Klkb1 (kallikrein B1) - Rat Genome Database

Name: Klkb1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Klkb1 (kallikrein B1) Rattus norvegicus

Analyze

Symbol:

Klkb1

Name:

kallikrein B1

RGD ID:

67382

Description:

Predicted to enable serine-type endopeptidase activity. Involved in liver regeneration. Located in extracellular space. Used to study inflammatory bowel disease. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in lupus nephritis and systemic lupus erythematosus. Orthologous to human KLKB1 (kallikrein B1); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1,3,5-trinitro-1,3,5-triazinane.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

fletcher factor; kallikrein B, plasma 1; Kalp1; KALP15; kininogenin; Klk3; MGC108748; PK; Plasma kallikrein; plasma prekallikrein; RATKALP15

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KLKB1 (kallikrein B1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Klkb1 (kallikrein B, plasma 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Klkb1 (kallikrein B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KLKB1 (kallikrein B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KLKB1 (kallikrein B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Klkb1 (kallikrein B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KLKB1 (kallikrein B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KLKB1 (kallikrein B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Klkb1 (kallikrein B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Klkb1 (kallikrein B, plasma 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	KLKB1 (kallikrein B1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Sb	Alliance	DIOPT (OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	klkb1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	46,958,634 - 46,982,054 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	46,958,707 - 46,982,053 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	52,351,649 - 52,374,892 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	55,728,965 - 55,752,309 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	50,991,039 - 51,014,284 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	50,151,127 - 50,175,407 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	50,152,008 - 50,175,458 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	49,874,943 - 49,898,364 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	50,248,935 - 50,272,279 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	50,248,906 - 50,272,347 (+)	NCBI
Celera	16	44,949,240 - 44,972,564 (+)	NCBI		Celera
Cytogenetic Map	16	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

autistic disorder (ISO)

Bietti crystalline corneoretinal dystrophy (ISO)

carotid artery thrombosis (ISO)

corneal dystrophy (ISO)

Diabetic Nephropathies (ISO)

Enterocolitis (IEP,IMP)

Experimental Arthritis (IEP,IMP)

factor XI deficiency (ISO)

genetic disease (ISO)

glomerulonephritis (ISO)

hemorrhagic disease (ISO)

Herpes Simplex Encephalitis 1 (ISO)

hypertension (ISO)

inflammatory bowel disease (IMP)

liver cirrhosis (IEP)

lupus nephritis (ISO)

Prekallikrein Deficiency (ISO)

pulmonary embolism (ISO)

Sepsis (IMP)

systemic lupus erythematosus (ISO)

thrombosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (EXP)

1,3,5-trinitro-1,3,5-triazinane (EXP)

1-naphthyl isothiocyanate (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3H-1,2-dithiole-3-thione (EXP)

6-oxoprostaglandin F1alpha (ISO)

acetamide (EXP)

aconitine (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

ammonium chloride (EXP)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chlorohydrocarbon (EXP)

chlorpromazine (ISO)

chondroitin sulfate (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

decabromodiphenyl ether (EXP)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dichlorine (EXP)

dorsomorphin (ISO)

entinostat (ISO)

flutamide (EXP)

furan (EXP)

gingerol (ISO)

glucose (ISO)

glutathione (EXP)

iron trichloride (ISO)

kojic acid (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

methotrexate (ISO)

methylmercury chloride (EXP)

N-nitrosodiethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

nimesulide (ISO)

nitrofen (EXP)

O-methyleugenol (ISO)

ozone (EXP)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (EXP,ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

rose bengal (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

splitomicin (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

Tributyltin oxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

Triptolide (ISO)

triptonide (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation (IEA)

fibrinolysis (IEA)

inflammatory response (IEA)

liver regeneration (IEP)

plasminogen activation (ISO)

positive regulation of fibrinolysis (ISO)

proteolysis (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IDA,ISO)

Molecular Function

protein binding (ISO)

serine-type endopeptidase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

acenocoumarol pharmacodynamics pathway (ISO)

alteplase pharmacodynamics pathway (ISO)

aminocaproic acid pharmacodynamics pathway (ISO)

anistreplase pharmacodynamics pathway (ISO)

aprotinin pharmacodynamics pathway (ISO)

argatroban pharmacodynamics pathway (ISO)

bivalirudin pharmacodynamics pathway (ISO)

coagulation cascade pathway (IEA)

complement system pathway (IEA)

dicoumarol pharmacodynamics pathway (ISO)

enoxaparin pharmacodynamics pathway (ISO)

fondaparinux pharmacodynamics pathway (ISO)

heparin pharmacodynamics pathway (ISO)

kallikrein-kinin cascade pathway (ISO)

phenindione pharmacodynamics pathway (ISO)

reteplase pharmacodynamics pathway (ISO)

tranexamic acid pharmacodynamics pathway (ISO)

