RGD PMID:12244051 more ... protein heterodimerization activity ISO RGD:1353168 1624291 UniProtKB:P24522 (PMID:20460379) RGD PMID:20460379 protein heterodimerization activity IEA UniProtKB:O14965 , ensembl:ENSP000002169111600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein kinase activity ISO RGD:1552819 1624291 (MGI:MGI:3831656, PMID:9245792) RGD MGI:MGI:3831656 , PMID:9245792 protein kinase activity ISS UniProtKB:O14965 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein kinase activity ISO RGD:1353168 1624291 (PMID:14580337), (PMID:19801554), (PMID:21600873) RGD PMID:14580337 more ... protein kinase binding ISO RGD:1353168 1624291 UniProtKB:P53350 (PMID:18615013) RGD PMID:18615013 protein kinase binding IEA UniProtKB:O14965 , ensembl:ENSP000002169111600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein serine/threonine kinase activity IDA 619665 RGD protein serine/threonine kinase activity ISO RGD:1353168 1624291 (PMID:13678582), (PMID:18566290), (PMID:21807936), (PMID:28218735) RGD PMID:13678582 more ... ubiquitin protein ligase binding ISO RGD:1552819 1624291 UniProtKB:Q810L3 (MGI:MGI:3575445 , PMID:15793587) RGD MGI:MGI:3575445 , PMID:15793587 ubiquitin protein ligase binding IEA UniProtKB:P97477 , ensembl:ENSMUSP000000289971600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
