Atp7b (ATPase copper transporting beta) - Rat Genome Database

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Gene: Atp7b (ATPase copper transporting beta) Chinchilla lanigera
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Symbol: Atp7b
Name: ATPase copper transporting beta
RGD ID: 8922156
Description: ENCODES a protein that exhibits ATP binding (ortholog); copper ion binding (ortholog); copper ion transmembrane transporter activity (ortholog); INVOLVED IN cellular response to copper ion (ortholog); cellular response to manganese ion (ortholog); circadian rhythm (ortholog); PARTICIPATES IN cisplatin drug pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Anhaptoglobinemia (ortholog); Animal Disease Models (ortholog); FOUND IN apical part of cell (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATPase, Cu++ transporting, beta polypeptide; copper-transporting ATPase 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554315,229,126 - 5,269,616 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554315,228,395 - 5,297,120 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Atp7b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554315,229,126 - 5,269,616 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554315,228,395 - 5,297,120 (-)NCBIChiLan1.0ChiLan1.0
ATP7B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381351,932,669 - 52,012,132 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1351,930,436 - 52,012,125 (-)EnsemblGRCh38hg38GRCh38
GRCh371352,506,805 - 52,586,268 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361351,404,806 - 51,483,631 (-)NCBINCBI36Build 36hg18NCBI36
Build 341351,404,805 - 51,483,631NCBI
Celera1333,555,444 - 33,634,269 (-)NCBICelera
Cytogenetic Map13q14.3NCBI
HuRef1333,295,317 - 33,374,147 (-)NCBIHuRef
CHM1_11352,473,433 - 52,553,190 (-)NCBICHM1_1
T2T-CHM13v2.01351,147,339 - 51,226,948 (-)NCBIT2T-CHM13v2.0
Atp7b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39822,482,799 - 22,550,347 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl822,482,801 - 22,550,321 (-)EnsemblGRCm39 Ensembl
GRCm38821,992,783 - 22,060,074 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl821,992,785 - 22,060,305 (-)EnsemblGRCm38mm10GRCm38
MGSCv37823,104,820 - 23,170,546 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36823,459,893 - 23,525,619 (-)NCBIMGSCv36mm8
Celera823,490,671 - 23,556,555 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map810.78NCBI
Atp7b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,654,725 - 76,726,092 (+)NCBIGRCr8
mRatBN7.21669,952,286 - 70,024,404 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,951,778 - 70,023,636 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1675,225,956 - 75,297,317 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,664,533 - 78,736,202 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,913,825 - 73,985,530 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,865,516 - 74,944,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,865,516 - 74,945,286 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01674,495,179 - 74,575,822 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,607,988 - 74,680,080 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11674,608,239 - 74,679,614 (+)NCBI
Celera1667,837,288 - 67,908,140 (+)NCBICelera
RH 3.4 Map16664.21RGD
Cytogenetic Map16q12.5NCBI
ATP7B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21453,366,970 - 53,447,808 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11352,012,774 - 52,091,309 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01333,063,698 - 33,144,528 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11351,808,491 - 51,888,488 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1351,810,555 - 51,851,839 (-)Ensemblpanpan1.1panPan2
ATP7B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.122162,474 - 225,599 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl22191,888 - 225,266 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha22227,530 - 260,908 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.022144,381 - 208,578 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl22163,718 - 208,552 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12295,838 - 129,431 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.022145,387 - 179,042 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.022163,429 - 197,022 (+)NCBIUU_Cfam_GSD_1.0
Atp7b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945161,210,231 - 161,278,988 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365654,694,281 - 4,763,773 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365654,694,294 - 4,763,661 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP7B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1115,876,612 - 15,942,064 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11115,892,549 - 15,942,070 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21116,218,277 - 16,263,614 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP7B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1329,817,712 - 29,899,302 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl329,816,860 - 29,899,077 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605713,915,907 - 13,997,411 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp7b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247482,113,094 - 2,205,856 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247482,112,574 - 2,183,994 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000007000   ⟹   ENSCLAP00000006888
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554315,229,126 - 5,269,616 (-)Ensembl
RefSeq Acc Id: XM_005387611   ⟹   XP_005387668
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554315,228,395 - 5,277,923 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005387612   ⟹   XP_005387669
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554315,229,126 - 5,297,120 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005387614   ⟹   XP_005387671
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554315,229,126 - 5,271,523 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005387668 (Get FASTA)   NCBI Sequence Viewer  
  XP_005387669 (Get FASTA)   NCBI Sequence Viewer  
  XP_005387671 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000006888
  ENSCLAP00000006888.1
RefSeq Acc Id: XP_005387669   ⟸   XM_005387612
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YL85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005387668   ⟸   XM_005387611
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YL85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005387671   ⟸   XM_005387614
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YL85 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000006888   ⟸   ENSCLAT00000007000
Protein Domains
HMA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000004851 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000007000 ENTREZGENE
  ENSCLAT00000007000.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.100 UniProtKB/TrEMBL
  3.40.1110.10 UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/TrEMBL
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/TrEMBL
InterPro ATPase_P-typ_cyto_dom_N UniProtKB/TrEMBL
  ATPase_P-typ_P_site UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom_sf UniProtKB/TrEMBL
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/TrEMBL
  HAD_sf UniProtKB/TrEMBL
  Heavy-metal-associated_CS UniProtKB/TrEMBL
  HMA_Cu_ion-bd UniProtKB/TrEMBL
  HMA_dom UniProtKB/TrEMBL
  HMA_dom_sf UniProtKB/TrEMBL
  P-typ_ATPase_IB UniProtKB/TrEMBL
  P_typ_ATPase UniProtKB/TrEMBL
  P_typ_ATPase_HD_dom UniProtKB/TrEMBL
NCBI Gene Atp7b ENTREZGENE
PANTHER ATP7, ISOFORM B UniProtKB/TrEMBL
  COPPER-TRANSPORTING ATPASE 2 UniProtKB/TrEMBL
Pfam E1-E2_ATPase UniProtKB/TrEMBL
  HMA UniProtKB/TrEMBL
  Hydrolase UniProtKB/TrEMBL
PRINTS CATATPASE UniProtKB/TrEMBL
  CUATPASEI UniProtKB/TrEMBL
PROSITE ATPASE_E1_E2 UniProtKB/TrEMBL
  HMA_1 UniProtKB/TrEMBL
  HMA_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF55008 UniProtKB/TrEMBL
  SSF56784 UniProtKB/TrEMBL
  SSF81653 UniProtKB/TrEMBL
  SSF81665 UniProtKB/TrEMBL
UniProt A0A8C2YL85 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Atp7b  ATPase copper transporting beta    ATPase, Cu++ transporting, beta polypeptide  Symbol and/or name change 5135510 APPROVED