warfarin pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Gene structure and chromosomal localization of plasma kallikrein.	Beaubien G, etal., Biochemistry 1991 Feb 12;30(6):1628-35.
2.	Plasma-kallikrein clearance during liver regeneration after partial hepatectomy in the rat.	Braulio VB, etal., Liver. 1998 Dec;18(6):371-7.
3.	Role of plasma kallikrein-kinin system activation in synovial recruitment of endothelial progenitor cells in experimental arthritis.	Dai J, etal., Arthritis Rheum. 2012 Nov;64(11):3574-82. doi: 10.1002/art.34607.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Plasma prekallikrein: a risk marker for hypertension and nephropathy in type 1 diabetes.	Jaffa AA, etal., Diabetes. 2003 May;52(5):1215-21.
7.	PF-04886847 (an inhibitor of plasma kallikrein) attenuates inflammatory mediators and activation of blood coagulation in rat model of lipopolysaccharide (LPS)-induced sepsis.	Kolte D, etal., Cardiovasc Hematol Agents Med Chem. 2012 Jun;10(2):154-66.
8.	The fate of plasma kallikrein in normal and kininogen-deficient rats.	Kouyoumdjian M and Damas J, Arch Physiol Biochem. 1998 Feb;106(1):25-32.
9.	Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans.	Liu K, etal., J Clin Invest. 2009 Apr;119(4):911-23. doi: 10.1172/JCI36728.
10.	Prolylcarboxypeptidase: a cardioprotective enzyme.	Mallela J, etal., Int J Biochem Cell Biol. 2009 Mar;41(3):477-81. doi: 10.1016/j.biocel.2008.02.022. Epub 2008 Feb 29.
11.	The kallikrein-kinin system: current and future pharmacological targets.	Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
12.	Hepatic clearance of tissue-type plasminogen activator and plasma kallikrein in experimental liver fibrosis.	Nagaoka MR, etal., Liver Int. 2003 Dec;23(6):476-83.
13.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
14.	[Components of kallikrein-kinin system in the urine of patients with glomerulonephritis].	Paskhina TS, etal., Vopr Med Khim. 1990 Jul-Aug;36(4):62-9.
15.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
16.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
17.	GOA pipeline	RGD automated data pipeline
18.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	Comprehensive gene review and curation	RGD comprehensive gene curation
21.	The cDNA structure of rat plasma kallikrein.	Seidah NG, etal., DNA 1989 Oct;8(8):563-74.
22.	Selective plasma kallikrein inhibitor attenuates acute intestinal inflammation in Lewis rat.	Stadnicki A, etal., Dig Dis Sci. 1996 May;41(5):912-20.
23.	Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution.	Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
24.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:89876	PMID:1298973	PMID:12477932	PMID:17440623	PMID:23533145	PMID:34241810

Genomics

Comparative Map Data

Klkb1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	46,958,634 - 46,982,054 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	46,958,707 - 46,982,053 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	52,351,649 - 52,374,892 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	55,728,965 - 55,752,309 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	50,991,039 - 51,014,284 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	50,151,127 - 50,175,407 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	50,152,008 - 50,175,458 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	49,874,943 - 49,898,364 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	50,248,935 - 50,272,279 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	50,248,906 - 50,272,347 (+)	NCBI
Celera	16	44,949,240 - 44,972,564 (+)	NCBI		Celera
Cytogenetic Map	16	q11	NCBI

KLKB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	186,210,853 - 186,258,471 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	186,226,438 - 186,258,471 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	187,148,661 - 187,179,625 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	187,385,666 - 187,416,619 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	187,523,820 - 187,554,773	NCBI
Celera	4	184,471,184 - 184,503,982 (+)	NCBI		Celera
Cytogenetic Map	4	q35.2	NCBI
HuRef	4	182,900,717 - 182,930,974 (+)	NCBI		HuRef
CHM1_1	4	187,125,087 - 187,156,065 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	189,554,481 - 189,598,453 (+)	NCBI		T2T-CHM13v2.0

Klkb1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	45,719,725 - 45,747,872 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	45,719,726 - 45,747,896 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	45,266,688 - 45,294,835 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	45,266,689 - 45,294,859 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	46,354,796 - 46,380,189 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	46,768,488 - 46,807,283 (-)	NCBI		MGSCv36	mm8
Celera	8	47,956,504 - 47,981,825 (-)	NCBI		Celera
Cytogenetic Map	8	B1.1	NCBI
cM Map	8	25.17	NCBI

Klkb1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	22,833,982 - 22,856,389 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	22,835,544 - 22,856,355 (-)	NCBI	ChiLan1.0	ChiLan1.0

KLKB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	4	184,307,425 - 184,350,153 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	178,398,359 - 178,429,448 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	190,604,901 - 190,636,300 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	190,604,901 - 190,636,300 (+)	Ensembl	panpan1.1		panPan2

KLKB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	44,492,735 - 44,517,854 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	44,469,632 - 44,540,292 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	44,979,694 - 45,003,202 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	46,683,089 - 46,736,876 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	46,706,236 - 46,730,702 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
ROS_Cfam_1.0 Ensembl	16	46,683,106 - 46,700,880 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	44,675,226 - 44,698,533 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	45,288,025 - 45,311,430 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	45,418,960 - 45,442,647 (-)	NCBI		UU_Cfam_GSD_1.0

