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Gene: Aurka (aurora kinase A) Mus musculus
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Symbol: Aurka
Name: aurora kinase A
RGD ID: 1552819
Description: Exhibits histone serine kinase activity and ubiquitin protein ligase binding activity. Involved in several processes, including microtubule cytoskeleton organization; positive regulation of oocyte maturation; and protein localization to centrosome. Localizes to axon hillock; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including central nervous system; germ cell of gonad; neural retina; node; and orbito-sphenoid. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Orthologous to human AURKA (aurora kinase A); INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI; AIRK1; Ar; ARK-1; Ark1; Au; AU019385; aurora 2; aurora A; aurora family kinase 1; Aurora-A; aurora-related kinase 1; aurora/IPL1-related kinase 1; AW539821; Ayk; Ayk1; I; IA; IAK; IAK1; ipl1- and aurora-related kinase 1; serine/threonine kinase 6; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A; serine/threonine-protein kinase Ayk1; Stk; Stk6
Orthologs:
Homo sapiens (human) : AURKA (aurora kinase A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Aurka (aurora kinase A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aurka (aurora kinase A)
Pan paniscus (bonobo/pygmy chimpanzee) : AURKA (aurora kinase A)
Canis lupus familiaris (dog) : AURKA (aurora kinase A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aurka (aurora kinase A)
Sus scrofa (pig) : AURKA (aurora kinase A)
Chlorocebus sabaeus (African green monkey) : AURKA (aurora kinase A)
Heterocephalus glaber (naked mole-rat) : Aurka (aurora kinase A)
more info ...
Related Pseudogenes: Gm15916   Gm17914   Gm3017  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392172,198,110 - 172,212,820 (-)NCBI
GRCm382172,356,190 - 172,370,886 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2172,356,190 - 172,370,535 (-)EnsemblGRCm38mm10GRCm38
MGSCv372172,181,696 - 172,196,006 (-)NCBIGRCm37mm9NCBIm37
MGSCv362172,047,401 - 172,061,711 (-)NCBImm8
Celera2178,315,373 - 178,329,688 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map294.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Aurka
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552819
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-11-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.