Klkb1 (kallikrein B1) - Rat Genome Database

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Gene: Klkb1 (kallikrein B1) Rattus norvegicus
Analyze
Symbol: Klkb1
Name: kallikrein B1
RGD ID: 67382
Description: Predicted to enable serine-type endopeptidase activity. Involved in liver regeneration. Located in extracellular space. Used to study inflammatory bowel disease. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in lupus nephritis and systemic lupus erythematosus. Orthologous to human KLKB1 (kallikrein B1); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: fletcher factor; kallikrein B, plasma 1; Kalp1; KALP15; kininogenin; Klk3; MGC108748; PK; Plasma kallikrein; plasma prekallikrein; RATKALP15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21646,958,634 - 46,982,054 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1646,958,707 - 46,982,053 (+)Ensembl
Rnor_6.01650,151,127 - 50,175,407 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,152,008 - 50,175,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,874,943 - 49,898,364 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,248,935 - 50,272,279 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11650,248,906 - 50,272,347 (+)NCBI
Celera1644,949,240 - 44,972,564 (+)NCBICelera
Cytogenetic Map16q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
6-oxoprostaglandin F1alpha  (ISO)
acetamide  (EXP)
aconitine  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chlorohydrocarbon  (EXP)
chlorpromazine  (ISO)
chondroitin sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
flutamide  (EXP)
furan  (EXP)
gingerol  (ISO)
glucose  (ISO)
glutathione  (EXP)
iron trichloride  (ISO)
kojic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methylmercury chloride  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nimesulide  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
rose bengal  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
splitomicin  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular space  (IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Gene structure and chromosomal localization of plasma kallikrein. Beaubien G, etal., Biochemistry 1991 Feb 12;30(6):1628-35.
2. Plasma-kallikrein clearance during liver regeneration after partial hepatectomy in the rat. Braulio VB, etal., Liver. 1998 Dec;18(6):371-7.
3. Role of plasma kallikrein-kinin system activation in synovial recruitment of endothelial progenitor cells in experimental arthritis. Dai J, etal., Arthritis Rheum. 2012 Nov;64(11):3574-82. doi: 10.1002/art.34607.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Plasma prekallikrein: a risk marker for hypertension and nephropathy in type 1 diabetes. Jaffa AA, etal., Diabetes. 2003 May;52(5):1215-21.
7. PF-04886847 (an inhibitor of plasma kallikrein) attenuates inflammatory mediators and activation of blood coagulation in rat model of lipopolysaccharide (LPS)-induced sepsis. Kolte D, etal., Cardiovasc Hematol Agents Med Chem. 2012 Jun;10(2):154-66.
8. The fate of plasma kallikrein in normal and kininogen-deficient rats. Kouyoumdjian M and Damas J, Arch Physiol Biochem. 1998 Feb;106(1):25-32.
9. Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. Liu K, etal., J Clin Invest. 2009 Apr;119(4):911-23. doi: 10.1172/JCI36728.
10. Prolylcarboxypeptidase: a cardioprotective enzyme. Mallela J, etal., Int J Biochem Cell Biol. 2009 Mar;41(3):477-81. doi: 10.1016/j.biocel.2008.02.022. Epub 2008 Feb 29.
11. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
12. Hepatic clearance of tissue-type plasminogen activator and plasma kallikrein in experimental liver fibrosis. Nagaoka MR, etal., Liver Int. 2003 Dec;23(6):476-83.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. [Components of kallikrein-kinin system in the urine of patients with glomerulonephritis]. Paskhina TS, etal., Vopr Med Khim. 1990 Jul-Aug;36(4):62-9.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. The cDNA structure of rat plasma kallikrein. Seidah NG, etal., DNA 1989 Oct;8(8):563-74.
22. Selective plasma kallikrein inhibitor attenuates acute intestinal inflammation in Lewis rat. Stadnicki A, etal., Dig Dis Sci. 1996 May;41(5):912-20.
23. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:89876   PMID:1298973   PMID:12477932   PMID:17440623   PMID:23533145   PMID:34241810  


Genomics

Comparative Map Data
Klkb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21646,958,634 - 46,982,054 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1646,958,707 - 46,982,053 (+)Ensembl
Rnor_6.01650,151,127 - 50,175,407 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,152,008 - 50,175,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,874,943 - 49,898,364 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,248,935 - 50,272,279 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11650,248,906 - 50,272,347 (+)NCBI
Celera1644,949,240 - 44,972,564 (+)NCBICelera
Cytogenetic Map16q11NCBI
KLKB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384186,210,853 - 186,258,471 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4186,208,979 - 186,258,471 (+)EnsemblGRCh38hg38GRCh38
GRCh374187,148,661 - 187,179,625 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364187,385,666 - 187,416,619 (+)NCBINCBI36hg18NCBI36
Build 344187,523,820 - 187,554,773NCBI
Celera4184,471,184 - 184,503,982 (+)NCBI
Cytogenetic Map4q35.2NCBI
HuRef4182,900,717 - 182,930,974 (+)NCBIHuRef
CHM1_14187,125,087 - 187,156,065 (+)NCBICHM1_1
T2T-CHM13v2.04189,567,910 - 189,598,453 (+)NCBI
Klkb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39845,719,725 - 45,747,872 (-)NCBIGRCm39mm39
GRCm39 Ensembl845,719,726 - 45,747,896 (-)Ensembl
GRCm38845,266,688 - 45,294,835 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,266,689 - 45,294,859 (-)EnsemblGRCm38mm10GRCm38
MGSCv37846,354,796 - 46,380,189 (-)NCBIGRCm37mm9NCBIm37
MGSCv36846,768,488 - 46,807,283 (-)NCBImm8
Celera847,956,504 - 47,981,825 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map825.17NCBI
Klkb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540322,833,982 - 22,856,389 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540322,835,544 - 22,856,355 (-)NCBIChiLan1.0ChiLan1.0
KLKB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14190,604,901 - 190,636,300 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4190,604,901 - 190,636,300 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04178,398,359 - 178,429,448 (+)NCBIMhudiblu_PPA_v0panPan3
KLKB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11644,492,735 - 44,517,854 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1644,469,632 - 44,540,292 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1644,979,694 - 45,003,202 (-)NCBI
ROS_Cfam_1.01646,683,089 - 46,736,876 (-)NCBI
ROS_Cfam_1.0 Ensembl1646,706,236 - 46,730,702 (-)Ensembl
UMICH_Zoey_3.11644,675,226 - 44,698,533 (-)NCBI
UNSW_CanFamBas_1.01645,288,025 - 45,311,430 (-)NCBI
UU_Cfam_GSD_1.01645,418,960 - 45,442,647 (-)NCBI
Klkb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494334,872,449 - 34,882,567 (+)NCBI
SpeTri2.0NW_0049365543,227,395 - 3,256,710 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLKB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1547,071,556 - 47,103,624 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11547,071,581 - 47,100,272 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21553,912,808 - 53,941,527 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLKB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17132,143,514 - 132,173,189 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl7132,144,420 - 132,173,187 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037112,465,874 - 112,497,290 (+)NCBIVero_WHO_p1.0
Klkb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476917,067,342 - 17,087,408 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462476917,066,055 - 17,088,587 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D16Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21646,975,842 - 46,975,959 (+)MAPPERmRatBN7.2
Rnor_6.01650,169,198 - 50,169,312NCBIRnor6.0
Rnor_5.01649,892,155 - 49,892,269UniSTSRnor5.0
RGSC_v3.41650,266,069 - 50,266,184RGDRGSC3.4
RGSC_v3.41650,266,070 - 50,266,184UniSTSRGSC3.4
RGSC_v3.11650,266,144 - 50,266,259RGD
Celera1644,966,375 - 44,966,469UniSTS
RH 3.4 Map16461.1RGD
RH 3.4 Map16461.1UniSTS
Cytogenetic Map16q11UniSTS