Klkb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	34,872,449 - 34,882,567 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936554	3,228,735 - 3,256,710 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936554	3,227,395 - 3,256,710 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KLKB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	47,071,556 - 47,103,622 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	47,071,581 - 47,100,272 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	53,912,808 - 53,941,527 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KLKB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	132,143,514 - 132,173,189 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	132,144,420 - 132,173,187 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	112,465,874 - 112,497,290 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Klkb1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624769	17,067,342 - 17,087,408 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624769	17,066,055 - 17,088,587 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Klkb1
201 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	173
Count of miRNA genes:	122
Interacting mature miRNAs:	132
Transcripts:	ENSRNOT00000019237
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	832236	59492508	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	832236	59492508	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	832236	59492508	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	832236	59492508	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4227609	46975965	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	4227609	48972724	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	49227609	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	60252231	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70215	Niddm29	Non-insulin dependent diabetes mellitus QTL 29	3.54		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	16	19004435	75226532	Rat
2302057	Pia29	Pristane induced arthritis QTL 29	3.6	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	16	21735975	66735975	Rat
8694453	Bw172	Body weight QTL 172	8.33	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	16	24325513	69325513	Rat
6903294	Stl30	Serum triglyceride level QTL 30	2.6	0.0013	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	16	25152793	70152793	Rat
1298529	Arunc1	Aerobic running capacity QTL 1	4		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	31951520	60148445	Rat
1578768	Stresp22	Stress response QTL 22	2.8		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	16	35288870	80288870	Rat
2293690	Bss45	Bone structure and strength QTL 45	5.13	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	16	37752156	82752156	Rat
2300163	Bmd64	Bone mineral density QTL 64	5.3	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	16	37752156	82752156	Rat
7205510	Activ5	Activity QTL 5	3.78	0.00028	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	42396345	84729064	Rat
631833	Sach2	Saccharin preference QTL 2	4	0.01	consumption behavior trait (VT:0002069)	calculated saccharin drink intake rate (CMO:0001613)	16	43024842	50166018	Rat

Markers in Region

D16Wox13

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	46,975,842 - 46,975,959 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	50,169,198 - 50,169,312	NCBI	Rnor6.0
Rnor_5.0	16	49,892,155 - 49,892,269	UniSTS	Rnor5.0
RGSC_v3.4	16	50,266,069 - 50,266,184	RGD	RGSC3.4
RGSC_v3.4	16	50,266,070 - 50,266,184	UniSTS	RGSC3.4
RGSC_v3.1	16	50,266,144 - 50,266,259	RGD
Celera	16	44,966,375 - 44,966,469	UniSTS
RH 3.4 Map	16	461.1	RGD
RH 3.4 Map	16	461.1	UniSTS
Cytogenetic Map	16	q11	UniSTS

D16Mgh5

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	46,975,801 - 46,975,965 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	50,169,157 - 50,169,318	NCBI	Rnor6.0
Rnor_5.0	16	49,892,114 - 49,892,275	UniSTS	Rnor5.0
RGSC_v3.4	16	50,266,028 - 50,266,190	RGD	RGSC3.4
RGSC_v3.4	16	50,266,029 - 50,266,190	UniSTS	RGSC3.4
RGSC_v3.1	16	50,266,103 - 50,266,265	RGD
Celera	16	44,966,334 - 44,966,475	UniSTS
Cytogenetic Map	16	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			41	33	6	33					5	9
Low	1	9	14	6	11	6	8	9	17	21	6		8
Below cutoff		1	2	2		2		1	39	4	10

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012725	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006253121	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008771252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008771253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AH003184	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC089815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473995	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M30282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M58590	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000019237 ⟹ ENSRNOP00000019237

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	46,958,707 - 46,982,053 (+)	Ensembl
Rnor_6.0 Ensembl	16	50,152,008 - 50,175,458 (+)	Ensembl

RefSeq Acc Id:

NM_012725 ⟹ NP_036857

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	46,958,707 - 46,982,054 (+)	NCBI
Rnor_6.0	16	50,152,062 - 50,175,407 (+)	NCBI
Rnor_5.0	16	49,874,943 - 49,898,364 (+)	NCBI
RGSC_v3.4	16	50,248,935 - 50,272,279 (+)	RGD
Celera	16	44,949,240 - 44,972,564 (+)	RGD

Sequence:

