Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Atp7b (ATPase copper transporting beta) Rattus norvegicus
Symbol: Atp7b
Name: ATPase copper transporting beta
RGD ID: 2180
Description: Exhibits copper ion binding activity; copper ion transmembrane transporter activity; and zinc ion binding activity. Involved in several processes, including cellular response to metal ion; copper ion export; and lactation. Localizes to several cellular components, including basolateral plasma membrane; bicellular tight junction; and trans-Golgi network. Predicted to colocalize with cytoplasmic vesicle. Used to study Wilson disease. Human ortholog(s) of this gene implicated in Wilson disease. Orthologous to human ATP7B (ATPase copper transporting beta); PARTICIPATES IN cisplatin drug pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATPase Cu++ transporting beta polypeptide (same as Wilson disease); ATPase, Cu++ transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease); copper pump 2; copper-transporting ATPase 2; Hts; PINA; PINA gene, promoter; pineal night-specific ATPase; Wd; wilson disease-associated protein homolog
Homo sapiens (human) : ATP7B (ATPase copper transporting beta)  HGNC  Alliance
Mus musculus (house mouse) : Atp7b (ATPase, Cu++ transporting, beta polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp7b (ATPase copper transporting beta)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP7B (ATPase copper transporting beta)
Canis lupus familiaris (dog) : ATP7B (ATPase copper transporting beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp7b (ATPase copper transporting beta)
Sus scrofa (pig) : ATP7B (ATPase copper transporting beta)
Chlorocebus sabaeus (African green monkey) : ATP7B (ATPase copper transporting beta)
Heterocephalus glaber (naked mole-rat) : Atp7b (ATPase copper transporting beta)
more info ...
Allele / Splice: Atp7bhts  
Genetic Models: LEC/Hok
Is Marker For: Strains:   LEC/Tj   WKAH.LEC-Atp7bhts/Tj  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01674,865,516 - 74,944,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,865,516 - 74,945,286 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01674,495,179 - 74,575,822 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,607,988 - 74,680,080 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11674,608,239 - 74,679,614 (+)NCBI
Celera1667,837,288 - 67,908,140 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
RH 3.4 Map16664.21RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Atp7b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2180
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.