D16Mgh5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21646,975,801 - 46,975,965 (+)MAPPERmRatBN7.2
Rnor_6.01650,169,157 - 50,169,318NCBIRnor6.0
Rnor_5.01649,892,114 - 49,892,275UniSTSRnor5.0
RGSC_v3.41650,266,028 - 50,266,190RGDRGSC3.4
RGSC_v3.41650,266,029 - 50,266,190UniSTSRGSC3.4
RGSC_v3.11650,266,103 - 50,266,265RGD
Celera1644,966,334 - 44,966,475UniSTS
Cytogenetic Map16q11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164302484250166018Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:173
Count of miRNA genes:122
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000019237
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 41 33 6 33 5 9
Low 1 9 14 6 11 6 8 9 17 21 6 8
Below cutoff 1 2 2 2 1 39 4 10

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019237   ⟹   ENSRNOP00000019237
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,958,707 - 46,982,053 (+)Ensembl
Rnor_6.0 Ensembl1650,152,008 - 50,175,458 (+)Ensembl
RefSeq Acc Id: NM_012725   ⟹   NP_036857
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21646,958,707 - 46,982,054 (+)NCBI
Rnor_6.01650,152,062 - 50,175,407 (+)NCBI
Rnor_5.01649,874,943 - 49,898,364 (+)NCBI
RGSC_v3.41650,248,935 - 50,272,279 (+)RGD
Celera1644,949,240 - 44,972,564 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253121   ⟹   XP_006253183
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21646,958,634 - 46,982,054 (+)NCBI
Rnor_6.01650,151,127 - 50,175,407 (+)NCBI
Rnor_5.01649,874,943 - 49,898,364 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771253   ⟹   XP_008769475
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21646,965,199 - 46,982,054 (+)NCBI
Rnor_6.01650,158,603 - 50,175,407 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036857   ⟸   NM_012725
- Peptide Label: precursor
- UniProtKB: Q5FVS2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253183   ⟸   XM_006253121
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008769475   ⟸   XM_008771253
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000019237   ⟸   ENSRNOT00000019237
Protein Domains
Apple   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14272-F1-model_v2 AlphaFold P14272 1-638 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700110
Promoter ID:EPDNEW_R10634
Type:initiation region
Name:Klkb1_1
Description:kallikrein B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01650,152,042 - 50,152,102EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
16 50158638 50158639 C A snv HXB2/IpcvMcwi (2019)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
16 49888842 49888843 G A snv HTX/Kyo (KyushuU), BUF/MNa (KyushuU)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
16 46965283 46965284 C A snv HXB2/IpcvMcwi (2019)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:67382 AgrOrtholog
BioCyc Gene G2FUF-11311 BioCyc
Ensembl Genes ENSRNOG00000014118 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019237 ENTREZGENE
  ENSRNOP00000019237.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019237 ENTREZGENE
  ENSRNOT00000019237.6 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7369524 IMAGE-MGC_LOAD
InterPro Apple UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pan_app UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25048 UniProtKB/TrEMBL
MGC_CLONE MGC:108748 IMAGE-MGC_LOAD
NCBI Gene 25048 ENTREZGENE
Pfam PAN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klkb1 PhenoGen
PRINTS APPLEDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE APPLE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART APPLE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC234460
UniProt KLKB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5FVS2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-26 Klkb1  kallikrein B1  Klkb1  kallikrein B, plasma 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 Klkb1        Symbol and Name status set to provisional 70820 PROVISIONAL
2005-07-20   kallikrein B, plasma 1  Klkb1    Name updated 1299863 APPROVED
2004-12-14 Klkb1    Klk3  kallikrein B, plasma 1  Data Merged 737654 APPROVED
2002-06-10 Klkb1        Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Klk3  kallikrein B, plasma 1      Symbol and Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation, and inflammation