show sequence

TGAAGACTAGCTTCATGTGAAGACTCCTTCTCCTCCAGCAGCACAAAGCAACCATCCTTCCAGG
ATGATTTTATTCAAACAAGTGGGTTATTTTGTTTCCTTGTTCGCTACAGTTTCCTGTGGGTGTC
TGTCACAACTGTATGCAAATACCTTCTTCAGAGGTGGGGATCTGGCTGCCATCTACACCCCGGA
TGCCCAGCACTGTCAGAAGATGTGCACGTTTCACCCCAGGTGCCTGCTCTTCAGCTTCCTTGCC
GTGAGTCCAACCAAGGAGACAGATAAAAGGTTTGGGTGCTTCATGAAAGAGAGCATTACAGGGA
CTTTGCCAAGAATACACCGGACAGGGGCCATTTCTGGTCATTCTTTAAAACAGTGTGGCCATCA
ATTAAGTGCTTGCCACCAAGACATATACGAAGGACTGGATATGAGAGGGTCCAACTTTAATATA
TCTAAGACCGACAGTATTGAAGAATGCCAGAAACTGTGCACAAATAATATTCACTGCCAATTTT
TCACATATGCTACAAAAGCATTTCACAGACCAGAGTACAGGAAGAGTTGCCTGCTGAAGCGCAG
TTCAAGTGGAACGCCCACCAGTATAAAGCCAGTGGACAACCTGGTGTCTGGATTCTCACTGAAG
TCCTGTGCTCTCTCAGAGATCGGTTGCCCCATGGATATTTTCCAGCACTTTGCCTTTGCAGACC
TGAATGTAAGCCATGTCGTCACCCCCGATGCCTTCGTGTGTCGCACCGTTTGCACCTTCCATCC
CAACTGCCTCTTCTTCACATTCTACACGAATGAGTGGGAGACGGAATCACAGAGGAATGTTTGT
TTTCTTAAGACATCTAAAAGTGGAAGACCAAGTCCCCCTATTATTCAAGAAAATGCTGTATCTG
GATACAGTCTCTTCACCTGCAGAAAAGCTCGCCCTGAACCCTGCCATTTCAAGATTTACTCTGG
AGTTGCCTTCGAAGGGGAAGAACTGAACGCGACCTTCGTGCAGGGAGCAGATGCGTGCCAAGAG
ACTTGTACAAAGACCATCCGCTGTCAGTTTTTTACTTACTCATTGCTTCCCCAAGACTGCAAGG
CAGAGGGGTGTAAATGTTCCTTAAGGTTATCCACGGATGGCTCTCCAACTAGGATCACCTATGA
GGCACAGGGGAGCTCTGGTTATTCTCTGAGACTGTGTAAAGTTGTGGAGAGCTCTGACTGTACG
ACAAAAATAAATGCACGTATTGTGGGAGGAACAAACTCTTCTTTAGGAGAGTGGCCATGGCAGG
TCAGCCTGCAAGTAAAGTTGGTTTCTCAGAATCATATGTGTGGAGGGTCCATCATTGGACGCCA
ATGGATACTGACGGCTGCCCATTGCTTTGATGGGATTCCCTATCCAGACGTGTGGCGTATATAT
GGCGGGATTCTTAATCTGTCAGAGATTACAAACAAAACGCCTTTCTCAAGTATAAAGGAGCTTA
TTATTCATCAGAAATACAAAATGTCAGAAGGCAGTTACGATATTGCCTTAATAAAGCTTCAGAC
ACCGTTGAATTATACTGAATTCCAAAAACCAATATGCCTGCCTTCCAAAGCTGACACAAATACA
ATTTATACCAACTGCTGGGTGACTGGATGGGGCTACACAAAGGAACGAGGTGAGACCCAAAATA
TTCTACAAAAGGCAACTATTCCCTTGGTACCAAATGAAGAATGCCAGAAAAAATATAGAGATTA
TGTTATAACCAAGCAGATGATCTGTGCTGGCTACAAAGAAGGTGGAATAGATGCTTGTAAGGGA
GATTCCGGTGGCCCCTTAGTTTGCAAACATAGTGGAAGGTGGCAGTTGGTGGGTATCACCAGCT
GGGGCGAAGGCTGTGCCCGCAAGGAGCAACCAGGAGTCTACACCAAAGTTGCTGAGTACATTGA
CTGGATATTGGAGAAGATACAGAGCAGCAAGGAAAGAGCTCTGGAGACATCTCCAGCATGAGGA
GGCTGGGTACTGATGGGGAAGAGCCCAGCTGGCACCAGCTTTACCACCTGCCCTCAAGTCCTAC
TAGAGCTCCAGAGTTCTCTTCTGCAAAATGTCGATAGTGGTGTCTACCTCGCATCCTTACCATA
GGATTAAAAGTCCAAATGTAGACACAGTTGCTAAAGACAGCGCCATGCTCAAGCGTGCTTCCTG
CCTTGAGCAACAGGAACGCCAATGAGAACTATCCAAAGATTACCAAGCCTGTTTGGAAATAAAA
TGGTCAAAGGATTTTTATTAGGTAGTGAAATTAGGTAGTTGTCCTTGGAACCATTCTCATGTAA
CTGTTGACTCTGGACCTCAGCAGATCACAGTTACCTTCTGTCCACTTCTGACATTTGTGTACTG
GAACCTGATGCTGTTCTTCCACTTGGAGCAAAGAACTGAGAAACCTGGTTCTATCCATTGGGAA
AAAGAGATCTTTGTAACATTTCCTTTACAATAAAAAGATGTTCTACTTGGACTTGAAAAAAAAA
AAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006253121 ⟹ XP_006253183

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	46,958,634 - 46,982,054 (+)	NCBI
Rnor_6.0	16	50,151,127 - 50,175,407 (+)	NCBI
Rnor_5.0	16	49,874,943 - 49,898,364 (+)	NCBI

