RGD Reference Report - The LEC rat: a model for human hepatitis, liver cancer, and much more. - Rat Genome Database

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The LEC rat: a model for human hepatitis, liver cancer, and much more.

Authors: Mori, M  Hattori, A  Sawaki, M  Tsuzuki, N  Sawada, N  Oyamada, M  Sugawara, N  Enomoto, K 
Citation: Mori M, etal., Am J Pathol. 1994 Jan;144(1):200-4.
RGD ID: 15036817
Pubmed: PMID:8291609   (View Abstract at PubMed)
PMCID: PMC1887108   (View Article at PubMed Central)

The LEC rat is an inbred mutant strain with spontaneous hepatitis isolated from Long-Evans rats. Since approximately 40% of LEC rats die of fulminant hepatitis, the rat serves an animal model for studying the pathogenesis and treatment of human fulminant hepatitis. The remaining 60% of LEC rats survive and develop chronic (prolonged) hepatitis and subsequently develop liver cancer. Therefore, the LEC rat serves an important animal model for studying the significance of chronic hepatitis in the development of human liver cancer, which often develops in association with chronic hepatitis. The LEC rat can also be used as an animal model of Wilson's disease, since recent studies have disclosed high copper accumulation in the liver and low ceruloplasmin concentration in the serum of this mutant rat.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Atp7bRatincreased liver copper level  IAGP  RGD 
Atp7bhtsRatincreased liver copper level  IAGP  RGD 
LEC/HokRatincreased liver copper level  IAGP  RGD 
Objects Annotated

Genes (Rattus norvegicus)
Atp7b  (ATPase copper transporting beta)
Atp7bhts  (ATPase copper transporting beta; hepatitis)

Genes (Mus musculus)
Atp7b  (ATPase, copper transporting, beta polypeptide)

Genes (Homo sapiens)
ATP7B  (ATPase copper transporting beta)

Strains
LEC/Hok  (Long Evans Cinnamon)


Additional Information