Sequence:

show sequence

ACTCAGGTCATCAGGCTTGATGGCAAATGCTTTTGACCTACTGAGATGTCTTGTAAGCTCCACG
ATGATTTTAGACTTTTAAAGCTTGCTTCACTGGGCAAACCTAGTAGTCATGTATCTCATCAATG
GATTCTGGGTTAGCCAACTGTGTAGTTAGAGTTGGATATGCAAGGCTAGGTTTGAATCTTGGGT
CCACAGAAAAGAGCATTGCATCAGGGTCCACCGTGATTACATTGATGACTGAATTCCTAGAGCC
CATGCTTGAATCCTCAGATCAGTGGGGCCACGATCTTATGATTGAGGACTGCCTTAACATGTTG
ATATTGAAATGAACCTGAAAACTGAGCCTCCAGTGGCCATGTTAACGAACTCAAGCCCGTGGGC
ATGGGTTTGTTCCTGAATCTACAATCGCTGTCCTGGAAATGAGCCCTGGAAATGGGACAATCTG
GTGGCTGGCCTGAGGTATCATCCTGGAGCCTGGGTCTGCAGGGTCAGCCTGATAACTGGGATTT
CCTGGAATGGACTTGTTTACATCTGTCTTTATTCATAGGGAACACATCGCCATTCTGTGCTGCC
CAGGCTTAGTAGCAGGGTTTTATGGTTAAAGTGAAGGATCGAACACTCTTCAATGCCTATTCAC
TATGTCCACAGTTTCACCGGGGGCTGTAACCTATCATCTGGCTTTCTTAACACTTGGAAAGGCA
TGGGGAATTGTTCCCATGGATTCTTCTGCAAAGGGATGCGTGGTGGAGATTCCAATTTTGTCAT
GGTGTTTACATGACTTTCTGGAATCGGTAACATATTAAGTACTTGAACCTGGACTGGAAGGTCC
ATGGACTGTATTGACAGGTCAAACAGAAGACACTGATGCCAGAAGCCCAGTGTCAACACTGGAG
CCAAGCAGAGACCAACCTCAGTGCCATATTCGGAGAGCTTGAAGACTAGCTTCATGTGAAGACT
CCTTCTCCTCCAGCAGCACAAAGCAACCATCCTTCCAGGATGATTTTATTCAAACAAGTGGGTT
ATTTTGTTTCCTTGTTCGCTACAGTTTCCTGTGGGTGTCTGTCACAACTGTATGCAAATACCTT
CTTCAGAGGTGGGGATCTGGCTGCCATCTACACCCCGGATGCCCAGCACTGTCAGAAGATGTGC
ACGTTTCACCCCAGGTGCCTGCTCTTCAGCTTCCTTGCCGTGAGTCCAACCAAGGAGACAGATA
AAAGGTTTGGGTGCTTCATGAAAGAGAGCATTACAGGGACTTTGCCAAGAATACACCGGACAGG
GGCCATTTCTGGTCATTCTTTAAAACAGTGTGGCCATCAATTAAGTGCTTGCCACCAAGACATA
TACGAAGGACTGGATATGAGAGGGTCCAACTTTAATATATCTAAGACCGACAGTATTGAAGAAT
GCCAGAAACTGTGCACAAATAATATTCACTGCCAATTTTTCACATATGCTACAAAAGCATTTCA
CAGACCAGAGTACAGGAAGAGTTGCCTGCTGAAGCGCAGTTCAAGTGGAACGCCCACCAGTATA
AAGCCAGTGGACAACCTGGTGTCTGGATTCTCACTGAAGTCCTGTGCTCTCTCAGAGATCGACC
TGAATGTAAGCCATGTCGTCACCCCCGATGCCTTCGTGTGTCGCACCGTTTGCACCTTCCATCC
CAACTGCCTCTTCTTCACATTCTACACGAATGAGTGGGAGACGGAATCACAGAGGAATGTTTGT
TTTCTTAAGACATCTAAAAGTGGAAGACCAAGTCCCCCTATTATTCAAGAAAATGCTGTATCTG
GATACAGTCTCTTCACCTGCAGAAAAGCTCGCCCTGAACCCTGCCATTTCAAGATTTACTCTGG
AGTTGCCTTCGAAGGGGAAGAACTGAACGCGACCTTCGTGCAGGGAGCAGATGCGTGCCAAGAG
ACTTGTACAAAGACCATCCGCTGTCAGTTTTTTACTTACTCATTGCTTCCCCAAGACTGCAAGG
CAGAGGGGTGTAAATGTTCCTTAAGGTTATCCACGGATGGCTCTCCAACTAGGATCACCTATGA
GGCACAGGGGAGCTCTGGTTATTCTCTGAGACTGTGTAAAGTTGTGGAGAGCTCTGACTGTACG
ACAAAAATAAATGCACGTATTGTGGGAGGAACAAACTCTTCTTTAGGAGAGTGGCCATGGCAGG
TCAGCCTGCAAGTAAAGTTGGTTTCTCAGAATCATATGTGTGGAGGGTCCATCATTGGACGCCA
ATGGATACTGACGGCTGCCCATTGCTTTGATGGGATTCCCTATCCAGACGTGTGGCGTATATAT
GGCGGGATTCTTAATCTGTCAGAGATTACAAACAAAACGCCTTTCTCAAGTATAAAGGAGCTTA
TTATTCATCAGAAATACAAAATGTCAGAAGGCAGTTACGATATTGCCTTAATAAAGCTTCAGAC
ACCGTTGAATTATACTGAATTCCAAAAACCAATATGCCTGCCTTCCAAAGCTGACACAAATACA
ATTTATACCAACTGCTGGGTGACTGGATGGGGCTACACAAAGGAACGAGGTGAGACCCAAAATA
TTCTACAAAAGGCAACTATTCCCTTGGTACCAAATGAAGAATGCCAGAAAAAATATAGAGATTA
TGTTATAACCAAGCAGATGATCTGTGCTGGCTACAAAGAAGGTGGAATAGATGCTTGTAAGGGA
GATTCCGGTGGCCCCTTAGTTTGCAAACATAGTGGAAGGTGGCAGTTGGTGGGTATCACCAGCT
GGGGCGAAGGCTGTGCCCGCAAGGAGCAACCAGGAGTCTACACCAAAGTTGCTGAGTACATTGA
CTGGATATTGGAGAAGATACAGAGCAGCAAGGAAAGAGCTCTGGAGACATCTCCAGCATGAGGA
GGCTGGGTACTGATGGGGAAGAGCCCAGCTGGCACCAGCTTTACCACCTGCCCTCAAGTCCTAC
TAGAGCTCCAGAGTTCTCTTCTGCAAAATGTCGATAGTGGTGTCTACCTCGCATCCTTACCATA
GGATTAAAAGTCCAAATGTAGACACAGTTGCTAAAGACAGCGCCATGCTCAAGCGTGCTTCCTG
CCTTGAGCAACAGGAACGCCAATGAGAACTATCCAAAGATTACCAAGCCTGTTTGGAAATAAAA
TGGTCAAAGGATTTTTATTAGGTAGTGAAATTAGGTAGTTGTCCTTGGAACCATTCTCATGTAA
CTGTTGACTCTGGACCTCAGCAGATCACAGTTACCTTCTGTCCACTTCTGACATTTGTGTACTG
GAACCTGATGCTGTTCTTCCACTTGGAGCAAAGAACTGAGAAACCTGGTTCTATCCATTGGGAA
AAAGAGATCTTTGTAACATTTCCTTTACAATAAAAAGATGTTCTACTTGGACTTGA

hide sequence

RefSeq Acc Id:

XM_008771253 ⟹ XP_008769475

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	46,965,199 - 46,982,054 (+)	NCBI
Rnor_6.0	16	50,158,603 - 50,175,407 (+)	NCBI

Sequence:

show sequence

ATGCCCAGCACTGTCAGAAGATGTGCACGTTTCACCCCAGGTGCCTGCTCTTCAGCTTCCTTGC
CGTGAGTCCAACCAAGGAGACAGATAAAAGGTAAGATGTCCGTGAGATCCAACCAAGGAGACAG
ATAAAAGGTTTGGGTGCTTCATGAAAGAGAGCATTACAGGGACTTTGCCAAGAATACACCGGAC
AGGGGCCATTTCTGGTCATTCTTTAAAACAGTGTGGCCATCAATTAAGTGCTTGCCACCAAGAC
ATATACGAAGGACTGGATATGAGAGGGTCCAACTTTAATATATCTAAGACCGACAGTATTGAAG
AATGCCAGAAACTGTGCACAAATAATATTCACTGCCAATTTTTCACATATGCTACAAAAGCATT
TCACAGACCAGAGTACAGGAAGAGTTGCCTGCTGAAGCGCAGTTCAAGTGGAACGCCCACCAGT
ATAAAGCCAGTGGACAACCTGGTGTCTGGATTCTCACTGAAGTCCTGTGCTCTCTCAGAGATCG
GTTGCCCCATGGATATTTTCCAGCACTTTGCCTTTGCAGACCTGAATGTAAGCCATGTCGTCAC
CCCCGATGCCTTCGTGTGTCGCACCGTTTGCACCTTCCATCCCAACTGCCTCTTCTTCACATTC
TACACGAATGAGTGGGAGACGGAATCACAGAGGAATGTTTGTTTTCTTAAGACATCTAAAAGTG
GAAGACCAAGTCCCCCTATTATTCAAGAAAATGCTGTATCTGGATACAGTCTCTTCACCTGCAG
AAAAGCTCGCCCTGAACCCTGCCATTTCAAGATTTACTCTGGAGTTGCCTTCGAAGGGGAAGAA
CTGAACGCGACCTTCGTGCAGGGAGCAGATGCGTGCCAAGAGACTTGTACAAAGACCATCCGCT
GTCAGTTTTTTACTTACTCATTGCTTCCCCAAGACTGCAAGGCAGAGGGGTGTAAATGTTCCTT
AAGGTTATCCACGGATGGCTCTCCAACTAGGATCACCTATGAGGCACAGGGGAGCTCTGGTTAT
TCTCTGAGACTGTGTAAAGTTGTGGAGAGCTCTGACTGTACGACAAAAATAAATGCACGTATTG
TGGGAGGAACAAACTCTTCTTTAGGAGAGTGGCCATGGCAGGTCAGCCTGCAAGTAAAGTTGGT
TTCTCAGAATCATATGTGTGGAGGGTCCATCATTGGACGCCAATGGATACTGACGGCTGCCCAT
TGCTTTGATGGGATTCCCTATCCAGACGTGTGGCGTATATATGGCGGGATTCTTAATCTGTCAG
AGATTACAAACAAAACGCCTTTCTCAAGTATAAAGGAGCTTATTATTCATCAGAAATACAAAAT
GTCAGAAGGCAGTTACGATATTGCCTTAATAAAGCTTCAGACACCGTTGAATTATACTGAATTC
CAAAAACCAATATGCCTGCCTTCCAAAGCTGACACAAATACAATTTATACCAACTGCTGGGTGA
CTGGATGGGGCTACACAAAGGAACGAGGTGAGACCCAAAATATTCTACAAAAGGCAACTATTCC
CTTGGTACCAAATGAAGAATGCCAGAAAAAATATAGAGATTATGTTATAACCAAGCAGATGATC
TGTGCTGGCTACAAAGAAGGTGGAATAGATGCTTGTAAGGGAGATTCCGGTGGCCCCTTAGTTT
GCAAACATAGTGGAAGGTGGCAGTTGGTGGGTATCACCAGCTGGGGCGAAGGCTGTGCCCGCAA
GGAGCAACCAGGAGTCTACACCAAAGTTGCTGAGTACATTGACTGGATATTGGAGAAGATACAG
AGCAGCAAGGAAAGAGCTCTGGAGACATCTCCAGCATGAGGAGGCTGGGTACTGATGGGGAAGA
GCCCAGCTGGCACCAGCTTTACCACCTGCCCTCAAGTCCTACTAGAGCTCCAGAGTTCTCTTCT
GCAAAATGTCGATAGTGGTGTCTACCTCGCATCCTTACCATAGGATTAAAAGTCCAAATGTAGA
CACAGTTGCTAAAGACAGCGCCATGCTCAAGCGTGCTTCCTGCCTTGAGCAACAGGAACGCCAA
TGAGAACTATCCAAAGATTACCAAGCCTGTTTGGAAATAAAATGGTCAAAGGATTTTTATTAGG
TAGTGAAATTAGGTAGTTGTCCTTGGAACCATTCTCATGTAACTGTTGACTCTGGACCTCAGCA
GATCACAGTTACCTTCTGTCCACTTCTGACATTTGTGTACTGGAACCTGATGCTGTTCTTCCAC
TTGGAGCAAAGAACTGAGAAACCTGGTTCTATCCATTGGGAAAAAGAGATCTTTGTAACATTTC
CTTTACAATAAAAAGATGTTCTACTTGGACTTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_036857	(Get FASTA)	NCBI Sequence Viewer
	XP_006253183	(Get FASTA)	NCBI Sequence Viewer
	XP_008769475	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41463	(Get FASTA)	NCBI Sequence Viewer
	AAA42069	(Get FASTA)	NCBI Sequence Viewer
	AAA74563	(Get FASTA)	NCBI Sequence Viewer
	AAH89815	(Get FASTA)	NCBI Sequence Viewer
	EDL78854	(Get FASTA)	NCBI Sequence Viewer
	EDL78855	(Get FASTA)	NCBI Sequence Viewer
	P14272	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_036857 ⟸ NM_012725
- Peptide Label:	precursor
- UniProtKB:	P14272 (UniProtKB/Swiss-Prot), Q5FVS2 (UniProtKB/TrEMBL), A6JPR7 (UniProtKB/TrEMBL), F7FQ32 (UniProtKB/TrEMBL)
- Sequence:	show sequence MILFKQVGYFVSLFATVSCGCLSQLYANTFFRGGDLAAIYTPDAQHCQKMCTFHPRCLLFSFLA VSPTKETDKRFGCFMKESITGTLPRIHRTGAISGHSLKQCGHQLSACHQDIYEGLDMRGSNFNI SKTDSIEECQKLCTNNIHCQFFTYATKAFHRPEYRKSCLLKRSSSGTPTSIKPVDNLVSGFSLK SCALSEIGCPMDIFQHFAFADLNVSHVVTPDAFVCRTVCTFHPNCLFFTFYTNEWETESQRNVC FLKTSKSGRPSPPIIQENAVSGYSLFTCRKARPEPCHFKIYSGVAFEGEELNATFVQGADACQE TCTKTIRCQFFTYSLLPQDCKAEGCKCSLRLSTDGSPTRITYEAQGSSGYSLRLCKVVESSDCT TKINARIVGGTNSSLGEWPWQVSLQVKLVSQNHMCGGSIIGRQWILTAAHCFDGIPYPDVWRIY GGILNLSEITNKTPFSSIKELIIHQKYKMSEGSYDIALIKLQTPLNYTEFQKPICLPSKADTNT IYTNCWVTGWGYTKERGETQNILQKATIPLVPNEECQKKYRDYVITKQMICAGYKEGGIDACKG DSGGPLVCKHSGRWQLVGITSWGEGCARKEQPGVYTKVAEYIDWILEKIQSSKERALETSPA hide sequence

RefSeq Acc Id:	XP_006253183 ⟸ XM_006253121
- Peptide Label:	isoform X1
- UniProtKB:	P14272 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MILFKQVGYFVSLFATVSCGCLSQLYANTFFRGGDLAAIYTPDAQHCQKMCTFHPRCLLFSFLA VSPTKETDKRFGCFMKESITGTLPRIHRTGAISGHSLKQCGHQLSACHQDIYEGLDMRGSNFNI SKTDSIEECQKLCTNNIHCQFFTYATKAFHRPEYRKSCLLKRSSSGTPTSIKPVDNLVSGFSLK SCALSEIDLNVSHVVTPDAFVCRTVCTFHPNCLFFTFYTNEWETESQRNVCFLKTSKSGRPSPP IIQENAVSGYSLFTCRKARPEPCHFKIYSGVAFEGEELNATFVQGADACQETCTKTIRCQFFTY SLLPQDCKAEGCKCSLRLSTDGSPTRITYEAQGSSGYSLRLCKVVESSDCTTKINARIVGGTNS SLGEWPWQVSLQVKLVSQNHMCGGSIIGRQWILTAAHCFDGIPYPDVWRIYGGILNLSEITNKT PFSSIKELIIHQKYKMSEGSYDIALIKLQTPLNYTEFQKPICLPSKADTNTIYTNCWVTGWGYT KERGETQNILQKATIPLVPNEECQKKYRDYVITKQMICAGYKEGGIDACKGDSGGPLVCKHSGR WQLVGITSWGEGCARKEQPGVYTKVAEYIDWILEKIQSSKERALETSPA hide sequence

RefSeq Acc Id:	XP_008769475 ⟸ XM_008771253
- Peptide Label:	isoform X2
- UniProtKB:	A6JPR8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKESITGTLPRIHRTGAISGHSLKQCGHQLSACHQDIYEGLDMRGSNFNISKTDSIEECQKLCT NNIHCQFFTYATKAFHRPEYRKSCLLKRSSSGTPTSIKPVDNLVSGFSLKSCALSEIGCPMDIF QHFAFADLNVSHVVTPDAFVCRTVCTFHPNCLFFTFYTNEWETESQRNVCFLKTSKSGRPSPPI IQENAVSGYSLFTCRKARPEPCHFKIYSGVAFEGEELNATFVQGADACQETCTKTIRCQFFTYS LLPQDCKAEGCKCSLRLSTDGSPTRITYEAQGSSGYSLRLCKVVESSDCTTKINARIVGGTNSS LGEWPWQVSLQVKLVSQNHMCGGSIIGRQWILTAAHCFDGIPYPDVWRIYGGILNLSEITNKTP FSSIKELIIHQKYKMSEGSYDIALIKLQTPLNYTEFQKPICLPSKADTNTIYTNCWVTGWGYTK ERGETQNILQKATIPLVPNEECQKKYRDYVITKQMICAGYKEGGIDACKGDSGGPLVCKHSGRW QLVGITSWGEGCARKEQPGVYTKVAEYIDWILEKIQSSKERALETSPA hide sequence

RefSeq Acc Id:

ENSRNOP00000019237 ⟸ ENSRNOT00000019237

Protein Domains

Apple Peptidase S1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P14272-F1-model_v2	AlphaFold	P14272	1-638	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:67382	AgrOrtholog
BioCyc Gene	G2FUF-11311	BioCyc
Ensembl Genes	ENSRNOG00000014118	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000019237	ENTREZGENE
	ENSRNOP00000019237.3	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019237	ENTREZGENE
	ENSRNOT00000019237.6	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Hepatocyte Growth Factor	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7369524	IMAGE-MGC_LOAD
InterPro	Apple	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pan_app	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_S1_PA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25048	UniProtKB/TrEMBL
MGC_CLONE	MGC:108748	IMAGE-MGC_LOAD
NCBI Gene	25048	ENTREZGENE
PANTHER	PLASMA KALLIKREIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRANSMEMBRANE PROTEASE SERINE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PAN_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Trypsin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Klkb1	PhenoGen
PRINTS	APPLEDOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CHYMOTRYPSIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	APPLE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	APPLE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC234460
UniProt	A6JPR7	ENTREZGENE, UniProtKB/TrEMBL
	A6JPR8	ENTREZGENE, UniProtKB/TrEMBL
	F7FQ32	ENTREZGENE, UniProtKB/TrEMBL
	KLKB1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5FVS2	ENTREZGENE
UniProt Secondary	Q5FVS2	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-26	Klkb1	kallikrein B1	Klkb1	kallikrein B, plasma 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-09-30	Klkb1				Symbol and Name status set to provisional	70820	PROVISIONAL
2005-07-20		kallikrein B, plasma 1	Klkb1		Name updated	1299863	APPROVED
2004-12-14	Klkb1		Klk3	kallikrein B, plasma 1	Data Merged	737654	APPROVED
2002-06-10	Klkb1				Symbol and Name status set to approved	70586	APPROVED
2002-06-10	Klk3	kallikrein B, plasma 1			Symbol and Name updated	70585	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_process	participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation, and inflammation

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)